Cesar V. Borlongan, Ph.D.
Department of Neurosurgery and Brain Repair MDC 78University of South Florida College of Medicine
12901 Bruce B. Downs Blvd
Tampa, FL 33612
|Research Focus||Stem cell therapy|
Neonatal hypoxic-ischemic injury
Traumatic brain injury
|Research Description||My laboratory embodies translational "bench to clinic" research in advancing cell therapy for stroke and other CNS diseases. Clinically relevant animal models of human neurological disorders are used to test effectiveness and safety, as well as mechanisms of action of stem cells, which are pivotal parameters for clinical application.|
Yasuhara T, Matsukawa N, Hara K, Maki M, Ali MM, Yu SJ, Bae E, Yu G, Xu L, McGrogan M, Bankiewicz K, Case C, Borlongan CV. Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals. Stem Cells Dev. 2009 Dec;18(10):1501-14.
Yasuhara T, Hara K, Maki M, Xu L, Yu G, Ali MM, Masuda T, Yu SJ, Bae EK, Hayashi T, Matsukawa N, Kaneko Y, Kuzmin-Nichols N, Ellovitch S, Cruz EL, Klasko SK, Sanberg CD, Sanberg PR, Borlongan CV. Mannitol facilitates neurotrophic factor upregulation and behavioral recovery in neonatal hypoxic-ischemic rats with human umbilical cord blood grafts. J Cell Mol Med. 2009 Feb 4.
Borlongan CV, Hayashi T, Oeltgen PR, Su TP, Wang Y. Hibernation-like state induced by an opioid peptide protects against experimental stroke. BMC Biol. 2009 Jun 17;7:31.