John C.M. Tsibris, Ph.D.
B.Sc., University of Athens, Greece, 1955-59
Ph.D., Cornell University, 1962-65
Biographical Sketch
Dr. Tsibris studied Chemistry at the University of Athens and after completing his military service in the Greek Air Force came to the US to study Biochemistry at Cornell. He has been in the faculty at the University of Florida (1971-79) and University of Illinois at Chicago (1979-1988) and in 1988 moved to Tampa as Professor in the Department of Ob-Gyn. He has a joint appointment in the Department of Molecular Medicine. He is married and has two children, Athe Michael N. Tsibris and Evangeline J. Tsibris CummingsCurrent Research
Dr. Tsibris works in the lab on the mechanisms that regulate the formation and growth of uterine fibroids and the increased vasculature at the tumor's periphery; he and Dr. Kathy B. Porter developed a method to induce uterine fibroids in the guinea pig model. Immunoprecipitation and membrane proteomics reveal the nearest-neighbors of GluR2 during angiogenesis in fibroids and of VEGFR-2 in normal and preeclamptic placenta. Such information defines their upstream-downstream pathways and may lead to novel therapeutic interventions. Other experiments relate to a test of a cervical mucus enzyme, a peroxidase. As its levels change during the menstrual cycle, they can mark the woman's fertile period even in the presence of vaginal infections, our current goal.
Major Publications
Tsibris JCM, Porter KB, Jazayeri A, Tzimas G, Nau H, Huang H, Kuparadze K, Porter GW, O'Brien WF, Spellacy WN (1999) Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor ?, Retinoid X Receptor a and all-trans Retinoic Acid than Myometrium. Cancer Research 59:5737.
Jazayeri A, Politz L, Tsibris JCM, Queen T, Spellacy WN (2000) Fetal Erythropoietin Levels in Pregnancies Complicated by Meconium Passage: Does Meconium Suggest Fetal Hypoxia? Amer. J. Obstet. Gynecol. 183:188.
Tsibris JCM, Segars J, Coppola D, Mane S, Wilbanks G, O'Brien WF, Spellacy WN (2002) Insights from gene arrays on the development and growth regulation of uterine leiomyomata. Fertil. Steril. 78:114.
Tsibris JC, Maas S, Segars JH, Nicosia SV, Enkemann SA, O'Brien WF, Spellacy WN. (2003) New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2. Biochem. Biophys. Res. Commun. 312: 249.
Tsibris J. (2004) The guinea pig model for uterine leiomyomata: gene-hormone interaction? Fertil. Steril. 82: 988.
McCarthy JM, Gilbert-Barness E, Tsibris JCM, Spellacy WN. (2007) Are placental chorionic capillary nucleated red blood cell counts useful compared to umbilical cord blood tests? Fetal Diagn. Ther. 22: 121.
Spellacy WN, McCarthy JM, Tsibris JCM, Gilbert-Barness E, Downes KL (2009) Fetal umbilical cord blood erythropoietin, interleukin-6, pH, pO2, pCO2 and base excess levels in histologic and/or clinical chorioamnionitis: Is the response only inflammatory? Fetal Pediatr. Pathol. 28:239.
Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li, M, Liang P, Ge WW, Tsibris JCM, Keefe DL, Liu L. (2011) Telomere length marks authentic pluripotency of ES/iPS cells. Cell Research, Feb 1 [Epub ahead of print].