Wenlong Bai, Ph.D.

Professor, College Of Medicine Pathology & Cell Biology

Professor, Department Of Oncologic Sciences

Professor, Non Usf Health

College Of Medicine Pathology & Cell Biology

Professor with tenure, Departments of Pathology and Cell Biology, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 64
Tampa, FL 33612

Academic Email: wbai@health.usf.edu

Academic Phone: (813) 974-0563

View My C.V.


  • PHD, Biochemistry and Molecular Biology, University Of Texas Health Sciences Center At Houston, 1992
  • Certificate, An Intensive English for Science and Technology Program, Guangzhou English Language Center, Zhongshan (Sun Yatsen) University - UCLA, 1985
  • B.S., Zoology, Lanzhou University, 1983

Academic Philosophy

"My academic philosophy is to provide first class education to our students through active engagement in basic and translational research that will keep both the educators and the students in the forefront of the biomedical field."

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology

Research Interests

  • Research in my laboratory focuses on the role of steroid hormone and vitamin D receptors in the development and treatment of human cancers. On-going research projects include the study of the functional interaction between PTEN tumor suppressor, FOXO factors and the androgen receptor in the growth and apoptosis of prostate cancer cells, the investigation of the role of the estrogen receptor in mediating the tissue-specific agonistic and antagonistic activity of Selective Estrogen Receptor Modulators, SERMs, in breast and endometrial cancer cells, and the study of the functions of vitamin D and its receptors in ovarian cancer development, treatment and prevention. The overall objective of the research is, through the elucidation of the mechanism of action of steroid hormones and vitamin D in human cancer cells, to develop new hormonal therapeutic strategies for cancer patients or to improve patients response to existing hormonal or anti-hormone therapies.


  • CBIS (Memeber, 2011 - Present)
  • ASBMB (Member, 2009 - Present)
  • American Association of Molecular Biology and Biochemistry (Member, 2004 - Present)
  • American Association for the Advancement of Science (Member, 2003 - Present)
  • Endocrine Society (Member, 1998 - Present)
  • FASEB (Member, 1998 - Present)

Recent Publications

  • Jiang, F.Saunders, BO.Haller, E.Livingston, S.Nicosia, SV.Bai, W. Conditionally immortal ovarian cell lines for investigating the influence of ovarian stroma on the estrogen sensitivity and tumorigenicity of ovarian surface epithelial cells. In vitro cellular & developmental biology. Animal. 39(7) : 304-12http://www.ncbi.nlm.nih.gov/pubmed/12964904
  • Kasiappan, R.Sun, Y.Lungchukiet, P.Quarni, W.Zhang, X.Bai, W. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer research. 74(21) : 6194-204, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25252917
  • Zhang, M.Xiang, S.Joo, HY.Wang, L.Williams, KA.Liu, W.Hu, C.Tong, D.Haakenson, J.Wang, C.Zhang, S.Pavlovicz, RE.Jones, A.Schmidt, KH.Tang, J.Dong, H.Shan, B.Fang, B.Radhakrishnan, R.Glazer, PM.Matthias, P.Koomen, J.Seto, E.Bepler, G.Nicosia, SV.Chen, J.Li, C.Gu, L.Li, GM.Bai, W.Wang, H.Zhang, X. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular cell. 55(1) : 31-46, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24882211
  • Lungchukiet, P.Sun, Y.Kasiappan, R.Quarni, W.Nicosia, SV.Zhang, X.Bai, W. Suppression of epithelial ovarian cancer invasion into the omentum by 1α,25-dihydroxyvitamin D3 and its receptor. The Journal of steroid biochemistry and molecular biology. , 2014. http://www.ncbi.nlm.nih.gov/pubmed/25448740
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration J Biol Chem. , 2013.
  • Kasiappan, R.Shen, Z.Tse, AK.Jinwal, U.Tang, J.Lungchukiet, P.Sun, Y.Kruk, P.Nicosia, SV.Zhang, X.Bai, W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498. The Journal of biological chemistry. 287(49) : 41297-309, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23055531
  • Kumar, N.Crocker, T.Smith, T.Pow-Sang, J.Spiess, PE.Connors, S.Chornukur, G.Dickinson, SI.Bai, W.Williams, CR.Salup, R.Fu, W. Prostate Cancer Chemoprevention Targeting High Risk Populations: Model for Trial Design and Outcome Measures. Journal of cancer science & therapy. 2011(S3) , 2012. http://www.ncbi.nlm.nih.gov/pubmed/22422102
  • Wang, L.Xiang, S.Williams, KA.Dong, H.Bai, W.Nicosia, SV.Khochbin, S.Bepler, G.Zhang, X. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PloS one. 7(9) : e44265, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22957056
  • Yang Y, Tse AK, Li P, Ma Q, Xiang S, Nicosia SV, Seto E, Zhang X, Bai W. Suppression of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation Oncogene. [Epub ahead of print](PMID: 21242980 [PubMed - as supplied by publisher]) , 2011.
  • Shen, Z.Zhang, X.Tang, J.Kasiappan, R.Jinwal, U.Li, P.Hann, S.Nicosia, SV.Wu, J.Zhang, X.Bai, W. The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells. Molecular and cellular endocrinology. 338(1-2) : 58-67, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21458521
  • Zhang, Y.Dong, H.Li, Z.Xiang, S.Zhu, Y.Zhang, M.Liu, J.Bai, W.Nicosia, SV.Chen, J.Zhao, RJ.Zhang, X. Bing De Ling, a Chinese herbal formula, inhibits cancer cells growth via p53. Frontiers in bioscience (Elite edition). 2: 221-30, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20036872
  • Qiuping Ma, Wei Fu, Pengfei Li, Santo V. Nicosia, Guido Jenster, Xiaohong Zhang and Wenlong Bai Repression of AR N/C Interaction and AIB1 Recruitment by FoxO1 and Its Involvement in the Suppression of AR Activity by PTEN Tumor Suppressor Molecular Endocrinology. (23) : 213-225, 2009.
  • Wei Fu, Qiuping Ma, Yonghua Yang, Xiaohong Zhang, Santo V. Nicosia, Jiandong Chen and Wenlong Bai MDM2 acts downstream of p53 as E3 ligase to promote FOXO ubiquitination and degradation Journal of Biological Chemistry. , 2009.
  • Zhang Y, Dong H, Li Z, Xiang S, Zhu Y, Zhang M, Liu J, Bai W, Nicosia SV, Chen J, Zhao R-J and Zhang X Bing De Ling®, a Chinese herbal formula, inhibits cancer cells growth via p53 Frontiers in Bioscience. , 2009.
  • Zhang, Y.Zhang, M.Dong, H.Yong, S.Li, X.Olashaw, N.Kruk, PA.Cheng, JQ.Bai, W.Chen, J.Nicosia, SV.Zhang, X. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. , 2008. http://www.ncbi.nlm.nih.gov/pubmed/18850005
  • Yang, Y.Fu, W.Chen, J.Olashaw, N.Zhang, X.Nicosia, SV.Bhalla, K.Bai, W. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature cell biology. 9(11) : 1253-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17934453
  • Lwin, T.Hazlehurst, LA.Dessureault, S.Lai, R.Bai, W.Sotomayor, E.Moscinski, LC.Dalton, WS.Tao, J. Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood. 110(5) : 1631-8, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17502456
  • Zhang, X.Nicosia, SV.Bai, W. Vitamin D receptor is a novel drug target for ovarian cancer treatment. Current cancer drug targets. 6(3) : 229-44, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16712459
  • Zhang, X.Li, P.Bao, J.Nicosia, SV.Wang, H.Enkemann, SA.Bai, W. Suppression of death receptor-mediated apoptosis by 1,25-dihydroxyvitamin D3 revealed by microarray analysis. The Journal of biological chemistry. 280(42) : 35458-68, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16093247
  • Zhang, X.Jiang, F.Li, P.Li, C.Ma, Q.Nicosia, SV.Bai, W. Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. Clinical cancer research : an official journal of the American Association for Cancer Research. 11(1) : 323-8, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15671562
  • Yang, Y.Hou, H.Haller, EM.Nicosia, SV.Bai, W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. The EMBO journal. 24(5) : 1021-32, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15692560
  • Li, P.Li, C.Zhao, X.Zhang, X.Nicosia, SV.Bai, W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. The Journal of biological chemistry. 279(24) : 25260-7, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15075339
  • Jiang, F.Bao, J.Li, P.Nicosia, SV.Bai, W. Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase. The Journal of biological chemistry. 279(51) : 53213-21, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15485861
  • Nicosia, SV.Wilbanks, GD.Saunders, B.Mayer, J.Cardosi, RJ.Kruk, PA.Cheng, J.Bai, W.Coppola, D.Fiorica, J. Cytology of human ovarian surface epithelial brushings. Cancer. 102(1) : 1-10, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14968412
  • Li, P.Lee, H.Guo, S.Unterman, TG.Jenster, G.Bai, W. AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR. Molecular and cellular biology. 23(1) : 104-18, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12482965
  • Nicosia, SV.Bai, W.Cheng, JQ.Coppola, D.Kruk, PA. Oncogenic pathways implicated in ovarian epithelial cancer. Hematology/oncology clinics of North America. 17(4) : 927-43, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12959183
  • Jiang, F.Li, P.Fornace, AJ.Nicosia, SV.Bai, W. G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer. The Journal of biological chemistry. 278(48) : 48030-40, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14506229
  • Lee, H.Bai, W. Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Molecular and cellular biology. 22(16) : 5835-45, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12138194
  • Pengfei Li, Santo V. Nicosia and *Wenlong Bai. Journal of Biological Chemistry Antagonism between PTEN/Mmac1/Tep-1 and Androgen Receptor in Growth and Apoptosis of Prostate Cancer Cells.. 276: 20444-20450, 2001.
  • Wenlong Bai, Beatriz Oliveros-Saunders, Qiang Wang, and Santo V. Nicosia. Estrogen Stimulation of Epithelial Ovarian Cancer Precursor Cells. In Vitro Cellular & Developmental Biology-Animal. 36: 657-666, 2000.
  • Heehyoung Lee, Feng Jiang, Qiang Wang, Santo V. Nicosia, Jianhua Yang, Bing Su and Wenlong Bai. MEKK1 Activation of Human Estrogen Receptor and Stimulation of the Agonist Activity of 4-Hydoxytamoxifen in Endometrial and Ovarian Cancer Cells. Molecular Endocrinology. 14: 1882-1896, 2000.
  • Pham, CD.Vuyyuru, VB.Yang, Y.Bai, W.Singh, B. Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos. Oncogene. 18(30) : 4287-94, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10439036
  • Wenlong Bai, Brian Rowan, Victoria Allgood, Bert W. O Malley and Nancy L. Weigel. Differential Phosphorylation of Chicken Progesterone Receptor in Hormone-dependent and Ligand-independent Activation. Journal of Biological Chemistry. 271: 10457-10463, 1997.
  • Bai, W.Weigel, NL. Phosphorylation of Ser211 in the chicken progesterone receptor modulates its transcriptional activity. The Journal of biological chemistry. 271(22) : 12801-6, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8662804
  • Bai, W.Weigel, NL. Phosphorylation and steroid hormone action. Vitamins and hormones. 51: 289-313, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7483325
  • Weigel, NL.Bai, W.Zhang, Y.Beck, CA.Edwards, DP.Poletti, A. Phosphorylation and progesterone receptor function. The Journal of steroid biochemistry and molecular biology. 53(1-6) : 509-14, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7626502
  • Zhang, Y.Bai, W.Allgood, VE.Weigel, NL. Multiple signaling pathways activate the chicken progesterone receptor. Molecular endocrinology (Baltimore, Md.). 8(5) : 577-84, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8058067
  • Bai, W.Tullos, S.Weigel, NL. Phosphorylation of Ser530 facilitates hormone-dependent transcriptional activation of the chicken progesterone receptor. Molecular endocrinology (Baltimore, Md.). 8(11) : 1465-73, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7877616
  • Bai, W.Arlinghaus, RB.Singh, B. Association of v-Mos with soluble vimentin in vitro and in transformed cells. Oncogene. 8(8) : 2207-12, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8336943
  • Bai, W.Singh, B.Yang, Y.Ramagli, LS.Nash, M.Herzog, NK.Arlinghaus, RB. The physical interactions between p37env-mos and tubulin structures. Oncogene. 7(3) : 493-500, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1532247
  • Bai, W.Singh, B.Yang, Y.Arlinghaus, RB. Evidence for interaction between v-Mos and a p34cdc2 isoform, p35cdk. Oncogene. 7(9) : 1757-63, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1323818
  • Bai, WL.Singh, B.Karshin, WL.Shonk, RA.Arlinghaus, RB. Phosphorylation of v-mos Ser 47 by the mitotic form of p34cdc2. Oncogene. 6(10) : 1715-23, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1833715

Positions Held

  • Associate Professor (Departments of Pathology and Interdisciplinary Oncology, College of Medicine, University of South Florida 2003 - 2008)
  • Assistant Professor (Tenure Track) (Department of Pathology, College of Medicine, University of South Florida 1997 - 2003)


  • 2005 Moffitt Cancer Center Team Award (Moffitt- FAMU Grant Team - 2005)
  • Million Dollar Researcher for Outstanding Research Achievements (University of South Florida - 2005)
  • Individual Research Fellowship Award (NIH - 1994)
  • Training Grant Award in Molecular Endocrinology (NIDDK - 1993)
  • Welch Pre-doctoral Fellowship Award (Welch Foundation - 1988)
  • CUSBEA Fellow (China-United States Biochemistry and Molecular Biology Examination and Application Program - 1984)