MarzennaWiranowska

Marzenna Wiranowska, Ph.D.

Associate Professor, College Of Medicine Pathology & Cell Biology

College Of Medicine Pathology & Cell Biology

Associate Professor, Department Pathology & Cell Biology, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 11
Tampa, FL 33612

Academic Email: mwiranow@health.usf.edu

Academic Phone: (813) 974-3289

Education

  • PHD, Virology-Immunology, Polish Academy Of Sciences, 1980
  • M.S., Microbiology-Immunology, Medical Academy of Warsaw, 1974
  • B.S., Biology, Warsaw University, 1972

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology
  • Neuroscience

Research Interests

  • In my current research I am focusing on the biology and treatment of glioma using in vitro and in vivo models. Specific areas of research include: 1) studies of the extracellular matrix in the brain and its role in glioma invasion; 2) evaluation of the cellular entry and cellular localization of chlorotoxin, a scorpion derived 36 amino acid peptide designated as TM601 in glioma and other tumor cells.(TM601 was tested in Phase II clinical trials in adult recurrent glioma and in Phase I in various other tumors);and 3) evaluation of thermo-responsive double packaged system for localized delivery of therapeutics to glioma and other tumors such as ovarian carcinoma.

Memberships

  • USF Health Sciences Center Neuroscience Program (Founding Faculty Member/Group Leader for Brain Tumors Study Group, 1997 - Present)
  • American Association for Cancer Research (Member, 1993 - Present)
  • Moffitt Cancer Center Program (Member, 1993 - Present)
  • Neuro-Tumor Club, American Association for Cancer Research (Member, 1997 - 2000)
  • Eastern Cooperative Oncology Group (ECOG) (Member, 1994 - 2000)
  • Society for Neuroscience (Member, 1993 - 2000)
  • International Society for Interferon Research (Member, 1980 - 2000)
  • Tampa Bay Area Chapter Society for Neuroscience (Member, 1991 - 1999)
  • Tampa Bay Area Chapter Society for Neuroscience (Secretary/Treasurer, 1991 - 1993)

Recent Publications

  • Roijani M.V., Wiranowska, M., and Roijani A.M. Matrix Metalloproteinases and Their Inhibitors-Friend or Foe in Tumor Microenvironment Tumor Microenvironment (Ed Dietmar W. Siemann) J. Wiley and Sons, Ltd.. : 53-76, 2011.
  • Wiranowska, M, Ladd, S., Moscinski, L.C., Hill, B., Haller, E., Mikecz, K., Plass, A. Modulation of hyaluronan production by CD44 positive glioma cells. International Journal of Cancer. 127: 532-542, 2010.
  • Wiranowska, M. and Plaas, A. Cytokines and Extracellular Matrix Remodeling in the Central Nervous System In: Neuroimmune Biology. 6, Cytokines and the Brain, Elsevier B.V. Science., 2008.
  • Wiranowska, M.Ladd, S.Smith, SR.Gottschall, PE. CD44 adhesion molecule and neuro-glial proteoglycan NG2 as invasive markers of glioma. Brain Cell Biology. 35(2-3) : 159-72, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17957481
  • Ma, XC.Gottschall, PE.Chen, LT.Wiranowska, M.Phelps, CP. Role and mechanisms of interleukin-1 in the modulation of neurotoxicity. Neuroimmunomodulation. 10(4) : 199-207, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12584407
  • Wiranowska, M.Rojiani, AM.Gottschall, PE.Moscinski, LC.Johnson, J.Saporta, S. CD44 expression and MMP-2 secretion by mouse glioma cells: effect of interferon and anti-CD44 antibody. Anticancer Research. 20(6B) : 4301-6, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11205262
  • Wiranowska, M.Ransohoff, J.Weingart, JD.Phelps, C.Phuphanich, S.Brem, H. Interferon-containing controlled-release polymers for localized cerebral immunotherapy. Journal of Interferon & Cytokine Research. 18(6) : 377-85, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9660244
  • Wiranowska, M.Tresser, N.Saporta, S. The effect of interferon and anti-CD44 antibody on mouse glioma invasiveness in vitro. Anticancer Research. 18(5A) : 3331-8, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9858905
  • Menzies, R., Phelps, C.Wiranowska, M.Oliver, J.Chen, L.Horvath, E.Hall, N. The effect of interferon-alpha on the pituitary-adrenal axis. Journal of Interferon & Cytokine Research. 16(8) : 619-29, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8877733
  • Naidu, KA.Wiranowska, M.Phuphanich, S.Prockop, LD. Modulation of glioma cell growth and 5-lipoxygenase expression by interferon. Anticancer Research. 16(6B) : 3475-82, 1996. http://www.ncbi.nlm.nih.gov/pubmed/9042209
  • Wiranowska, M.Prockop, LD.Naidu, AK.Saporta, S.Kori, S.Kulkarni, AP. Interferon entry through the blood-brain barrier in glioma and its effect on lipoxygenase activity. Anticancer Research. 14(3A) : 1121-6, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7521151
  • Wiranowska, M.Naidu, AK. Interferon effect on glycosaminoglycans in mouse glioma in vitro. Journal of Neuro-Oncology. 18(1) : 9-17, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8057139
  • Naidu, AK.Wiranowska, M.Kori, SH.Roetzheim, KC.Kulkarni, AP. Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma. Journal of Neuro-Oncology. 16(1) : 1-10, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8410136
  • Naidu, AK.Wiranowska, M.Kori, SH.Prockop, LD.Kulkarni, AP. Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon. Anticancer Research. 13(5A) : 1469-75, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8239523
  • Wiranowska, M. Blood-brain barrier and treatment of central nervous system tumors. The Journal of the Florida Medical Association. 79(10) : 707-10, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1460453
  • Wiranowska, M.Gonzalvo, AA.Saporta, S.Gonzalez, OR.Prockop, LD. Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model. Journal of Neuro-Oncology. 14(3) : 225-36, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1281226
  • Wiranowska, M.Wilson, TC.Thompson, K.Prockop, LD. Cerebral interferon entry in mice after osmotic alteration of blood-brain barrier. Journal of Interferon Research. 9(3) : 353-62, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2746023
  • Wiranowska, M.Wilson, TC.Bencze, KS.Prockop, LD. A mouse model for the study of blood-brain barrier permeability. Journal of Neuroscience Methods. 26(2) : 105-9, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3216678
  • Zheng, QY.Wiranowska, M.Sadlik, JR.Hadden, JW. Purified podophyllotoxin (CPH-86) inhibits lymphocyte proliferation but augments macrophage proliferation. International Journal of Immunopharmacology. 9(5) : 539-49, 1987. http://www.ncbi.nlm.nih.gov/pubmed/2442110
  • Wiranowska, M.Kaido, T.Caspritz, G.Cook, J.Hadden, J. Interleukin-2 and coculture with thymic epithelial cells synergistically induce prothymocyte differentiation and proliferation. Thymus. 10(3-4) : 231-45, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3501186
  • Wiranowska-Stewart, M.Hadden, JW. Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production. International Journal of Immunopharmacology. 8(1) : 63-9, 1986. http://www.ncbi.nlm.nih.gov/pubmed/2420734
  • von Wussow, P.Chen, YS.Wiranowska-Stewart, M.Stewart II, WE. Induction of human gamma-interferon in lymphoid cells by Staphylococcus enterotoxin B; partial purification. Journal of Interferon Research. 2(1) : 11-20, 1982. http://www.ncbi.nlm.nih.gov/pubmed/6180098
  • Wiranowska-Stewart, M.Stewart II, WE. Determination of human leukocyte populations involved in production of interferons alpha and gamma. Journal of Interferon Research. 1(2) : 233-44, 1981. http://www.ncbi.nlm.nih.gov/pubmed/6180054
  • von Wussow, P.Platsoucas, CD.Wiranowska-Stewart, M.Stewart II, WE. Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells. Journal of Immunology. 127(3) : 1197-200, 1981. http://www.ncbi.nlm.nih.gov/pubmed/6167620
  • Wiranowska-Stewart, M. Heterogeneity of human gamma interferon preparations: evidence for presence of alpha interferon. Journal of Interferon Research. 1(2) : 315-21, 1981. http://www.ncbi.nlm.nih.gov/pubmed/6180062
  • Wiranowska-Stewart, M.Lin, LS.Braude, IA. Stewart II, WE. Production, partial purification and characterization of human and murine interferons--type II. Molecular Immunology. 17(5) : 625-33, 1980. http://www.ncbi.nlm.nih.gov/pubmed/6163960
  • Stewart II, WE.Wiranowska-Stewart, M.Koistinen, V.Cantell, K. Effect of glycosylation inhibitors on the production and properties of human leukocyte interferon. Virology. 97(2) : 473-6, 1979. http://www.ncbi.nlm.nih.gov/pubmed/224593
  • Hanley, DF.Wiranowska-Stewart, M.Stewart II, WE. Pharmacology of interferons I. Pharmacologic distinctions between human leukocyte and fibroblast interferons. International Journal of Immunopharmacology. 1(3) : 219-26, 1979. http://www.ncbi.nlm.nih.gov/pubmed/95249
  • Stewart II, WE.Chudzio, T.Lin, LS.Wiranowska-Stewart, M. Interferoids: in vitro and in vivo conversion of native interferons to lower molecular weight forms. Proceedings of the National Academy of Sciences of the United States of America. 75(10) : 4814-8, 1978. http://www.ncbi.nlm.nih.gov/pubmed/217001
  • Lin, LS.Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Characterization of the heterogeneous molecules of human interferons: differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons. The Journal of General Virology. 39(1) : 125-30, 1978. http://www.ncbi.nlm.nih.gov/pubmed/25313
  • Lin, LS.Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Characterization of the size and charge heterogeneities of human leukocyte interferon populations. Archives of Virology. 56(3) : 269-72, 1978. http://www.ncbi.nlm.nih.gov/pubmed/637729
  • Wiranowska-Stewart, M. and Stewart II, W.E. The role of chromosome 21 in sensitivity to human interferons The Journal of General Virology. 37: 629-633, 1977.
  • Lin, L.S., Wiranowska-Stewart, M., Chudzio, T., and Stewart II, W.E. Characterization of the molecular heterogeneities of human interferons: Differences in the cross-species antiviral activities of various molecular populations in human leukocyte interferons The Journal of General Virology. 39: 259-264, 1977.
  • Stewart II, WE.Lin, L.Chudzio, T.Wiranowska-Stewart, M. Molecular alterations of interferons. Texas Reports on Biology and Medicine. 35: 193-7, 1977. http://www.ncbi.nlm.nih.gov/pubmed/358448
  • Stewart II, W.E., Wiranowska-Stewart, M., and LeGoff, S. Characterization of the distinct molecular populations of Type I mouse interferons The Journal of General Virology. 37: 277-284, 1977.
  • Stewart II, WE.Lin, LS.Wiranowska-Stewart, M.Cantell, K. Elimination of size and charge heterogeneities of human leukocyte interferons by chemical cleavage. Proceedings of the National Academy of Sciences of the United States of America. 74(10) : 4200-4, 1977. http://www.ncbi.nlm.nih.gov/pubmed/200907
  • Wiranowska-Stewart, M.Chudzio, T.Stewart II, WE. Repeated 'superinduction' of interferon in human diploid fibroblast cultures. The Journal of General Virology. 37(1) : 221-3, 1977. http://www.ncbi.nlm.nih.gov/pubmed/915483
  • Szmigielski, S.Jeljaszewicz, J.Wiranowska, M. Acute staphylococcal infections in rabbits irradiated with 3-GHz microwaves. Annals of the New York Academy of Sciences. 247: 305-11, 1975. http://www.ncbi.nlm.nih.gov/pubmed/1054237
  • Szmigielski, S.Luczak, M.Wiranowska, M. Effect of microwaves (3GHz) on cell function and virus replication in cell cultures irradiated in vitro. Annals of the New York Academy of Sciences. 247: 263-74, 1975. http://www.ncbi.nlm.nih.gov/pubmed/46732
  • Szmigielski, S.Luczak, M.Wiranowska, M. Karyometric observations of WISH cell cultures irradiated with 3 GHz microwaves. Folia Histochemica et Cytochemica. 13(3-4) : 151-9, 1975. http://www.ncbi.nlm.nih.gov/pubmed/1205415

Positions Held

  • Associate Professor (Department of Anatomy, College of Medicine, University of South Florida 1995 - 2006)
  • Associate Professor (Department of Neurology, College of Medicine, University of South Florida 1994 - 1995)
  • Assistant Professor (Department of Neurology, College of Medicine, University of South Florida 1986 - 1994)
  • Associate in Research (Department of Internal Medicine, College of Medicine, University of South Florida 1985 - 1986)
  • Research Associate (Immunopharmacology Program, College of Medicine, University of South Florida 1982 - 1985)
  • Research Associate (Interferon Laboratories, Memorial Sloan-Kettering Cancer Center 1980 - 1981)
  • Research Assistant (Interferon Laboratories, Memorial Sloan-Kettering Cancer Center 1976 - 1980)
  • Research Assistant (Department of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer 1975 - 1976)
  • Research Assistant (Department of Histology and Biostructure, Medical Academy of Warsaw 1974 - 1975)

Awards/Honors

  • Special Invite: Author in the book project under working title Glioma, ISBN 978-953-307-379-8 (INTECH Open Access Publisher - 2011)
  • Invited Speaker for the 16th World Congress on Advances in Oncology and 14th International Symposium (Spandidos Publications Ltd. Athens Greece - 2011)
  • Participant (National Cancer Institute-Mouse Models of Human Cancer Consortium - 2005)
  • Special invite as Subject Specialist (Infography Fields of Knowledge in the area of "Malignant Glioma" - 2001)
  • Special invite: International collaborative study to develop international standards for interferon (World Health Organization (WHO) - 1995)
  • Basic Science Teaching Award (Department of Neurology, University of South Florida - 1993)