XiaohongZhang

Xiaohong Zhang, M.S., Ph.D.

Assoc Professor, College Of Medicine Pathology & Cell Biology

College Of Medicine Pathology & Cell Biology

Associate Professor, Department Pathology and Cell Biology, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 64
Tampa, FL 33612

Academic Email: xzhang1@health.usf.edu

Academic Phone: (813) 974-1288

View My C.V.

Education

  • PHD, Molecular Biology, University Of Texas Health Science Center At Houston, 1998
  • B.S., Biology, Beijing Normal University, 1989

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology

Research Interests

  • Our research is focused on the role of histone deacetylases (HDACs) in cancer. Among the18 HDACs, our endeavors deal primarily with HDAC6, a class IIB HDAC. In particular, we are interested in studying HDAC6’s functions in stress response, as well as how HDAC6’s activities are regulated by physiological and pathological cues. Our recent research indicates that HDAC6 plays an important role in the DNA damage response and DNA repair by regulating DNA mismatch repair proteins. In addition, we have also found that HDAC6’s activities are governed by the extracelluar signal-regulated kinase (ERK1). Our future studies will validate our findings in animal models and human samples as well as identify novel HDAC6 substrates.

Memberships

  • American Association for Cancer Research (AACR) (Member, 2006 - Present)
  • American Association for the Advancement of Science (AAAS) (Member, 2001 - Present)
  • American Society for Cell Biology (Member, 2000 - 2006)

Recent Publications

  • Zhang M, Xiang S, Joo H-Y, Wang L, Williams K, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, Dong H, S HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSa Molecular Cell. , 2014.
  • Kasiappan R, Sun Y, Lungchukiet P, Quarni W, Zhang, Bai W Vitamin D Suppresses leptin stimulation of cancer growth through MicroRNA Cancer Research. , 2014.
  • Sun Y, Kaiappan R, Tan J, Webb PL, Quarni W, Zhang X, Bai W A novel function of the Fe65 neuronal adaptor in estrogen receptor action in breast cancer cells Jouranl of Biological Chemistry. , 2014.
  • Haakenson J and Zhang X HDAC6 and Ovarian Cancer International Journal of Molecular Sciences. , 2013.
  • Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai Extracellular Signal-Regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration. Journal of Biological Chemistry. , 2013.
  • Kasiappan R., Shen Z., Tse AKW., Jinwal U., Tang J., Lungchukiet P., Sun Y., Kruk P., Nicosia SV., Zhang X., Bai W. 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through mircoRNA-49 Journal of Biological Chemistry. 287(49) : 41297-309, 2012.
  • Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia, SV, Khochbin S, Bepler G, Zhang X Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells PLoS ONE. 7(9) , 2012.
  • Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Wiu H, Zhang X, Wang Y, Chen G, and Wang Y. Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression Oncogene. : 3153, 2010.
  • Ma, Q., Fu, W., Li, P., Nicosia, S., Jenster, G., Zhang, X., and Bai, W. Repression of Androgen Receptor N- and C-Terminal Interaction and Coactivator Recruitment by FoxO1 and its Involvement in Receptor Suppression by the PTEN Tumor Suppressor Mol. Endocrinology. 2(23) : 213-225, 2009.
  • Zhang, Y., Dong, H., Li, Z., Xiang, S., Zhu, Y., Zhang, M., Liu, J., Bai, W., Nicosia, S., Chen, J., Zhao, R-J and Zhang, X Bing De Ling®, a Chinese herbal formula, induces G1/S arrest in cancer cells via p53 Frontiers in Bioscience (accepted). , 2009.
  • Zhang, Y., Zhang, M., Dong, H., Yong, S., Li, X., Olashaw, N., Kruk, P.A., Cheng, J.Q., Bai, W., Chen, J., Nicosia, S.V., and Zhang, X Deacetylation of Cortacin by SIRT1 Promotes Cell Migration Oncogene. 3(28) : 445-600, 2009.
  • Gregoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J., Wong, J., Seto, E., and Yang, X-J Negative regulation of MEF2-dependent transcription by histone deacetylase 3. Mol. Cell. Biol.. 4(27) : 1280-1295, 2007.
  • Hu, X.Cui, D.Moscinski, LC.Zhang, X.Maccachero, V.Zuckerman, KS. TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells. Cytokine. 37(2) : 155-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17459720
  • Yuan, Z.Zhang, X.Sengupta, N.Lane, WS.Seto, E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molecular cell. 27(1) : 149-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17612497
  • Zhang, X.Yuan, Z.Zhang, Y.Yong, S.Salas-Burgos, A.Koomen, J.Olashaw, N.Parsons, JT.Yang, XJ.Dent, SR.Yao, TP.Lane, WS.Seto, E. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Molecular cell. 27(2) : 197-213, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17643370
  • Villagra, A.Ulloa, N.Zhang, X.Yuan, Z.Sotomayor, E.Seto, E. Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. The Journal of biological chemistry. 282(49) : 35457-70, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17925399
  • Feng, W., Lu, Z., Luo, R. Z., Zhang, X., Seto, E., Liao, W.S.L. and Yu, Y Multiple histone deacetylases (HDACs) repress tumor suppressor gene ARHI in breast cancer. In. J. Cancer. 8(120) : 1664-1668, 2007.
  • Gao Z., Chiao, P., Zhang, X., Zhang, X., Lazer, M., Seto E., Young HA., and Ye J. Coactivators and corepressors of NF-kB in IkB alpha gene promoter. J. Biol. Chem.. (280) : 21091-21098, 2005.
  • Zhang, X., Ozawa, Y., Lee H., Wen, Y-D., Tan, T-H, Wadzinski, B.E. and Seto, E. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4 Genes & Dev.. 19: 827-839, 2005.
  • Glozak, MA., Sengupta N., Zhang, X., and Seto E.( Acetylation and deacetylation of non-histone proteins (review) Gene. (363) : 15-23, 2005.
  • Nguyen, N.Zhang, X.Olashaw, N.Seto, E. Molecular cloning and functional characterization of the transcription factor YY2. The Journal of biological chemistry. 279(24) : 25927-34, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15087442
  • Li, P.Li, C.Zhao, X.Zhang, X.Nicosia, SV.Bai, W. p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. The Journal of biological chemistry. 279(24) : 25260-7, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15075339
  • Zhang, X.Wharton, W.Yuan, Z.Tsai, SC.Olashaw, N.Seto, E. Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3. Molecular and cellular biology. 24(12) : 5106-18, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15169878
  • Zhang, X.Ma, L.Enkemann, SA.Pledger, WJ. Role of Gadd45alpha in the density-dependent G1 arrest induced by p27(Kip1). Oncogene. 22(27) : 4166-74, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12833139
  • Weiss, C., Schneider, S., Wagner, E. F., Zhang, X., Seto, E., and Bohmann, D. JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J. 22: 3686-3695, 2003.
  • Rezai-Zadeh, N.Zhang, X.Namour, F.Fejer, G.Wen, YD.Yao, YL.Gyory, I.Wright, K.Seto, E. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes & development. 17(8) : 1019-29, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12704081
  • Hu, X.Bryington, M.Fisher, AB.Liang, X.Zhang, X.Cui, D.Datta, I.Zuckerman, KS. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. The Journal of biological chemistry. 277(19) : 16528-37, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11864973
  • Hu, X.Zhang, X.Zhong, Q.Fisher, AB.Bryington, M.Zuckerman, KS. Differential effects of transforming growth factor on cell cycle regulatory molecules in human myeloid leukemia cells. Oncogene. 20(47) : 6840-50, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11687963
  • Zhang, X.Wharton, W.Donovan, M.Coppola, D.Croxton, R.Cress, WD.Pledger, WJ. Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1). Molecular biology of the cell. 11(6) : 2117-30, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10848633
  • Zhang, X., Xing, G., and Saunders, G. F. Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1 Anticancer Res. (19) : 1641-1648, 1999.
  • Zhang, X., Xing, G., Fraizer, G. C., and Saunders, G. F. ). Transactivation of an intronic hematopoietic-specific enhancer of the human Wilms' tumor 1 gene by GATA-1 and c-Myb. J Biol Chem. (272) : 29272-29280, 1997.
  • Fraizer, G. C., Shimamura, R., Zhang, X., and Saunders, G. F. PAX 8 regulates human WT1 transcription through a novel DNA binding site. J Biol Chem. (272) : 30678-30687, 1997.
  • Fraizer, G. C., Patmasiriwat, P., Zhang, X., and Saunders, G. F. Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow. Blood. (86) : 4704-4706, 1995.
  • Cheung, P. H., Luo, W., Qiu, Y., Zhang, X., Earley, K., Millirons, P., and Lin, S. H. Structure and function of C-CAM1. The first immunoglobulin domain is required for intercellular adhesion. . J Biol Chem. (268) : 24303-24310, 1993.

Positions Held

  • Research Scientist (Interdisciplinary Oncology Program, College of Medicine, University of South Florida 2004 - 2006)
  • Instructor (Interdisciplinary Oncology Program, College of Medicine, H.Lee Moffitt Cancer Center at University of South Florida 2002 - 2004)
  • Research Associate (Interdisciplinary Oncology Program, College of Medicine, H. Lee Moffitt Cancer Center at University of South Florida 1998 - 2002)

Awards/Honors

  • Outstanding Research Achievement Award (The University of South Florida - 2014)
  • Liz Tilberis Scholar (Ovarian Cancer Research Fund - 2011)
  • Marsha Rivkin Scholar (Marsha Rivkin Center for Ovarain Cancer Research - 2007)