Alison E. Willing, Ph.D.
Department of Neurosurgery and Brain Repair MDC 78University of South Florida College of Medicine
12901 Bruce B. Downs Blvd
Tampa, FL 33612
|Research Focus||Stem cell therapy|
|Research Description||My laboratory focuses on mechanisms underlying cell death and regeneration in stroke. In particular, I am interested in revealing the role of inflammation as a major contributing factor to stroke progression and an ideal target for interventions that produce neuroprotection and neurorestoration. I am also interested in similarities and differences in cell therapy treatment for ischemic damage to heart and brain.|
Jiang L, Saporta S, Chen N, Sanberg CD, Sanberg P, Willing AE. The Effect of Human Umbilical Cord Blood Cells on Survival and Cytokine Production by Post-Ischemic Astrocytes in Vitro. Stem Cell Reviews and Reports, 6: 523-531, 2010. PMID: 19788371, epub ahead of print August 2010(doi: 10.1007/s12015-010-9174-x).
Rowe DD, Leonardo CC, Hall AA, Shahaduzzaman M, Collier LA, Willing AE*, Pennypacker KR*. Cord blood administration induces oligodendrocyte survival through alterations in gene expression. Brain Research, 1366:172-188, epub ahead of print October 2010 (doi:10.1016/j.brainres.2010.09.078).
Chen N, Newcomb J, Garbuzova-Davis S, Sanberg CD, Sanberg PR, Willing AE. Human umbilical cord blood cells have trophic effects on young and aging hippocampal neuron in vitro. Aging & Disease. 1(3):173-190, 2010.
Sanberg PR, Park D-H, Kuzmin-Nichols N., Cruz LE, Buffolo E, Willing AE. Monocyte transplantation as an alternative to stem cells for brain and other body ischemia repair. Journal of Celluluar and Molecular Medicine, 14(3): 553-563, 2010