John C.M. Tsibris, Ph.D.
Professor of Obstetrics and Gynecology, Department of Obstretrics and Gynecology
- Ph.D., Cornell University, 1962-65
- B.Sc., University of Athens, Greece, 1955-59
Dr. Tsibris works in the lab on the mechanisms that regulate the formation and growth of uterine fibroids and the increased vasculature at the tumor's periphery; he and Dr. Kathy B. Porter developed a method to induce uterine fibroids in the guinea pig model. Immunoprecipitation and membrane proteomics reveal the nearest-neighbors of GluR2 during angiogenesis in fibroids and of VEGFR-2 in normal and preeclamptic placenta. Such information defines their upstream-downstream pathways and may lead to novel therapeutic interventions. Other experiments relate to a test of a cervical mucus enzyme, a peroxidase. As its levels change during the menstrual cycle, they can mark the woman's fertile period even in the presence of vaginal infections, our current goal.