Angel Luciano, M.D., FAAP
After completing his training in pediatrics, neonatology and a post-doctoral research fellowship in immunology, Dr. Luciano joined the faculty at Case Western Reserve University-Rainbow Babies and Children’s Hospital in Cleveland, Ohio in 2008. While in Ohio, Dr. Luciano served as Assistant Professor of Pediatrics, teacher of the Medical Spanish Course for medical students in the CWRU-School of Medicine Applied Medical Spanish Program, and was a member of the Committee for the Neonatology-Physiology Core Curriculum Development. In 2010, Dr. Luciano re-located to Tampa to continue his research in developmental immunology. Dr. Luciano has an interest in academic medicine, including the teaching of medical students, residents and fellows. His primary scholarly interests include the role of intrauterine exposure to bacterial products and its effects on the development of the immune system in premature infants. He is also interested in the role of bacterial translocation in HIV infection.
Education & Training
| B.S. | University of Puerto Rico - Mayaguez Campus, 1997 |
| M.D. | University of Puerto Rico School of Medicine, 2001 |
| Pediatric Residency | University of Texas Medical Branch, Galveston, 2004 |
| Neonatology Fellowship | Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland, 2008 |
| Post-Doctoral Research Fellowship | Case Western Reserve University, 2008 |
Board Certifications
- American Board of Pediatrics
- Neonatal and Perinatal Medicine
Scholarly Interests
- Developmental Immunology
- HIV
Selected Publications
Maricruz Crespo, Denise G. Martinez, Adam Cerissi, Brenda Rivera-Reyes, Helene B. Bernstein, Michael M. Lederman, Scott F. Sieg and Angel A. Luciano. Neonatal T cell Maturation and Homing Receptor Responses to Toll-Like Receptor Ligands Differ from Those of Adult Naïve T Cells: Relationship to Prematurity. Pediatr Res 2012 Feb;71(2):136-43. doi: 10.1038/pr.2011.26. Epub 2011 Dec 21
Benigno Rodriguez, Douglas A. Bazdar, Nicholas Funderburg, Robert Asaad, Angel A. Luciano, Gopal Yadavalli, Robert C. Kalayjian, Michael M. Lederman and Scott F. Sieg. Frequencies of FoxP3+ naïve T cells are related to both viral load and naïve T cell proliferation responses in HIV disease. J Leukoc Biol. 2011 Sep;90(3):621-8. Epub 2011 Jun 7.
AA. Luciano, Yu H, Jackson L,Wolfe L and Helene B. Bernstein. Preterm Labor and Chorioamnionitis are Associated with Neonatal T cell Activation. PLoS ONE 2011 6(2): e16698
Funderburg NT, Mayne E, Sieg SF, Asaad R, Jiang W, Kalinowska M, Luciano AA et al. Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood 115(2):161-7, 2009
Funderburg* N, Luciano* AA, Jiang W, Rodriguez B, Sieg SF, Lederman MM. Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One 3(4):e1915, 2008. (*first co-authors)
Luciano AA, Lederman MM, Valentin-Torres A, Bazdar A, Sieg SF. Impaired induction of CD27 and CD28 predicts naive CD4 T cell proliferation defects in HIV disease. J Immunol 179(6):3543-9, 2007.
Ryan ET, Crean TI, Kochi SK, John M, Luciano AA, Killeen KP, et al. Development of a delta-ginA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae. Infect Immun 68(1): 221-6, 2000
