R. Douglas Shytle, Ph.D.
Department of Neurosurgery and Brain Repair MDC 78University of South Florida College of Medicine
12901 Bruce B. Downs Blvd
Tampa, FL 33612
|Research Focus||Neuropsyhiatric disorders|
|Research Description||My laboratory has engaged in innovative drug discovery projects, focusing on modulating the nicotinic receptor ligands as potent therapeutic agents for neuropsychiatric disorders. Parallel studies in my laboratory have also demonstrated the robust therapeutic effects of nutrition and herbal medicine for a Alzheimer's disease and other neurological disorders.|
Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. Int J Pharm. 2010 Jan 18
Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B Jr, Fink RC, Alberte RS. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr Alzheimer Res. 2009 Dec;6(6):564-71.
Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation. 2008 Sep 25;5:41.