Kendra Vehik

Kendra Vehik, MPH, PhD

Associate Professor, Health Informatics Institute

Contact Info 3650 Spectrum Blvd.
STE 100
Tampa FL 33612

Academic Email: kendra.vehik@epi.usf.edu

Academic Phone:(813) 396-2693

Education

  • PhD, Analytic Health Sciences, University of Colorado, 2007
  • M.P.H., Epidemiology and Biostatistics, George Washington University, 1996
  • B.S., Biology, University of Arizona, 1993

Research Interests

  • Her research interests are focused on type 1 diabetes including prevention, clinical/translational and quality of life research. Much of her published work has been focused on identifying probable risk factors associated with type 1 diabetes in order to develop more directed hypotheses to prevent the onset of autoimmunity and clinical disease. She has expertise in epidemiologic and biostatistical methodologies associated with case/control, longitudinal and clinical trial designs. Dr. Vehik has firsthand knowledge and experience working with many type 1 clinical projects coordinated by the Pediatric Epidemiology Center, including The Environmental Determinants of Diabetes in the Young (TEDDY), TrialNet Network and the Diabetes Prevention Trial – Type 1 (DPT-1) studies. Her main diabetes expertise lies in identifying stable and informative risk factors and validating the identified risk factors as triggers and/or accelerators of autoimmunity and clinical disease. She has authored many high impact peer-reviewed publications that have focused on determining risk factors associated with type 1 diabetes focused on in utero and early life environmental exposures (body size and growth patterns, nutrition, infections), genetic susceptibility, clinical outcomes in delaying onset and population-based temporal trends in risk factors and type 1 diabetes. Her long time interests are in identifying early life risk factors, exploring how changes in these risk factors over time and potential gene-environment interactions contribute to the risk of autoantibody seroconversion and surrogate biomarkers for prediction, diagnosis and risk of type 1 diabetes, and delaying or stopping the onset of diabetes.

Recent Publications

  • Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. PLoS medicine. 15(4) : e1002548, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29614081
  • Uusitalo U, Lee HS, Andrén Aronsson C, Vehik K, Yang J, Hummel S, Silvis K, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Virtanen SM, Norris JM. Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes care. 41(3) : 522-530, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29343517
  • Lynch KF, Lee HS, Törn C, Vehik K, Krischer JP, Larsson HE, Haller MJ, Hagopian WA, Rewers MJ, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Hyöty H, Bonifacio E, Lernmark Å. Gestational respiratory infections interacting with offspring HLA and CTLA-4 modifies incident β-cell autoantibodies. Journal of autoimmunity. 86: 93-103, 2018. http://www.ncbi.nlm.nih.gov/pubmed/28941965
  • Köhler M, Beyerlein A, Vehik K, Greven S, Umlauf N, Lernmark Å, Hagopian WA, Rewers M, She JX, Toppari J, Akolkar B, Krischer JP, Bonifacio E, Ziegler AG. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study. Acta diabetologica. 54(11) : 1009-1017, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28856522
  • Roth R, Baxter J, Vehik K, Hopkins D, Killian M, Gesualdo P, Melin J, Simell B, Strauss E, Lernmark Å, Johnson SB. The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study. Developmental psychobiology. 59(5) : 658-667, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28555778
  • Beyerlein A, Uusitalo UM, Virtanen SM, Vehik K, Yang J, Winkler C, Kersting M, Koletzko S, Schatz D, Aronsson CA, Elding Larsson H, Krischer JP, Ziegler AG, Norris JM, Hummel S. Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years: Results from the Prospective TEDDY Study. Obesity (Silver Spring, Md.). 25(8) : 1435-1441, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28650578
  • Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, Simell V, Koletzko S, Liu E, Simell OG, Toppari J, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian WA, She JX, Akolkar B, Schatz DA, Atkinson MA, Blaser MJ, Krischer JP, Hyöty H, Agardh D, Triplett EW. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. JAMA pediatrics. 171(12) : 1217-1225, 2017. http://www.ncbi.nlm.nih.gov/pubmed/29052687
  • Haghighi M, Johnson SB, Qian X, Lynch KF, Vehik K, Huang S. Corrigendum: A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Scientific reports. 7: 39723, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28462922
  • Haghighi M, Johnson SB, Qian X, Lynch KF, Vehik K, Huang S. A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Scientific reports. 6: 30828, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27561809
  • Elding Larsson H, Vehik K, Haller MJ, Liu X, Akolkar B, Hagopian W, Krischer J, Lernmark Å, She JX, Simell O, Toppari J, Ziegler AG, Rewers M. Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study. Diabetes. 65(7) : 1988-95, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26993064
  • Vehik K, Lynch KF, Schatz DA, Akolkar B, Hagopian W, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Lernmark Å, Bonifacio E, Krischer JP. Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study. Diabetes care. 39(9) : 1535-42, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27311490
  • Shive MS, Stanish WD, McCormack R, Forriol F, Mohtadi N, Pelet S, Desnoyers J, Méthot S, Vehik K, Restrepo A. BST-CarGel® Treatment Maintains Cartilage Repair Superiority over Microfracture at 5 Years in a Multicenter Randomized Controlled Trial. Cartilage. 6(2) : 62-72, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26069709
  • Andrén Aronsson C, Uusitalo U, Vehik K, Yang J, Silvis K, Hummel S, Virtanen SM, Norris JM. Age at first introduction to complementary foods is associated with sociodemographic factors in children with increased genetic risk of developing type 1 diabetes. Maternal & child nutrition. 11(4) : 803-14, 2015. http://www.ncbi.nlm.nih.gov/pubmed/24034553
  • Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, Rewers MJ. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes care. 38(5) : 808-13, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25665818
  • Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, León-Novelo LG, Vehik K, Casella G, Simell O, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian W, She JX, Krischer JP, Akolkar B, Schatz DA, Atkinson MA, Triplett EW. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes care. 38(2) : 329-32, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25519450
  • Yang J, Lernmark Å, Uusitalo UM, Lynch KF, Veijola R, Winkler C, Larsson HE, Rewers M, She JX, Ziegler AG, Simell OG, Hagopian WA, Akolkar B, Krischer JP, Vehik K. Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. International journal of obesity (2005). 38(12) : 1491-6, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24694666
  • Elding Larsson H, Vehik K, Gesualdo P, Akolkar B, Hagopian W, Krischer J, Lernmark Å, Rewers M, Simell O, She JX, Ziegler A, Haller MJ. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatric diabetes. 15(2) : 118-26, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24034790
  • Lin Y, Qian X, Krischer J, Vehik K, Lee HS, Huang S. A rule-based prognostic model for type 1 diabetes by identifying and synthesizing baseline profile patterns. PloS one. 9(6) : 42-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24926781
  • Hummel S, Vehik K, Uusitalo U, McLeod W, Aronsson CA, Frank N, Gesualdo P, Yang J, Norris JM, Virtanen SM. Infant feeding patterns in families with a diabetes history - observations from The Environmental Determinants of Diabetes in the Young (TEDDY) birth cohort study. Public health nutrition. 17(12) : 2853-62, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24477208
  • Aronsson CA, Vehik K, Yang J, Uusitalo U, Hay K, Joslowski G, Riikonen A, Ballard L, Virtanen SM, Norris JM. Use of dietary supplements in pregnant women in relation to sociodemographic factors - a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Public health nutrition. 16(8) : 1390-402, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23452986
  • Adl AA, Qian X, Xu P, Vehik K, Krischer JP. Feature ranking based on synergy networks to identify prognostic markers in DPT-1. EURASIP journal on bioinformatics & systems biology. 2013(1) : 12, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24050757
  • Vehik K, Fiske SW, Logan CA, Agardh D, Cilio CM, Hagopian W, Simell O, Roivainen M, She JX, Briese T, Oikarinen S, Hyoty H, Ziegler AG, Rewers M, Lernmark A, Akolkar B, Krischer JP, Burkhardt BR. Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY. Diabetes/metabolism research and reviews. 29(7) : 557-67, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23674484
  • Vehik K, Ajami NJ, Hadley D, Petrosino JF, Burkhardt BR. The changing landscape of type 1 diabetes: recent developments and future frontiers. Current diabetes reports. 13(5) : 642-50, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23912764
  • Salami F, Abels M, Hyöty H, Vaziri-Sani F, Aronsson C, Vehik K, Delli A, Hagopian W, Rewers M, Ziegler A, Simell O, Akolkar B, Krischer J, She J, Lernmark A. DETECTION OF LACTOBACILLI IN MONTHLY MAIL-IN STOOL SAMPLES FROM 3-18 MONTHS OLD INFANTS AT GENETIC RISK FOR TYPE 1 DIABETES. International journal of probiotics & prebiotics. 7(3) : 135-144, 2012. http://www.ncbi.nlm.nih.gov/pubmed/25045339
  • Bollepalli S Smith LB Vasquez A Rodriguez H Vehik K. Addressing the burdens of type 1 diabetes in youth. Clinical Practice. 9(4) : 409-24, 2012.
  • Baxter J, Vehik K, Johnson SB, Lernmark B, Roth R, Simell T. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study. Contemporary clinical trials. 33(4) : 633-40, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22484339
  • Vehik K, Dabelea D. Why are C-section deliveries linked to childhood type 1 diabetes? Diabetes. 61(1) : 36-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22187373
  • Jaiswal M, Crume T, Vehik K, Scherzinger A, Stamm E, Hamman RF, Dabelea D. Is low birth weight associated with adiposity in contemporary U.S. youth? The Exploring Perinatal Outcomes among Children (EPOCH) Study. Journal of developmental origins of health and disease. 3(3) : 166-72, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23050071
  • Vehik K, Cuthbertson D, Boulware D, Beam CA, Rodriguez H, Legault L, Hyytinen M, Rewers MJ, Schatz DA, Krischer JP. Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth. Diabetes care. 35(9) : 1821-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22699293
  • Crume TL Ogden L West NA Vehik KS Scherzinger A Daniels S McDuffie R Bichoff K Hamman RF Norris JM Dabelea D. Association of Exposure to Diabetes In Utero with Adiposity and Fat Distribution in a Multi-Ethnic Population of Youth: The EPOCH Study. Diabetologia. 54(1) : 87-92, 2011.
  • Hagopian WA, Erlich H, Lernmark A, Rewers M, Ziegler AG, Simell O, Akolkar B, Vogt R, Blair A, Ilonen J, Krischer J, She J. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatric Diabetes. 12(8) : 733-43, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21564455
  • Elding Larsson H, Vehik K, Bell R, Dabelea D, Dolan L, Pihoker C, Knip M, Veijola R, Lindblad B, Samuelsson U, Holl R, Haller MJ. Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes care. 34(11) : 2347-52, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21972409
  • Lernmark B, Johnson SB, Vehik K, Smith L, Ballard L, Baxter J, McLeod W, Roth R, Simell T. Enrollment experiences in a pediatric longitudinal observational study: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Contemporary Clinical Trials. 32(4) : 517-23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21419878
  • Vehik K, Dabelea D. The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes/metabolism research and reviews. 27(1) : 3-13, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21218503
  • Vehik K, Haller MJ, Beam CA, Schatz DA, Wherrett DK, Sosenko JM, Krischer JP. Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood. Diabetes Care. 34(2) : 358-62, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21270193
  • Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP. Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes Care. 34(7) : 1585-90, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21610124
  • Vehik K, Beam CA, Mahon JL, Schatz DA, Haller MJ, Sosenko JM, Skyler JS, Krischer JP. Development of autoantibodies in the TrialNet Natural History Study. Diabetes Care. 34(9) : 1897-901, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21750277
  • Richesson R, Vehik K. Patient registries: utility, validity and inference. Advances in Experimental Medicine and Biology. 686: 87-104, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20824441
  • Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Dabelea D. Childhood growth and age at diagnosis with Type 1 diabetes in Colorado young people. Diabetic medicine : a journal of the British Diabetic Association. 26(10) : 961-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19900226
  • Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Rewers M, Dabelea D. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diabetes care. 31(7) : 1392-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18356404
  • Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith G, Bloch C, Rewers M, Dabelea D. Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth. Diabetes care. 30(3) : 503-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17327312