General Surgery Residency

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Research

Throughout the course of training, there are numerous opportunities for mentored clinical and basic science projects. About a third of our residents elect to spend a dedicated two years in research, although this is not required. Recent such endeavors include:

  • Surgical Oncology, Moffitt Cancer Center
  • Surgical Oncology, National Cancer Institute
  • Wound Healing, James A. Haley VA Hospital
  • Tissue Morphogenesis, Brigham and Women’s Hospital

All residents are supported in endeavors to present/publish research. Current topics of interest within our department may be found at: http://health.usf.edu/medicine/surgery/research/index.htm

Recent resident publications include:

Book Chapters

  • Cox J, Toomey P, Tummel E, Gabordi R, Cox CE. “Ablative Therapies in Benign and Malignant Disease”. In: Cameron J, Cameron A, eds. Current Surgical Therapy: Expert Consult. 11th ed. Philadelphia, PA: Saunders (ELSEVIER); 2014: 587-591.
  • Campbell M, Sanchez J, Rasheid S, Tummel E, Velanovich V. “Pre-procedural Considerations”. In: Principles of Flexible Endoscopy. Springer Business Media, 2013.
  • Tummel E, Galwankar S. “Thrombosis”. In: Textbook of Emergency Medicine. David S, ed. Lippincott, Williams and Wilkins, 2012.
  • Tummel E, Galwankar S. “Embolism”. In: Textbook of Emergency Medicine. David S, ed. Lippincott, Williams and Wilkins, 2012.
  • Fernandez A, Toloza E. “Gene Therapy for Lung Cancer”. In: Cardiothoracic Surgery Review. Franco K, Thourani V, eds. Lippincott, Williams and Wilkins, 2012.
  • Mullinax J, Langan R, Raiji M, Avital I. “The Role of RNA-interference in Targeting the Cancer Stem Cell and Clinical Trials for Cancer”. In: Regulatory RNAs: Basics, Methods, and Applications. Mallick B and Ghosh Z, eds. Springer-Verlag, 2012.
  • Mullinax J, Hernandez J, Barry L, Rosemurgy A. “How Busy Clinicians Can Write Scholarly Papers”. In: Writing: Processes, Tools, and Techniques. Martens N, ed. Nova Science Publishing, 2010.

Peer-Reviewed Journals

  • Hernandez J, Dimou F, Weber J, Khaldoun A, Hoffe S, Shridhar R, Karl R, Meredith K. Defining the Learning Curve for Robotic-assisted Esophagogastrectomy. J Gastrointest Surg. 2013
  • Toomey, Golkar, Hernandez, Luberice, Clark, Donn, Marcadis, Vice, Okpaleke, Alsina, Rosemurgy. Outcomes after transjugular portosystemic stent shunt: a “bridge” to nowhere. Am J Surg. 2013; 205: 441-446.
  • Toomey P, Vohra N, Ghansah T, Sarnaik A, Pilon-Thomas S. Immunotherapy for gastrointestinal malignancies. Cancer Control. 2013; 20:32-42.
  • Clark W, Paidas C, Germain D, Guidi C, Pinka H, Kayton M. Delayed presentation of complete pancreatic ductal transection in children: management of two cases without resection. Pediatr Surg Int. 2013; 29:401-405.
  • Langan RC, Gill F, Raiji MT, Mullinax JE, Pittaluga S, Pandalai P, Davis J, Perkins K, Avital I, Rudloff U. Autoimmune Pancreatitis in the Autoimmune Lymphoproliferative Syndrome (ALPS): A Sheep in Wolves' Clothing? Pancreas. 2013; 42:363-366.
  • Toomey P, Hernandez J, Golkar F, Ross S, Luberice K, Rosemurgy A. Pancreatic Adenocarcinoma: Complete Tumor Extirpation Improves Survival Benefit Despite Larger Tumors for Patients Who Undergo Distal Pancreatectomy and Splenectomy. J Gastrointest Surg. 2012; 16:376-81.
  • Langan RC, Mullinax J, Ray S, Raiji MT, Schaub N, Xin HW, Koizumi T, Steinberg SM, Anderson A, Wiegand G, Butcher D, Anver M, Bilchik AJ, Stojadinovic A, Rudloff U, Avital I. A Pilot Study Assessing the Potential Role of non-CD133 Colorectal Cancer Stem Cells as Biomarkers. J Cancer. 2012;3:231-40.
  • Mathur A, Steffensen TS, Paidas CN, Ogera P, Kayton ML. The perforated appendiceal carcinoid in children: a surgical dilemma. J Pediatr Surg. 2012; 47:1155-8.
  • Rosemurgy A, Luberice K, Paul H, Co F, Vice M, Toomey P, Choung E, Ross S. Readmissions After Pancreaticoduodenectomy: Efforts Need to Focus on Patient Expectations and Nonhospital Medical Care. Am Surg. 2012;78:837-43.
  • Chen, Hernandez, McCarthy, Humphries, Clark, Gruidl, Coppola, Shibata, Yeatman. Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic Adenocarcinoma. J Gastrointest Surg. 2012; 16:905-912.
  • Hernandez J, Hemphries L, Keeling W, Golkar F, Dimou F, Garrett J, Sommers K. Robotic Lobectomy: Flattening the Learning Curve. Journal of Robotic Surgery. 2012; 6:41-45.
  • Ray S, Langan RC, Mullinax J, Koizumi T, Xin H, Wiegand GW, Anderson A, Stojadinovic A, Thorgeirsson S, Rudloff U, Avital I. Establishment of Human Ultra-Low Passage Colorectal Cancer Cell Lines Using Spheroids from Fresh Surgical Specimens Suitable for In Vitro and In Vivo Studies. J of Cancer. 2012; 3:196-206.
  • Clark W, Silva M, Donn N, Luberice K, Humphries LA, Paul H, Hernandez J, Rosemurgy A. Targeting Early Deaths Following Pancreaticoduodenectomy to Improve Survival. J Gastrointest Surg. 2012; 10:1869-74.
  • Mullinax J, Hernandez J, Toomey P, Villadolid D, Bowers C, Cooper J, Rosemurgy A Survival After Pancreatectomy For Pancreatic Adenocarcinoma is Not Impacted By Performance Status. Am J Surg. 2012; 204:704-8.
  • Xin H, Hari D, Mullinax J, Ambe C, Koizumi T, Ray S, Anderson A, Wiegand G, Garfield S, Thorgeirsson S, Avital I. Tumor Initiating Label-Retaining-Cells In Human Gastrointestinal Cancers Undergo Asymmetric Cell Division. Stem Cells. 2012; 30:591-8.
  • Prowler VL, Hernandez JM, Sommers KE. Colonic hiatal herniation following transhiatal esophagogastrectomy. Am Surgeon. 2012; 78:E340-1.
  • Clark W, Golkar F, Luberice K, Toomey P, Paul H, Marcadis A, Okpaleke C, Vice M, Hernandez J, Alsina A, Rosemurgy AS. Uncovering the truth about covered stents: is there a difference between covered versus uncovered stents with transjugular intrahepatic portosystemic shunts? Am J Surg. 2011.
  • Wiegand G, Xin H, Anderson A, Mullinax J, Jaiswal K, Wiegand A, Avital I. Cellular Spectroscopy: Applications to Cancer Stem Cell Characterization. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7902, art. no. 79021G 2011.
  • Mullinax J, Zager J, Gonzalez R. Current Diagnosis and Management of Retroperitoneal Sarcoma: A Systematic Review of the Literature. Cancer Control. 2011; 18:177-87.
  • Mullinax J, Allins A, Avital I. Laparoscopic Management of Amyand’s Hernia: A Modern Approach to A Historic Diagnosis. J Gastrointest Surg. 2011; 15:533-535.
  • Mathur A, Hernandez J, Shaheen F, Shroff M, Dahal S, Morton C, Farrior T, Kedar R, Rosemurgy A. Preoperative computed tomography measurements of pancreatic steatosis and visceral fat: prognostic markers for dissemination and lethality of pancreatic adenocarcinoma. HPB. 2011;13:404-10.
  • Zenilman ME, Chow WB, Ko CY, Ibrahim AM, Makary MA, Lagoo-Deenadayalan S, Dardik A, Boyd CA, Riall TS, Sosa JA, Tummel E, Gould LJ, Segev DL, Berger JC. New Developments in Geriatric Surgery. Curr Probl Surg. 2011; 48:670-754.
  • Tummel E, Gould, L. The Effects of Aging on Mitochondrial Manganese Superoxide Dismutase Expression in Ischemic Rat Skin. J Surgical Research. 2011.
  • Tummel E, Moor A, Gould L. The Effects of Hyperbaric Oxygen Therapy on Mitochondrial Manganese Superoxide Dismutase Expression in Ischemic Rat Skin. Plastic & Reconstructive Surgery. 2010.
  • Clark W, Hernandez J, McKeon BA, Villadolid D, Al-Saadi S, Mullinax J, Ross S, Rosemurgy A. Surgical Shunting versus Transjugular Intrahepatic Portasystemic Shunting for Bleeding Varices Resulting from Portal Hypertension anti Cirrhosis: A Meta-Analysis. Am Surgeon. 2010: 76:857-864.
  • Clark W, Hernandez J, McKeon BA, Kahn A, Morton C, Toomey P, Mullinax J, Ross S, Rosemurgy A. Surgery residency training programmes have greater impact on outcomes after pancreaticoduodenectomy than hospital volume or surgeon frequency. HPB (Oxford). 2010; 12:68-72.
  • Toomey P, Ross S, Albrink M, Rosemurgy A. Increasing the Relevance of Laparoendoscopic Single-site Surgery. Asian J of Endo Surg. 2010; 3:60–65.
  • Toomey P, Hernandez J, Morton C, Duce L, Farrior T, Villadolid D, Ross S, Rosemurgy A. Resection of portovenous structures to obtain microscopically negative margins during pancreaticoduodenectomy for pancreatic adenocarcinoma is worthwhile. Am Surg. 2009; 75:804-10.
  • Hernandez J, Mullinax J, Clark W, Toomey P, Villadolid D, Morton C, Ross S, Rosemurgy A. Survival After Pancreaticoduodenectomy is not improved by extending resections to achieve negative margins. Ann Surg. 2009; 250:76-80.
  • Hernandez J, Morton C, Clark W, Mullinax J, Mathur A, Marcadis A, Babel N, Ross S, Goldin S, Rosemurgy A. Pancreaticoduodenectomy for suspected periampullary cancers: the mimes of malignancy. HPB (Oxford). 2009; 11:578-84.
  • Zyromski NJ, Mathur A, Pitt HA, Wade TE, Wang S, Nakshatri P, Swartz-Basile DA, Nakshatri H. Obesity potentiates the growth and dissemination of pancreatic cancer. Surgery. 2009; 146:258-63.
  • Mathur A, Zyromski NJ, Pitt HA, Al-Azzawi H, Walker JJ, Saxena R, Lillemoe KD. Pancreatic steatosis promotes dissemination and lethality of pancreatic cancer. JACS. 2009; 208:989-94.
  • Zyromski NJ, Mathur A, Gowda GA, Murphy C, Swartz-Basile DA, Wade TE, Pitt HA, Raftery D. Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology. Pancreatology. 2009;9:410-9.
  • Zyromski NJ, Mathur A, Pitt HA, Wade TE, Wang S, Swartz-Basile DA, Prather AD, Lillemoe KD. Cannabinoid receptor-1 blockade attenuates acute pancreatitis in obesity by an adiponectin mediated mechanism. J Gastrointest Surg. 2009; 13:831-8.
  • Evans KA, Clark CW, Vogel SB, Behrns KE. Surgical Management of Failed Endoscopic Treatment of Pancreatic Disease. J Gastrointest Surg. 2008; 12:1924-9.
  • Mathur A, Sandrasegaran K, Zyromski NJ, Marine MB, Sherman S, Lehman GA, Pitt, HA. Fatty Pancreas- A Risk Factor for the Development of SOD-Pancreatitis. Gastro Endoscopy. 2008; 67:AB328.
  • Mathur A, Zyromski N, Wade T, Wang S, Swartz-Basile D, Pitt H. Ezetimibe ameliorates pancreatic steatosis: At what cost? Pancreas. 2008; 37:484.
  • Hernandez J, Cowgill S, Al-Saadi S, Villadolid D, Ross S, Kraemer E, Shapiro M, Mullinax J, Cooper J, Goldin S, Zervos E, Rosemurgy A. Aggressive Approach to Extrahepatic Cholangiocarcinomas Warranted Because Margin Status and Stage Do Not Impact Survival After Resection. Ann Surg Oncol. 2008; 15:807-14.
  • Zyromski NJ, Mathur A, Pitt HA, Lu D, Gripe JT, Walker JJ, Yancey K, Wade TE, Swartz-Basile DA. A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2008; 295:G552-8.
  • Mathur A, Yancey KW, Lu D, Swartz-Basile DA, Lillemoe KD, Pitt HA, Zyromski NJ. Leptin resistance results in increased accumulation of toxic pancreatic fat. Pancreas. 2007; 35:415.
  • Al-Azzawi HH, Mathur A, Lu D, Swartz-Basile DA, Nakeeb A, Pitt HA. Resistin-Like Molecule Alpha Reduces Gallbladder Optimal Tension. J Gastrointest Surg. 2007; 11:95-100.
  • Al-Azzawi HH, Mathur A, Lu D, Swartz-Basile DA, Nakeeb A, Pitt HA. Pioglitazone Increases Gallbladder Volume in Insulin-Resistant Obese Mice. J Surg Res. 2006; 136:192-7.
  • Swartz-Basile DA, Lu D, Basile DP, Graewin SJ, Al-Azzawi H, Kiely JM, Mathur A, Yancey K, Pitt HA.Leptin regulates gallbladder genes related to absorption and secretion. Am J Physiol Gastrointest Liver Physiol. 2007; 293:G84-90.
  • Mathur A, Al-Azzawi HH, Lu D, Yancey KW, Swartz-Basile DA, Nakeeb A, Pitt HA. Steatocholecystitis: The Influence of Obesity and Dietary Carbohydrates. J Surg Res. 2007.
  • Mathur A, Walker JJ, Al-Azzawi HH, Lu D, Swartz-Basile A D, Nakeeb A, Pitt HA. Ezetimibe Ameliorates Cholecystosteatosis. Surgery. 2007; 142:228-33.
  • Mathur A, Marine M, Lu D, Swartz-Basile DA, Saxena R, Zyromski NJ, Pitt HA. Nonalcoholic Fatty Pancreas Disease. HPB. 2007; 9:312-318.
  • Mathur A, Pitt HA, Marine M, Saxena R, C. Max Schmidt, Howard TJ, Nakeeb A, Zyromski NZ, Lillemoe KD. Fatty Pancreas: A Factor in Postoperative Pancreatic Fistula. Ann Surgery. 2007; 246:1058-64.
  • Mathur A, Megan M, Al-Azzawi HH, Lu D, Swartz-Basile DA, Nakeeb A, Pitt HA. High Dietary Carbohydrates decrease gallbladder volume and enhance cholesterol crystal formation. Surgery. 2007; 141:654-9.
  • Cowgill S, Thometz D, Clark W, Villadolid D, Carey E, Pinkas D, Zervos E, Rosemurgy A. Conventional Predictors of Survival Poorly Predict and Significantly Under Predict Survival after H-graft Portacaval Shunts. J Gastrointest Surg. 2007; 11:89-94.
  • Rosemurgy A, Clark W, Carey E, Thometz D, Villadolid D, Pinkas D, Rakita S, Zervos E. Survival and Variceal Rehemorrhage after Shunting Support Small Diameter Prosthetic H-graft Portacaval Shunt. J Gastrointest Surg. 2007; 11:325-32.