John C.M. Tsibris, Ph.D.
Biographical Sketch | Interests | Current Research | Major Publications
B.Sc., University of Athens, Greece, 1959
Ph.D., Cornell University, 1965
E-Mail: jtsibris@hsc.usf.edu
FAX: (813) 974-5109
Biographical Sketch
Dr. Tsibris studied Chemistry at the University of Athens and after completing his military service in the Greek Air Force came to the US to study Biochemistry at Cornell. He has been in the faculty at the University of Florida (1971-79) and University of Illinois at Chicago (1979-1988) and in 1988 moved to Tampa as Professor in the Department of Ob-Gyn. He has a joint appointment in Biochemistry and Molecular Biology and is a member of the H. Lee Moffitt Cancer Center and Research Institute. He is married and has two children, Athe Michael N. Tsibris and Evangeline J. Tsibris Cummings. Interests
Neo-vascularization pathways in human leiomyomata, membrane proteomics
Current Research
Dr. Tsibris works in the lab on the mechanisms that regulate the formation and growth of uterine fibroids and has developed with Dr. K.B. Porter a method to induce uterine fibroids in the guinea pig model. Other experiments relate to a method that predicts ovulation in women by 3-5 days, and on markers of fetal hypoxia in umbilical cord blood. To reduce the size and symptoms of fibroids, Dr. Tsibris and coworkers have gained new insights from DNA-arrays and proteomics to identify the molecular signaling pathways that sustain fibroid angiogenesis and those that might restrain it.
Major Publications
Tsibris, J.C.M., Porter,K.B., Jazayeri, A., Tzimas, G., Nau, H., Huang, H., Kuparadze, K., Porter, G.W., O'Brien, W.F., Spellacy, W.N. (1999) Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor ?, Retinoid X Receptor a and All-trans Retinoic Acid than Myometrium. Cancer Research 59:5737-5744.
Jazayeri, A., Politz, L., Tsibris, J.C.M., Queen, T., Spellacy, W.N. (2000) Fetal Erythropoietin Levels in Pregnancies Complicated by Meconium Passage: Does Meconium Suggest Fetal Hypoxia? Amer. J. Obstet. Gynecol. 183:188-190.
Tsibris, J.C.M., Segars, J., Coppola, D., Mane, S., Wilbanks, G., O'Brien, W.F., Spellacy, W.N. (2002) Insights from gene arrays on the development and growth regulation of uterine leiomyomata. Fertil. Steril. 78:114-121.
Tsibris, J.C., Maas, S., Segars, J.H., Nicosia, S.V., Enkemann, S.A., O'Brien, W.F., Spellacy, W.N. (2003) New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochem. Biophys. Res. Commun. 312: 249-254.
Tsibris, J. (2004) The guinea pig model for uterine leiomyomata: gene-hormone interaction? Fertil. Steril. 82: 988-9.