Jeffrey Krischer

Jeffrey Krischer, PHD

Distinguished Professor, College of Medicine Neurology

Professor, College of Medicine Internal Medicine

Division Chief, Health Informatics Institute

Distinguished Prof & Director, Health Informatics Institute

Contact Info 3650 Spectrum Blvd
Tampa FL 33612

Academic Email: jkrische@health.usf.edu

Academic Phone:(813) 396-9512

View My C.V.

Education

  • PHD, Applied Mathematics, Harvard University, 1974
  • MS, Applied Mathematics, Harvard University, 1969
  • BS, Mathematics/Computer Science, Illinois Institute of Technology, 1968

Recent Publications

  • Krischer J, Cronholm PF, Burroughs C, McAlear CA, Borchin R, Easley E, Davis T, Kullman J, Carette S, Khalidi N, Koening C, Langford CA, Monach P, Moreland L, Pagnoux C, Specks U, Sreih AG, Ytterberg S, Merkel PA. Experience With Direct-to-Patient Recruitment for Enrollment Into a Clinical Trial in a Rare Disease: A Web-Based Study. Journal of medical Internet research. 19(2) : e50, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28246067
  • Smith LB, Lynch KF, Kurppa K, Koletzko S, Krischer J, Liu E, Johnson SB, Agardh D. Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics. 139(3) , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28219962
  • Krischer JP, Lynch KF, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Toppari J, Ziegler AG, Akolkar B. Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study. Diabetes care. 40(9) : 1194-1202, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28646072
  • Lönnrot M, Lynch KF, Elding Larsson H, Lernmark Å, Rewers MJ, Törn C, Burkhardt BR, Briese T, Hagopian WA, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Hyöty H. Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study. Diabetologia. , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28770319
  • Beyerlein A, Uusitalo UM, Virtanen SM, Vehik K, Yang J, Winkler C, Kersting M, Koletzko S, Schatz D, Aronsson CA, Elding Larsson H, Krischer JP, Ziegler AG, Norris JM, Hummel S. Intake of Energy and Protein is Associated with Overweight Risk at Age 5.5 Years: Results from the Prospective TEDDY Study. Obesity (Silver Spring, Md.). 25(8) : 1435-1441, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28650578
  • Langford CA, Cuthbertson D, Ytterberg SR, Khalidi N, Monach PA, Carette S, Seo P, Moreland LW, Weisman M, Koening CL, Sreih AG, Spiera R, McAlear CA, Warrington KJ, Pagnoux C, McKinnon K, Forbess LJ, Hoffman GS, Borchin R, Krischer JP, Merkel PA. A Randomized, Double-Blind Trial of Abatacept (CTLA-4Ig) for the Treatment of Takayasu Arteritis. Arthritis & rheumatology (Hoboken, N.J.). 69(4) : 846-853, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28133931
  • Tamura RN, Krischer JP, Pagnoux C, Micheletti R, Grayson PC, Chen YF, & Merkel PA. A small n sequential multiple assignment randomized trial design for use in rare disease research. Contemporary Clinical Trials. 46: 48-51, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26586608
  • Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer J, Hazucha MJ, Knowles MR. Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents. Annals of the American Thoracic Society. 13(8) : 1305-13, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27070726
  • Fouts A, Pyle L, Yu L, Miao D, Michels A, Krischer J, Sosenko J, Gottlieb P, Steck AK. Do Electrochemiluminescence Assays Improve Prediction of Time to Type 1 Diabetes in Autoantibody-Positive TrialNet Subjects? Diabetes care. , 2016. http://www.ncbi.nlm.nih.gov/pubmed/27456836
  • Haghighi M Johnson SB Qian X Lynch KF Vehik K Huang S; TEDDY Study Group . A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study. Sci Rep.. 6: 30828, 2016.
  • Ismail HM, White KS, Krischer JP, Chase HP, Cuthbertson D, & Palmer JP. First test effect in intravenous glucose tolerance testing. Pediatric Diabetes. 16(2) : 129-37, 2015. http://www.ncbi.nlm.nih.gov/pubmed/23944770
  • Roth R, Lynch K, Lernmark B, Baxter J, Simell T, Smith L, Swartling U, Ziegler AG, & Johnson SB. Maternal anxiety about a child's diabetes risk in the TEDDY study: the potential role of life stress, postpartum depression, and risk perception. Pediatric Diabetes. 16(4) : 287-98, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25082392
  • Bellur S, Jain M, Cuthbertson D, Krakow D, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Krischer J, Mullins M, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B, & Nagamani SC. Cesarean delivery is not associated with decreased at-birth fracture rates in osteogenesis imperfecta. Genetics in Medicine: Official Journal of the American College of Medical Genetics. , 2015. http://www.ncbi.nlm.nih.gov/pubmed/26426884
  • Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, Skyler JS, Sosenko JM, & Ziegler AG. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 38(10) : 1964-74, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26404926
  • Robson JC, Milman N, Tomasson G, Dawson J, Cronholm PF, Kellom K, Shea J, Ashdown S, Boers M, Boonen A, Casey GC, Farrar JT, Gebhart D, Krischer J, Lanier G, McAlear CA, Peck J, Sreih AG, Tugwell PS, Luqmani RA, & Merkel PA. Exploration, Development, and Validation of Patient-reported Outcomes in Antineutrophil Cytoplasmic Antibody-associated Vasculitis Using the OMERACT Process. The Journal of Rheumatology. 42(11) : 2204-9, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26329344
  • Beyerlein A, Liu X, Uusitalo UM, Harsunen M, Norris JM, Foterek K, Virtanen SM, Rewers MJ, She JX, Simell O, Lernmark Å, Hagopian W, Akolkar B, Ziegler AG, Krischer JP, & Hummel S. Dietary intake of soluble fiber and risk of islet autoimmunity by 5 y of age: results from the TEDDY study. The American Journal of Clinical Nutrition. 102(2) : 345-52, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26156735
  • Yang J, Lynch KF, Uusitalo UM, Foterek K, Hummel S, Silvis K, Andrén Aronsson C, Riikonen A, Rewers M, She JX, Ziegler AG, Simell OG, Toppari J, Hagopian WA, Lernmark Å, Akolkar B, Krischer JP, Norris JM, Virtanen SM, & Johnson SB. Factors associated with longitudinal food record compliance in a paediatric cohort study. Public Health Nutrition. : 1-10, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26088478
  • Hadley D, Hagopian W, Liu E, She JX, Simell O, Akolkar B, Ziegler AG, Rewers M, Krischer JP, Chen WM, Onengut-Gumuscu S, Bugawan TL, Rich SS, Erlich H, & Agardh D. HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study. The American Journal of Gastroenterology. 110(6) : 915-20, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26010309
  • Hao W, Greenbaum CJ, Krischer JP, Cuthbertson D, Marks JB, & Palmer JP. The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance. Diabetes Care. 38(5) : 891-6, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25720600
  • Steck AK, Vehik K, Bonifacio E, Lernmark A, Ziegler AG, Hagopian WA, She J, Simell O, Akolkar B, Krischer J, Schatz D, & Rewers MJ. Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY). Diabetes Care. 38(5) : 808-13, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25665818
  • Krischer JP, Lynch KF, Schatz DA, Ilonen J, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Bonifacio E. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia. 58(5) : 980-7, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25660258
  • Herold KC, Usmani-Brown S, Ghazi T, Lebastchi J, Beam CA, Bellin MD, Ledizet M, Sosenko JM, Krischer JP, & Palmer JP. β cell death and dysfunction during type 1 diabetes development in at-risk individuals. The Journal of Clinical Investigation. 125(3) : 1163-73, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25642774
  • Aronsson CA, Lee HS, Liu E, Uusitalo U, Hummel S, Yang J, Hummel M, Rewers M, She JX, Simell O, Toppari J, Ziegler AG, Krischer J, Virtanen SM, Norris JM, Agardh D. Age at gluten introduction and risk of celiac disease. Pediatrics. 135(2) : 239-45, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25601977
  • Miao D, Steck AK, Zhang L, Guyer KM, Jiang L, Armstrong T, Muller SM, Krischer J, Rewers M, & Yu L. Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk. Diabetes Technology & Therapeutics. 17(2) : 119-27, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25562486
  • Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, & Palmer JP. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care. 38(2) : 271-6, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25519451
  • Kemppainen KM, Ardissone AN, Davis-Richardson AG, Fagen JR, Gano KA, León-Novelo LG, Vehik K, Casella G, Simell O, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian W, She JX, Krischer JP, Akolkar B, Schatz DA, Atkinson MA, & Triplett EW. Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care. 38(2) : 329-32, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25519450
  • Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, & Leigh MW. Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype. American Journal of Respiratory and Critical Care Medicine. 191(3) : 316-24, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25493340
  • Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J. Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. Diabetes. 64(5) : 1818-29, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25422107
  • Bingley PJ, Boulware DC, Krischer JP. The implications of autoantibodies to a single islet antigen in relatives with normal glucose tolerance: development of other autoantibodies and progression to type 1 diabetes. Diabetologia. , 2015. http://www.ncbi.nlm.nih.gov/pubmed/26676824
  • Lin Y, Qian X, Krischer J, Vehik K, Lee HS, & Huang S. A rule-based prognostic model for type 1 diabetes by identifying and synthesizing baseline profile patterns. PloS One. 9(6) : e91095, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24926781
  • Goldberg CS, Lu M, Sleeper LA, Mahle WT, Gaynor JW, Williams IA, Mussatto KA, Ohye RG, Graham EM, Frank DU, Jacobs JP, Krawczeski C, Lambert L, Lewis A, Pemberton VL, Sananes R, Sood E, Wechsler SB, Bellinger DC, & Newburger JW. Factors associated with neurodevelopment for children with single ventricle lesions. The Journal of Pediatrics. 165(3) : 490-496.e8, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24952712
  • Batshaw ML, Groft SC, & Krischer JP. Research into rare diseases of childhood. JAMA. 311(17) : 1729-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24794360
  • Xu P, Qian X, Schatz DA, Cuthbertson D, & Krischer JP. Distribution of C-peptide and its determinants in North American children at risk for type 1 diabetes. Diabetes Care. 37(7) : 1959-65, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24760262
  • Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, & Zariwala MA. Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype. American Journal of Respiratory and Critical Care Medicine. 189(6) : 707-17, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24568568
  • Sosenko JM, Skyler JS, Mahon J, Krischer JP, Greenbaum CJ, Rafkin LE, Beam CA, Boulware DC, Matheson D, Cuthbertson D, Herold KC, Eisenbarth G, & Palmer JP. Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes. Diabetes Care. 37(4) : 979-84, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24550217
  • Lee HS, Burkhardt BR, McLeod W, Smith S, Eberhard C, Lynch K, Hadley D, Rewers M, Simell O, She JX, Hagopian B, Lernmark A, Akolkar B, Ziegler AG, & Krischer JP. Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Diabetes/Metabolism Research and Reviews. 30(5) : 424-34, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24339168
  • Hadley D, Cheung RK, Becker DJ, Girgis R, Palmer JP, Cuthbertson D, Krischer JP, & Dosch HM. Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial. Clinical and Vaccine Immunology: CVI. 21(2) : 203-11, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24334687
  • Langford CA, Monach PA, Specks U, Seo P, Cuthbertson D, McAlear CA, Ytterberg SR, Hoffman GS, Krischer JP, & Merkel PA. An open-label trial of abatacept (CTLA4-IG) in non-severe relapsing granulomatosis with polyangiitis (Wegener's). Annals of the Rheumatic Diseases. 73(7) : 1376-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24323392
  • Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS. Costimulation modulation with abatacept in patients with recent-onset type 1 diabetes: follow-up 1 year after cessation of treatment. Diabetes care. 37(4) : 1069-75, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24296850
  • Elding Larsson H, Vehik K, Gesualdo P, Akolkar B, Hagopian W, Krischer J, Lernmark Å, Rewers M, Simell O, She JX, Ziegler A, Haller MJ. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatric diabetes. 15(2) : 118-26, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24034790
  • Pescovitz MD, Greenbaum CJ, Bundy B, Becker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, Moran A, Raskin P, Rodriguez H, Schatz DA, Wherrett DK, Wilson DM, Krischer JP, Skyler JS. B-lymphocyte depletion with rituximab and β-cell function: two-year results. Diabetes care. 37(2) : 453-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24026563
  • Aiyagari R, Rhodes JF, Shrader P, Radtke WA, Bandisode VM, Bergersen L, Gillespie MJ, Gray RG, Guey LT, Hill KD, Hirsch R, Kim DW, Lee KJ, Pelech AN, Ringewald J, Takao C, Vincent JA, Ohye RG. Impact of pre-stage II hemodynamics and pulmonary artery anatomy on 12-month outcomes in the Pediatric Heart Network Single Ventricle Reconstruction trial. The Journal of thoracic and cardiovascular surgery. 148(4) : 1467-74, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24332668
  • McCrindle BW, Zak V, Breitbart RE, Mahony L, Shrader P, Lai WW, Burns KM, Colan SD, Williams RV, Goldberg D, Hill KD, Khaikin S, Atz AM. The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure. Pediatric cardiology. 35(4) : 632-40, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24264999
  • Franciscus M, Nucci A, Bradley B, Suomalainen H, Greenberg E, Laforte D, Kleemola P, Hyytinen M, Salonen M, Martin MJ, Catte D, Catteau J. Recruitment and retention of participants for an international type 1 diabetes prevention trial: a coordinators' perspective. Clinical trials (London, England). 11(2) : 150-8, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24216218
  • Lambert LM, Pike NA, Medoff-Cooper B, Zak V, Pemberton VL, Young-Borkowski L, Clabby ML, Nelson KN, Ohye RG, Trainor B, Uzark K, Rudd N, Bannister L, Korsin R, Cooper DS, Pizarro C, Zyblewski SC, Bartle BH, Williams RV. Variation in feeding practices following the Norwood procedure. The Journal of pediatrics. 164(2) : 237-42.e1, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24210923
  • Lehtonen E, Ormisson A, Nucci A, Cuthbertson D, Sorkio S, Hyytinen M, Alahuhta K, Berseth C, Salonen M, Taback S, Franciscus M, González-Frutos T, Korhonen TE, Lawson ML, Becker DJ, Krischer JP, Knip M, Virtanen SM. Use of vitamin D supplements during infancy in an international feeding trial. Public health nutrition. 17(4) : 810-22, 2014. http://www.ncbi.nlm.nih.gov/pubmed/23795865
  • Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld PD, Klein GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, Paridon SM, Pemberton VL, Pierpont ME, Pyeritz RE, Radojewski E, Roman MJ, Sharkey AM, Stylianou MP, Wechsler SB, Young LT, Mahony L. Atenolol versus losartan in children and young adults with Marfan's syndrome. The New England journal of medicine. 371(22) : 2061-71, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25405392
  • Guglin M, Lynch K, Krischer J. Heart failure as a risk factor for diabetes mellitus. Cardiology. 129(2) : 84-92, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25138610
  • Nathan M, Sleeper LA, Ohye RG, Frommelt PC, Caldarone CA, Tweddell JS, Lu M, Pearson GD, Gaynor JW, Pizarro C, Williams IA, Colan SD, Dunbar-Masterson C, Gruber PJ, Hill K, Hirsch-Romano J, Jacobs JP, Kaltman JR, Kumar SR, Morales D, Bradley SM, Kanter K, Newburger JW. Technical performance score is associated with outcomes after the Norwood procedure. The Journal of thoracic and cardiovascular surgery. 148(5) : 2208-13, 2214.e1-6, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25037617
  • Krischer JP, Gopal-Srivastava R, Groft SC, Eckstein DJ. The Rare Diseases Clinical Research Network's organization and approach to observational research and health outcomes research. Journal of general internal medicine. 29 Suppl 3: S739-44, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25029976
  • Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D. Risk of pediatric celiac disease according to HLA haplotype and country. The New England journal of medicine. 371(1) : 42-9, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24988556
  • Knip M, Åkerblom HK, Becker D, Dosch HM, Dupre J, Fraser W, Howard N, Ilonen J, Krischer JP, Kordonouri O, Lawson ML, Palmer JP, Savilahti E, Vaarala O, Virtanen SM. Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial. JAMA. 311(22) : 2279-87, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24915259
  • Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castaño L, Wägner A, Lervang HH, Perrild H, Mandrup-Poulsen T. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet. 381(9881) : 1905-15, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23562090
  • Ravishankar C, Zak V, Williams IA, Bellinger DC, Gaynor JW, Ghanayem NS, Krawczeski CD, Licht DJ, Mahony L, Newburger JW, Pemberton VL, Williams RV, Sananes R, Cook AL, Atz T, Khaikin S, Hsu DT. Association of impaired linear growth and worse neurodevelopmental outcome in infants with single ventricle physiology: a report from the pediatric heart network infant single ventricle trial. The Journal of pediatrics. 162(2) : 250-6.e2, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22939929
  • Quenan S, Strueven V, Saxer N, Laffitte E, Kaya G, Krischer J, Hafezi F, Le Gal FA. Pruritic acquired nevus of Ota. Dermatology (Basel, Switzerland). 227(2) : 186-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24060704
  • Adl AA, Qian X, Xu P, Vehik K, Krischer JP. Feature ranking based on synergy networks to identify prognostic markers in DPT-1. EURASIP journal on bioinformatics & systems biology. 2013(1) : 12, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24050757
  • Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR. Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia. Annals of the American Thoracic Society. 10(6) : 574-81, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24024753
  • Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP. Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants. Diabetes. 62(12) : 4179-83, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23863814
  • Sosenko JM, Skyler JS, Palmer JP, Krischer JP, Yu L, Mahon J, Beam CA, Boulware DC, Rafkin L, Schatz D, Eisenbarth G. The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients. Diabetes care. 36(9) : 2615-20, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23818528
  • Krischer JP. The use of intermediate endpoints in the design of type 1 diabetes prevention trials. Diabetologia. 56(9) : 1919-24, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23744306
  • Vehik K, Fiske SW, Logan CA, Agardh D, Cilio CM, Hagopian W, Simell O, Roivainen M, She JX, Briese T, Oikarinen S, Hyoty H, Ziegler AG, Rewers M, Lernmark A, Akolkar B, Krischer JP, Burkhardt BR. Methods, quality control and specimen management in an international multicentre investigation of type 1 diabetes: TEDDY. Diabetes/metabolism research and reviews. 29(7) : 557-67, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23674484
  • Lee HS, Briese T, Winkler C, Rewers M, Bonifacio E, Hyoty H, Pflueger M, Simell O, She JX, Hagopian W, Lernmark A, Akolkar B, Krischer JP, Ziegler AG. Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia. 56(8) : 1705-11, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23657799
  • Akers AL, Ball KL, Clancy M, Comi AM, Faughnan ME, Gopal-Srivastava R, Jacobs TP, Kim H, Krischer J, Marchuk DA, McCulloch CE, Morrison L, Moses M, Moy CS, Pawlikowska L, Young WL. Brain Vascular Malformation Consortium: Overview, Progress and Future Directions. The Journal of rare disorders. 1(1) : 5, 2013. http://www.ncbi.nlm.nih.gov/pubmed/25221778
  • Monach PA, Warner RL, Tomasson G, Specks U, Stone JH, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Iklé D, Kallenberg CG, Krischer J, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Johnson KJ, Merkel PA. Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. Annals of the rheumatic diseases. 72(8) : 1342-50, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22975753
  • Ashizawa T, Figueroa KP, Perlman SL, Gomez CM, Wilmot GR, Schmahmann JD, Ying SH, Zesiewicz TA, Paulson HL, Shakkottai VG, Bushara KO, Kuo SH, Geschwind MD, Xia G, Mazzoni P, Krischer JP, Cuthbertson D, Holbert AR, Ferguson JH, Pulst SM, Subramony SH. Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; a prospective observational study. Orphanet journal of rare diseases. 8: 177, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24225362
  • Buckingham B, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Tamborlane WV. Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes. Diabetes care. 36(12) : 4030-5, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24130350
  • Lacro RV, Guey LT, Dietz HC, Pearson GD, Yetman AT, Gelb BD, Loeys BL, Benson DW, Bradley TJ, De Backer J, Forbus GA, Klein GL, Lai WW, Levine JC, Lewin MB, Markham LW, Paridon SM, Pierpont ME, Radojewski E, Selamet Tierney ES, Sharkey AM, Wechsler SB, Mahony L. Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy. American heart journal. 165(5) : 828-835.e3, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23622922
  • Williams RV, Margossian R, Lu M, Atz AM, Bradley TJ, Jay Campbell M, Colan SD, Gallagher D, Lai WW, Pearson GD, Prakash A, Shirali G, Cohen MS. Factors impacting echocardiographic imaging after the Fontan procedure: a report from the pediatric heart network fontan cross-sectional study. Echocardiography (Mount Kisco, N.Y.). 30(9) : 1098-106, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23614708
  • , Buckingham BA, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Cantwell M. The effects of inpatient hybrid closed-loop therapy initiated within 1 week of type 1 diabetes diagnosis. Diabetes technology & therapeutics. 15(5) : 401-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23570538
  • Aronsson CA, Vehik K, Yang J, Uusitalo U, Hay K, Joslowski G, Riikonen A, Ballard L, Virtanen SM, Norris JM. Use of dietary supplements in pregnant women in relation to sociodemographic factors - a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Public health nutrition. 16(8) : 1390-402, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23452986
  • Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX. Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. The Lancet. Respiratory medicine. 1(6) : 445-52, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24159565
  • Couluris M, Kinder BW, Xu P, Gross-King M, Krischer J, Panos RJ. Treatment of idiopathic pulmonary fibrosis with losartan: a pilot project. Lung. 190(5) : 523-7, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22810758
  • Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, Olbrich H, Becker-Heck A, Schmidts M, Werner C, Omran H, Zariwala MA. Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure. Thorax. 67(5) : 433-41, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22184204
  • Vehik K, Cuthbertson D, Boulware D, Beam CA, Rodriguez H, Legault L, Hyytinen M, Rewers MJ, Schatz DA, Krischer JP. Performance of HbA1c as an early diagnostic indicator of type 1 diabetes in children and youth. Diabetes care. 35(9) : 1821-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22699293
  • Sosenko JM, Skyler JS, Mahon J, Krischer JP, Beam CA, Boulware DC, Greenbaum CJ, Rafkin LE, Cowie C, Cuthbertson D, Palmer JP. The application of the diabetes prevention trial-type 1 risk score for identifying a preclinical state of type 1 diabetes. Diabetes care. 35(7) : 1552-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22547092
  • Yu L, Boulware DC, Beam CA, Hutton JC, Wenzlau JM, Greenbaum CJ, Bingley PJ, Krischer JP, Sosenko JM, Skyler JS, Eisenbarth GS, Mahon JL. Zinc transporter-8 autoantibodies improve prediction of type 1 diabetes in relatives positive for the standard biochemical autoantibodies. Diabetes care. 35(6) : 1213-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22446173
  • Richesson RL, Sutphen R, Shereff D, Krischer JP. The Rare Diseases Clinical Research Network Contact Registry update: features and functionality. Contemporary clinical trials. 33(4) : 647-56, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22405970
  • Monach PA, Kümpers P, Lukasz A, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Carette S, Ding L, Hoffman GS, Iklé D, Kallenberg CG, Khalidi NA, Langford CA, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Haubitz M, Merkel PA. Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PloS one. 7(1) : e30197, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22279570
  • Shurin S, Krischer J, Groft SC. Clinical trials In BMT: ensuring that rare diseases and rarer therapies are well done. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(1 Suppl) : S8-11, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22226117
  • Nucci AM, Becker DJ, Virtanen SM, Cuthbertson D, Softness B, Huot C, Wasikowa R, Dosch HM, Akerblom HK, Knip M. Growth differences between North American and European children at risk for type 1 diabetes. Pediatric diabetes. 13(5) : 425-31, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22251851
  • Statland JM, Bundy BN, Wang Y, Rayan DR, Trivedi JR, Sansone VA, Salajegheh MK, Venance SL, Ciafaloni E, Matthews E, Meola G, Herbelin L, Griggs RC, Barohn RJ, Hanna MG. Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. JAMA. 308(13) : 1357-65, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23032552
  • Statland JM, Bundy BN, Wang Y, Trivedi JR, Raja Rayan D, Herbelin L, Donlan M, McLin R, Eichinger KJ, Findlater K, Dewar L, Pandya S, Martens WB, Venance SL, Matthews E, Amato AA, Hanna MG, Griggs RC, Barohn RJ. A quantitative measure of handgrip myotonia in non-dystrophic myotonia. Muscle & nerve. 46(4) : 482-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22987687
  • Salami F, Abels M, Hyöty H, Vaziri-Sani F, Aronsson C, Vehik K, Delli A, Hagopian W, Rewers M, Ziegler A, Simell O, Akolkar B, Krischer J, She J, Lernmark A. DETECTION OF LACTOBACILLI IN MONTHLY MAIL-IN STOOL SAMPLES FROM 3-18 MONTHS OLD INFANTS AT GENETIC RISK FOR TYPE 1 DIABETES. International journal of probiotics & prebiotics. 7(3-4) : 135-144, 2012. http://www.ncbi.nlm.nih.gov/pubmed/25045339
  • Ghanayem NS, Allen KR, Tabbutt S, Atz AM, Clabby ML, Cooper DS, Eghtesady P, Frommelt PC, Gruber PJ, Hill KD, Kaltman JR, Laussen PC, Lewis AB, Lurito KJ, Minich LL, Ohye RG, Schonbeck JV, Schwartz SM, Singh RK, Goldberg CS. Interstage mortality after the Norwood procedure: Results of the multicenter Single Ventricle Reconstruction trial. The Journal of thoracic and cardiovascular surgery. 144(4) : 896-906, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22795436
  • Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, Frank DU, Lu M, Pizarro C, Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L, Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P. Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. The Journal of thoracic and cardiovascular surgery. 144(4) : 882-95, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22704284
  • Pasquali SK, Ohye RG, Lu M, Kaltman J, Caldarone CA, Pizarro C, Dunbar-Masterson C, Gaynor JW, Jacobs JP, Kaza AK, Newburger J, Rhodes JF, Scheurer M, Silver E, Sleeper LA, Tabbutt S, Tweddell J, Uzark K, Wells W, Mahle WT, Pearson GD. Variation in perioperative care across centers for infants undergoing the Norwood procedure. The Journal of thoracic and cardiovascular surgery. 144(4) : 915-21, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22698562
  • Baxter J, Vehik K, Johnson SB, Lernmark B, Roth R, Simell T. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study. Contemporary clinical trials. 33(4) : 633-40, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22484339
  • Newburger JW, Sleeper LA, Bellinger DC, Goldberg CS, Tabbutt S, Lu M, Mussatto KA, Williams IA, Gustafson KE, Mital S, Pike N, Sood E, Mahle WT, Cooper DS, Dunbar-Masterson C, Krawczeski CD, Lewis A, Menon SC, Pemberton VL, Ravishankar C, Atz TW, Ohye RG, Gaynor JW. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation. 125(17) : 2081-91, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22456475
  • Tweddell JS, Sleeper LA, Ohye RG, Williams IA, Mahony L, Pizarro C, Pemberton VL, Frommelt PC, Bradley SM, Cnota JF, Hirsch J, Kirshbom PM, Li JS, Pike N, Puchalski M, Ravishankar C, Jacobs JP, Laussen PC, McCrindle BW. Intermediate-term mortality and cardiac transplantation in infants with single-ventricle lesions: risk factors and their interaction with shunt type. The Journal of thoracic and cardiovascular surgery. 144(1) : 152-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22341427
  • Xu P, Beam CA, Cuthbertson D, Sosenko JM, Skyler JS, Krischer JP. Prognostic accuracy of immunologic and metabolic markers for type 1 diabetes in a high-risk population: receiver operating characteristic analysis. Diabetes care. 35(10) : 1975-80, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22787174
  • , Akerblom HK, Krischer J, Virtanen SM, Berseth C, Becker D, Dupré J, Ilonen J, Trucco M, Savilahti E, Koski K, Pajakkala E, Fransiscus M, Lough G, Bradley B, Koski M, Knip M. The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up. Diabetologia. 54(3) : 627-33, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21153533
  • Lane JB, Lee HS, Smith LW, Cheng P, Percy AK, Glaze DG, Neul JL, Motil KJ, Barrish JO, Skinner SA, Annese F, McNair L, Graham J, Khwaja O, Barnes K, Krischer JP. Clinical severity and quality of life in children and adolescents with Rett syndrome. Neurology. 77(20) : 1812-8, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22013176
  • Monach PA, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Ikle D, Kallenberg CG, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Gu YZ, Snyder RD, Merkel PA. Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis and rheumatism. 63(12) : 3988-97, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21953143
  • Sosenko JM, Skyler JS, Palmer JP, Krischer JP, Cuthbertson D, Yu L, Schatz DA, Orban T, Eisenbarth G. A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants. Diabetes care. 34(11) : 2435-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21911777
  • Pescovitz MD, Torgerson TR, Ochs HD, Ocheltree E, McGee P, Krause-Steinrauf H, Lachin JM, Canniff J, Greenbaum C, Herold KC, Skyler JS, Weinberg A. Effect of rituximab on human in vivo antibody immune responses. The Journal of allergy and clinical immunology. 128(6) : 1295-1302.e5, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21908031
  • Mahon JL, Beam CA, Marcovina SM, Boulware DC, Palmer JP, Winter WE, Skyler JS, Krischer JP. Comparison of two insulin assays for first-phase insulin release in type 1 diabetes prediction and prevention studies. Clinica chimica acta; international journal of clinical chemistry. 412(23-24) : 2128-31, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21843518
  • Oster-Granite ML, Parisi MA, Abbeduto L, Berlin DS, Bodine C, Bynum D, Capone G, Collier E, Hall D, Kaeser L, Kaufmann P, Krischer J, Livingston M, McCabe LL, Pace J, Pfenninger K, Rasmussen SA, Reeves RH, Rubinstein Y, Sherman S, Terry SF, Whitten MS, Williams S, McCabe ER, Maddox YT. Down syndrome: national conference on patient registries, research databases, and biobanks. Molecular Genetics and Metabolism. 104(1) : 13-22, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21835664
  • Yu L, Herold K, Krause-Steinrauf H, McGee PL, Bundy B, Pugliese A, Krischer J, Eisenbarth GS. Rituximab selectively suppresses specific islet antibodies. Diabetes. 60(10) : 2560-5, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21831969
  • Levis S, Strickman-Stein N, Ganjei-Azar P, Xu P, Doerge DR, Krischer J. Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial. Archives of internal medicine. 171(15) : 1363-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21824950
  • Williams RV, Zak V, Ravishankar C, Altmann K, Anderson J, Atz AM, Dunbar-Masterson C, Ghanayem N, Lambert L, Lurito K, Medoff-Cooper B, Margossian R, Pemberton VL, Russell J, Stylianou M, Hsu D. Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial. The Journal of pediatrics. 159(6) : 1017-22.e2, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21784436
  • Couluris M, Schnapf BM, Casey A, Xu P, Gross-King M, Krischer J. How to measure secondhand smoke exposure in a pediatric clinic setting. Archives of pediatrics & adolescent medicine. 165(7) : 670-1, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21727281
  • Wherrett DK, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Herold KC, Marks JB, Monzavi R, Moran A, Orban T, Palmer JP, Raskin P, Rodriguez H, Schatz D, Wilson DM, Krischer JP, Skyler JS. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet (London, England). 378(9788) : 319-27, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21714999
  • Sosenko JM, Skyler JS, Mahon J, Krischer JP, Beam CA, Boulware DC, Greenbaum CJ, Rafkin LE, Cowie C, Cuthbertson D, Palmer JP. Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. Diabetes care. 34(8) : 1785-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21680724
  • Knip M, Virtanen SM, Becker D, Dupré J, Krischer JP, Åkerblom HK. Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). The American journal of clinical nutrition. 94(6 Suppl) : 1814S-1820S, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21653795
  • Hagopian WA, Erlich H, Lernmark A, Rewers M, Ziegler AG, Simell O, Akolkar B, Vogt R, Blair A, Ilonen J, Krischer J, She J. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatric diabetes. 12(8) : 733-43, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21564455
  • Sterner Y, Törn C, Lee HS, Larsson H, Winkler C, McLeod W, Lynch K, Simell O, Ziegler A, Schatz D, Hagopian W, Rewers M, She JX, Krischer JP, Akolkar B, Lernmark A. Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. Journal of perinatology : official journal of the California Perinatal Association. 31(12) : 764-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21527903
  • Greenbaum CJ, Buckingham B, Chase HP, Krischer J. Metabolic tests to determine risk for type 1 diabetes in clinical trials. Diabetes/metabolism research and reviews. 27(6) : 584-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21488143
  • McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. The New England journal of medicine. 364(17) : 1595-606, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21410393
  • Ziegler AG, Pflueger M, Winkler C, Achenbach P, Akolkar B, Krischer JP, Bonifacio E. Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. Journal of autoimmunity. 37(1) : 3-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21376535
  • Lee HS, Paik MC, Rundek T, Sacco RL, Dong C, Krischer JP. Heritability Estimation using Regression Models for Correlation. Journal of biometrics & biostatistics. 2(119) , 2011. http://www.ncbi.nlm.nih.gov/pubmed/22457844
  • Vehik K, Beam CA, Mahon JL, Schatz DA, Haller MJ, Sosenko JM, Skyler JS, Krischer JP. Development of autoantibodies in the TrialNet Natural History Study. Diabetes care. 34(9) : 1897-901, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21750277
  • Vehik K, Cuthbertson D, Ruhlig H, Schatz DA, Peakman M, Krischer JP. Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial. Diabetes care. 34(7) : 1585-90, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21610124
  • Vehik K, Haller MJ, Beam CA, Schatz DA, Wherrett DK, Sosenko JM, Krischer JP. Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood. Diabetes care. 34(2) : 358-62, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21270193
  • Seminara J, Tuchman M, Krivitzky L, Krischer J, Lee HS, Lemons C, Baumgartner M, Cederbaum S, Diaz GA, Feigenbaum A, Gallagher RC, Harding CO, Kerr DS, Lanpher B, Lee B, Lichter-Konecki U, McCandless SE, Merritt JL, Oster-Granite ML, Seashore MR, Stricker T, Summar M, Waisbren S, Yudkoff M, Batshaw ML. Establishing a consortium for the study of rare diseases: The Urea Cycle Disorders Consortium. Molecular genetics and metabolism. 100 Suppl 1: S97-105, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20188616
  • Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. American journal of respiratory and critical care medicine. 181(12) : 1345-54, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20167854
  • Sosenko JM, Mahon J, Rafkin L, Lachin JM, Krause-Steinrauf H, Krischer JP, Cuthbertson D, Palmer JP, Thompson C, Greenbaum CJ, Skyler JS. A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants. Pediatric diabetes. , 2010. http://www.ncbi.nlm.nih.gov/pubmed/20522170
  • Sosenko JM, Skyler JS, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Cuthbertson D, Cowie C, Herold K, Eisenbarth G, Palmer JP. Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial-type 1 (DPT-1). Diabetes. 59(10) : 2386-9, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20682683
  • Sosenko JM, Palmer JP, Rafkin LE, Krischer JP, Cuthbertson D, Greenbaum CJ, Eisenbarth G, Skyler JS. Trends of earlier and later responses of C-peptide to oral glucose challenges with progression to type 1 diabetes in diabetes prevention trial-type 1 participants. Diabetes care. 33(3) : 620-5, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20032282
  • Levis S, Strickman-Stein N, Doerge DR, Krischer J. Design and baseline characteristics of the soy phytoestrogens as replacement estrogen (SPARE) study--a clinical trial of the effects of soy isoflavones in menopausal women. Contemporary clinical trials. 31(4) : 293-302, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20230914
  • Bonifacio E, Yu L, Williams AK, Eisenbarth GS, Bingley PJ, Marcovina SM, Adler K, Ziegler AG, Mueller PW, Schatz DA, Krischer JP, Steffes MW, Akolkar B. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. The Journal of clinical endocrinology and metabolism. 95(7) : 3360-7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20444913
  • Richesson RL, Smith SB, Malloy J, Krischer JP. Achieving standardized medication data in clinical research studies: two approaches and applications for implementing RxNorm. Journal of medical systems. 34(4) : 651-7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20703919
  • Xu P, Wu Y, Zhu Y, Dagne G, Johnson G, Cuthbertson D, Krischer JP, Sosenko JM, Skyler JS. Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes. Diabetes care. 33(12) : 2508-13, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20807869
  • Sorkio S, Cuthbertson D, Bärlund S, Reunanen A, Nucci AM, Berseth CL, Koski K, Ormisson A, Savilahti E, Uusitalo U, Ludvigsson J, Becker DJ, Dupré J, Krischer JP, Knip M, Akerblom HK, Virtanen SM. Breastfeeding patterns of mothers with type 1 diabetes: results from an infant feeding trial. Diabetes/metabolism research and reviews. 26(3) : 206-11, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20474068
  • Roesch LF, Casella G, Simell O, Krischer J, Wasserfall CH, Schatz D, Atkinson MA, Neu J, Triplett EW. Influence of fecal sample storage on bacterial community diversity. The open microbiology journal. 3: 40-6, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19440250
  • Sosenko JM, Palmer JP, Rafkin-Mervis L, Krischer JP, Cuthbertson D, Mahon J, Greenbaum CJ, Cowie CC, Skyler JS. Incident dysglycemia and progression to type 1 diabetes among participants in the Diabetes Prevention Trial-Type 1. Diabetes care. 32(9) : 1603-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19487644
  • Orban T, Sosenko JM, Cuthbertson D, Krischer JP, Skyler JS, Jackson R, Yu L, Palmer JP, Schatz D, Eisenbarth G. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes care. 32(12) : 2269-74, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19741189
  • Richesson RL, Lee HS, Cuthbertson D, Lloyd J, Young K, Krischer JP. An automated communication system in a contact registry for persons with rare diseases: scalable tools for identifying and recruiting clinical research participants. Contemporary clinical trials. 30(1) : 55-62, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18804556
  • Richesson RL, Malloy JF, Paulus K, Cuthbertson D, Krischer JP. An automated standardized system for managing adverse events in clinical research networks. Drug safety : an international journal of medical toxicology and drug experience. 31(10) : 807-22, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18759506
  • Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatment-related cachexia. Journal of pediatric hematology/oncology. 30(11) : 791-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18989154
  • Krischer MM, Xu P. Determinants of psychological functioning in patients undergoing radiotherapy: a descriptive study. Journal of psychosocial oncology. 26(4) : 1-13, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19042269
  • Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ichiwata T, Tanaka N, Yamaguchi E, Eda R, Oishi K, Tsuchihashi Y, Kaneko C, Nukiwa T, Sakatani M, Krischer JP, Nakata K. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. American journal of respiratory and critical care medicine. 177(7) : 752-62, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18202348
  • Sosenko JM, Palmer JP, Rafkin-Mervis L, Krischer JP, Cuthbertson D, Matheson D, Skyler JS. Glucose and C-peptide changes in the perionset period of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes care. 31(11) : 2188-92, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18650369
  • Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC. Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy individuals. Blood. , 2008. http://www.ncbi.nlm.nih.gov/pubmed/18845791
  • Richesson RL, Fung KW, Krischer JP. Heterogeneous but "standard" coding systems for adverse events: Issues in achieving interoperability between apples and oranges. Contemporary clinical trials. 29(5) : 635-45, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18406213
  • Moyers S, Richesson R, Krischer J. Trans-atlantic data harmonization in the classification of medicines and dietary supplements: a challenge for epidemiologic study and clinical research. International journal of medical informatics. 77(1) : 58-67, 2008. http://www.ncbi.nlm.nih.gov/pubmed/17289429
  • Andrews JE, Patrick TB, Richesson RL, Brown H, Krischer JP. Comparing heterogeneous SNOMED CT coding of clinical research concepts by examining normalized expressions. Journal of biomedical informatics. 41(6) : 1062-9, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18328789
  • Kumar NB, Besterman-Dahan K, Kang L, Pow-Sang J, Xu P, Allen K, Riccardi D, Krischer JP. Results of a Randomized Clinical Trial of the Action of Several Doses of Lycopene in Localized Prostate Cancer: Administration Prior to Radical Prostatectomy. Clinical medicine. Urology [electronic resource]. 1: 1-14, 2008. http://www.ncbi.nlm.nih.gov/pubmed/20354574
  • Krischer MM, Xu P, Meade CD, Jacobsen PB. Self-administered stress management training in patients undergoing radiotherapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 25(29) : 4657-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17876009
  • Richesson R, Syed A, Guillette H, Tuttle MS, Krischer J. A web-based SNOMED CT browser: distributed and real-time use of SNOMED CT during the clinical research process. Studies in health technology and informatics. 129(Pt 1) : 631-5, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17911793
  • Richesson RL, Krischer J. Data standards in clinical research: gaps, overlaps, challenges and future directions. Journal of the American Medical Informatics Association: JAMIA. 14(6) : 687-96, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17712081
  • Xu P, Cuthbertson D, Greenbaum C, Palmer JP, Krischer JP. Role of insulin resistance in predicting progression to type 1 diabetes. Diabetes care. 30(9) : 2314-20, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17536068
  • Andrews JE, Richesson RL, & Krischer J. Variation of SNOMED CT coding of clinical research concepts among coding experts. Journal of the American Medical Informatics Association: JAMIA. 14(4) : 497-506, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17460128
  • Richesson RL, Young K, Lloyd J, Adams T, Guillette H, Malloy J, Krischer JP. An automated communication system in a Contact Registry for persons with rare diseases: tools for retaining potential clinical research participants. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. : 1094, 2007. http://www.ncbi.nlm.nih.gov/pubmed/18694191
  • Richesson R, Young K, Guillette H, Tuttle M, Abbondondolo M, Krischer J. Standard terminology on demand: facilitating distributed and real-time use of SNOMED CT during the clinical research process. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium. : 1076, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17238695
  • Richesson RL, Andrews JE, & Krischer JP. Use of SNOMED CT to represent clinical research data: a semantic characterization of data items on case report forms in vasculitis research. Journal of the American Medical Informatics Association: JAMIA. 13(5) : 536-46, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16799121
  • Roetzheim RG, Christman LK, Jacobsen PB, Cantor AB, Schroeder J, Abdulla R, Hunter S, Chirikos TN, & Krischer JP. A randomized controlled trial to increase cancer screening among attendees of community health centers. Annals of Family Medicine. 2(4) : 294-300, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15335126
  • Krischer J. The biostatistics of prediction. Autoimmunity. 37(4) : 261-3, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15518038
  • Fink E, Kokku PK, Nikiforou S, Hall LO, Goldgof DB, Krischer JP. Selection of patients for clinical trials: an interactive web-based system. Artificial intelligence in medicine. 31(3) : 241-54, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15302090
  • Sutphen R, Xu Y, Wilbanks GD, Fiorica J, Grendys EC, LaPolla JP, Arango H, Hoffman MS, Martino M, Wakeley K, Griffin D, Blanco RW, Cantor AB, Xiao YJ, Krischer JP. Lysophospholipids are potential biomarkers of ovarian cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 13(7) : 1185-91, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15247129
  • Krischer JP, Cuthbertson DD, Greenbaum C. Male sex increases the risk of autoimmunity but not type 1 diabetes. Diabetes care. 27(8) : 1985-90, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15277428
  • Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. The Journal of clinical endocrinology and metabolism. 88(1) : 103-8, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12519837
  • Chirikos TN, Ruckdeschel JC, Krischer JP. Impact of clinical trials on the cost of cancer care. Medical care. 39(4) : 373-83, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11329524
  • Roetzheim RG, Gonzalez EC, Ferrante JM, Pal N, Van Durme DJ, Krischer JP. Effects of health insurance and race on breast carcinoma treatments and outcomes. Cancer. 89(11) : 2202-13, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11147590
  • Roetzheim RG, Pal N, Gonzalez EC, Ferrante JM, Van Durme DJ, Krischer JP. Effects of health insurance and race on colorectal cancer treatments and outcomes. American journal of public health. 90(11) : 1746-54, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11076244
  • Roetzheim RG, Pal N, van Durme DJ, Wathington D, Ferrante JM, Gonzalez EC, Krischer JP. Increasing supplies of dermatologists and family physicians are associated with earlier stage of melanoma detection. Journal of the American Academy of Dermatology. 43(2 Pt 1) : 211-8, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10906640
  • Roetzheim RG, Pal N, Tennant C, Voti L, Ayanian JZ, Schwabe A, Krischer JP. Effects of health insurance and race on early detection of cancer. Journal of the National Cancer Institute. 91(16) : 1409-15, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10451447
  • Roetzheim RG, Pal N, Gonzalez EC, Ferrante JM, Van Durme DJ, Ayanian JZ, Krischer JP. The effects of physician supply on the early detection of colorectal cancer. The Journal of family practice. 48(11) : 850-8, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10907621
  • Cantor AB, Krischer JP, Cuthbertson DD, Schatz DA, Riley WJ, Malone J, Schwartz S, Quattrin T, Maclaren NK. Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM. The Journal of clinical endocrinology and metabolism. 80(12) : 3739-43, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8530627
  • Papaconstantinou C, Krischer JP. An automated patient registration and treatment randomization system. Journal of medical systems. 19(6) : 445-56, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8750375