The primary aim of this study is to test the effect of a pre-intubation oral application of chlorhexidine (CHX) on the development of ventilator-associated pneumonia (VAP) in a variety of mechanically ventilated, critically ill adults. Secondary aims are 1) to test the effect of a pre-intubation oral application of CHX on early endotracheal tube colonization in mechanically ventilated adults, and 2) to explore potential biomarkers of VAP development and resolution.
Public Health Relevance
Ventilator-associated pneumonia is a serious complication in mechanically ventilated critically ill patients. The intervention tested in this project (swabbing the mouth with chlorhexidine before the endotracheal tube is inserted) could reduce the risk of ventilator-associated pneumonia.