John Tsibris, PHD

Director, College Of Medicine Obstetrics & Gynecology

Professor, College Of Medicine Molecular Medicine

Professor, College Of Medicine Obstetrics & Gynecology

Contact Info 12901 Bruce B. Downs Blvd.
MDC-18
Tampa, FL 33612

Academic Email: jtsibris@health.usf.edu

Academic Phone: (813) 974-7025

Education

  • PHD, Biochemistry, Cornell University, 1966

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular Sciences
  • Cellular and Molecular Biology
  • Women & Children's Health

Research Interests

  • Proteomic analysis of tissues from the fetal compartment of term placentas has revealed a molecular network of the VEGF receptor 2 (VEGFR2) that could intersect the VEGFR2 signal transduction pathway to support fetal growth and possibly labor.
  • Our focus is on solubilized membrane proteins that associate with VEGFR2. A new enzymatic reaction of VEGFR2 to form nucleoside polyphosphates may synergize with membrane and soluble receptors, e.g. purinergic receptors P2Y, to regulate vascular tone and contractions. We correlate clinical data of normotensive and preeclamptic patients with new protein-protein associations of membrane and soluble proteins in the placenta hoping to uncover new regulators of placental vascularization/angiogenesis and of labor.
  • Proteomic methods are used to discover protein networks regulating leiomyoma growth in women and in our guinea pig model, and to optimize our cervical mucus peroxidase test for a 3-5 day prediction of ovulation in women.

Memberships

  • Society for Gynecologic Investigation (Member, 1980 - Present)
  • American Society for Biochemistry and Molecular Biology (Member, 1970 - Present)
  • American Chemical Society (Member, 1967 - Present)

Recent Publications

  • Tsibris, J, Stanley Stevens, S., Seeley, K., Bell-Temin, H., Steffensen, T., Paidas-Teefey, C., Okuka, M., Whiteman, V., Spellacy, W Membrane proteomic study of the VEGF receptor-2 network in the fetal compartment of human placentas near term Amer. J. Obstet. Gynecol.. 210(1) : S401, 2014.
  • Huang, J.Okuka, M.Lu, W.Tsibris, JC.McLean, MP.Keefe, DL.Liu, L. Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke. Reproductive toxicology (Elmsford, N.Y.). 35: 89-95, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22824788
  • Spellacy, W.N., Gilbert-Barness, E., Tsibris, J.C., Downes, K.L. Umbilical Cord Knots and Cord Blood Gases, Erythropoietin and Nucleated Red Blood Cell Levels: A Study of Possible Chronic Fetal Hypoxia. Fetal Pediatr. Pathol.. 32(2) : 158-161, 2013.
  • Louis, J., Ho, S., Tsibris, J., Shaw, A., Luciano, A. Symptoms of sleep disturbance are associated with elevated umbilical cord C-reactive peptide. Amer. J. Obstet. Gynecol.. 208: Suppl 1 S87, 2013.
  • Huang, J.Wang, F.Okuka, M.Liu, N.Ji, G.Ye, X.Zuo, B.Li, M.Liang, P.Ge, WW.Tsibris, JC.Keefe, DL.Liu, L. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell research. 21(5) : 779-92, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21283131