LynnWecker

Lynn Wecker, PhD

Distinguished Professor, College Of Medicine Molecular Pharmacology & Physiology

Distinguished Professor, College Of Medicine Psychiatry And Behavioral Neurosciences

Distinguished Professor, Physical Therapy & Rehabilitation Sciences

Professor, College Of Medicine Neurology

Professor, Non Usf Health

College Of Medicine Psychiatry And Behavioral Neurosciences

Contact Info MDC 14
3515 East Fletcher Avenue
Tampa, FL 33647

Academic Email: lwecker@health.usf.edu

Academic Phone: (813) 974-5189

Education

  • PHD, Pharmacology, University Of Florida, 1972

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • Dr. Wecker's general interests are to understand how brain chemistry affects or determines behaviors with an emphasis on the etiology and treatment of neuropsychiatric and neuromotor disorders. Multidisciplinary approaches are used to elucidate how age, drugs of abuse, and environmental and genetic factors affect both brain chemistry and behavior. A major emphasis has focused on cholinergic mechanisms in the brain, particularly on the role and regulation of nicotinic receptors. Early studies demonstrated that sustained supplementation of rats with choline supports the synthesis of acetylcholine during conditions of increased neuronal demand and increases the density of neuronal nicotinic receptors in the brain. Since that time studies have focused on characterizing the regulation of alpha4beta2 nicotinic receptors and have demonstrated that these receptors are regulated by phosphorylation/dephosphorylation mechanisms that alter receptor formation, maturation and expression, and that sustained nicotinic receptor activation modifies these events.
  • Current studies are investigating the role of neuronal nicotinic receptors in ataxia, and mechanisms mediating the neurotrophic actions of nicotinic agonists. Concurrent investigations are elucidating the role of these receptors in mediating both nicotine and alcohol addiction, and how perturbations in receptor expression during adolescence can predispose the adult brain to drug-seeking behavior. Results from these studies will further our understanding of the role and regulation of these receptors in neuropsychiatric and neuromotor disorders, and may lead to new strategies for the treatment of these disorders.

Memberships

  • Federation of American Societies for Experimental Biology (FASEB) (Treasurer, 2012 - Present)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) (President, 2011 - 2012)
  • Federation of American Societies for Experimental Biology (FASEB) (Treasurer-elect, 2011 - 2012)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) (President-elect, 2010 - 2011)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) (Secretary/Treasurer, 2006 - 2007)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) (Program Committee Chair, 1999 - 2002)

Recent Publications

  • Philpot, R.M., Engberg, M.E. and Wecker, L. Ethanol Conditioned Place Preference and Alterations in ΔFosB Following Adolescent Nicotine Administration Differ in Rats Exhibiting High or Low Behavioral Reactivity to a Novel Environment Behav. Brain Res. 262: 101-108, 2014.
  • Wecker, L.Engberg, ME.Philpot, RM.Lambert, CS.Kang, CW.Antilla, JC.Bickford, PC.Hudson, CE.Zesiewicz, TA.Rowell, PP. Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia. Neuropharmacology. 73: 75-86, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23711550
  • Fernandez, J.W., Grizzell, J.A. and Wecker, L. The role of estrogen receptor  and nicotinic cholinergic receptors in postpartum depression Prog. Neuropsychopharm. Biol. Psychiat.. 40: 199-206, 2013.
  • Zesiewicz, TA.Greenstein, PE.Sullivan, KL.Wecker, L.Miller, A.Jahan, I.Chen, R.Perlman, SL. A randomized trial of varenicline (Chantix) for the treatment of spinocerebellar ataxia type 3. Neurology. 78(8) : 545-50, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22323747
  • Philpot, RM.Engberg, ME.Wecker, L. Effects of nicotine exposure on locomotor activity and pCREB levels in the ventral striatum of adolescent rats. Behavioural brain research. 230(1) : 62-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22301350
  • Papke, RL.Wecker, L.Stitzel, JA. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. The Journal of pharmacology and experimental therapeutics. 333(2) : 501-18, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20100906
  • Pollock, VV.Pastoor, T.Katnik, C.Cuevas, J.Wecker, L. Cyclic AMP-dependent protein kinase A and protein kinase C phosphorylate alpha4beta2 nicotinic receptor subunits at distinct stages of receptor formation and maturation. Neuroscience. 158(4) : 1311-25, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19101612
  • Philpot, RM.Wecker, L.Kirstein, CL. Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 27(8) : 805-15, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19712739
  • Ikonomovic, MD.Wecker, L.Abrahamson, EE.Wuu, J.Counts, SE.Ginsberg, SD.Mufson, EJ.Dekosky, ST. Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease. Archives of neurology. 66(5) : 646-51, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19433665
  • Philpot, RM.Wecker, L. Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling. Behavioral neuroscience. 122(4) : 861-75, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18729640
  • Pollock, VV.Pastoor, TE.Wecker, L. Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor alpha4 subunits. Journal of neurochemistry. 103(2) : 456-66, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17897355
  • Severance, EG.Zhang, H.Cruz, Y.Pakhlevaniants, S.Hadley, SH.Amin, J.Wecker, L.Reed, C.Cuevas, J. The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. Molecular pharmacology. 66(3) : 420-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15322233
  • Pacheco, MA.Pastoor, TE.Wecker, L. Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Brain research. Molecular brain research. 114(1) : 65-72, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12782394
  • Guo, X.Wecker, L. Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor alpha4 subunits. Journal of neurochemistry. 82(2) : 439-47, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12124445
  • Wecker, L.Guo, X.Rycerz, AM.Edwards, SC. Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of alpha4 neuronal nicotinic receptor subunits. Journal of neurochemistry. 76(3) : 711-20, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11158241
  • Hsu, YN.Edwards, SC.Wecker, L. Nicotine enhances the cyclic AMP-dependent protein kinase-mediated phosphorylation of alpha4 subunits of neuronal nicotinic receptors. Journal of neurochemistry. 69(6) : 2427-31, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9375675
  • Clark, MA.Williams, JF.Gottschall, PE.Wecker, L. Effects of phenobarbital and interleukin-6 on cytochrome P4502B1 and 2B2 in cultured rat hepatocytes. Biochemical pharmacology. 51(5) : 701-6, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8615908
  • Hsu, YN.Amin, J.Weiss, DS.Wecker, L. Sustained nicotine exposure differentially affects alpha 3 beta 2 and alpha 4 beta 2 neuronal nicotinic receptors expressed in Xenopus oocytes. Journal of neurochemistry. 66(2) : 667-75, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8592138
  • Yu, ZJ.Wecker, L. Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. Journal of neurochemistry. 63(1) : 186-94, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7911509
  • Anandatheerthavarada, HK.Williams, JF.Wecker, L. The chronic administration of nicotine induces cytochrome P450 in rat brain. Journal of neurochemistry. 60(5) : 1941-4, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8473908
  • Anandatheerthavarada, HK.Williams, JF.Wecker, L. Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1. Biochemical and biophysical research communications. 194(1) : 312-8, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8333846
  • Zawia, N.Arendash, GW.Wecker, L. Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain. Brain research. 589(2) : 333-7, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1393599
  • Coutcher, JB.Cawley, G.Wecker, L. Dietary choline supplementation increases the density of nicotine binding sites in rat brain. The Journal of pharmacology and experimental therapeutics. 262(3) : 1128-32, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1326624
  • Dolezal, V.Wecker, L. Modulation of acetylcholine release from rat striatal slices: interaction between 4-aminopyridine and atropine. The Journal of pharmacology and experimental therapeutics. 258(3) : 762-6, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1890618
  • Wecker, L. The synthesis and release of acetylcholine by depolarized hippocampal slices is increased by increased choline available in vitro prior to stimulation. Journal of neurochemistry. 57(4) : 1119-27, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1895099
  • Dolezal, V.Wecker, L. Muscarinic receptor blockade increases basal acetylcholine release from striatal slices. The Journal of pharmacology and experimental therapeutics. 252(2) : 739-43, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2313598
  • Miller, LG.Greenblatt, DJ.Roy, RB.Lopez, F.Wecker, L. Dietary choline intake modulates benzodiazepine receptor binding and gamma-aminobutyric acidA receptor function in mouse brain. The Journal of pharmacology and experimental therapeutics. 248(1) : 1-6, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2536422
  • Wecker, L.Cawley, G.Rothermel, S. Acute choline supplementation in vivo enhances acetylcholine synthesis in vitro when neurotransmitter release is increased by potassium. Journal of neurochemistry. 52(2) : 568-75, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2562990
  • Wecker, L.Reinhardt, RR. Adenosine inhibits choline kinase activity and decreases the phosphorylation of choline in striatal synaptosomes. Journal of neurochemistry. 50(6) : 1945-51, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2836562
  • Wecker, L. Influence of dietary choline availability and neuronal demand on acetylcholine synthesis by rat brain. Journal of neurochemistry. 51(2) : 497-504, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3392542
  • Wecker, L.Rothermel, S.Cawley, G. Chronic choline supplementation attenuates the behavioral effects of pentobarbital. Pharmacology, biochemistry, and behavior. 28(4) : 469-75, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3432313
  • Flynn, CJ.Wecker, L. Concomitant increases in the levels of choline and free fatty acids in rat brain: evidence supporting the seizure-induced hydrolysis of phosphatidylcholine. Journal of neurochemistry. 48(4) : 1178-84, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3819725
  • Flynn, CJ.Wecker, L. Elevated choline levels in brain. A non-cholinergic component of organophosphate toxicity. Biochemical pharmacology. 35(18) : 3115-21, 1986. http://www.ncbi.nlm.nih.gov/pubmed/3753519
  • Wecker, L. Neurochemical effects of choline supplementation. Canadian journal of physiology and pharmacology. 64(3) : 329-33, 1986. http://www.ncbi.nlm.nih.gov/pubmed/3708441
  • Wecker, L.Trommer, BA. Effects of chronic (dietary) choline availability on the transport of choline across the blood-brain barrier. Journal of neurochemistry. 43(6) : 1762-5, 1984. http://www.ncbi.nlm.nih.gov/pubmed/6491676
  • Reinhardt, RR.Wecker, L.Cook, PF. Kinetic mechanism of choline kinase from rat striata. The Journal of biological chemistry. 259(12) : 7446-52, 1984. http://www.ncbi.nlm.nih.gov/pubmed/6330058
  • Reinhardt, RR.Wecker, L. Evidence for membrane-associated choline kinase activity in rat striatum. Journal of neurochemistry. 41(3) : 623-9, 1983. http://www.ncbi.nlm.nih.gov/pubmed/6308165
  • Schmidt, DE.Wecker, L. CNS effects of choline administration: evidence for temporal dependence. Neuropharmacology. 20(6) : 535-9, 1981. http://www.ncbi.nlm.nih.gov/pubmed/7242873
  • Wecker, L.Dettbarn, WD.Schmidt, DE. Choline administration: modification of the central actions of atropine. Science (New York, N.Y.). 199(4324) : 86-7, 1978. http://www.ncbi.nlm.nih.gov/pubmed/17569493

Awards/Honors

  • Outstanding Faculty Award (USF - 2013)
  • Fifth Annual Theodore M. Brody Distinguished Lecturer (Michigan State University - 2012)
  • Elected Fellow (American Association for the Advancement of Science - 2012)
  • Interprofessionalism Award (USF Health School of Physical Therapy & Rehabilitation Sciences - 2011)
  • Presidential Faculty Award for Excellence (USF - 2003)
  • Faculty Outstanding Teacher Award (USF College of Medicine - 1999)
  • Professorial Excellence Program Award (USF - 1998)
  • Invited Member (The Dana Alliance for Brain Initiatives - 1998)
  • Sophomore Class Outstanding Instructor (USF College of Medicine Class of 1999 - 1998)
  • Most Outstanding Pre-Clinical Professor Award (USF College of Medicine Class of 1998 - 1997)
  • Distinguished Teaching Award (USF College of Medicine Class of 1996 - 1996)
  • Distinguished Research Professor (University of South Florida - 1995)
  • Alumni Honor Roll (State University of New York - 1995)
  • Young Environmental Scientist Health Research Grant Award (National Institute of Environmental Health Sciences - 1979)
  • Outstanding Young Scientist Award (Smith Kline and French Laboratories - 1979)
  • Distinguished Young Alumnus Award (State University of New York College at Cortland - 1978)
  • Andrew W. Mellon Foundation Teacher-Scientist Award (Andrew W. Mellon Foundation - 1975)