Faculty

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Juan Sanchez-Ramos, MD, PhD

Endowed Chair, College Of Medicine Neurology

Professor, College Of Medicine Molecular Pharmacology & Physiology

Professor, College Of Medicine Neurology

Professor, Neurology, University of South Florida

Contact Info 13320 Laurel Drive
Tampa, FL 33612

Academic Email: jsramos@health.usf.edu

Academic Phone: (813) 974-5841

View My C.V.

Education

  • MD, Medicine, University Of Illinois, 1981
  • PHD, University Of Chicago*, 1976
  • PhD, Pharmacology and Physiology, University of Chicago, 1976

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • Neurodegeneration, neurotoxicology and adult stem cell biology

Memberships

  • American Neurological Association (Fellow, 1992 - Present)
  • Movement Disorder Society (Member, 1986 - Present)
  • American Academy of Neurology (Active Member, 1985 - Present)
  • American Association for the Advancement of Science (Member, 1976 - Present)

Recent Publications

  • Sanchez-Ramos, JZ. Neon neurons. Neurology. 80(19) : 1815, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23650234
  • Song, S.Song, S.Cao, C.Lin, X.Li, K.Sava, V.Sanchez-Ramos, J. Hippocampal neurogenesis and the brain repair response to brief stereotaxic insertion of a microneedle. Stem cells international. 2013: 205878, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23554817
  • Catlow, BJ.Song, S.Paredes, DA.Kirstein, CL.Sanchez-Ramos, J. Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. Experimental brain research. 228(4) : 481-91, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23727882
  • Velez-Lago, FM.Thompson, A.Oyama, G.Hardwick, A.Sporrer, JM.Zeilman, P.Foote, KD.Bowers, D.Ward, HE.Sanchez-Ramos, J.Okun, MS. Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington's disease. Stereotactic and functional neurosurgery. 91(2) : 129-33, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23343665
  • 12. Pennington A, Sava V, Song S, Patel N, Sanchez-Ramos J Direct Actions of Granulocyte-Colony Stimulating Factor on Human Neuronal and Monocytic Cell Lines J Alzheimers Dis Parkinsonism. 3: 121, 2013.
  • 2. Darwin K, Nichols P, Brocht A, Dorsey ER, Beck C, Biglan K, and Shoulson I, Treatment of chorea in Huntington disease Neurotherapeutics. 10(1) : 173, 2013.
  • Huntington Study Group COHORT Investigators. Natural history of Huntington disease JAMA Neurol. 70(12) : 1520-30, 2013.
  • 10. Shijie Song, Amanda Rowe, Kunyu Li, Vasyl Sava and J. Sanchez-Ramos Neuroprotective effects of bone marrow stromal cells in cocultures of fetal dopaminergic neurons Journal of Neurodegeneration and Regeneration. : 27-36, 2013.
  • 11. Briony Catlow, Shijie Song, Daniel Paredes, Cheryl Kirstein and J. Sanchez-Ramos Effect of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Exp. Brain Research. 228: 481-91, 2013.
  • 1. Nichols P, Darwin K, Brocht A, Dorsey ER, Beck C, Biglan K, and Shoulson I Safety of tetrabenazine in a longitudinal cohort study of individuals with Huntington disease Neurotherapeutics. 10(1) : 172-3, 2013.
  • Sanchez-Ramos, J.Cimino, C.Avila, R.Rowe, A.Chen, R.Whelan, G.Lin, X.Cao, C.Ashok, R. Pilot study of granulocyte-colony stimulating factor for treatment of Alzheimer's disease. Journal of Alzheimer's disease : JAD. 31(4) : 843-55, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22751169
  • Weyna, DR.Cheney, ML.Shan, N.Hanna, M.Zaworotko, MJ.Sava, V.Song, S.Sanchez-Ramos, JR. Improving Solubility and Pharmacokinetics of Meloxicam via Multiple-Component Crystal Formation. Molecular pharmaceutics. , 2012. http://www.ncbi.nlm.nih.gov/pubmed/22642304
  • Huntington Study Group COHORT Investigators Characterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study. PLos One. 7(2) : e29522, 2012.
  • Sanchez-Ramos, J.Reimer, D.Zesiewicz, T.Sullivan, K.Nausieda, PA. Quantitative analysis of tremors in welders. International journal of environmental research and public health. 8(5) : 1478-90, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21655131
  • Song, S.Sava, V.Rowe, A.Li, K.Cao, C.Mori, T.Sanchez-Ramos, J. Granulocyte-colony stimulating factor (G-CSF) enhances recovery in mouse model of Parkinson's disease. Neuroscience letters. 487(2) : 153-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20951187
  • Apostolatos, H.Apostolatos, A.Vickers, T.Watson, JE.Song, S.Vale, F.Cooper, DR.Sanchez-Ramos, J.Patel, NA. Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35. The Journal of biological chemistry. 285(34) : 25987-95, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20547768
  • Arendash, GW.Sanchez-Ramos, J.Mori, T.Mamcarz, M.Lin, X.Runfeldt, M.Wang, L.Zhang, G.Sava, V.Tan, J.Cao, C. Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. Journal of Alzheimer's disease : JAD. 19(1) : 191-210, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20061638
  • Catlow, BJ.Badanich, KA.Sponaugle, AE.Rowe, AR.Song, S.Rafalovich, I.Sava, V.Kirstein, CL.Sanchez-Ramos, J. Effects of MDMA ("ecstasy") during adolescence on place conditioning and hippocampal neurogenesis. European journal of pharmacology. 628(1-3) : 96-103, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19932093
  • Butterfield, LC.Cimino, CR.Oelke, LE.Hauser, RA.Sanchez-Ramos, J. The independent influence of apathy and depression on cognitive functioning in Parkinson's disease. Neuropsychology. 24(6) : 721-30, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20853956
  • Roscoe, LA.Corsentino, E.Watkins, S.McCall, M.Sanchez-Ramos, J. Well-being of family caregivers of persons with late-stage Huntington's disease: lessons in stress and coping. Health communication. 24(3) : 239-48, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19415556
  • Sanchez-Ramos, J.Song, S.Sava, V.Catlow, B.Lin, X.Mori, T.Cao, C.Arendash, GW. Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience. 163(1) : 55-72, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19500657
  • Catlow, BJ.Rowe, AR.Clearwater, CR.Mamcarz, M.Arendash, GW.Sanchez-Ramos, J. Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice. Brain research. 1256: 173-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19135431
  • Sanchez-Ramos, J.Song, S.Cao, C.Arendash, G. The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review. BMC neuroscience. 9 Suppl 2: S3, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19090991
  • Song, S.Sanchez-Ramos, J. Preparation of neural progenitors from bone marrow and umbilical cord blood. Methods in molecular biology (Clifton, N.J.). 438: 123-34, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18369754
  • Sava, V.Velasquez, A.Song, S.Sanchez-Ramos, J. Dieldrin elicits a widespread DNA repair and antioxidative response in mouse brain. Journal of biochemical and molecular toxicology. 21(3) : 125-35, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17623884
  • Sava, V.Velasquez, A.Song, S.Sanchez-Ramos, J. Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A. Toxicological sciences : an official journal of the Society of Toxicology. 98(1) : 187-97, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17449898
  • Song, S.Song, S.Zhang, H.Cuevas, J.Sanchez-Ramos, J. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem cells and development. 16(5) : 747-56, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17999596
  • Walczak, P.Chen, N.Eve, D.Hudson, J.Zigova, T.Sanchez-Ramos, J.Sanberg, PR.Sanberg, CD.Willing, AE. Long-term cultured human umbilical cord neural-like cells transplanted into the striatum of NOD SCID mice. Brain research bulletin. 74(1-3) : 155-63, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17683802
  • Zesiewicz, TA.Ward, CL.Hauser, RA.Sanchez-Ramos, J.Staffetti, JF.Sullivan, KL. A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor. Movement disorders : official journal of the Movement Disorder Society. 22(2) : 279-82, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17149715
  • Vesely, BA.Alli, A.Song, S.Sanchez-Ramos, J.Fitz, SR.Gower, WR.Vesely, DL. Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cells. Cardiology. 105(4) : 226-33, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16534199
  • Zesiewicz, TA.Sullivan, KL.Hauser, RA.Sanchez-Ramos, J. Open-label pilot study of levetiracetam (Keppra) for the treatment of chorea in Huntington's disease. Movement disorders : official journal of the Movement Disorder Society. 21(11) : 1998-2001, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16941461
  • Sanchez-Ramos, J. Stem cells from umbilical cord blood. Seminars in reproductive medicine. 24(5) : 358-69, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17123231
  • Kamath, SG.Chen, N.Enkemann, SA.Sanchez-Ramos, J. Transcriptional profile of NeuroD expression in a human fetal astroglial cell line. Gene expression. 12(2) : 123-36, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15892453
  • Sava, V.Mosquera, D.Song, S.Cardozo-Pelaez, F.Sánchez-Ramos, JR. Effects of melanin and manganese on DNA damage and repair in PC12-derived neurons. Free radical biology & medicine. 36(9) : 1144-54, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15082068
  • Song, S.Sanchez-Ramos, J. Brain as the Sea of Marrow. Experimental neurology. 184(1) : 54-60, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14637080
  • Willing, AE.Vendrame, M.Mallery, J.Cassady, CJ.Davis, CD.Sanchez-Ramos, J.Sanberg, PR. Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke. Cell transplantation. 12(4) : 449-54, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12911133
  • Mosquera, DI.Stedeford, T.Cardozo-Pelaez, F.Sanchez-Ramos, J. Strain-specific differences in the expression and activity of Ogg1 in the CNS. Gene expression. 11(1) : 47-53, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12691525
  • Sanchez-Ramos, JR. Neural cells derived from adult bone marrow and umbilical cord blood. Journal of neuroscience research. 69(6) : 880-93, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12205681
  • Cardozo-Pelaez, F.Stedeford, TJ.Brooks, PJ.Song, S.Sánchez-Ramos, JR. Effects of diethylmaleate on DNA damage and repair in the mouse brain. Free radical biology & medicine. 33(2) : 292-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12106825
  • Zigova, T.Song, S.Willing, AE.Hudson, JE.Newman, MB.Saporta, S.Sanchez-Ramos, J.Sanberg, PR. Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell transplantation. 11(3) : 265-74, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12075992

Positions Held

  • Associate Professor (Neurology, University of Miami 1987 - 1996)
  • Post-doctoral Fellow (Neurology, University of Miami 1985 - 1987)
  • Neurology Resident (Neurology, University of Chicago 1982 - 1985)
  • Intern (Medicine, University of Chicago 1981 - 1982)

Awards/Honors

  • Award for animation entitled “Dancing DNA” (University of Chicago, Sights and Sounds of Science Competition - 2004)
  • Outstanding Research Award for Nationally Recognized Research (Unviersity of South Florida - 2003)
  • Helen Ellis Endowed Chair (University of South Floria - 1996)
  • "Prix de la qualite de la Realisation technique" (Concours Interanationale des Technologie de la Creation, Paris, France - 1991)
  • Clinical Investigator Development Award (NIH - 1989)
  • Bertram A. Richardson Foreign Scholarship (University of Illinois College of Medicine - 1981)
  • James Scholar Program of Independent Studies (University of Illinois College of Medicine - 1978)
  • NIH Pre-doctoral Fellowship (University of Chicago, Dept of Pharmacological and Physiological Sciences - 1971)