Grants

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Transforming Healthcare Transforming Lives:
Creating the Nursing Leaders of Tomorrow and the Research that Improves Health

Genomic Instability: Oncogenic Mechanisms of HPV Oncoproteins

Robert Wood Johnson Foundation
11/15/2011 - 11/14/2013

Cumulative Award:
$243,223

Elizabeth Kostas-Polston

Abstract

The purpose of this controlled experimental design cell culture model study is to measure the transforming activities of Human Papillomavirus (HPV) 16 E7 & E6. In vitro transformation will be conducted while transfecting HPV 16 E7 & E6 oncogenes into primary, baby mouse kidney (BMK) cells. Primary, BMK cells will then be co-transfected with HPV 14 & 21 E6 proteins to determine the effect on the oncogenic activities of HPV 16 oncogenes.

Public Health Relevance

These laboratory experiments should lead to important insights into strategies that may be used to inhibit the oncogenic activity of HR HPVs.