John P. Cannon, Ph.D.
Dr. Cannon received his Ph.D. from Baylor College of Medicine in 1997 and remained at Baylor as a postdoctoral fellow until 2000. In 2000 he joined USF as a postdoctoral fellow in the laboratory of Dr. Gary W. Litman and in 2005 he was promoted to Assistant Professor. Dr. Cannon's major research interests are the mechanisms of innate immune recognition of pathogens and the differential regulation of immune responses to pathogenic versus commensal or innocuous microbes.
Education & Training
| B.S. | University of Miami, Florida, 1990 |
| Ph.D | Baylor College of Medicine, Houston, Texas, 1997 |
Scholarly Activity
- Investigation of ligand binding by recombinant immune receptors in membrane-bound and soluble forms.
- Dissection of downstream signaling pathways affected by engagement of immune regulatory receptors.
- Human translational research on signaling activity of variants of the calcium sensing receptor. (In collaboration with Division of Endocrinology)
Selected Publications
Cannon JP, Haire RN, Litman GW. Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate. Nature Immunology, 2002, 3, 1200-1207.
Cannon JP, Haire RN, Schnitker N, Mueller MG, Litman GW. Individual protochordates possess unique immune-type receptor repertoires. Current Biology, 2004, 14, R465-466.
Litman GW, Cannon JP, Dishaw LJ. Reconstructing immune phylogeny: new perspectives. Nature Reviews Immunology, 2005, 5, 866-879.
Hernández Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA. Ancient evolutionary origin of diversified variable regions revealed by crystal structures of an amphioxus VCBP. Nature Immunology, 2006, 7, 875-882.
Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA. A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition. Immunity, 2008, 29, 228-237.
