R. Douglas Shytle, Ph.D.
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Department of Neurosurgery and Brain Repair MDC 78 University of South Florida College of Medicine12901 Bruce B. Downs Blvd Tampa, FL 33612 Tel: 813-974-9171 Fax: 813-974-3078 email: dshytle@health.usf.edu |
Professional Snapshot
| Research Focus | Neuropsyhiatric disorders Tourette's syndrome Depression Alzheimer's disease Nicotinic receptor Nutrition Herbal medicine |
| Research Description | My laboratory has engaged in innovative drug discovery projects, focusing on modulating the nicotinic receptor ligands as potent therapeutic agents for neuropsychiatric disorders. Parallel studies in my laboratory have also demonstrated the robust therapeutic effects of nutrition and herbal medicine for a Alzheimer's disease and other neurological disorders. |
| Recent Publications |
Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. Int J Pharm. 2010 Jan 18 Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B Jr, Fink RC, Alberte RS. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr Alzheimer Res. 2009 Dec;6(6):564-71. Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation. 2008 Sep 25;5:41. |
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