Hye-Seung Lee

Hye-Seung Lee, PHD

Professor, Health Informatics Institute

Professor, COPH Epidemiology & Biostatistics

Contact Info 3650 Spectrum Blvd. Suite 100
Tampa FL 33612

Academic Email: hlee@health.usf.edu

Academic Phone:(813) 396-9535

View My C.V.


  • PHD, Columbia University, 2006

Recent Publications

  • Killian JT Jr Lane JB Lee HS Pelham JH Skinner SA Kaufmann WE Glaze DG Neul JL Percy AK. Caretaker Quality of Life in Rett Syndrome: Disorder Features and Psychological Predictors. Pediatr Neurol.. 58: 67-74, 2016.
  • Leigh MW Ferkol TW Davis SD Lee HS Rosenfeld M Dell SD Sagel SD Milla C Olivier KN Sullivan KM Zariwala MA Pittman JE Shapiro AJ Carson JL Krischer J Hazucha MJ Knowles MR. Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents. Ann Am Thorac Soc.. 13(8) : 1305-13, 2016.
  • Argula RG Kokosi M Lo P Kim HJ Ravenel JG Meyer C Goldin J Lee HS Strange C McCormack FX; MILES Study Investigators. A Novel Quantitative Computed Tomographic Analysis Suggests How Sirolimus Stabilizes Progressive Air Trapping in Lymphangioleiomyomatosis. Ann Am Thorac Soc.. 13(3) : 342-9, 2016.
  • Tarquinio DC Hou W Neul JL Kaufmann WE Glaze DG Motil KJ Skinner SA Lee H-S Percy AK. The changing face of survival in Rett Syndrome and MECP2-related disorders. To appear in Pediatric Neurology Pediatr Neurol.. 53(5) : 402-411, 2015.
  • Davis SD Ferkol TW Rosenfeld M Lee H-S Dell SD Sagel SD Zariwala MA Pittman JE Shapiro1 AJ Carson JL Krischer JP Hazucha MJ Cooper ML Knowles MR and Leigh MW. Clinical Features of Childhood Primary Ciliary Dyskinesia by Genotype and Ultrastructural Phenotype. American Journal of Respiratory and Critical Care Medicine. 191(3) : 316-324, 2015.
  • Agardh D Lee H-S Kurppa K Ville S Aronsson CA Jörneus O Hummel M Liu E Sibylle K. Clinical Features of Celiac Disease: A Prospective Birth Cohort. Pediatrics. 135(4) : 627-634, 2015.
  • Aronsson CA Lee H-S Liu E Uusitalo U Hummel S Yang J Hummel M Rewers M She J-X Simell O Toppari J Ziegler A-G Krischer JP Virtanen SM Norris JM Agardh D for the TEDDY Study Group. Age at Gluten Introduction and Risk of Celiac Disease. Pediatrics. 135(2) : 239-245, 2015.
  • Torn C Hadley D Lee H-S Hagopian WA Lernmark A Simell O Rewers M Ziegler A-G Schatz D Akolkar B Onengut-Gumuscu S Chen W-M Toppari J Mykkanen J Ilonen J Rich S She J-X Steck A Krischer JP and the TEDDY study group. Role of Type 1 diabetes associated SNPs on risk of autoantibody positivity in the TEDDY Study. Diabetes. 64: 1818-1829, 2015.
  • Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D. Risk of pediatric celiac disease according to HLA haplotype and country. The New England Journal of Medicine. 371(1) : 42-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24988556
  • Lin Y Qian X Krischer JP Vehik K Lee H-S and Huang S. A Rule-Based Prognostic Model for Type 1 Diabetes by Identifying and Synthesizing Baseline Profile Patterns. PLoS ONE. 9(9) : e109514, 2014.
  • Neul JL Lane JB Lee H-S Greets S Barrish JO Annese F McNair L Barnes K Skinner SA Motil KJ Glaze DG Kaufmann WE and Percy AK. Developmental delay in Rett syndrome: data from the natural history study. Journal of Neurodevelopmental Disorders. 6(1) : 20, 2014.
  • Lee H-S Burkhardt BR McLeod W Smith S Eberhard C Lynch K Hadley D Rewers M Simell O She J-X Hagopian W Lernmark A Akolkar B Ziegler A-G Krischer JP and the TEDDY study group. Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes/Metabolism Research and Reviews. 30(5) : 424-434, 2014.
  • Mc Guire PJ Tarasenka TN Wang T Levy E Zerfas PM Moran T Lee H-S Bequette BJ and Diaz GA. Acute metabolic decompensation due to influenza in a mouse model of ornithine transcarbamylase deficiency. Disease Models & Mechanisms. 7(2) : 205-213, 2014.
  • Gold J-A Ruth C Osann K Flodman P McManus B Lee H-S Donkervoort S Khare M Roof E Dykens E Driscoll DJ Butler MG Heinemann J Cassidy S Kimonis VE. Frequency of Prader–Willi syndrome in births conceived via assisted reproductive technology. Genetics in Medicine. 16(2) : 164-169, 2014.
  • Lu M Lee H-S Hadley D Huang JZ and Qian X. Supervised Categorical Principal Component Analysis for Genome-wide Association Analyses. BMC Genomics. 15, 2014.
  • Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MA. Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype. American Journal of Respiratory and Critical Care Medicine. 189(6) : 707-17, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24568568
  • Johnson SB, Lynch KF, Lee HS, Smith L, Baxter J, Lernmark B, Roth R, Simell T. At high risk for early withdrawal: using a cumulative risk model to increase retention in the first year of the TEDDY study. Journal of Clinical Epidemiology. 67(6) : 609-11, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24725640
  • Swigris JJ, Lee HS, Cohen M, Inoue Y, Moss J, Singer LG, Young LR, McCormack FX. St. George's Respiratory Questionnaire has longitudinal construct validity in lymphangioleiomyomatosis. Chest. 143(6) : 1671-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23328755
  • Lee HS, Briese T, Winkler C, Rewers M, Bonifacio E, Hyoty H, Pflueger M, Simell O, She JX, Hagopian W, Lernmark A, Akolkar B, Krischer JP, Ziegler AG. Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia. 56(8) : 1705-11, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23657799
  • Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX. Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. The Lancet. Respiratory medicine. 1(6) : 445-52, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24159565
  • Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR. Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia. Annals of the American Thoracic Society. 10(6) : 574-81, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24024753
  • McGuire PJ, Lee HS, Summar ML. Infectious precipitants of acute hyperammonemia are associated with indicators of increased morbidity in patients with urea cycle disorders. The Journal of Pediatrics. 163(6) : 1705-1710.e1, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24084106
  • Motil KJ, Caeg E, Barrish JO, Geerts S, Lane JB, Percy AK, Annese F, McNair L, Skinner SA, Lee HS, Neul JL, Glaze DG. Gastrointestinal and nutritional problems occur frequently throughout life in girls and women with Rett syndrome. Journal of Pediatric Gastroenterology and Nutrition. 55(3) : 292-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22331013
  • Tarquinio DC, Motil KJ, Hou W, Lee HS, Glaze DG, Skinner SA, Neul JL, Annese F, McNair L, Barrish JO, Geerts SP, Lane JB, Percy AK. Growth failure and outcome in Rett syndrome: specific growth references. Neurology. 79(16) : 1653-61, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23035069
  • McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. The New England Journal of Medicine. 364(17) : 1595-606, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21410393
  • Johnson SB Lee H-S Baxter J Lernmark B Roth R and Simell T for the TEDDY Study Group. The environmental determinants of diabetes in the young (TEDDY) study: Predictors of early study withdrawal among participants with no family history of type 1 diabetes. Pediatrics Diabetes. 12: 165-171, 2011.
  • Lee H-S Paik MC Rundek T Sacco RL Dong C Krischer JP. Heritability estimation using regression models for correlation. Journal of Biometrics & Biostatistics. 2(119) : 2666, 2011.
  • Sterner Y, Törn C, Lee HS, Larsson H, Winkler C, McLeod W, Lynch K, Simell O, Ziegler A, Schatz D, Hagopian W, Rewers M, She JX, Krischer JP, Akolkar B, Lernmark A. Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. Journal of Perinatology : Official journal of the California Perinatal Association. 31(12) : 764-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21527903
  • Lane JB, Lee HS, Smith LW, Cheng P, Percy AK, Glaze DG, Neul JL, Motil KJ, Barrish JO, Skinner SA, Annese F, McNair L, Graham J, Khwaja O, Barnes K, Krischer JP. Clinical severity and quality of life in children and adolescents with Rett syndrome. Neurology. 77(20) : 1812-8, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22013176
  • Tan WH, Bacino CA, Skinner SA, Anselm I, Barbieri-Welge R, Bauer-Carlin A, Beaudet AL, Bichell TJ, Gentile JK, Glaze DG, Horowitz LT, Kothare SV, Lee HS, Nespeca MP, Peters SU, Sahoo T, Sarco D, Waisbren SE, Bird LM. Angelman syndrome: Mutations influence features in early childhood. American Journal of Medical Genetics. Part A. 155A(1) : 81-90, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21204213
  • Glaze DG, Percy AK, Skinner S, Motil KJ, Neul JL, Barrish JO, Lane JB, Geerts SP, Annese F, Graham J, McNair L, Lee HS. Epilepsy and the natural history of Rett syndrome. Neurology. 74(11) : 909-12, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20231667
  • Gentile JK, Tan WH, Horowitz LT, Bacino CA, Skinner SA, Barbieri-Welge R, Bauer-Carlin A, Beaudet AL, Bichell TJ, Lee HS, Sahoo T, Waisbren SE, Bird LM, Peters SU. A neurodevelopmental survey of Angelman syndrome with genotype-phenotype correlations. Journal of Developmental and Behavioral Pediatrics : JDBP. 31(7) : 592-601, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20729760
  • Percy AK Neul JL Glaze DG Motil KJ Skinner SA Khwaja O Lee H-S Lane JB Barrish JO Annese F McNair L Graham J Barnes K. Rett syndrome diagnostic criteria: lessons from the natural history study. Annals of Neurology. 68: 951-955, 2010.
  • Seminara J, Tuchman M, Krivitzky L, Krischer J, Lee HS, Lemons C, Baumgartner M, Cederbaum S, Diaz GA, Feigenbaum A, Gallagher RC, Harding CO, Kerr DS, Lanpher B, Lee B, Lichter-Konecki U, McCandless SE, Merritt JL, Oster-Granite ML, Seashore MR, Stricker T, Summar M, Waisbren S, Yudkoff M, Batshaw ML. Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium. Molecular genetics and metabolism. 100 Suppl 1: S97-105, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20188616