Center of Excellence for Aging & Brain Repair

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SvitlanaGarbuzova-Davis

Svitlana Garbuzova-Davis, PhD, D.Sc

Assoc Professor, Center Of Excellence For Aging & Brain Repair

Center Of Excellence For Aging & Brain Repair

Contact Info 12901 Bruce B. Downs Blvd., MDC 78
Tampa, FL 33612

Academic Email: sgarbuzo@health.usf.edu

Academic Phone: (813) 974-3189

Education

  • PHD, Biological Sciences, Kharkiv State University, 1999
  • DSc, Physiology of man and animals, Ukraine National Academy of Science, 1999

Academic Philosophy

"Translational research has concentrated on development of cell therapies for ALS and Sanfilippo Syndrome. One of my current focuses is investigation of blood-CNS barrier damage in ALS and potential approaches for repair."

Interdisciplinary and Emerging Signature Programs

  • Neurodegenerative Disease
  • Neuroscience

Research Interests

  • My laboratory is focused on translational research examining the therapeutic effects of transplanting human umbilical cord blood in mouse models of ALS and Sanfilippo Syndrome. One current focus of mine is deciphering the mechanisms of the blood-CNS barrier damage in ALS and stroke and engendering barrier repair to restore neurovascular unit functionality in patients with these or other neurovascular diseases.

Memberships

  • American Heart Association (Member, 2014 - Present)
  • International Brain Barrier Society (Member, 2012 - Present)
  • American Society for Neural Therapy and Repair (Member, 2011 - Present)
  • Society for Neuroscience (Member, 2002 - Present)
  • International Behavioral Society (Member, 2002 - 2005)

Recent Publications

  • Willing, AE.Garbuzova-Davis, SN.Zayko, O.Derasari, HM.Rawls, AE.James, CR.Mervis, RF.Sanberg, CD.Kuzmin-Nichols, N.Sanberg, PR. Repeated Administrations of Human Umbilical Cord Blood Cells Improve Disease Outcomes in a Mouse Model of Sanfilippo Syndrome Type III B. Cell transplantation. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24380668
  • Rodrigues, MC.Sanberg, PR.Cruz, LE.Garbuzova-Davis, S. The innate and adaptive immunological aspects in neurodegenerative diseases. Journal of neuroimmunology. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24161471
  • Garbuzova-Davis, S.Rodrigues, MC.Hernandez-Ontiveros, DG.Tajiri, N.Frisina-Deyo, A.Boffeli, SM.Abraham, JV.Pabon, M.Wagner, A.Ishikawa, H.Shinozuka, K.Haller, E.Sanberg, PR.Kaneko, Y.Borlongan, CV. Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model. PloS one. 8(5) : e63553, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23675488
  • Garbuzova-Davis, S.Mirtyl, S.Sallot, SA.Hernandez-Ontiveros, DG.Haller, E.Sanberg, PR. Blood-brain barrier impairment in MPS III patients. BMC neurology. 13: 174, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24225396
  • Garbuzova-Davis, S.Rodrigues, MC.Mirtyl, S.Turner, S.Mitha, S.Sodhi, J.Suthakaran, S.Eve, DJ.Sanberg, CD.Kuzmin-Nichols, N.Sanberg, PR. Multiple intravenous administrations of human umbilical cord blood cells benefit in a mouse model of ALS. PloS one. 7(2) : e31254, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22319620
  • Garbuzova-Davis, S.Hernandez-Ontiveros, DG.Rodrigues, MC.Haller, E.Frisina-Deyo, A.Mirtyl, S.Sallot, S.Saporta, S.Borlongan, CV.Sanberg, PR. Impaired blood-brain/spinal cord barrier in ALS patients. Brain research. 1469: 114-28, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22750125
  • Rodrigues, MC.Voltarelli, JC.Sanberg, PR.Borlongan, CV.Garbuzova-Davis, S. Immunological aspects in amyotrophic lateral sclerosis. Translational stroke research. 3(3) : 331-40, 2012. http://www.ncbi.nlm.nih.gov/pubmed/24323808
  • Rodrigues, MC.Hernandez-Ontiveros, DG.Louis, MK.Willing, AE.Borlongan, CV.Sanberg, PR.Voltarelli, JC.Garbuzova-Davis, S. Neurovascular aspects of amyotrophic lateral sclerosis. International review of neurobiology. 102: 91-106, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22748827
  • Garbuzova-Davis, S.Rodrigues, MC.Hernandez-Ontiveros, DG.Louis, MK.Willing, AE.Borlongan, CV.Sanberg, PR. Amyotrophic lateral sclerosis: a neurovascular disease. Brain research. 1398: 113-25, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21632035
  • Garbuzova-Davis, S.Louis, MK.Haller, EM.Derasari, HM.Rawls, AE.Sanberg, PR. Blood-brain barrier impairment in an animal model of MPS III B. PloS one. 6(3) : e16601, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21408219
  • Chen, N.Newcomb, J.Garbuzova-Davis, S.Davis Sanberg, C.Sanberg, PR.Willing, AE. Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons in Vitro. Aging and disease. 1(3) : 173-190, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21234285
  • Garbuzova-Davis, S.Woods, RL.Louis, MK.Zesiewicz, TA.Kuzmin-Nichols, N.Sullivan, KL.Miller, AM.Hernandez-Ontiveros, DG.Sanberg, PR. Reduction of circulating endothelial cells in peripheral blood of ALS patients. PloS one. 5(5) : e10614, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20485543
  • Sanberg, PR.Eve, DJ.Willing, AE.Garbuzova-Davis, S.Tan, J.Sanberg, CD.Allickson, JG.Cruz, LE.Borlongan, CV. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell transplantation. , 2010. http://www.ncbi.nlm.nih.gov/pubmed/20887684
  • Garbuzova-Davis, S.Sanberg, PR. Feasibility of cell therapy for amyotrophic lateral sclerosis. Experimental neurology. 216(1) : 3-6, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19084005
  • Gografe, SI.Sanberg, PR.Chamizo, W.Monforte, H.Garbuzova-Davis, S. Novel pathologic findings associated with urinary retention in a mouse model of mucopolysaccharidosis type IIIB. Comparative medicine. 59(2) : 139-46, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19389305
  • Garbuzova-Davis, S.Klasko, SK.Sanberg, PR. Intravenous administration of human umbilical cord blood cells in an animal model of MPS III B. The Journal of comparative neurology. 515(1) : 93-101, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19399896
  • Saleh, IA.Zesiewicz, T.Xie, Y.Sullivan, KL.Miller, AM.Kuzmin-Nichols, N.Sanberg, PR.Garbuzova-Davis, S. Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression. Journal of neuroimmunology. 215(1-2) : 96-101, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19682755
  • Ajmo, CT.Vernon, DO.Collier, L.Hall, AA.Garbuzova-Davis, S.Willing, A.Pennypacker, KR. The spleen contributes to stroke-induced neurodegeneration. Journal of neuroscience research. 86(10) : 2227-34, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18381759
  • Willing, AE.Garbuzova-Davis, S.Sanberg, PR.Saporta, S. Routes of stem cell administration in the adult rodent. Methods in molecular biology (Clifton, N.J.). 438: 383-401, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18369773
  • Garbuzova-Davis, S.Sanberg, CD.Kuzmin-Nichols, N.Willing, AE.Gemma, C.Bickford, PC.Miller, C.Rossi, R.Sanberg, PR. Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PloS one. 3(6) : e2494, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18575617
  • Sanberg, PR.Willing, AE.Garbuzova-Davis, S.Bickford, PC.Van Loveren, H.Klasko, SK.Sanberg, CD.Borlongan, CV.Eve, DJ. Navigating cellular repair for the central nervous system. Clinical neurosurgery. 55: 133-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19248678
  • Garbuzova-Davis, S.Saporta, S.Sanberg, PR. Implications of blood-brain barrier disruption in ALS. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. 9(6) : 375-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18608097

Awards/Honors

  • Platinum Dean’s Recognition Award for achievements and leadership in education and research/ (USF - 2010)
  • Dean’s Bonus Award for excellence in teaching and research (USF - 2009)
  • Award for mentoring exceptional undergraduate students (Honors College, USF - 2008)
  • SIPIN Award (USF - 2008)