ThomasTaylor-Clark

Thomas Taylor-Clark, PHD

Assistant Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B Downs Blvd
Tampa, FL 33612

Academic Email: ttaylorc@health.usf.edu

Academic Phone: (813) 974-7749

View My C.V.

Education

  • PHD, Pharmacology, University College London, 2004

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular
  • Environmental & Global Health
  • Neuroscience
  • Pulmonary Physiology

Research Interests

  • Our interests lie in the role of nociceptive (defensive) sensory nerves in health and disease. Aberrant nociceptor stimulation contributes to unpleasant/debilitating sensations and inappropriate reflexes. Our focus is primarily on the sensory nerves of the airways. Activation of these nerves leads to cough, mucus secretion, bronchospasm, wheeze. In addition, activation of airway nerves contributes to autonomic regulatory control of the heart.
  • To gain understanding of these events we study the electrical excitability of sensory nerves, investigating the interaction of inflammation, oxidative stress and inhaled pollutants (e.g. particulate matter and ozone) on receptors and ion channels expressed on nociceptive sensory nerves. Using a combination of electrophysiological, imaging and molecular biological techniques we are able to study ion channel/receptor function and nerve activation at multiple levels, from single channels to single cells to intact tissue to the whole animal.

Recent Publications

  • Nesuashvili, L.Hadley, SH.Bahia, PK.Taylor-Clark, TE. Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves via Transient Receptor Potential (TRP) Channels. Molecular pharmacology. 83(5) : 1007-19, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23444014
  • Hooper, JS.Hadley, SH.Mathews, A.Taylor-Clark, TE. Store-operated calcium entry in vagal sensory nerves is independent of Orai channels. Brain research. 1503: 7-15, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23399679
  • Bahia, PK.Bennett, ES.Taylor-Clark, TE. Reductions in external divalent cations evoke novel voltage-gated currents in sensory neurons. PloS one. 7(2) : e31585, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22328938
  • McAlexander, MA.Taylor-Clark, T. The role of transient receptor potential channels in respiratory symptoms and pathophysiology. Advances in experimental medicine and biology. 704: 969-86, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21290336
  • Taylor-Clark, T. Histamine in allergic rhinitis. Advances in experimental medicine and biology. 709: 33-41, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21713687
  • Brozmanova, M.Ru, F.Surdenikova, L.Mazurova, L.Taylor-Clark, T.Kollarik, M. Preferential activation of the vagal nodose nociceptive subtype by TRPA1 agonists in the guinea pig esophagus. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(10) : e437-45, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21883700
  • Taylor-Clark, TE.Undem, BJ. Sensing pulmonary oxidative stress by lung vagal afferents. Respiratory physiology & neurobiology. 178(3) : 406-13, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21600314
  • Nassenstein, C.Taylor-Clark, TE.Myers, AC.Ru, F.Nandigama, R.Bettner, W.Undem, BJ. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. The Journal of physiology. 588(Pt 23) : 4769-83, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20937710
  • Taylor-Clark, TE.Undem, BJ. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. The Journal of physiology. 588(Pt 3) : 423-33, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20008466
  • Taylor-Clark, TE.Ghatta, S.Bettner, W.Undem, BJ. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Molecular pharmacology. 75(4) : 820-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19171673
  • Taylor-Clark, TE.Nassenstein, C.McAlexander, MA.Undem, BJ. TRPA1: a potential target for anti-tussive therapy. Pulmonary pharmacology & therapeutics. 22(2) : 71-4, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19150409
  • Taylor-Clark, TE.Kiros, F.Carr, MJ.McAlexander, MA. Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. American journal of respiratory cell and molecular biology. 40(6) : 756-62, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19059884
  • Nassenstein, C.Kwong, K.Taylor-Clark, T.Kollarik, M.Macglashan, DM.Braun, A.Undem, BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. The Journal of physiology. 586(6) : 1595-604, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18218683
  • Taylor-Clark, TE.Undem, BJ.Macglashan, DW.Ghatta, S.Carr, MJ.McAlexander, MA. Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1). Molecular pharmacology. 73(2) : 274-81, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18000030
  • Taylor-Clark, TE. Insights into the mechanisms of histamine-induced inflammation in the nasal mucosa. Pulmonary pharmacology & therapeutics. 21(3) : 455-60, 2008. http://www.ncbi.nlm.nih.gov/pubmed/17904400
  • Taylor-Clark, TE.Nassenstein, C.Undem, BJ. Leukotriene D4 increases the excitability of capsaicin-sensitive nasal sensory nerves to electrical and chemical stimuli. British journal of pharmacology. 154(6) : 1359-68, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18500362
  • Taylor-Clark, TE.McAlexander, MA.Nassenstein, C.Sheardown, SA.Wilson, S.Thornton, J.Carr, MJ.Undem, BJ. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. The Journal of physiology. 586(14) : 3447-59, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18499726
  • Taylor-Clark, T.Undem, BJ. Transduction mechanisms in airway sensory nerves. Journal of applied physiology (Bethesda, Md. : 1985). 101(3) : 950-9, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16645193
  • Taylor-Clark, T.Foreman, J. Histamine-mediated mechanisms in the human nasal airway. Current opinion in pharmacology. 5(3) : 214-20, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15907905
  • Taylor-Clark, T.Sodha, R.Warner, B.Foreman, J. Histamine receptors that influence blockage of the normal human nasal airway. British journal of pharmacology. 144(6) : 867-74, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15685206
  • Taylor-Clark, TE.Kollarik, M.MacGlashan, DW.Undem, BJ. Nasal sensory nerve populations responding to histamine and capsaicin. The Journal of allergy and clinical immunology. 116(6) : 1282-8, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16337460