PaulaBickfordJ-5970-2012

Paula Bickford, PHD

Professor, CENTER OF EXCELLENCE FOR AGING & BRAIN REPAIR

Professor, COLLEGE OF MEDICINE MOLECULAR PHARMACOLOGY & PHYSIOLOGY

Professor, NON USF HEALTH

CENTER OF EXCELLENCE FOR AGING & BRAIN REPAIR

Academic Email: pbickfor@health.usf.edu

Academic Phone: (813) 974-3238

View My C.V.

Education

  • PHD, Pharmacology, University Of Colorado, 1984

Interdisciplinary and Emerging Signature Programs

  • Neurodegenerative Disease
  • Neuroscience

Recent Publications

  • Pabon MM, Bachstetter AD, Hudson CE, Gemma C, Bickford PC. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of neuroinflammation. 8(1) : 9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21266082
  • Acosta S, Jernberg J, Sanberg CD, Sanberg PR, Small BJ, Gemma C, Bickford PC. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation research. 13(5) : 581-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20586644
  • Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 58(6) : 679-90, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20014277
  • Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PloS one. 5(5) : e10496, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20463965
  • Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International journal of pharmaceutics. 389(1-2) : 207-12, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20083179
  • Shytle DR, Tan J, Ehrhart J, Smith AJ, Sanberg CD, Sanberg PR, Anderson J, Bickford PC. Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study. Medical science monitor : international medical journal of experimental and clinical research. 16(1) : BR1-5, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20037479
  • Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B, Fink RC, Alberte RS. Optimized turmeric extracts have potent anti-amyloidogenic effects. Current Alzheimer research. 6(6) : 564-71, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19715544
  • Bachstetter AD, Morganti JM, Jernberg J, Schlunk A, Mitchell SH, Brewster KW, Hudson CE, Cole MJ, Harrison JK, Bickford PC, Gemma C. Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiology of aging. , 2009. http://www.ncbi.nlm.nih.gov/pubmed/20018408
  • Berglöf E, Small BJ, Bickford PC, Strömberg I. Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. The Journal of comparative neurology. 515(1) : 72-82, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19399894
  • Morgan D, Landreth G, Bickford P. The promise and perils of an Alzheimer disease vaccine: a video debate. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 4(1) : 1-3, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18946741
  • Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's disease : JAD. 15(4) : 605-14, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19096159
  • Bachstetter AD, Pabon MM, Cole MJ, Hudson CE, Sanberg PR, Willing AE, Bickford PC, Gemma C. Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC neuroscience. 9: 22, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18275610
  • Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. Journal of neuroinflammation. 5: 41, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18817573
  • Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation research. 11(5) : 891-901, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18789000
  • Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age (Dordrecht, Netherlands). 30(4) : 263-72, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19424850
  • Zhu Y, Hou H, Nikolic WV, Ehrhart J, Rrapo E, Bickford P, Giunta B, Tan J. CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PloS one. 3(5) : e2135, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18478117
  • Willis LM, Small BJ, Bickford PC, Umphlet CD, Moore AB, Granholm AC. Dietary blueberry supplementation affects growth but not vascularization of neural transplants. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(6) : 1150-64, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18285804
  • Yasuhara T, Hara K, Maki M, Masuda T, Sanberg CD, Sanberg PR, Bickford PC, Borlongan CV. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation research. 11(1) : 201-14, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18260778
  • Garbuzova-Davis S, Sanberg CD, Kuzmin-Nichols N, Willing AE, Gemma C, Bickford PC, Miller C, Rossi R, Sanberg PR. Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PloS one. 3(6) : e2494, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18575617