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Gabriel De Erausquin, MD, PhD, MSc

Endowed Chair, College Of Medicine Psychiatry And Behavioral Neurosciences

Assoc Professor, College Of Medicine Neurology

Assoc Professor, College Of Medicine Psychiatry And Behavioral Neurosciences

Director, Roskamp Laboratory of Brain Development, Modulation and Repair, Psychiatry and Behavioral Neurosciences, USF

Director, Center for Neuromodulation, Psychiatry and Behavioral Neurosciences, USF

Education

  • Fellowship, DBS in Movement Disorders, Washington University, 2003
  • Residency, Neurology, Washington University, 1998
  • Residency, Psychiatry, Yale University School of Medicine, 1995
  • Internship, Transitional Internship, Hospital of Saint Raphael, 1992
  • Medical School, Universidad De Buenos Aires, 1986
  • Graduate, Universidad De Buenos Aires, 1993
  • MD, Universidad De Buenos Aires, 1986

Biography

I am studying the mechanism of susceptibility to environmental and genetic changes during development of mesencephalic neurons. I am convinced that this type of research will yield insights that will permit us to design strategies to prevent the devastating symptoms of psychosis. The Surgeon General's Report on Mental Health 1999 states that ANDquot;the burden of mental illness on health and productivity ... has long been profoundly underestimated. Data developed by the massive Global Burden of Disease study ... reveal that mental illness, including suicide, ranks second in the burden of disease in established market economiesANDquot;, and that ANDquot;active psychosis seen in schizophrenia is equal in disability burden to quadriplegiaANDquot;. Thus, according to the Surgeon General's recommendations, research of the kind I am carrying out is well aligned with the Nation's priorities in health research. We use imaging, electrophysiology and genetic techniques to establish the relevance of our basic resarch findings in patients with schizophrenia, or in youth with high risk of developing this disease.
In addition, I am interested in the applications of brain stimulation techniques to treat the most difficult cases of neuropsychiatric (such as treatment refractory depression) and movement disorders (such as Parkinson disease, dystonia or disabling tremor). Our research in this field is focused on improving the targets and methods for stimulation, and on personalizing the treatment to each case in order to optimize the outcomes.

Locations

  • Primary Address , 3515 E. Fletcher Avenue Tampa, FL 33613
  • Secondary Address , 2 Tampa General Circle Tampa, FL 33606
  • USF Academic Address , 3515 E. Fletcher Avenue Tampa, FL 33613
  • Mail Point , MDC 14 ,
  • Physical Billing Address , 12901 Bruce B Downs BLVD Tampa, FL 33612

Clinical Interests

  • 1. Movement Disorders.
  • 2. Behavioral Neurology.
  • 3. Treatment refractory depression
  • 4. Psychotic disorders
  • 5. Neuroimaging.
  • 6 Electrophysiology

Research Interests

  • 1. Studies on the pathophysiology of schizophrenia during brain development. These include studies in mouse models and in neuronal lines derived from patient's skin via reprogramming, to address the specific influence of genetic variations on the susceptibility of neurons to negative environmental events.
  • 2. Development of a strategy for primary prevention of schizophrenia based on a combination of phenomics (based on a specific pathophysiology) and genomics using machine learning and optimization research.
  • 3. Personalization of patient selection for neuromodulation techniques based on predictive maps derived from unbiased search of the variable space and optimization research.
  • 4. Optimized prediction of outcomes in treatment refractory depression treated with neuromodulation techniqes.

Philosophy

I am convinced that personalization means more than the individual genetic pattern of our body (important as this may be). No amount of technology can replace the trust of each person on his or her personal physician, and this trust can only be developed if physicians have a genuine interest in the person who is their patient. With this in mind, I also favor strategies leading to prevention over symptomatic treatment, and I focus my efforts in minimizing the negative impact of medical interventions on quality of life.

Specialties

  • NeurologyPsychiatry-General

Memberships

  • Movement Disorders Society (Member, 2004 - Present)
  • American College of Psychiatrists (Member, 2003 - Present)
  • Society for Neurosciences (Member, 1991 - Present)

Selected Publications

de Erausquin, GA.
[Mechanism of molecular action of neuroleptics].
Vertex (Buenos Aires, Argentina). 14(51) : 36-44http://www.ncbi.nlm.nih.gov/pubmed/12690408

De Erausquin, GA.
[Neurodevelopment and schizophrenia].
Vertex (Buenos Aires, Argentina). 13(49) : 189-97http://www.ncbi.nlm.nih.gov/pubmed/12404020

Zorumski, CF.de Erausquin, G.Dokucu, M.Svrakic, D.Garcia, K.Jarvis, M.
Brain stimulation AND the treatment of refractory psychiatric disorders.
Missouri medicine. 105(1) : 57-61http://www.ncbi.nlm.nih.gov/pubmed/18300607

Zorumski, CF.de Erausquin, G.Dokucu, M.Svrakic, D.Garcia, K.Jarvis, M.
Brain stimulation AND the treatment of refractory psychiatric disorders.
Missouri medicine. 105(1) : 57-61http://www.ncbi.nlm.nih.gov/pubmed/18300607

Landreau, F.Galeano, P.Caltana, LR.Masciotra, L.Chertcoff, A.Pontoriero, A.Baumeister, E.Amoroso, M.Brusco, HA.Tous, MI.Savy, VL.Lores Arnaiz, Mdel R.de Erausquin, GA.
Effects of two commonly found strains of influenza a virus on developing dopaminergic neurons, in relation to the pathophysiology of schizophrenia.
PloS one. 7(12) : e51068, 2012.
http://www.ncbi.nlm.nih.gov/pubmed/23251423

Benítez, BA.Belálcazar, HM.Anastasía, A.Mamah, DT.Zorumski, CF.Mascó, DH.Herrera, DG.de Erausquin, GA.
Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.
Neuropharmacology. 60(7-8) : 1176-86, 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21044638

Ladaga, GJ.Lezica, FP.Barboni, AM.Picos, JA.de Erausquin, GA.
Pharmacokinetics of a single oral administration of cefalexin in mares and foals.
The Veterinary record. 168(16) : 431a, 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21498439

Anastasía, A.Wojnacki, J.de Erausquin, GA.Mascó, DH.
Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson's disease.
Neuroscience. 195: 100-11, 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21871541

O'Leary, JC.Dharia, S.Blair, LJ.Brady, S.Johnson, AG.Peters, M.Cheung-Flynn, J.Cox, MB.de Erausquin, G.Weeber, EJ.Jinwal, UK.Dickey, CA.
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
PloS one. 6(9) : e24840, 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21935478

Anastasía, A.Torre, L.de Erausquin, GA.Mascó, DH.
Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson's disease.
Journal of neurochemistry. 109(3) : 755-65, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19245661

Alemán, GG.de Erausquin, GA.Micheli, F.
Cognitive disturbances in primary blepharospasm.
Movement disorders : official journal of the Movement Disorder Society. 24(14) : 2112-20, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19705473

Lezica, FP.Filip, R.Gorzalczany, S.Ferraro, G.de Erausquin, GA.Rivas, C.Ladaga, GJ.
Prevalence of ergot derivatives in natural ryegrass pastures: detection and pathogenicity in the horse.
Theriogenology. 71(3) : 422-31, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/18823653

Anastasía, A.Torre, L.de Erausquin, GA.Mascó, DH.
Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson's disease.
Journal of neurochemistry. 109(3) : 755-65, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19245661

Alemán, GG.de Erausquin, GA.Micheli, F.
Cognitive disturbances in primary blepharospasm.
Movement disorders : official journal of the Movement Disorder Society. 24(14) : 2112-20, 2009.
http://www.ncbi.nlm.nih.gov/pubmed/19705473

Anastasia, A.de Erausquin, GA.Wojnacki, J.Mascó, DH.
Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease.
Journal of neurochemistry. 103(4) : 1542-52, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17854351

Tabbal, SD.Revilla, FJ.Mink, JW.Schneider-Gibson, P.Wernle, AR.de Erausquin, GA.Perlmutter, JS.Rich, KM.Dowling, JL.
Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease.
Neurosurgery. 61(3 Suppl) : 119-27; discussion 127-9, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17876242

Mamah, D.Wang, L.Barch, D.de Erausquin, GA.Gado, M.Csernansky, JG.
Structural analysis of the basal ganglia in schizophrenia.
Schizophrenia research. 89(1-3) : 59-71, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17071057

Ladaga, GJ.Lezica, FP.Ferraro, G.De Erausquin, GA.
Some pharmacodynamic effects of eformoterol in the horse.
Journal of veterinary pharmacology and therapeutics. 30(5) : 496-9, 2007.
http://www.ncbi.nlm.nih.gov/pubmed/17803747

Dorsey, DA.Mascó, DH.Dikranian, K.Hyrc, K.Masciotra, L.Faddis, B.Soriano, M.Gru, AA.Goldberg, MP.de Erausquin, GA.
Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons.
Apoptosis : an international journal on programmed cell death. 11(4) : 535-44, 2006.
http://www.ncbi.nlm.nih.gov/pubmed/16532276

Gonzalez Aleman, G.Florenzano, N.Padilla, E.Bourdieu, M.Guerrero, G.Calvó, M.Alberio, G.Strejilevich, S.de Erausquin, GA.
A 37-year-old woman with celiac disease, recurrent psychosis, and Parkinsonism.
Movement disorders : official journal of the Movement Disorder Society. 21(5) : 729-31, 2006.
http://www.ncbi.nlm.nih.gov/pubmed/16547920

Calvó de Padilla, M.Padilla, E.González Alemán, G.Bourdieu, M.Guerrero, G.Strejilevich, S.Escobar, JI.Svrakic, N.Cloninger, CR.de Erausquin, GA.
Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina.
Schizophrenia research. 83(2-3) : 299-302, 2006.
http://www.ncbi.nlm.nih.gov/pubmed/16480854

Strejilevich, SA.Palatnik, A.Avila, R.Bustin, J.Cassone, J.Figueroa, S.Gimenez, M.de Erausquin, GA.
Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics.
Psychiatry research. 133(2-3) : 277-80, 2005.
http://www.ncbi.nlm.nih.gov/pubmed/15741003

Zhang, PL.Santos, JM.Newcomer, J.Pelfrey, BA.Johnson, MC.de Erausquin, GA.
Impact of atypical antipsychotics on quality of life, self-report of symptom severity, and demand of services in chronically psychotic patients.
Schizophrenia research. 71(1) : 137-44, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15374581

de Erausquin, GA.
Transactivation of cell death signals by glutamate transmission in dopaminergic neurons.
Critical reviews in neurobiology. 16(1-2) : 107-19, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15581406

Yamada, KA.Rensing, N.Izumi, Y.De Erausquin, GA.Gazit, V.Dorsey, DA.Herrera, DG.
Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation.
Pediatric research. 55(3) : 372-9, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/14681492

Moulder, KL.Meeks, JP.Shute, AA.Hamilton, CK.de Erausquin, G.Mennerick, S.
Plastic elimination of functional glutamate release sites by depolarization.
Neuron. 42(3) : 423-35, 2004.
http://www.ncbi.nlm.nih.gov/pubmed/15134639

de Erausquin, GA.Hyrc, K.Dorsey, DA.Mamah, D.Dokucu, M.Mascó, DH.Walton, T.Dikranian, K.Soriano, M.García Verdugo, JM.Goldberg, MP.Dugan, LL.
Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons.
Molecular pharmacology. 63(4) : 784-90, 2003.
http://www.ncbi.nlm.nih.gov/pubmed/12644578

Abi-Dargham, A.Laruelle, M.Krystal, J.D'Souza, C.Zoghbi, S.Baldwin, RM.Seibyl, J.Mawlawi, O.de Erasquin, G.Charney, D.Innis, RB.
No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 20(6) : 650-61, 1999.
http://www.ncbi.nlm.nih.gov/pubmed/10327433

Bremner, JD.Bronen, RA.De Erasquin, G.Vermetten, E.Staib, LH.Ng, CK.Soufer, R.Charney, DS.Innis, RB.
Development and Reliability of a Method for Using Magnetic Resonance Imaging for the Definition of Regions of Interest for Positron Emission Tomography.
Clinical positron imaging : official journal of the Institute for Clinical P.E.T. 1(3) : 145-159, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/14516589

Abi-Dargham, A.Gandelman, MS.DeErausquin, GA.Zea-Ponce, Y.Zoghbi, SS.Baldwin, RM.Laruelle, M.Charney, DS.Hoffer, PB.Neumeyer, JL.Innis, RB.
SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37(7) : 1129-33, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8965183

Isaacs, KR.de Erausquin, G.Strauss, KI.Jacobowitz, DM.Hanbauer, I.
Differential effects of excitatory amino acids on mesencephalic neurons expressing either calretinin or tyrosine hydroxylase in primary cultures.
Brain research. Molecular brain research. 36(1) : 114-26, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/9011746

De Erausquin, GA.Costa, E.Hanbauer, I.
Calcium homeostasis, free radical formation, and trophic factor dependence mechanisms in Parkinson's disease.
Pharmacological reviews. 46(4) : 467-82, 1994.
http://www.ncbi.nlm.nih.gov/pubmed/7899474

de Erausquin, G.Brooker, G.Costa, E.Hanbauer, I.
Persistent AMPA receptor stimulation alters [Ca2+]i homeostasis in cultures of embryonic dopaminergic neurons.
Brain research. Molecular brain research. 21(3-4) : 303-11, 1994.
http://www.ncbi.nlm.nih.gov/pubmed/7513376

Fohrman, EB.de Erausquin, G.Costa, E.Wojcik, WJ.
Muscarinic m3 receptors and dynamics of intracellular Ca2+ cerebellar granule neurons.
European journal of pharmacology. 245(3) : 263-71, 1993.
http://www.ncbi.nlm.nih.gov/pubmed/8101492

De Erausquin, G.Brooker, G.Costa, E.Wojcik, WJ.
Stimulation of high affinity gamma-aminobutyric acidB receptors potentiates the depolarization-induced increase of intraneuronal ionized calcium content in cerebellar granule neurons.
Molecular pharmacology. 42(3) : 407-14, 1992.
http://www.ncbi.nlm.nih.gov/pubmed/1328842

Apud, JA.Grayson, DR.De Erausquin, E.Costa, E.
Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat.
Neuropharmacology. 31(1) : 1-8, 1992.
http://www.ncbi.nlm.nih.gov/pubmed/1311807

Faiman, CP.de Erausquin, GA.Baratti, CM.
Modulation of memory retrieval by pre-testing vasopressin: involvement of a central cholinergic nicotinic mechanism.
Methods and findings in experimental and clinical pharmacology. 14(8) : 607-13, 1992.
http://www.ncbi.nlm.nih.gov/pubmed/1494301

de Erausquin, G.Brooker, G.Hanbauer, I.
K(+)-evoked dopamine release depends on a cytosolic Ca2+ pool regulated by N-type Ca2+ channels.
Neuroscience letters. 145(2) : 121-5, 1992.
http://www.ncbi.nlm.nih.gov/pubmed/1334537

Faiman, CP.de Erausquin, GA.Baratti, CM.
The enhancement of retention induced by vasopressin in mice may be mediated by an activation of central nicotinic cholinergic mechanisms.
Behavioral and neural biology. 56(2) : 183-99, 1991.
http://www.ncbi.nlm.nih.gov/pubmed/1759940

de Erausquin, GA.Manev, H.Guidotti, A.Costa, E.Brooker, G.
Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells.
Proceedings of the National Academy of Sciences of the United States of America. 87(20) : 8017-21, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/2236016

Baratti, CM.de Erausquin, GA.Faiman, CP.
Brain opioid peptides may participate in the reversal of pentylenetetrazol-induced amnesia.
Methods and findings in experimental and clinical pharmacology. 12(7) : 451-6, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/2087144

Manev, H.Favaron, M.De Erausquin, G.Guidotti, A.Brooker, G.Costa, E.
Destabilization of ionized Ca2+ homeostasis in excitatory amino acid neurotoxicity: antagonism by glycosphingolipids.
Cell biology international reports. 14(1) : 3-14, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/2185894

Favaron, M.Manev, H.Siman, R.Bertolino, M.Szekely, AM.DeErausquin, G.Guidotti, A.Costa, E.
Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.
Proceedings of the National Academy of Sciences of the United States of America. 87(5) : 1983-7, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/1689850

Manev, H.Bertolino, M.DeErausquin, G.
Amiloride blocks glutamate-operated cationic channels and protects neurons in culture from glutamate-induced death.
Neuropharmacology. 29(12) : 1103-10, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/1963475

de Erausquin, GA.Pitra, JC.Rey, RB.Faiman, CP.Baratti, CM.
A novel non-invasive method to measure skin potential response: some pharmacological evidence.
Methods and findings in experimental and clinical pharmacology. 11(12) : 765-70, 1989.
http://www.ncbi.nlm.nih.gov/pubmed/2626083

Baratti, CM.Faiman, CP.de Erausquin, GA.
Facilitation of inhibitory avoidance by hypertonic saline is reversed by a vasopressin and a nicotinic antagonist.
Behavioral and neural biology. 51(3) : 424-35, 1989.
http://www.ncbi.nlm.nih.gov/pubmed/2525022

Faiman, CP.de Erausquin, GA.Baratti, CM.
Vasopressin modulates the activity of nicotinic cholinergic mechanisms during memory retrieval in mice.
Behavioral and neural biology. 50(1) : 112-9, 1988.
http://www.ncbi.nlm.nih.gov/pubmed/2900001

Faiman, CP.De Erausquin, GA.Baratti, CM.
Mecamylamine prevents the enhancement of retention induced by lysine vasopressin in mice.
Behavioral and neural biology. 48(3) : 434-9, 1987.
http://www.ncbi.nlm.nih.gov/pubmed/3689289