Gabriel A. De Erausquin, MD, PhD, MSc

Endowed Chair, College Of Medicine Psychiatry And Behavioral Neurosciences

Professor, College Of Medicine Neurology

Professor, College Of Medicine Psychiatry And Behavioral Neurosciences

Director, Center for Neuromodulation, Psychiatry and Behavioral Neurosciences, USF

Director, Roskamp Laboratory of Brain Development, Modulation and Repair, Psychiatry and Behavioral Neurosciences, USF

Contact Info 3515 E Fletcher Ave
MDC14
Tampa, FL 33613

Academic Email: gdeeraus@health.usf.edu

Academic Phone: (813) 974-6570

Education

  • M.Sc., Genetic Epidemiology, Washington University School of Medicine, 2008
  • PhD, Behavioral Pharmacology, Universidad De Buenos Aires*, 1990
  • Ph.D., Behavioral Pharmacology, Universidad de Buenos Aires, 1990
  • MD, Medicine, Universidad De Buenos Aires*, 1986
  • M.D., Medicine, Universidad de Buenos Aires, 1986

Interdisciplinary and Emerging Signature Programs

  • Biomedical Engineering & Nanomedicine
  • Neuroscience

Research Interests

  • 1. Studies on the pathophysiology of schizophrenia during brain development. These include studies in mouse models and in neuronal lines derived from patient's skin via reprogramming, to address the specific influence of genetic variations on the susceptibility of neurons to negative environmental events.
  • 2. Development of a strategy for primary prevention of schizophrenia based on a combination of phenomics (based on a specific pathophysiology) and genomics using machine learning and optimization research.
  • 3. Personalization of patient selection for neuromodulation techniques based on predictive maps derived from unbiased search of the variable space and optimization research.
  • 4. Optimized prediction of outcomes in treatment refractory depression treated with neuromodulation techniqes.

Memberships

  • Movement Disorders Society (Member, 2004 - Present)
  • American College of Psychiatrists (Member, 2003 - Present)
  • Society for Neurosciences (Member, 1991 - Present)

Recent Publications

  • de Erausquin, GA. [Mechanism of molecular action of neuroleptics]. Vertex (Buenos Aires, Argentina). 14(51) : 36-44http://www.ncbi.nlm.nih.gov/pubmed/12690408
  • Zorumski, CF.de Erausquin, G.Dokucu, M.Svrakic, D.Garcia, K.Jarvis, M. Brain stimulation & the treatment of refractory psychiatric disorders. Missouri medicine. 105(1) : 57-61http://www.ncbi.nlm.nih.gov/pubmed/18300607
  • De Erausquin, GA. [Neurodevelopment and schizophrenia]. Vertex (Buenos Aires, Argentina). 13(49) : 189-97http://www.ncbi.nlm.nih.gov/pubmed/12404020
  • Landreau, F.Galeano, P.Caltana, LR.Masciotra, L.Chertcoff, A.Pontoriero, A.Baumeister, E.Amoroso, M.Brusco, HA.Tous, MI.Savy, VL.Lores Arnaiz, Mdel R.de Erausquin, GA. Effects of two commonly found strains of influenza a virus on developing dopaminergic neurons, in relation to the pathophysiology of schizophrenia. PloS one. 7(12) : e51068, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23251423
  • O'Leary, JC.Dharia, S.Blair, LJ.Brady, S.Johnson, AG.Peters, M.Cheung-Flynn, J.Cox, MB.de Erausquin, G.Weeber, EJ.Jinwal, UK.Dickey, CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PloS one. 6(9) : e24840, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21935478
  • Anastasía, A.Wojnacki, J.de Erausquin, GA.Mascó, DH. Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson's disease. Neuroscience. 195: 100-11, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21871541
  • Ladaga, GJ.Lezica, FP.Barboni, AM.Picos, JA.de Erausquin, GA. Pharmacokinetics of a single oral administration of cefalexin in mares and foals. The Veterinary record. 168(16) : 431a, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21498439
  • Benítez, BA.Belálcazar, HM.Anastasía, A.Mamah, DT.Zorumski, CF.Mascó, DH.Herrera, DG.de Erausquin, GA. Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons. Neuropharmacology. 60(7-8) : 1176-86, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21044638
  • Lezica, FP.Filip, R.Gorzalczany, S.Ferraro, G.de Erausquin, GA.Rivas, C.Ladaga, GJ. Prevalence of ergot derivatives in natural ryegrass pastures: detection and pathogenicity in the horse. Theriogenology. 71(3) : 422-31, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18823653
  • Anastasía, A.Torre, L.de Erausquin, GA.Mascó, DH. Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson's disease. Journal of neurochemistry. 109(3) : 755-65, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19245661
  • Alemán, GG.de Erausquin, GA.Micheli, F. Cognitive disturbances in primary blepharospasm. Movement disorders : official journal of the Movement Disorder Society. 24(14) : 2112-20, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19705473
  • Ladaga, GJ.Lezica, FP.Ferraro, G.De Erausquin, GA. Some pharmacodynamic effects of eformoterol in the horse. Journal of veterinary pharmacology and therapeutics. 30(5) : 496-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17803747
  • Mamah, D.Wang, L.Barch, D.de Erausquin, GA.Gado, M.Csernansky, JG. Structural analysis of the basal ganglia in schizophrenia. Schizophrenia research. 89(1-3) : 59-71, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17071057
  • Tabbal, SD.Revilla, FJ.Mink, JW.Schneider-Gibson, P.Wernle, AR.de Erausquin, GA.Perlmutter, JS.Rich, KM.Dowling, JL. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease. Neurosurgery. 61(3 Suppl) : 119-27; discussion 127-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17876242
  • Anastasia, A.de Erausquin, GA.Wojnacki, J.Mascó, DH. Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease. Journal of neurochemistry. 103(4) : 1542-52, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17854351
  • Dorsey, DA.Mascó, DH.Dikranian, K.Hyrc, K.Masciotra, L.Faddis, B.Soriano, M.Gru, AA.Goldberg, MP.de Erausquin, GA. Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons. Apoptosis : an international journal on programmed cell death. 11(4) : 535-44, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16532276
  • Calvó de Padilla, M.Padilla, E.González Alemán, G.Bourdieu, M.Guerrero, G.Strejilevich, S.Escobar, JI.Svrakic, N.Cloninger, CR.de Erausquin, GA. Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina. Schizophrenia research. 83(2-3) : 299-302, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16480854
  • Gonzalez Aleman, G.Florenzano, N.Padilla, E.Bourdieu, M.Guerrero, G.Calvó, M.Alberio, G.Strejilevich, S.de Erausquin, GA. A 37-year-old woman with celiac disease, recurrent psychosis, and Parkinsonism. Movement disorders : official journal of the Movement Disorder Society. 21(5) : 729-31, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16547920
  • Strejilevich, SA.Palatnik, A.Avila, R.Bustin, J.Cassone, J.Figueroa, S.Gimenez, M.de Erausquin, GA. Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics. Psychiatry research. 133(2-3) : 277-80, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15741003
  • Moulder, KL.Meeks, JP.Shute, AA.Hamilton, CK.de Erausquin, G.Mennerick, S. Plastic elimination of functional glutamate release sites by depolarization. Neuron. 42(3) : 423-35, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15134639
  • Zhang, PL.Santos, JM.Newcomer, J.Pelfrey, BA.Johnson, MC.de Erausquin, GA. Impact of atypical antipsychotics on quality of life, self-report of symptom severity, and demand of services in chronically psychotic patients. Schizophrenia research. 71(1) : 137-44, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15374581
  • Yamada, KA.Rensing, N.Izumi, Y.De Erausquin, GA.Gazit, V.Dorsey, DA.Herrera, DG. Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation. Pediatric research. 55(3) : 372-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14681492
  • de Erausquin, GA. Transactivation of cell death signals by glutamate transmission in dopaminergic neurons. Critical reviews in neurobiology. 16(1-2) : 107-19, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15581406
  • de Erausquin, GA.Hyrc, K.Dorsey, DA.Mamah, D.Dokucu, M.Mascó, DH.Walton, T.Dikranian, K.Soriano, M.García Verdugo, JM.Goldberg, MP.Dugan, LL. Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons. Molecular pharmacology. 63(4) : 784-90, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12644578
  • Abi-Dargham, A.Laruelle, M.Krystal, J.D'Souza, C.Zoghbi, S.Baldwin, RM.Seibyl, J.Mawlawi, O.de Erasquin, G.Charney, D.Innis, RB. No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 20(6) : 650-61, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10327433
  • Bremner, JD.Bronen, RA.De Erasquin, G.Vermetten, E.Staib, LH.Ng, CK.Soufer, R.Charney, DS.Innis, RB. Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography. Clinical positron imaging : official journal of the Institute for Clinical P.E.T. 1(3) : 145-159, 1998. http://www.ncbi.nlm.nih.gov/pubmed/14516589
  • Abi-Dargham, A.Gandelman, MS.DeErausquin, GA.Zea-Ponce, Y.Zoghbi, SS.Baldwin, RM.Laruelle, M.Charney, DS.Hoffer, PB.Neumeyer, JL.Innis, RB. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37(7) : 1129-33, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8965183
  • Isaacs, KR.de Erausquin, G.Strauss, KI.Jacobowitz, DM.Hanbauer, I. Differential effects of excitatory amino acids on mesencephalic neurons expressing either calretinin or tyrosine hydroxylase in primary cultures. Brain research. Molecular brain research. 36(1) : 114-26, 1996. http://www.ncbi.nlm.nih.gov/pubmed/9011746
  • de Erausquin, G.Brooker, G.Costa, E.Hanbauer, I. Persistent AMPA receptor stimulation alters [Ca2+]i homeostasis in cultures of embryonic dopaminergic neurons. Brain research. Molecular brain research. 21(3-4) : 303-11, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7513376
  • De Erausquin, GA.Costa, E.Hanbauer, I. Calcium homeostasis, free radical formation, and trophic factor dependence mechanisms in Parkinson's disease. Pharmacological reviews. 46(4) : 467-82, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7899474
  • Fohrman, EB.de Erausquin, G.Costa, E.Wojcik, WJ. Muscarinic m3 receptors and dynamics of intracellular Ca2+ cerebellar granule neurons. European journal of pharmacology. 245(3) : 263-71, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8101492
  • Apud, JA.Grayson, DR.De Erausquin, E.Costa, E. Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat. Neuropharmacology. 31(1) : 1-8, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1311807
  • De Erausquin, G.Brooker, G.Costa, E.Wojcik, WJ. Stimulation of high affinity gamma-aminobutyric acidB receptors potentiates the depolarization-induced increase of intraneuronal ionized calcium content in cerebellar granule neurons. Molecular pharmacology. 42(3) : 407-14, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1328842
  • de Erausquin, G.Brooker, G.Hanbauer, I. K(+)-evoked dopamine release depends on a cytosolic Ca2+ pool regulated by N-type Ca2+ channels. Neuroscience letters. 145(2) : 121-5, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1334537
  • Faiman, CP.de Erausquin, GA.Baratti, CM. Modulation of memory retrieval by pre-testing vasopressin: involvement of a central cholinergic nicotinic mechanism. Methods and findings in experimental and clinical pharmacology. 14(8) : 607-13, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1494301
  • Faiman, CP.de Erausquin, GA.Baratti, CM. The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms. Behavioral and neural biology. 56(2) : 183-99, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1759940
  • Manev, H.Bertolino, M.DeErausquin, G. Amiloride blocks glutamate-operated cationic channels and protects neurons in culture from glutamate-induced death. Neuropharmacology. 29(12) : 1103-10, 1990. http://www.ncbi.nlm.nih.gov/pubmed/1963475
  • Favaron, M.Manev, H.Siman, R.Bertolino, M.Szekely, AM.DeErausquin, G.Guidotti, A.Costa, E. Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death. Proceedings of the National Academy of Sciences of the United States of America. 87(5) : 1983-7, 1990. http://www.ncbi.nlm.nih.gov/pubmed/1689850
  • Manev, H.Favaron, M.De Erausquin, G.Guidotti, A.Brooker, G.Costa, E. Destabilization of ionized Ca2+ homeostasis in excitatory amino acid neurotoxicity: antagonism by glycosphingolipids. Cell biology international reports. 14(1) : 3-14, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2185894
  • Baratti, CM.de Erausquin, GA.Faiman, CP. Brain opioid peptides may participate in the reversal of pentylenetetrazol-induced amnesia. Methods and findings in experimental and clinical pharmacology. 12(7) : 451-6, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2087144
  • de Erausquin, GA.Manev, H.Guidotti, A.Costa, E.Brooker, G. Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America. 87(20) : 8017-21, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2236016
  • de Erausquin, GA.Pitra, JC.Rey, RB.Faiman, CP.Baratti, CM. A novel non-invasive method to measure skin potential response: some pharmacological evidence. Methods and findings in experimental and clinical pharmacology. 11(12) : 765-70, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2626083
  • Baratti, CM.Faiman, CP.de Erausquin, GA. Facilitation of inhibitory avoidance by hypertonic saline is reversed by a vasopressin and a nicotinic antagonist. Behavioral and neural biology. 51(3) : 424-35, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2525022
  • Faiman, CP.de Erausquin, GA.Baratti, CM. Vasopressin modulates the activity of nicotinic cholinergic mechanisms during memory retrieval in mice. Behavioral and neural biology. 50(1) : 112-9, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2900001
  • Faiman, CP.De Erausquin, GA.Baratti, CM. Mecamylamine prevents the enhancement of retention induced by lysine vasopressin in mice. Behavioral and neural biology. 48(3) : 434-9, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3689289

Awards/Honors

  • Klerman Award in Clinical Psychiatry (NARSAD - 2008)
  • Young Faculty Award (National Parkinson Foundation - 1998)
  • S Weir Mitchell Award (American Academy of Neurology - 1997)
  • APA Dista Resident Research Award in Psychiatry (American Psychiatric Association - 1993)