Center of Excellence for Aging & Brain Repair

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ThomasFreeman

Thomas Freeman, MD

Professor, College Of Medicine Molecular Pharmacology & Physiology

Professor, College Of Medicine Neurosurgery

College Of Medicine Neurosurgery

Medical Director, Center of Excellence for Aging and Brain Repair, University of South Florida

Professor, College of Medicine, Department of Neurosurgery and Brain Repair, University of South Florida

Consultant, Division of Neurosurgery, James A. Haley Veterans Hospital

Contact Info 2 Tampa General Circle
Tampa, FL 33606

Academic Email: tfreeman@health.usf.edu

Academic Phone: (813) 259-0889

View My C.V.

Education

  • MD, Johns Hopkins University, 1981

Memberships

  • American Association of Neurological Surgeons (Fellow, 2010 - Present)
  • Florida Medical Association (Member, 2005 - Present)
  • Congress of Neurological Surgeons (Member, 1997 - Present)
  • American College of Surgeons (Fellow, 1997 - Present)

Recent Publications

  • Holt, DA.Nauert, GM.Othberg, AI.Randall, TS.Willing, AE.Widen, RH.Hauser, RA.Sanberg, PR.Olanow, CW.Freeman, TB. Infectious issues in human fetal neural transplantation. Cell transplantation. 6(6) : 553-6http://www.ncbi.nlm.nih.gov/pubmed/9440864
  • Saporta, S.Borlongan, C.Moore, J.Mejia-Millan, E.Jones, SL.Bonness, P.Randall, TS.Allen, RC.Freeman, TB.Sanberg, PR. Microcarrier enhanced survival of human and rat fetal ventral mesencephalon cells implanted in the rat striatum. Cell transplantation. 6(6) : 579-84http://www.ncbi.nlm.nih.gov/pubmed/9440867
  • Sanchez-Ramos, J.Song, S.Dailey, M.Cardozo-Pelaez, F.Hazzi, C.Stedeford, T.Willing, A.Freeman, TB.Saporta, S.Zigova, T.Sanberg, PR.Snyder, EY. The X-gal caution in neural transplantation studies. Cell transplantation. 9(5) : 657-67http://www.ncbi.nlm.nih.gov/pubmed/11144962
  • Kordower, JH.Styren, S.Clarke, M.DeKosky, ST.Olanow, CW.Freeman, TB. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell transplantation. 6(3) : 213-9http://www.ncbi.nlm.nih.gov/pubmed/9171154
  • Othberg, AI.Willing, AE.Cameron, DF.Anton, A.Saporta, S.Freeman, TB.Sanberg, PR. Trophic effect of porcine Sertoli cells on rat and human ventral mesencephalic cells and hNT neurons in vitro. Cell transplantation. 7(2) : 157-64http://www.ncbi.nlm.nih.gov/pubmed/9588597
  • Cisbani, G.Freeman, TB.Soulet, D.Saint-Pierre, M.Gagnon, D.Parent, M.Hauser, RA.Barker, RA.Cicchetti, F. Striatal allografts in patients with Huntington's disease: impact of diminished astrocytes and vascularization on graft viability. Brain : a journal of neurology. 136(Pt 2) : 433-43, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23378216
  • Galpern, WR.Corrigan-Curay, J.Lang, AE.Kahn, J.Tagle, D.Barker, RA.Freeman, TB.Goetz, CG.Kieburtz, K.Kim, SY.Piantadosi, S.Comstock Rick, A.Federoff, HJ. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet neurology. 11(7) : 643-50, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22710757
  • Sangala, JR.Nichols, T.Freeman, TB. Technique to minimize paraspinal muscle atrophy after posterior cervical fusion. Clinical neurology and neurosurgery. 113(1) : 48-51, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20956054
  • Borlongan, CV.Glover, LE.Tajiri, N.Kaneko, Y.Freeman, TB. The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders. Progress in neurobiology. 95(2) : 213-28, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21903148
  • Freeman, TB.Cicchetti, F.Bachoud-Lévi, AC.Dunnett, SB. Technical factors that influence neural transplant safety in Huntington's disease. Experimental neurology. 227(1) : 1-9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20849848
  • Phommachanh, V.Patil, YJ.McCaffrey, TV.Vale, F.Freeman, TB.Padhya, TA. Otolaryngologic management of delayed pharyngoesophageal perforation following anterior cervical spine surgery. The Laryngoscope. 120(5) : 930-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20422686
  • Olanow, CW.Gracies, JM.Goetz, CG.Stoessl, AJ.Freeman, T.Kordower, JH.Godbold, J.Obeso, JA. Clinical pattern and risk factors for dyskinesias following fetal nigral transplantation in Parkinson's disease: a double blind video-based analysis. Movement disorders : official journal of the Movement Disorder Society. 24(3) : 336-43, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19006186
  • Cicchetti, F.Saporta, S.Hauser, RA.Parent, M.Saint-Pierre, M.Sanberg, PR.Li, XJ.Parker, JR.Chu, Y.Mufson, EJ.Kordower, JH.Freeman, TB. Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 106(30) : 12483-8, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19620721
  • Kordower, JH.Chu, Y.Hauser, RA.Olanow, CW.Freeman, TB. Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Movement disorders : official journal of the Movement Disorder Society. 23(16) : 2303-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19006193
  • Kordower, JH.Chu, Y.Hauser, RA.Freeman, TB.Olanow, CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nature medicine. 14(5) : 504-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18391962
  • Soderstrom, KE.Meredith, G.Freeman, TB.McGuire, SO.Collier, TJ.Sortwell, CE.Wu, Q.Steece-Collier, K. The synaptic impact of the host immune response in a parkinsonian allograft rat model: Influence on graft-derived aberrant behaviors. Neurobiology of disease. 32(2) : 229-42, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18672063
  • Yantzer, BK.Freeman, TB.Lee, WE.Nichols, T.Inamasu, J.Guiot, B.Johnson, WM. Torsion-induced pressure distribution changes in human intervertebral discs: an in vitro study. Spine. 32(8) : 881-4, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17426632
  • Prehn, AW.Vawter, DE.Gervais, KG.DeVries, RG.Garrett, JE.Freeman, TB.McIndoo, TQ. Studying neurosurgical implants for Parkinson disease: a question of design. Neurology. 67(8) : 1503-5, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17060588
  • Furtado, S.Sossi, V.Hauser, RA.Samii, A.Schulzer, M.Murphy, CB.Freeman, TB.Stoessl, AJ. Positron emission tomography after fetal transplantation in Huntington's disease. Annals of neurology. 58(2) : 331-7, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16049929
  • Vawter, DE.Gervais, KG.Freeman, TB. Strategies for achieving high-quality IRB review. The American journal of bioethics : AJOB. 4(3) : 74-6; discussion W32, 2004. http://www.ncbi.nlm.nih.gov/pubmed/16192152
  • Olanow, CW.Goetz, CG.Kordower, JH.Stoessl, AJ.Sossi, V.Brin, MF.Shannon, KM.Nauert, GM.Perl, DP.Godbold, J.Freeman, TB. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Annals of neurology. 54(3) : 403-14, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12953276
  • Hauser, RA.Furtado, S.Cimino, CR.Delgado, H.Eichler, S.Schwartz, S.Scott, D.Nauert, GM.Soety, E.Sossi, V.Holt, DA.Sanberg, PR.Stoessl, AJ.Freeman, TB. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology. 58(5) : 687-95, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11889229
  • Zigova, T.Willing, AE.Saporta, S.Daadi, MM.McGrogan, MP.Randall, TS.Freeman, TB.Sanchez-Ramos, J.Sanberg, PR. Apoptosis in cultured hNT neurons. Brain research. Developmental brain research. 127(1) : 63-70, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11287065
  • Freeman, TB.Hauser, RA.Sanberg, PR.Saporta, S. Neural transplantation for the treatment of Huntington's disease. Progress in brain research. 127: 405-11, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11142038
  • Freeman, TB.Cicchetti, F.Hauser, RA.Deacon, TW.Li, XJ.Hersch, SM.Nauert, GM.Sanberg, PR.Kordower, JH.Saporta, S.Isacson, O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. 97(25) : 13877-82, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11106399
  • Zigova, T.Barroso, LF.Willing, AE.Saporta, S.McGrogan, MP.Freeman, TB.Sanberg, PR. Dopaminergic phenotype of hNT cells in vitro. Brain research. Developmental brain research. 122(1) : 87-90, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10915908
  • Sanchez-Ramos, J.Song, S.Cardozo-Pelaez, F.Hazzi, C.Stedeford, T.Willing, A.Freeman, TB.Saporta, S.Janssen, W.Patel, N.Cooper, DR.Sanberg, PR. Adult bone marrow stromal cells differentiate into neural cells in vitro. Experimental neurology. 164(2) : 247-56, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10915564
  • Willing, AE.Sudberry, JJ.Othberg, AI.Saporta, S.Poulos, SG.Cameron, DF.Freeman, TB.Sanberg, PR. Sertoli cells decrease microglial response and increase engraftment of human hNT neurons in the hemiparkinsonian rat striatum. Brain research bulletin. 48(4) : 441-4, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10357077
  • Hauser, RA.Freeman, TB.Snow, BJ.Nauert, M.Gauger, L.Kordower, JH.Olanow, CW. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Archives of neurology. 56(2) : 179-87, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10025423
  • Sanberg, PR.Borlongan, CV.Koutouzis, TK.Norgren, RB.Cahill, DW.Freeman, TB. Human fetal striatal transplantation in an excitotoxic lesioned model of Huntington's disease. Annals of the New York Academy of Sciences. 831: 452-60, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9616734
  • Sanberg, PR.Othberg, AI.Borlongan, CV.Saporta, S.Anton, A.Freeman, TB.Cahill, DW.Allen, RC.Cameron, DF. Transplantation of testis-derived Sertoli cells into the mammalian brain. Transplantation proceedings. 29(4) : 1926-8, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9193458
  • Sanberg, PR.Borlongan, CV.Othberg, AI.Saporta, S.Freeman, TB.Cameron, DF. Testis-derived Sertoli cells have a trophic effect on dopamine neurons and alleviate hemiparkinsonism in rats. Nature medicine. 3(10) : 1129-32, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9334725
  • Borlongan, CV.Koutouzis, TK.Freeman, TB.Hauser, RA.Cahill, DW.Sanberg, PR. Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid model. Brain research. Brain research protocols. 1(3) : 253-7, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9385062

Positions Held

  • Professor with tenure (Department of Pharmacology and Experimental Therapeutics, College of Medicine, University of South Florida 1999 - 2007)
  • Chief (Division of Neurosurgery, James A. Haley Veterans Hospital 1988 - 1992)

Awards/Honors

  • The Molly & Bernard Sanberg Memorial Award (American Society of Neural Therapy and Repair - 2013)
  • Best Doctors in America (US News and World Reports - 2010)
  • Top 1% of Neurosurgeons in the U.S. (US News and World Reports - 2010)
  • USF Platinum Dean's Recognition Award for "Exemplary Service and Excellence in teaching and research (University of South Florida - 2010)
  • America's Top Doctors (stle Connolly Medical LTD - 2001)