Center of Excellence for Aging & Brain Repair

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Sandra Acosta, PhD

Postdoctoral Scholar Research, Center Of Excellence For Aging & Brain Repair

Center Of Excellence For Aging & Brain Repair

Post Doctoral Fellow, Neurosurgery and Brain Repair, USF

Academic Email:

Academic Phone: (813) 974-8222


  • PhD, Medical Sciences, University Of South Florida, 2011
  • MSMS, Molecular Pharmacology and Physiology, USF, 2008
  • BS, Biomedical Science and Chemistry, USF, 2005

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • My research area is molecular/behavioral characterization and stem cell therapy of clinically relevant animal models of stroke, TBI and Parkinson’s disease. In our translational research laboratory, our main goal is to identify the mechanism of actions of these neurodegenerative diseases in order to understand and develop more effective cell-based therapeutic interventions in the clinic.

Recent Publications

  • Cerecedo-López, CD.Kim-Lee, JH.Hernandez, D.Acosta, SA.Borlongan, CV. Insulin-associated neuroinflammatory pathways as therapeutic targets for traumatic brain injury. Medical hypotheses. 82(2) : 171-4, 2014.
  • Tajiri, N.Acosta, SA.Shahaduzzaman, M.Ishikawa, H.Shinozuka, K.Pabon, M.Hernandez-Ontiveros, D.Kim, DW.Metcalf, C.Staples, M.Dailey, T.Vasconcellos, J.Franyuti, G.Gould, L.Patel, N.Cooper, D.Kaneko, Y.Borlongan, CV.Bickford, PC. Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(1) : 313-26, 2014.
  • Acosta, SA.Diamond, DM.Wolfe, S.Tajiri, N.Shinozuka, K.Ishikawa, H.Hernandez, DG.Sanberg, PR.Kaneko, Y.Borlongan, CV. Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. PloS one. 8(12) : e81585, 2013.
  • Acosta, SA.Franzese, N.Staples, M.Weinbren, NL.Babilonia, M.Patel, J.Merchant, N.Simancas, AJ.Slakter, A.Caputo, M.Patel, M.Franyuti, G.Franzblau, MH.Suarez, L.Gonzales-Portillo, C.Diamandis, T.Shinozuka, K.Tajiri, N.Sanberg, PR.Kaneko, Y.Miller, LW.Borlongan, CV. Human Umbilical Cord Blood for Transplantation Therapy in Myocardial Infarction. Journal of stem cell research & therapy. (Suppl 4) , 2013.
  • Shinozuka, K.Dailey, T.Tajiri, N.Ishikawa, H.Kim, DW.Pabon, M.Acosta, S.Kaneko, Y.Borlongan, CV. Stem Cells for Neurovascular Repair in Stroke. Journal of stem cell research & therapy. 4(4) : 12912, 2013.
  • Diamandis, T.Gonzales-Portillo, C.Gonzales-Portillo, GS.Staples, M.Borlongan, MC.Hernandez, D.Acosta, S.Borlongan, CV. Diabetes insipidus contributes to traumatic brain injury pathology via CD36 neuroinflammation. Medical hypotheses. 81(5) : 936-9, 2013.
  • Hernandez-Ontiveros, DG.Tajiri, N.Acosta, S.Giunta, B.Tan, J.Borlongan, CV. Microglia activation as a biomarker for traumatic brain injury. Frontiers in neurology. 4: 30, 2013.
  • Ishikawa, H.Caputo, M.Franzese, N.Weinbren, NL.Slakter, A.Patel, M.Stahl, CE.Jacotte, MA.Acosta, S.Franyuti, G.Shinozuka, K.Tajiri, N.van Loveren, H.Kaneko, Y.Borlongan, CV. Stroke in the eye of the beholder. Medical hypotheses. 80(4) : 411-5, 2013.
  • Acosta, SA.Tajiri, N.Shinozuka, K.Ishikawa, H.Grimmig, B.Diamond, DM.Diamond, D.Sanberg, PR.Bickford, PC.Kaneko, Y.Borlongan, CV. Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model. PloS one. 8(1) : e53376, 2013.
  • Shahaduzzaman, M.Acosta, S.Bickford, PC.Borlongan, CV. α-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury. Medical hypotheses. 81(4) : 675-80, 2013.
  • Staples, M.Acosta, S.Tajiri, N.Pabon, M.Kaneko, Y.Borlongan, CV. Delta opioid receptor and its peptide: a receptor-ligand neuroprotection. International journal of molecular sciences. 14(9) : 17410-9, 2013.
  • Dailey, T.Mosley, Y.Pabon, M.Acosta, S.Tajiri, N.van Loveren, H.Kaneko, Y.Borlongan, CV. Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy. Neuroreport. 24(18) : 1067-71, 2013.