Abstracts
Cardiovascular Research Lab

  • 2011

      The Linask Lab presented a poster at the Weinstein 2011 meeting in Cincinnati. The authors & titles: Lifeng Zhang, Mingda Han, & Kersti K. Linask. Modulation of Wnt/β-Catenin & Phosphatidylinositol Signaling by Lithium & Epigenetic-Related Effects.

      Dr. Kersti K. Linask presented a talk at the 2011 Research Society on Alcoholism meeting in Atlanta, GA, on June 25-29. She was also part of the NIAAA sponsored symposium on "Gene-nutrient interactions in disease development in alcoholics: Folates & retinoids". The talk is entitled: Folate Protection Of Fetal Alcohol Syndrome Associated Cardiac Defects By Modulation Of Wnt/Β-Catenin Signaling.

      Serrano, M., Brinez, P., Han, M., Lastra-Vicente, R., & K.K. Linask. 2010. Fetal Alcohol Syndrome: Cardiac birth defects & prevention with folate. Amer. J. Obst. Gyn. 203(1):75.e7-75.e15. The article was reported in Science Daily.

      Linask, K.L. & Linask, K.K. 2010. Calcium channel blockade in embryonic cardiac progenitor cells disrupts normal cardiac cell differentiation. Stem Cells & Development. (doi:10.1089/scd.2010.0192)

      Linask, K.K. & J.C. Huhta. 2010. Folate protection of congenital heart defects associated with canonical Wnt signaling & epigenetic. Curr. Opin. in Pediatrics. 22:561-566.

      Garita, B. M.W. Jenkins, M. Han, C. Zhou, M. VanAuker, A. M. Rollins, M. Watanabe, J.G. Fujimoto, & K. K. Linask. 2011. Blood Flow Dynamics of One Cardiac Cycle & Relationship to Mechanotransduction & Trabeculation during Heart Looping. Am. J P. Heart Circulatory Physiol. 300(3):H879-891. This article was a featured on Oct News.

  • 2010

      Serrano, M., P. Brinez, M. Han, and K. K. Linask. 2009. Folate Protection of Fetal Alcohol Syndrome Related Cardiac Defects by Modulation of Wnt/β-Catenin Signaling. XXII European Congress of Perinatal Medicine, Granada, May 26-29, 2010. Invited oral presentation.

      Garita, Barbara, Mingda Han, Michael W. Jenkins, Steven H. Seeholzer, Chao Zhou, Michael VanAuker, Andrew M. Rollins, Michiko Watanabe, James G. Fujimoto, and Kersti K. Linask. 2010. Optical Coherence Tomography (OCT) of the Looping Embryonic Heart: Mechanosensing Mechanisms. Weinstein Cardiovascular Development conference, Amsterdam, Netherlands, May, 2010.

  • 2009

      Serrano, M., P. Brinez, M. Han, and K. K. Linask. 2009. Folate Protection of Fetal Alcohol Syndrome Related Cardiac Defects by Modulation of Wnt/β-Catenin Signaling. American Heart Association 2009 National Meeting, Orlando, FL.

      Neves, Ana, Kersti K. Linask, James C. Huhta. 2009. Cardiovascular profile score in fetal right heart defects. 5th World Congress of Pediatric Cardiology and Cardiac Surgery, June 21-26, 2009 in Cairns, Australia.

      Jenkins, M.W., M. Gargesha, B. Ataya, D. L. Wilson, K. K. Linask, M. Watanabe and A. M. Rollins, “Imaging the embryonic heart with optical coherence tomography,” OSA/SPIE European Conferences on Biomedical Optics, Munich, Germany, 2009.

      Jenkins, M.W., M. Gargesha, S. Gu, D. L. Wilson, K. K. Linask, M. Watanabe and A. M. Rollins, “Optical coherence tomography technology advancements for studying the developing heart,” Weinstein Cardiovascular Development conference, San Francisco, CA May, 2009.

      Jenkins, M.W., M. Gargesha, B. Garita, A. P. Bishop, L. M. Barwick, K. K. Linask, D. L. Wilson and A. M. Rollins, “Ultrahigh temporal resolution for assessing embryonic cardiac dynamics using signal-free retrospective gated OCT,” presented at SPIE Photonics West/BiOS, San Jose, CA, 2009.

      Garita, Barbara, Michael Jenkins, Andrew Rollins, Michael VanAuker, and K. K. Linask. 2009. OCT Analysis of a Single Cardiac Cycle During Heart Looping: Relationships between Endocardium and Myocardium. Weinstein Conference on Cardiovascular Development annual meeting; San Francisco, May 8, 2009. San Francisco, CA.

      Serrano, Maria, M.D., Mingda Han, M.D., James C. Huhta, M.D., Rosana Lastra, B.A., Barbara Garita, Ph.D. and K. K. Linask, Ph.D. 2009. Folate suppresses Wnt/β-Catenin inhibition of cardiogenesis to protect against induction of congenital heart defects. Weinstein Conference on Cardiovascular Development annual meeting; San Francisco, May 8, 2009.

  • 2008

      Garita, Barbara, Michael Jenkins, Andrew Rollins, Michael VanAuker, and K. K. Linask. 2008. Cardiac Jelly Facilitates Cellular Communication between Endocardium and Myocardium during Heart Looping. American Society for Cell Biology. Dec. 13-17, 2008. San Francisco, CA.

      Serrano, Maria, M.D., Mingda Han, M.D., James C. Huhta, M.D., Rosana Lastra, B.A., Barbara Garita, Ph.D. and K. K. Linask, Ph.D. 2008. Folate suppresses Wnt/β-Catenin inhibition of cardiogenesis to protect against induction of congenital heart defects. American Heart Association 2008 Meeting, New Orleans, LA. Oral presentation.

      Lastra R, Han M, Serrano M, Huhta JC, Linask KK. 2008. Folate rescues inhibitory effects of Wnt/β-Catenin signaling during heart development. Presented at the 18th Annual USF Health Research Day; Tampa, FL, February 2008.

      Serrano M, Huhta J, Han M, Linask KK. 2008. One-time homocysteine exposure in early gestation causes intrauterine demise and cardiac valve dysfunction. Presented at the 18th Annual USF Health Research Day; Tampa, FL, February 2008.

      Linask, KK, Serrano, M, Han, M, Huhta, J, Manisastry, S .2008. Perspectives on Congenital Heart Defects Induced By the Timing of Lithium Exposure During Early Vertebrate Development. Ehrlich Meeting, Nurnberg, Germany.

      Serrano, M., Han, M., Jizhen Chen, Patrizia Trotta, Huhta, J.C., K.K. Linask. 2008. A single dose of lithium or homocysteine during mouse gestation on embryonic day 6.75 leads to abnormal valve development. Presented at the 2008 Annual Weinstein Meeting on Cardiovascular Development in Houston, TX.

      Serrano, M., Huhta, J.C., Han, M., K.K. Linask. 2008. One-time Homocysteine exposure in early gestation increases the risk of intrauterine demise and causes cardiac valve dysfunction in surviving mouse embryos. American Heart Association: Conference on Scientific Basis of Heart Failure in Children. May 14-16, 2008 in Estes Park, CO.

      Serrano, M, Huhta J, Han M, Linask KK. 2008. Folic acid rescue of cardiovascular dysfunction and intrauterine demise induced by single pulse dose of homocysteine in early gestation. 28th Society for Maternal-Fetal Medicine Annual Meeting in Dallas, TX. January 2008. Chosen for oral presentation out of a field of 1,047. Am J Obstet Gynecol 2007; 197:14, P29.

  • 2007

      Jizhen Chen , S.M. Manisastry, M. Han, I. Moskowitz, A. Juraszek, and K.K. Linask. Dept. of Pediatrics, Univ. South Florida, Children’s Research Institute, St. Petersburg, FL 33701; Dept. of Pathology, Cardiac Registry, Boston Children’s Hospital, Boston, MA 02115. One-time Exposure of Lithium on ED 6.75 in the Mouse Affects Tricuspid Valve Morphogenesis. Presented at the Experimental Biology Meeting, Washington, D.C., April 28-May 3, 2007.

      Justin Elder, Jacquelyn Gerhart, Christine Neely, Jessica Pfautz, Jordanna Perlman, Luis Narcisco, Kersti Linask, Karen Knudsen and Mindy George-Weinstein. 2007. Skeletal Muscle Founder Cells In The Early Chick Embryo. International Chick Meeting, April 11-14, Barcelona, Spain.

      Serrano, M.C., Linask, K.K., Acharya, G., Chen, J., Han, M., and Huhta, J.C. One-Time Lithium Dose in Early Gestation Causes Placental and Cardiac Dysfunction. 2007. 27th Annual Pregnancy Meeting TM February 5, 2007 - February 10, 2007. 27th Society for Maternal-Fetal Medicine. San Francisco, CA Am J Obstet Gynecol 2006: 195:210 P698. Oral presentation.

      Huhta J, Serrano M, G Acharya, Han M, Linask KK. 2007. Morphologic and functional characteristics of the CITED-2 knockout mouse embryo: A preliminary study. Presented at the 42rdAnnual Meeting Association for European Pediatric Cardiology, Warsaw May 16-19, 2007.

      Serrano M, Huhta J, Han M, Linask KK. 2007. One-time homocysteine exposure in early gestation causes intrauterine demise and cardiac valve dysfunction. Presented at the 5th Annual Symposium on Advances in Perinatal Cardiology, Saint Petersburg, Florida, October 11-13, 2007. Received first place prize.

  • 2006

      Serrano M, Acharya G, Han M, Linask KK, Huhta J. 2006. Morphologic and functional characteristics of the CITED-2 knockout mouse embryo: A preliminary study. Presented at the 4th Annual Symposium on Advances in Perinatal Cardiology, St Petersburg, FL November, 16-18 2006.

  • 2005

      Shyam M. Manisastry, Mingda Han, Jizhen Chen, Maria Serrano, James C. Huhta, and Kersti K. Linask. 2005. Analysis of Cardiac Teratogenicity of Lithium in the Mouse Embryo using Doppler Echocardiography: One time exposure at ED 6.75 results in abnormal cardiac function and dysmorphogenesis. 3rd International Congress on Developmental Origins of Health & Disease, Toronto, CA. Ped. Res. 58: PI-018.

      Shyam M. Manisastry, Mingda Han, Maria Serrano, and Kersti K. Linask. 2005. Cell and Molecular Analysis of Cardiac Teratogenicity of Lithium in the Chick Embryo: Early gestational exposure during gastrulation results in serious cardiac anomalies and changes in gene and protein expression patterns. 3rd International Congress on Developmental Origins of Health & Disease, Toronto, CA. Ped. Res. 58: P2-043.

      Han, M.D., D.H.Cai, P.R. Brauer, and K.K. Linask. 2005. MMP Inhibition leads to defects in cardiac tube development and randomization of heart looping by effects on cell proliferation in the L/R dorsal mesocardial folds. Weinstein Meeting, Tuscon, AZ.

      Manisastry, S.M., Han, M.D., and Linask, K.K. 2005. Effects of lithium exposure on early mouse embryonic heart development: An echocardiographic and pathological study. Weinstein Meeting. Tuscon, AZ.

      Manisastry, S.M., Han, M.D., and Linask, K.K. 2005. An anterior-posterior (A/P) progression of chick cardiac anomalies upon early embryonic exposure to lithium, Wnt 3A, and GSK-3 inhibitor: Effects on Notch, Dkk1 and Axin expression. Weinstein Meeting. Tucson, AZ.

      MyoD Positive Cells of the Pregastulating Embryo are Committed to the Skeletal Muscle Lineage. Society for Developmental Biology annual meeting, San Francisco, CA June 2005.

      Narciso,L., J. Gerhart, J. Perlman, C. Neely, K. Linask1, and M. George-Weinstein. 2005.

  • 2004

      Manisastry, S.M., Han, M.D., and Linask, K.K. 2004. An anterior-posterior (A/P) progression of cardiac anomalies are observed upon embryonic exposure to lithium, Wnt 3A, and noggin. Weinstein Meeting. Leiden, Netherlands.

      Manisastry, S.M., Han, M.D., and Linask, K.K. 2004. Effects of lithium and BMP inhibition on cardiac boundary formation. Experimental Biology Meeting (FASEB), Wash. D.C. April, 17-20, 2004. Platform presentation presented in two sessions. (Award in Priesley-Zeiss competition).

  • 2003

      Aiping Du , Jean M. Sanger, Kersti K. Linask and Joseph W. Sanger. 2003. Myofibrillogenesis in the first cardiomyocytes formed from isolated quail precardiac mesoderm. Weinstein Meeting, Boston, MA, May.

      Manohar, Shyam., Han, Ming-Da, and Linask, Kersti K. 2003. Anterior-posterior effects of lithium on neural tube and heart development. Weinstein Meeting, Boston, MA, May.

      Linask, K. K., M.D. Han, D.H.Cai, P.R. Brauer, and S.M. Manisastry. 2003. Roles for MMP-2 activity in the dorsal mesocardium during heart looping. Weinstein Meeting, Boston, MA, May.

  • 2002

      Linask Kersti, K, Ming-Da Han, YiPing Chen, and Thomas Brand. 2002. Modulation of Flectin Asymmetry during Heart Looping. Presented at American Heart Association Meeting, Dallas TX, May 18th.

  • 2001

      Linask, K.K. , Han, M.D., Artman, M., and Ludwig, C.A. 2001. Regulation of embryonic heartbeats. Weinstein meeting, Southwestern University of Texas at Dallas. June.

  • 2000

      Linask, K.K., Han, M.D., Artman, M., and C.A. Ludwig. 2000. Calcium modulation and the sodium-calcium exchanger: Effects on Early Heart Development. Weinstein meeting, Washington University at St. Louis.

      Linask, K.K., Han, M.D., and C.A. Ludwig. 2000. Embryonic expression patterns of sodium-calcium exchanger (NCX-1) and modulation of cardiac cell differentiation. FASEB 2000, San Diego, CA, April 15-18.

      Linask K.K., Han, M.d. and Ludwig C.A. 2000 Flectin Matrix Organization and Heart Looping. American Society for Cell Biology, San Francisco, December.