Soichi Haraguchi, PhD, MS
Dr. Haraguchi is originally from Hamamatsu, Japan, and has resided in the United States since 1989. He was a faculty member at the Hamamatsu University School of Medicine from 1976 to 1989, and emigrated to the U.S. in 1989 to accept a postdoctoral fellowship position in the Department of Pediatrics at USF. From 1994 to 2006, Dr. Haraguchi served as Clinical Director of the Retrovirology Laboratory at All Children’s Hospital. He was also a member of H. Lee Moffitt Cancer & Research Institute from 1995 to 2004. In 2006, Dr. Haraguchi joined the faculty of Division of Allergy, Immunology, and Rheumatology at USF. Dr. Haraguchi’s major research interest is the role of thymic infection in HIV disease progression.
Education & Training
| B.S. | University of Shizuoka College of Pharmaceutical Sciences, 1974 |
| M.S. | University of Shizuoka College of Pharmaceutical Sciences; Microbiology and Immunology, 1976 |
| Ph.D. | Hamamatsu University School of Medicine; Microbiology and Immunology, 1988 |
Scholarly Activity
- The role of thymic infection in HIV disease progression
- Toll-like receptor function and signaling of patients with immunodeficiency
- Physiological and pathological role of envelope proteins of endogenous retroviruses
Selected Publications
C Picard, A Puel, M Bonnet, C-L Ku, J Bustamante, K Yang, C Soudais, S Dupuis, J Feinberg, C Fieschi, C Elbim, R Hitchcock, D Lammas, G Davies, A Al-Ghonaium, H Al-Rayes, S Al-Jumaah, SAl-Hajjar, I Al-Mohsen, H Frayha, R Rucker, TR Hawn, A Aderem, H Tufenkeji, S Haraguchi, NK Day, RA Good, M-A Gougerot-Pocidalo, A Ozinsky, J-L Casanova. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003 Mar. 28, 299(5615):2076-2079.
T Fan, NK Day, V Luangwedchakarn, Yi Chang, S Ikehara, DL Lerner, S Haraguchi. The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide. Peptides 2005 Nov., 26(11):2165-2174.
S Haraguchi, NK Day, W Kamchaisatian, M Beigier-Pompadre, S Stenger, N Tangsinmankong, JW Sleasman, SV Pizzo, GJ Cianciolo. LMP-420, a small-molecule inhibitor of TNF-alpha, reduces replication of HIV-1 and Mycobacterium tuberculosis in human cells. AIDS Res. Ther. 2006 Mar. 31, 3:8.
SHaraguchi, RA Good, NK Day-Good. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol. Res. 2008, 41:46-55.
I Isnardi, Y-S Ng, I Srdanovic, R Motaghedi, JI Gallin, S Haraguchi, NK Day, J-L Cassanova, E Meffre. IRAK-4/MyD88-dependent Toll-like receptors are essential for the removal of human developing anti-nuclear B cells. Immunity 2008 Nov. 14, 29:746-757.
