Juan Sanchez-Ramos A-1188-2009

Juan Sanchez-Ramos, MD, PHD

Professor, College of Medicine Neurology

Professor, Department of Neurology

Director, Huntington Disease Center of Excellence

Professor, College of Medicine Molecular Pharmacology & Physiology

Movement Disorders & Huntington's Disease

Contact Info 13320 Laurel Drive
Tampa FL 33612

Academic Email: jsramos@health.usf.edu

Academic Phone:(813) 974-5841

View My C.V.

Education

  • MD, Medicine, University of Illinois, 1981
  • PHD, University of Chicago*, 1976
  • PhD, Pharmacology and Physiology, University of Chicago, 1976

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • Neurodegeneration, neurotoxicology and adult stem cell biology

Memberships

  • American Neurological Association (Fellow, 1992 - Present)
  • Movement Disorder Society (Member, 1986 - Present)
  • American Academy of Neurology (Active Member, 1985 - Present)
  • American Association for the Advancement of Science (Member, 1976 - Present)

Recent Publications

  • McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, Ross C, Shoulson I, Gilbert P, Mallonee WM, Guttman M, Wojcieszek J, Kumar R, LeDoux MS, Jenkins M, Rosas HD, Nance M, Biglan K, Como P, Dubinsky RM, Shannon KM, O'Suilleabhain P, Chou K, Walker F, Martin W, Wheelock VL, McCusker E, Jankovic J, Singer C, Sanchez-Ramos J, Scott B, Suchowersky O, Factor SA, Higgins DS, Molho E, Revilla F, Caviness JN, Friedman JH, Perlmutter JS, Feigin A, Anderson K, Rodriguez R, McFarland NR, Margolis RL, Farbman ES, Raymond LA, Suski V, Kostyk S, Colcher A, Seeberger L, Epping E, Esmail S, Diaz N, Fung WL, Diamond A, Frank S, Hanna P, Hermanowicz N, Dure LS, Cudkowicz M. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 88(2) : 152-159, 2017. http://www.ncbi.nlm.nih.gov/pubmed/27913695
  • Song S, Kong X, Acosta S, Sava V, Borlongan CV, Sanchez-Ramos J. Effects of an Inhibitor of Monocyte Recruitment on Recovery from Traumatic Brain Injury in Mice Treated with Granulocyte Colony-Stimulating Factor. International journal of molecular sciences. 18(7) , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28671601
  • Butterfield LC, Cimino CR, Salazar R, Sanchez-Ramos J, Bowers D, Okun MS. The Parkinson's Active Living (PAL) Program. Journal of geriatric psychiatry and neurology. 30(1) : 11-25, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28248557
  • Johnson PL, Potts GF, Sanchez-Ramos J, Cimino CR. Self-reported impulsivity in Huntington's disease patients and relationship to executive dysfunction and reward responsiveness. Journal of clinical and experimental neuropsychology. 39(7) : 694-706, 2017. http://www.ncbi.nlm.nih.gov/pubmed/27892808
  • Sava V Song S Kong X El Bassit G Patel N Daniel KG Sebti S Sanchez-Ramos J. Small Molecules that Mimic or Antagonize Actions of Granulocyte-Colony Stimulating Factor (G-CSF). J Drug Res Dev.. 32: http://dx.doi.org/10/16966/2470-1009.131, 2017.
  • Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte-colony stimulating factor promotes brain repair following traumatic brain injury by recruitment of microglia and increasing neurotrophic factor expression. Restorative neurology and neuroscience. 34(3) : 415-31, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26923619
  • Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injury. Journal of neuroscience research. 94(5) : 409-23, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26822127
  • Catlow B, Sanchez-Ramos J. Cannabinoids for the Treatment of Movement Disorders. Current Treatment Options in Neurology. 17(9) : 370, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26206230
  • Ugen KE, Lin X, Bai G, Liang Z, Cai J, Li K, Song S, Cao C, Sanchez-Ramos J. Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease. Human Vaccines & Immunotherapeutics. 11(4) : 922-30, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25714663
  • Hergert DC, Sanchez-Ramos J, Cimino CR. Examining Huntington's disease patient and informant concordance on frontally mediated behaviors. Journal of Clinical and Experimental Neuropsychology. 37(9) : 981-7, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26332177
  • Song S, Wang X, Sava V, Weeber EJ, Sanchez-Ramos J. In vivo administration of granulocyte colony-stimulating factor restores long-term depression in hippocampal slices prepared from transgenic APP/PS1 mice. Journal of Neuroscience Research. 92(8) : 975-80, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24664800
  • Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Sanberg PR, Sanchez-Ramos J, Song S, Kaneko Y, Borlongan CV. Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury. PloS One. 9(3) : e90953, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24621603
  • Sanchez-Ramos JZ. Neon neurons. Neurology. 80(19) : 1815, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23650234
  • Song S, Song S, Cao C, Lin X, Li K, Sava V, Sanchez-Ramos J. Hippocampal neurogenesis and the brain repair response to brief stereotaxic insertion of a microneedle. Stem Cells International. 2013: 205878, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23554817
  • Huntington Study Group HART Investigators (with J. Sanchez-Ramos) A randomized, double-blind, placebo-controlled trial of pridopidine in Huntington's disease. Movement Disorders: Official Journal of the Movement Disorder Society. 28(10) : 1407-15, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23450660
  • Marder K, Gu Y, Eberly S, Tanner CM, Scarmeas N, Oakes D, Shoulson I. Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease. JAMA Neurology. 70(11) : 1382-8, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24000094
  • Pennington A, Sava V, Song S, Patel N, Sanchez-Ramos J. Direct Actions of Granulocyte-Colony Stimulating Factor on Human Neuronal and Monocytic Cell Lines J Alzheimers Dis Parkinsonism. 3: 121, 2013.
  • Briony Catlow, Shijie Song, Daniel Paredes, Cheryl Kirstein and J. Sanchez-Ramos. Effect of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning Experimental Brain Research. 228: 481-91, 2013.
  • Shijie Song, Amanda Rowe, Kunyu Li, Vasyl Sava and J. Sanchez-Ramos. Neuroprotective effects of bone marrow stromal cells in cocultures of fetal dopaminergic neurons Journal of Neurodegeneration and Regeneration. : 27-36, 2013.
  • Huntington Study Group COHORT Investigators. Natural history of Huntington disease JAMA Neurology. 70(12) : 1520-30, 2013.
  • Darwin K, Nichols P, Brocht A, Dorsey ER, Beck C, Biglan K, and Shoulson I,. Treatment of chorea in Huntington disease Neurotherapeutics. 10(1) : 173, 2013.
  • Nichols P, Darwin K, Brocht A, Dorsey ER, Beck C, Biglan K, and Shoulson I. Safety of tetrabenazine in a longitudinal cohort study of individuals with Huntington disease Neurotherapeutics. 10(1) : 172-3, 2013.
  • Velez-Lago FM, Thompson A, Oyama G, Hardwick A, Sporrer JM, Zeilman P, Foote KD, Bowers D, Ward HE, Sanchez-Ramos J, Okun MS. Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington's disease. Stereotactic and Functional Neurosurgery. 91(2) : 129-33, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23343665
  • Catlow BJ, Song S, Paredes DA, Kirstein CL, Sanchez-Ramos J. Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. Experimental Brain Research. 228(4) : 481-91, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23727882
  • Huntington Study Group COHORT Investigators. Characterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study. PLos One. 7(2) : e29522, 2012.
  • Sanchez-Ramos J, Cimino C, Avila R, Rowe A, Chen R, Whelan G, Lin X, Cao C, Ashok R. Pilot study of granulocyte-colony stimulating factor for treatment of Alzheimer's disease. Journal of Alzheimer's Disease: JAD. 31(4) : 843-55, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22751169
  • Weyna DR, Cheney ML, Shan N, Hanna M, Zaworotko MJ, Sava V, Song S, Sanchez-Ramos JR. Improving Solubility and Pharmacokinetics of Meloxicam via Multiple-Component Crystal Formation. Molecular Pharmaceutics. , 2012. http://www.ncbi.nlm.nih.gov/pubmed/22642304
  • Friedman JH, Agarwal P, Alcalay R, Black KJ, Chou KL, Cote L, Dayalu P, Frank S, Hartlein J, Hauser RA, Lang AE, Marsh L, Marshall F, Moskowitz C, Ravina B, Riley D, Sanchez-Ramos J, Simon DK, Simuni T, Sutton J, Tuite P, Weintraub D, Zesiewicz T. Clinical vignettes in Parkinson's disease: a collection of unusual medication-induced hallucinations, delusions, and compulsive behaviours. The International Journal of Neuroscience. 121(8) : 472-6, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21663381
  • Sanchez-Ramos J, Reimer D, Zesiewicz T, Sullivan K, Nausieda PA. Quantitative analysis of tremors in welders. International Journal of Environmental Research and Public Health. 8(5) : 1478-90, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21655131
  • Song S, Sava V, Rowe A, Li K, Cao C, Mori T, Sanchez-Ramos J. Granulocyte-colony stimulating factor (G-CSF) enhances recovery in mouse model of Parkinson's disease. Neuroscience Letters. 487(2) : 153-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20951187
  • Catlow BJ, Badanich KA, Sponaugle AE, Rowe AR, Song S, Rafalovich I, Sava V, Kirstein CL, Sanchez-Ramos J. Effects of MDMA ("ecstasy") during adolescence on place conditioning and hippocampal neurogenesis. European journal of pharmacology. 628(1-3) : 96-103, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19932093
  • Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C. Electromagnetic field treatment protects against and reverses cognitive impairment in Alzheimer's disease mice. Journal of Alzheimer's Disease: JAD. 19(1) : 191-210, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20061638
  • Apostolatos H, Apostolatos A, Vickers T, Watson JE, Song S, Vale F, Cooper DR, Sanchez-Ramos J, Patel NA. Vitamin A metabolite, all-trans-retinoic acid, mediates alternative splicing of protein kinase C deltaVIII (PKCdeltaVIII) isoform via splicing factor SC35. The Journal of Biological Chemistry. 285(34) : 25987-95, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20547768
  • Butterfield LC, Cimino CR, Oelke LE, Hauser RA, Sanchez-Ramos J. The independent influence of apathy and depression on cognitive functioning in Parkinson's disease. Neuropsychology. 24(6) : 721-30, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20853956
  • Cheney ML, Shan N, Healey ER, Hanna M, Wotjas L, Zaworotko M, Sava S, Song S, & Sanchez-Ramos J. Effect of Crystal Form on Solubility and Pharmacokinetics: A Crystal Engineering Case Study of Lamotrigine Crystal Growth & Design. 10(1) : 394-405, 2010.
  • Kieburtz K, McDermott MP, Voss TS, Corey-Bloom J, Deuel LM, Dorsey ER, Factor S, Geschwind MD, Hodgeman K, Kayson E, Noonberg S, Pourfar M, Rabinowitz K, Ravina B, Sanchez-Ramos J, Seely L, Walker F, Feigin A. A randomized, placebo-controlled trial of latrepirdine in Huntington disease. Archives of Neurology. 67(2) : 154-60, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20142523
  • Boyd TD, Bennett SP, Mori T, Governatori N, Runfeldt M, Norden M, Padmanabhan J, Neame P, Wefes I, Sanchez-Ramos J, Arendash GW, Potter H. GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice. Journal of Alzheimer's Disease: JAD. 21(2) : 507-18, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20555144
  • Roscoe LA, Corsentino E, Watkins S, McCall M, Sanchez-Ramos J. Well-being of family caregivers of persons with late-stage Huntington's disease: lessons in stress and coping. Health communication. 24(3) : 239-48, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19415556
  • Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW. Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience. 163(1) : 55-72, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19500657
  • Catlow BJ, Rowe AR, Clearwater CR, Mamcarz M, Arendash GW, Sanchez-Ramos J. Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice. Brain research. 1256: 173-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19135431
  • Song S, Sanchez-Ramos J. Preparation of neural progenitors from bone marrow and umbilical cord blood. Methods in molecular biology (Clifton, N.J.). 438: 123-34, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18369754
  • Sanchez-Ramos J, Song S, Cao C, Arendash G. The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review. BMC neuroscience. 9 Suppl 2: S3, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19090991
  • Song S, Song S, Zhang H, Cuevas J, Sanchez-Ramos J. Comparison of neuron-like cells derived from bone marrow stem cells to those differentiated from adult brain neural stem cells. Stem cells and development. 16(5) : 747-56, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17999596
  • Sava V, Velasquez A, Song S, Sanchez-Ramos J. Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A. Toxicological sciences : an official journal of the Society of Toxicology. 98(1) : 187-97, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17449898
  • Sava V, Velasquez A, Song S, Sanchez-Ramos J. Dieldrin elicits a widespread DNA repair and antioxidative response in mouse brain. Journal of biochemical and molecular toxicology. 21(3) : 125-35, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17623884
  • Walczak P, Chen N, Eve D, Hudson J, Zigova T, Sanchez-Ramos J, Sanberg PR, Sanberg CD, Willing AE. Long-term cultured human umbilical cord neural-like cells transplanted into the striatum of NOD SCID mice. Brain research bulletin. 74(1-3) : 155-63, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17683802
  • Zesiewicz TA, Ward CL, Hauser RA, Sanchez-Ramos J, Staffetti JF, Sullivan KL. A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor. Movement disorders : official journal of the Movement Disorder Society. 22(2) : 279-82, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17149715
  • Zesiewicz TA, Sullivan KL, Hauser RA, Sanchez-Ramos J. Open-label pilot study of levetiracetam (Keppra) for the treatment of chorea in Huntington's disease. Movement disorders : official journal of the Movement Disorder Society. 21(11) : 1998-2001, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16941461
  • Vesely BA, Alli A, Song S, Sanchez-Ramos J, Fitz SR, Gower WR, Vesely DL. Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cells. Cardiology. 105(4) : 226-33, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16534199
  • Sanchez-Ramos J. Stem cells from umbilical cord blood. Seminars in reproductive medicine. 24(5) : 358-69, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17123231
  • Kamath SG, Chen N, Enkemann SA, Sanchez-Ramos J. Transcriptional profile of NeuroD expression in a human fetal astroglial cell line. Gene expression. 12(2) : 123-36, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15892453
  • Sava V, Mosquera D, Song S, Cardozo-Pelaez F, Sánchez-Ramos JR. Effects of melanin and manganese on DNA damage and repair in PC12-derived neurons. Free radical biology & medicine. 36(9) : 1144-54, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15082068
  • Mosquera DI, Stedeford T, Cardozo-Pelaez F, Sanchez-Ramos J. Strain-specific differences in the expression and activity of Ogg1 in the CNS. Gene expression. 11(1) : 47-53, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12691525
  • Willing AE, Vendrame M, Mallery J, Cassady CJ, Davis CD, Sanchez-Ramos J, Sanberg PR. Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke. Cell transplantation. 12(4) : 449-54, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12911133
  • Song S, Sanchez-Ramos J. Brain as the Sea of Marrow. Experimental neurology. 184(1) : 54-60, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14637080
  • Zigova T, Song S, Willing AE, Hudson JE, Newman MB, Saporta S, Sanchez-Ramos J, Sanberg PR. Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell transplantation. 11(3) : 265-74, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12075992
  • Cardozo-Pelaez F, Stedeford TJ, Brooks PJ, Song S, Sánchez-Ramos JR. Effects of diethylmaleate on DNA damage and repair in the mouse brain. Free radical biology & medicine. 33(2) : 292-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12106825
  • Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. Journal of neuroscience research. 69(6) : 880-93, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12205681

Positions Held

  • Associate Professor (Neurology, University of Miami 1987 - 1996)
  • Post-doctoral Fellow (Neurology, University of Miami 1985 - 1987)
  • Neurology Resident (Neurology, University of Chicago 1982 - 1985)
  • Intern (Medicine, University of Chicago 1981 - 1982)

Awards/Honors

  • Award for animation entitled “Dancing DNA” (University of Chicago, Sights and Sounds of Science Competition - 2004)
  • Outstanding Research Award for Nationally Recognized Research (Unviersity of South Florida - 2003)
  • Helen Ellis Endowed Chair (University of South Floria - 1996)
  • "Prix de la qualite de la Realisation technique" (Concours Interanationale des Technologie de la Creation, Paris, France - 1991)
  • Clinical Investigator Development Award (NIH - 1989)
  • Bertram A. Richardson Foreign Scholarship (University of Illinois College of Medicine - 1981)
  • James Scholar Program of Independent Studies (University of Illinois College of Medicine - 1978)
  • NIH Pre-doctoral Fellowship (University of Chicago, Dept of Pharmacological and Physiological Sciences - 1971)