BruceLindsey

Bruce Lindsey, Ph.D.

Distinguished Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Professor, Molecular Pharmacology and Physiology, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 8
Tampa, FL 33612

Academic Email: blindsey@health.usf.edu

Academic Phone: (813) 974-2590

Education

  • PhD, Neuroscience, University Of Pennsylvania, 1974
  • BA, Biology, Williams College, 1971

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • I have a long-standing interest in the analysis of neural circuits and sensory-motor integration. Early work described interactions among simultaneously recorded ensembles of sensory neurons and motor neurons. Statistical methods revealed evidence for roles of spike timing and synchrony in the “ensemble coding” and gain control of parallel proprioceptive input channels and the generation of motor neuron proprioceptive fields.
  • Subsequent research has focused on the mammalian brainstem network for respiratory motor pattern generation and circuit mechanisms for breathing-related airway defensive behaviors. My colleagues and I have enhanced and developed multi-array recording methods and high-throughput technologies for parallel spike train recordings and the analysis and representation of neuronal assemblies and their dynamics during breathing and its modulation by various sensory perturbations. Starting in the 1980s, we used multiple electrode arrays to identify pontine-medullary interactions and a "rostral-to-caudal polarity" of pre-premotor neuron excitation from what came to be called the pre-Bötzinger complex. Those results informed the development of computational network models. Specific model-derived predictions have motivated and guided subsequent experiments, including studies on: (i) transient network reconfiguration during cough and other airway defensive reflexes; (ii) baroreceptor-evoked influences on circuits modulating breathing and cardio-respiratory coupling; (iii) carotid chemoreceptor induced long-term facilitation of inspiratory drive – a respiratory “memory”; and (iv) intra-pontine and parallel circuits for pontomedullary interactions, including pathways through intervening raphé neurons.
  • Our current goals are to define the functional connectivity linking brainstem chemoresponsive regions to respiratory motor pattern generating circuits and the adaptive reconfiguration of the network during perturbations of blood gases, in asthma, and during breathing-related behaviors.

Memberships

  • American Physiological Society (Regular Member, 1981 - Present)
  • Society for Neuroscience (Regular Member, 1976 - Present)
  • AAAS (Member, 1971 - Present)

Recent Publications

  • Segers, LS.Nuding, SC.Ott, MM.Dean, JB.Bolser, DC.O'Connor, R.Morris, KF.Lindsey, BG. Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network. Journal of Neurophysiology. : jn.00542.2014, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25343784
  • Pitts, T.Rose, MJ.Mortensen, AN.Poliacek, I.Sapienza, CM.Lindsey, BG.Morris, KF.Davenport, PW.Bolser, DC. Coordination of cough and swallow: a meta-behavioral response to aspiration. Respiratory Physiology & Neurobiology. 189(3) : 543-51, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23998999
  • O'Connor, R.Segers, LS.Morris, KF.Nuding, SC.Pitts, T.Bolser, DC.Davenport, PW.Lindsey, BG. A joint computational respiratory neural network-biomechanical model for breathing and airway defensive behaviors. Frontiers in Physiology. 3: 264, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22934020
  • Segers, LS.Nuding, SC.Vovk, A.Pitts, T.Baekey, DM.O'Connor, R.Morris, KF.Lindsey, BG.Shannon, R.Bolser, DC. Discharge Identity of Medullary Inspiratory Neurons is Altered during Repetitive Fictive Cough. Frontiers in Physiology. 3: 223, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22754536
  • Ott, MM., Nuding, SC., Segers, LS., O'Connor, R., Morris, KF., Lindsey, BG. Central chemoreceptor modulation of breathing via multipath tuning in medullary ventrolateral respiratory column circuits. Journal of Neurophysiology. 107(2) : 603-17, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21994272
  • Lindsey, BG, Rybak, IA, Smith JC Computational models and emergent properties of respiratory neural networks. Comprehensive Physiology. 2(3) : 1619-70, 2012.
  • Ott, MM., Nuding, SC., Segers, LS., Lindsey, BG., Morris, KF. Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons. Journal of Neurophysiology. 105(6) : 2960-75, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21389310
  • Poliacek, I.Morris, KF.Lindsey, BG.Segers, LS.Rose, MJ.Corrie, LW.Wang, C.Pitts, TE.Davenport, PW.Bolser, DC. Blood pressure changes alter tracheobronchial cough: computational model of the respiratory-cough network and in vivo experiments in anesthetized cats. Journal of Applied Physiology. 111(3) : 861-73, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21719729
  • Morris, KF., Nuding, SC., Segers, LS., Baekey, DM., Shannon, R., Lindsey, BG., Dick, TE. Respiratory and Mayer Wave Related Discharge Patterns of Raphe and Pontine Neurons Change with Vagotomy. Journal of Applied Physiology. 109: 189-202, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20360432
  • Nuding, SC.Segers, LS.Baekey, DM.Dick, TE.Solomon, IC.Shannon, R.Morris, KF.Lindsey, BG. Pontine-ventral respiratory column interactions through raphe circuits detected using multi-array spike train recordings. Journal of Neurophysiology. 101(6) : 2943-60, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19297509
  • Nuding, SC.Segers, LS.Shannon, R.O'Connor, R.Morris, KF.Lindsey, BG. Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphé-pontomedullary respiratory network. Philosophical Transactions of the Royal Society of London. Series B, Biological sciences. 364(1529) : 2501-16, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19651652
  • Dick, TE., Shannon, R., Lindsey, BG., Nuding, SC., Segers, LS., Baekey, DM., Morris, KF. Pontine respiratory-modulated activity before and after vagotomy in decerebrate cats. Journal of Physiology. 586: 4265-82, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18599543
  • Rybak, IA., O'Connor, R., Ross, A., Shevtsova, NA., Nuding, SC., Segers, LS., Shannon, R., Dick, TE., Dunin-Barkowski, WL., Orem, JM., Solomon, IC., Morris, KF., Lindsey, BG. Reconfiguration of the Pontomedullary Respiratory Network: A Computational Modeling Study with Coordinated in Vivo Experiments. Journal of Neurophysiology. 100: 1770–99, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18650310
  • Segers, LS., Nuding, SC., Dick, TE., Shannon, R., Baekey, DM., Solomon, IC., Morris, KF., Lindsey, BG. Functional Connectivity in the Pontomedullary Respiratory Network. Journal of Neurophysiology. 100: 1749–17, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18632881
  • Lindsey, BG.Gerstein, GL. Two enhancements of the gravity algorithm for multiple spike train analysis. Journal of Neuroscience Methods. 150(1) : 116-27, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16105685
  • Baekey, DM.Morris, KF.Nuding, SC.Segers, LS.Lindsey, BG.Shannon, R. Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. Journal of Applied Physiology. 96(6) : 2057-72, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15133012
  • Shannon, R.Baekey, DM.Morris, KF.Nuding, SC.Segers, LS.Lindsey, BG. Pontine respiratory group neuron discharge is altered during fictive cough in the decerebrate cat. Respiratory Physiology & Neurobiology. 142(1) : 43-54, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15351303
  • Baekey, DM.Morris, KF.Nuding, SC.Segers, LS.Lindsey, BG.Shannon, R. Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat. Journal of Applied Physiology. 94(1) : 93-100, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12486018
  • Morris, KF.Baekey, DM.Nuding, SC.Dick, TE.Shannon, R.Lindsey, BG. Invited review: Neural network plasticity in respiratory control. Journal of Applied Physiology. 94(3) : 1242-52, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12571145
  • Baekey, DM., Morris, KF., Gestreau, C., Li, Z., Lindsey, BG., Shannon, R. Medullary respiratory neurones and control of laryngeal motoneurones during fictive eupnoea and cough in the cat. Journal of Physiology. 534(Pt. 2) : 565-81, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11454973
  • Morris, KF.Shannon, R.Lindsey, BG. Changes in cat medullary neurone firing rates and synchrony following induction of respiratory long-term facilitation. Journal of Physiology. 532(Pt 2) : 483-97, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11306666
  • Shannon, R., Baekey, DM., Morris, KF., Li, Z., Lindsey, BG. Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat. Journal of Physiology. 525 Pt 1: 207-24, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10811738
  • Arata, A.Hernandez, YM.Lindsey, BG.Morris, KF.Shannon, R. Transient configurations of baroresponsive respiratory-related brainstem neuronal assemblies in the cat. The Journal of Physiology. 525 Pt 2: 509-30, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10835051
  • Lindsey, BG, Morris, KF, Segers, LS, Shannon, R. Respiratory neuronal assemblies. Respiration Physiology. 122(2-3) : 183-96, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10967343
  • Li Z, Morris KF, Baekey DM, Shannon R, Lindsey BG. Responses of simultaneously recorded respiratory-related medullary neurons to stimulation of multiple sensory modalities. Journal of Neurophysiology. 82(1) : 176-87, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10400946
  • Li Z, Morris KF, Baekey DM, Shannon R, Lindsey BG. Multimodal medullary neurons and correlational linkages of the respiratory network. Journal of Neurophysiology. 82(1) : 188-201, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10400947
  • Lindsey, BG.Arata, A.Morris, KF.Hernandez, YM.Shannon, R. Medullary raphe neurones and baroreceptor modulation of the respiratory motor pattern in the cat. The Journal of Physiology. 512 ( Pt 3): 863-82, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9769428
  • Shannon, R.Baekey, DM.Morris, KF.Lindsey, BG. Ventrolateral medullary respiratory network and a model of cough motor pattern generation. Journal of Applied Physiology. 84(6) : 2020-35, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9609797
  • Lindsey, BG.Morris, KF.Shannon, R.Gerstein, GL. Repeated patterns of distributed synchrony in neuronal assemblies. Journal of Neurophysiology. 78(3) : 1714-9, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9310455
  • Morris KF, Arata A, Shannon R, Lindsey BG. Long-term facilitation of phrenic nerve activity in cats: responses and short time scale correlations of medullary neurones. Journal of Physiology. 490 ( Pt 2): 463-80, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8821143
  • Morris KF, Arata A, Shannon R, Lindsey BG. Inspiratory drive and phase duration during carotid chemoreceptor stimulation in the cat: medullary neurone correlations. Journal of Physiology. 491 ( Pt 1): 241-59, 1996. http://www.ncbi.nlm.nih.gov/pubmed/9011617
  • Balis UJ, Morris KF, Koleski J, Lindsey, BG. Simulations of a ventrolateral medullary neural network for respiratory rhythmogenesis inferred from spike train cross-correlation. Biological Cybernetics. 70(4) : 311-27, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8148410
  • Lindsey BG, Hernandez YM, Morris KF, Shannon R, Gerstein GL. Respiratory-related neural assemblies in the brain stem midline. Journal of Neurophysiology. 67(4) : 905-22, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1588390
  • Lindsey BG, Hernandez YM, Morris KF, Shannon R Functional connectivity between brain stem midline neurons with respiratory-modulated firing rates. Journal of Neurophysiology. 67(4) : 890-904, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1588389
  • Lindsey BG, Hernandez YM, Morris KF, Shannon R, Gerstein GL. Dynamic reconfiguration of brain stem neural assemblies: respiratory phase-dependent synchrony versus modulation of firing rates. Journal of Neurophysiology. 67(4) : 923-30, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1588391
  • Lindsey BG, Shannon R, Gerstein GL Gravitational representation of simultaneously recorded brainstem respiratory neuron spike trains. Brain Research. 483(2) : 373-8, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2706527
  • Lindsey BG, Segers LS, Shannon R Discharge patterns of rostrolateral medullary expiratory neurons in the cat: regulation by concurrent network processes. Journal of Neurophysiology. 61(6) : 1185-96, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2746319
  • Lindsey BG, Segers LS, Shannon R Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. II. Evidence for inhibitory actions of expiratory neurons. Journal of Neurophysiology. 57(4) : 1101-17, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3585455
  • Segers LS, Shannon R, Saporta S, Lindsey BG. Functional associations among simultaneously monitored lateral medullary respiratory neurons in the cat. I. Evidence for excitatory and inhibitory actions of inspiratory neurons. Journal of Neurophysiology. 57(4) : 1078-100, 1987. http://www.ncbi.nlm.nih.gov/pubmed/3295135
  • Lindsey BG Measurement and dissociation of joint influence of action potentials in concurrently active parallel channels on motor neuron activity in crayfish. Journal of Neurophysiology. 47(6) : 1160-73, 1982. http://www.ncbi.nlm.nih.gov/pubmed/7108577
  • Lindsey BG, Gerstein GL Interactions among an ensemble of chordotonal organ receptors and motor neurons of the crayfish claw. Journal of Neurophysiology. 42(2) : 383-99, 1979. http://www.ncbi.nlm.nih.gov/pubmed/422971

Positions Held

  • Chair (Department of Molecular Pharmacology and Physiology, University of South Florida 2006 - 2010)
  • Chair (Department of Physiology and Biophysics, College of Medicine, University of South Florida 1996 - 2006)
  • Interim Vice-President for Research (Office of Research, University of South Florida 2001 - 2003)

Awards/Honors

  • Distinguished University Health Professor (University of South Florida - 2007)
  • Outstanding Faculty Research Achievement Award (University of South Florida - 2005)
  • Javits Neuroscience Investigator Award (NINDS, NIH - 2004)