Center of Excellence for Aging & Brain Repair

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Yuji Kaneko, PHD

Assistant Professor, Center Of Excellence For Aging & Brain Repair

Center Of Excellence For Aging & Brain Repair

Contact Info 12901 Bruce B. Downs Blvd.
Tampa, FL 33612

Academic Email: ykaneko@health.usf.edu

Academic Phone: (813) 974-6281

View My C.V.

Education

  • PHD, Agriculture, Kagoshima University, 1996

Academic Philosophy

"My principal research aim is to bridge the gap of knowledge between basic science investigations and clinical applications."

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • My experiments are designed to explore the molecular mechanisms of gene/protein expression and modifications underlying ischemic or oxidative stress-induced cell death, with an eye towards exploiting the dynamic role of specific proteins for therapeutic intervention.

Recent Publications

  • Tajiri, N.Acosta, SA.Shahaduzzaman, M.Ishikawa, H.Shinozuka, K.Pabon, M.Hernandez-Ontiveros, D.Kim, DW.Metcalf, C.Staples, M.Dailey, T.Vasconcellos, J.Franyuti, G.Gould, L.Patel, N.Cooper, D.Kaneko, Y.Borlongan, CV.Bickford, PC. Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(1) : 313-26, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24381292
  • Kaneko, Y.Shojo, H.Burns, J.Staples, M.Tajiri, N.Borlongan, CV. DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway. Neurobiology of disease. 62: 56-61, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24060818
  • Acosta, SA.Diamond, DM.Wolfe, S.Tajiri, N.Shinozuka, K.Ishikawa, H.Hernandez, DG.Sanberg, PR.Kaneko, Y.Borlongan, CV. Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. PloS one. 8(12) : e81585, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24349091
  • Kaneko, Y.Tajiri, N.Shojo, H.Borlongan, CV. Oxygen-Glucose-Deprived Rat Primary Neural Cells Exhibit DJ-1 Translocation into Healthy Mitochondria: A Potent Stroke Therapeutic Target. CNS neuroscience & therapeutics. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24382215
  • Dailey, T.Mosley, Y.Pabon, M.Acosta, S.Tajiri, N.van Loveren, H.Kaneko, Y.Borlongan, CV. Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy. Neuroreport. 24(18) : 1067-71, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24169604
  • Shinozuka, K.Dailey, T.Tajiri, N.Ishikawa, H.Kaneko, Y.Borlongan, CV. Stem Cell Transplantation for Neuroprotection in Stroke. Brain sciences. 3(1) : 239-261, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24147217
  • Ishikawa, H.Tajiri, N.Shinozuka, K.Vasconcellos, J.Kaneko, Y.Lee, HJ.Mimura, O.Dezawa, M.Kim, SU.Borlongan, CV. Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation. Stroke; a journal of cerebral circulation. 44(12) : 3473-81, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24130140
  • Yu, S.Tajiri, N.Franzese, N.Franzblau, M.Bae, E.Platt, S.Kaneko, Y.Borlongan, CV. Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation. PloS one. 8(9) : e76329, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24086730
  • Shinozuka, K.Dailey, T.Tajiri, N.Ishikawa, H.Kim, DW.Pabon, M.Acosta, S.Kaneko, Y.Borlongan, CV. Stem Cells for Neurovascular Repair in Stroke. Journal of stem cell research & therapy. 4(4) : 12912, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24077523
  • Tajiri, N.Kaneko, Y.Shinozuka, K.Ishikawa, H.Yankee, E.McGrogan, M.Case, C.Borlongan, CV. Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site. PloS one. 8(9) : e74857, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24023965
  • Ishikawa, H.Tajiri, N.Vasconcellos, J.Kaneko, Y.Mimura, O.Dezawa, M.Borlongan, CV. Ischemic stroke brain sends indirect cell death signals to the heart. Stroke; a journal of cerebral circulation. 44(11) : 3175-82, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24008571
  • Dailey, T.Tajiri, N.Kaneko, Y.Borlongan, CV. Regeneration of neuronal cells following cerebral injury. Frontiers of neurology and neuroscience. 32: 54-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23859963
  • Tajiri, N.Dailey, T.Metcalf, C.Mosley, YI.Lau, T.Staples, M.van Loveren, H.Kim, SU.Yamashima, T.Yasuhara, T.Date, I.Kaneko, Y.Borlongan, CV. In vivo animal stroke models: a rationale for rodent and non-human primate models. Translational stroke research. 4(3) : 308-21, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23682299
  • Garbuzova-Davis, S.Rodrigues, MC.Hernandez-Ontiveros, DG.Tajiri, N.Frisina-Deyo, A.Boffeli, SM.Abraham, JV.Pabon, M.Wagner, A.Ishikawa, H.Shinozuka, K.Haller, E.Sanberg, PR.Kaneko, Y.Borlongan, CV. Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model. PloS one. 8(5) : e63553, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23675488
  • Ishikawa, H.Caputo, M.Franzese, N.Weinbren, NL.Slakter, A.Patel, M.Stahl, CE.Jacotte, MA.Acosta, S.Franyuti, G.Shinozuka, K.Tajiri, N.van Loveren, H.Kaneko, Y.Borlongan, CV. Stroke in the eye of the beholder. Medical hypotheses. 80(4) : 411-5, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23395299
  • Acosta, SA.Tajiri, N.Shinozuka, K.Ishikawa, H.Grimmig, B.Diamond, D.Sanberg, PR.Bickford, PC.Kaneko, Y.Borlongan, CV. Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model. PloS one. 8(1) : e53376, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23301065
  • Staples, M.Acosta, S.Tajiri, N.Pabon, M.Kaneko, Y.Borlongan, CV. Delta opioid receptor and its peptide: a receptor-ligand neuroprotection. International journal of molecular sciences. 14(9) : 17410-9, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23979422
  • Borlongan, CV.Burns, J.Tajiri, N.Stahl, CE.Weinbren, NL.Shojo, H.Sanberg, PR.Emerich, DF.Kaneko, Y.van Loveren, HR. Epidemiological survey-based formulae to approximate incidence and prevalence of neurological disorders in the United States: a meta-analysis. PloS one. 8(10) : e78490, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24205243
  • Acosta, SA.Franzese, N.Staples, M.Weinbren, NL.Babilonia, M.Patel, J.Merchant, N.Simancas, AJ.Slakter, A.Caputo, M.Patel, M.Franyuti, G.Franzblau, MH.Suarez, L.Gonzales-Portillo, C.Diamandis, T.Shinozuka, K.Tajiri, N.Sanberg, PR.Kaneko, Y.Miller, LW.Borlongan, CV. Human Umbilical Cord Blood for Transplantation Therapy in Myocardial Infarction. Journal of stem cell research & therapy. (Suppl 4) , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24307973
  • Glover, LE.Tajiri, N.Lau, T.Kaneko, Y.van Loveren, H.Borlongan, CV. Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model. PloS one. 7(3) : e33646, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22438975
  • Tajiri, N.Lau, T.Glover, LE.Shinozuka, K.Kaneko, Y.van Loveren, H.Borlongan, CV. Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection. Current pharmaceutical design. 18(25) : 3663-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22574980
  • Kaneko, Y.Tajiri, N.Shinozuka, K.Glover, LE.Weinbren, NL.Cortes, L.Borlongan, CV. Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells. Current pharmaceutical design. 18(25) : 3731-4, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22574986
  • Kaneko, Y.Cortes, L.Sanberg, C.Acosta, S.Bickford, PC.Borlongan, CV. Dietary Supplementations as Neuroprotective Therapies: Focus on NT-020 Diet Benefits in a Rat Model of Stroke. International journal of molecular sciences. 13(6) : 7424-44, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22837703
  • Tajiri, N.Acosta, S.Glover, LE.Bickford, PC.Jacotte Simancas, A.Yasuhara, T.Date, I.Solomita, MA.Antonucci, I.Stuppia, L.Kaneko, Y.Borlongan, CV. Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats. PloS one. 7(8) : e43779, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22912905
  • Kaneko, Y.Tajiri, N.Su, TP.Wang, Y.Borlongan, CV. Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system. PloS one. 7(10) : e47583, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23077646
  • Kaneko, Y.Tajiri, N.Yu, S.Hayashi, T.Stahl, CE.Bae, E.Mestre, H.Franzese, N.Rodrigues, A.Rodrigues, MC.Ishikawa, H.Shinozuka, K.Hethorn, W.Weinbren, N.Glover, LE.Tan, J.Achyuta, AH.van Loveren, H.Sanberg, PR.Shivsankar, S.Borlongan, CV. Nestin overexpression precedes caspase-3 upregulation in rats exposed to controlled cortical impact traumatic brain injury. Cell medicine. 4(2) : 55-63, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23101029
  • Rodrigues, MC.Glover, LE.Weinbren, N.Rizzi, JA.Ishikawa, H.Shinozuka, K.Tajiri, N.Kaneko, Y.Sanberg, PR.Allickson, JG.Kuzmin-Nichols, N.Garbuzova-Davis, S.Voltarelli, JC.Cruz, E.Borlongan, CV. Toward personalized cell therapies: autologous menstrual blood cells for stroke. Journal of biomedicine & biotechnology. 2011: 194720, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22162629
  • Borlongan, CV.Glover, LE.Tajiri, N.Kaneko, Y.Freeman, TB. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Progress in neurobiology. 95(2) : 213-28, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21903148
  • Kaneko, Y.Hayashi, T.Yu, S.Tajiri, N.Bae, EC.Solomita, MA.Chheda, SH.Weinbren, NL.Parolini, O.Borlongan, CV. Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection. Journal of pineal research. 50(3) : 272-80, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21269327
  • Borlongan, CV.Kaneko, Y.Maki, M.Yu, SJ.Ali, M.Allickson, JG.Sanberg, CD.Kuzmin-Nichols, N.Sanberg, PR. Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke. Stem cells and development. 19(4) : 439-52, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19860544
  • Kaneko, Y.Eve, DJ.Yu, S.Shojo, H.Bae, EC.Park, DH.Roschek, B.Alberte, RS.Sanberg, PR.Sanberg, CD.Bickford, PC.Borlongan, CV. Acute Treatment With Herbal Extracts Provides Neuroprotective Benefits in In Vitro and In Vivo Stroke Models, Characterized by Reduced Ischemic Cell Death and Maintenance of Motor and Neurological Functions. Cell medicine. 1(3) : 137-142, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21379315
  • Bachstetter, AD.Jernberg, J.Schlunk, A.Vila, JL.Hudson, C.Cole, MJ.Shytle, RD.Tan, J.Sanberg, PR.Sanberg, CD.Borlongan, C.Kaneko, Y.Tajiri, N.Gemma, C.Bickford, PC. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PloS one. 5(5) : e10496, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20463965
  • Shojo H, Kaneko Y, Mabuchi T, Kibayashi K, Adachi N, and Borlongan CV Traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury: A target for therapeutic intervention. Neuroscience. 171: 1273-1282, 2010.
  • Yu, S.Kaneko, Y.Bae, E.Stahl, CE.Wang, Y.van Loveren, H.Sanberg, PR.Borlongan, CV. Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain research. 1287: 157-63, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19573519
  • Yu, SJ.Soncini, M.Kaneko, Y.Hess, DC.Parolini, O.Borlongan, CV. Amnion: a potent graft source for cell therapy in stroke. Cell transplantation. 18(2) : 111-8, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19499700
  • Hayashi, T.Kaneko, Y.Yu, S.Bae, E.Stahl, CE.Kawase, T.van Loveren, H.Sanberg, PR.Borlongan, CV. Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats. Brain research. 1280: 172-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19464272
  • Matsukawa, N.Yasuhara, T.Hara, K.Xu, L.Maki, M.Yu, G.Kaneko, Y.Ojika, K.Hess, DC.Borlongan, CV. Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke. BMC neuroscience. 10: 126, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19807907