Lewis P. Rubin, MD
Dr. Rubin joined USF in 2008 as Division Chief and holder of the Pamela & Leslie Muma Chair in Neonatology. He received his M.Phil. and M.D. degrees from Yale U niversity, completed a residency in pediatrics at Children's Hospital in Boston and a newborn medicine fellowship at Children's Hospital, Brigham & Women's Hospital and Beth Israel Hospital. He also was a postdoctoral fellow in molecular endocrinology at Brigham & Women's Hospital. Dr. Rubin was a faculty member in Pediatrics and Social Medicine at Harvard Medical School, then associate professor of pediatrics and co-director of the Fetal Medicine Program at Women & Infants' Hospital and Brown Medical School in Providence, RI. He was recruited to USF from the Cleveland Clinic, where he served as Chairman of Neonatology, Co-Director of the Fetal Care Center and Staff Scientist in the Department of Cell Biology. He is a nationally-recognized authority on intensive care for premature babies and infants who have complex metabolic, cardiorespiratory or neurodevelopmental disorders or multiple congenital anomalies. He is listed in Best Doctors in America, 2007-2008.
Education & Training
| B.A. | New York University, 1973 |
| M.Phil. | Yale University, 1976 |
| M.D. | Yale University, 1982 |
| Pediatric Residency | Boston Children's Hospital, 1982-85 |
| Neonatology Fellowship | Joint Program in Neonatology (Harvard), 1985-88 |
| Postdoctoral Fellowship | Brigham & Women's Hospital, 1988-89 (Molecular Endocrinology) |
Board Certification
- American Board of Pediatrics
- Neonatal and Perinatal Medicine
Scholarly Activity
Dr. Rubin is well known for his research in perinatal biology and medicine, nutrition and metabolism, growth and evidence-based neonatal care. He is a member of the American Pediatric Society, serves on the editorial board of several scientific journals and has authored more than 60 peer-reviewed journal articles and a dozen book chapters and reviews. He has a long track record of NIH funding and is currently Principal Investigator or Co-PI on two major NIH grants.
The Rubin laboratory, located at the USF/All Children's Hospital Children's Research Institute in St. Petersburg, studies the interplay between environment and genetics, focusing on the effects of intrauterine stress, nutrition and other factors on fetal and newborn growth, development and epigenetic programming. He also directs several multisite clinical studies on neonatal nutrition and body composition.
Selected Publications
Sanchez-Esteban J, Wang Y, Gruppuso PA, Rubin LP. Mechanical stretch induces fetal lung type II cell differentiation via an epidermal growth factor receptor ERK MAP kinase signaling pathway. Am J Mol Cell Respir Biol 30:76-83, 2004
Rubin LP, Kovacs CA, De Paepe ME, Tsai SW, Torday JS, Kronenberg HM. Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev Dyn. 230:278-289, 2004
Jaleel MA, Tsai AC, Sarkar S, Freedman PV, Rubin LP. Stromal-derived growth factor (SDF-1) signalling regulates human placental trophoblast cell survival. Hum Mol Reprod. 10:901-909, 2004
Sanchez-Esteban J, Wang Y, Filardo EJ, Rubin LP, Ingber DE. Intregrins β1, α6 and α3 contribute to mechanical strain-induced differentiation of fetal type II cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol 290:L343-350, 2006
Gong X, Tsai SW, Yan B, Rubin LP. Cooperation between MEF2 and PPARγ in human intestinal β,β-carotene 15,15'-monooxygenase gene expression. BMC Mol Biol. 7:7, 2006
Rubin LP. Automated colorimetric blood culture systems in the diagnosis of neonatal sepsis. J Pediatr Infect Dis. 2:1-3, 2007
Rubin LP. Invited editorial: postnatal growth in preterm infants: too small, too big, or just right? J Pediatr. In press
