David EBirk

David E Birk, Ph.D.

College Of Medicine Molecular Pharmacology & Physiology

Professor, Orthopaedics & Sports Medicine, College of Medicine, University of South Florida

Professor, Molecular Pharmacology & Physiology, University of South Florida

Contact Info Department of Molecular Pharmacology & Physiology
12901 Bruce B. Downs Blvd., MDC 8
Tampa, FL 33612

Academic Email: dbirk@health.usf.edu

Academic Phone: (813) 974-8598

View My C.V.

Education

  • PHD, Anatomy, Wayne State University, 1981
  • MS, Biology, New York University, 1978
  • AB, Biology, Colgate University, 1973

Interdisciplinary and Emerging Signature Programs

  • Cellular and Molecular Biology

Research Interests

  • Our general research interests include the cell and developmental biology as well as pathobiology of the extracellular matrix. We made seminal contributions including the: elucidation of heterotypic fibril structure; demonstration that fibrils are initially assembled as protofibrils and the mature fibril assembles from these preformed intermediates; role of the fibroblast in compartmentalization of extracellular assembly events; and regulatory roles of small leucine rich proteoglycans, collagen V/XI, as well as collagens XII and XIV in matrix assembly. Our major focus is on acquisition and reacquisition of tissue-specific structure and function. We utilize mouse models to elucidate the regulatory mechanisms involved in normal development and the relationship between a dysfunctional regulatory step and pathobiology. In addition, my laboratory has an interest in wound healing and generalized fibrotic responses.

Memberships

  • Orthopaedic Research Society (Member, 2009 - Present)
  • American Society for Biochemistry and Molecular Biology (Member, 2008 - Present)
  • American Society for Matrix Biology (Member, (Council 2014-2017), 1998 - Present)
  • American Association of Anatomists (Member, 1981 - Present)
  • Association for Research in Vision and Opthhalmology (Member, 1979 - Present)
  • International Society for Matrix Biology (Member, (Council 2009-2012), 1986 - 2013)

Recent Publications

  • Chen S, Mienaltowski MJ, Birk DE. Regulation of corneal stroma extracellular matrix assembly Exp Eye Res, In press..
  • Chiquet, M.Birk, DE.Bönnemann, CG.Koch, M. Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils. The international journal of biochemistry & cell biology. 53C: 51-54, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24801612
  • Smith, SM.Zhang, G.Birk, DE. Collagen V localizes to pericellular sites during tendon collagen fibrillogenesis. Matrix biology : journal of the International Society for Matrix Biology. 33: 47-53, 2014. http://www.ncbi.nlm.nih.gov/pubmed/23954412
  • Mienaltowski, MJ.Adams, SM.Birk, DE. Tendon proper- and peritenon-derived progenitor cells have unique tenogenic properties. Stem cell research & therapy. 5(4) : 86, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25005797
  • Chen, S.Young, MF.Chakravarti, S.Birk, DE. Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly. Matrix biology : journal of the International Society for Matrix Biology. 35: 103-11, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24447998
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Kumar, A.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. The injury response of aged tendons in the absence of biglycan and decorin. Matrix biology : journal of the International Society for Matrix Biology. 35: 232-8, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24157578
  • Muir, AM.Ren, Y.Butz, DH.Davis, NA.Blank, RD.Birk, DE.Lee, SJ.Rowe, D.Feng, JQ.Greenspan, DS. Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice. Human molecular genetics. 23(12) : 3085-101, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24419319
  • Mienaltowski, MJ.Birk, DE. Structure, physiology, and biochemistry of collagens. Advances in experimental medicine and biology. 802: 5-29, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24443018
  • Mienaltowski, MJ.Birk, DE. Mouse models in tendon and ligament research. Advances in experimental medicine and biology. 802: 201-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24443029
  • Zou, Y.Zwolanek, D.Izu, Y.Gandhy, S.Schreiber, G.Brockmann, K.Devoto, M.Tian, Z.Hu, Y.Veit, G.Meier, M.Stetefeld, J.Hicks, D.Straub, V.Voermans, NC.Birk, DE.Barton, ER.Koch, M.Bönnemann, CG. Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in humans and mice. Human molecular genetics. 23(9) : 2339-52, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24334604
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Satchell, L.Kumar, A.Pathmanathan, L.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. The tendon injury response is influenced by decorin and biglycan. Annals of biomedical engineering. 42(3) : 619-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24072490
  • Pan, TC.Zhang, RZ.Arita, M.Bogdanovich, S.Adams, SM.Gara, SK.Wagener, R.Khurana, TS.Birk, DE.Chu, ML. A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16. The Journal of biological chemistry. 289(15) : 10293-307, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24563484
  • Buckley, MR.Huffman, GR.Iozzo, RV.Birk, DE.Soslowsky, LJ. The location-specific role of proteoglycans in the flexor carpi ulnaris tendon. Connective tissue research. 54(6) : 367-73, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23941206
  • Mienaltowski, MJ.Adams, SM.Birk, DE. Regional differences in stem cell/progenitor cell populations from the mouse achilles tendon. Tissue engineering. Part A. 19(1-2) : 199-210, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22871316
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Satchell, L.Kumar, A.Pathmanathan, L.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix biology : journal of the International Society for Matrix Biology. 32(1) : 3-13, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23178232
  • Chen, S.Birk, DE. The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. The FEBS journal. 280(10) : 2120-37, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23331954
  • Connizzo, BK.Sarver, JJ.Birk, DE.Soslowsky, LJ. Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. Journal of biomechanical engineering. 135(2) : 021019, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23445064
  • Dourte, LM.Pathmanathan, L.Mienaltowski, MJ.Jawad, AF.Birk, DE.Soslowsky, LJ. Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 31(9) : 1430-7, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23592048
  • Hemmavanh, C.Koch, M.Birk, DE.Espana, EM. Abnormal corneal endothelial maturation in collagen XII and XIV null mice. Investigative ophthalmology & visual science. 54(5) : 3297-308, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23599329
  • Pan, TC.Zhang, RZ.Markova, D.Arita, M.Zhang, Y.Bogdanovich, S.Khurana, TS.Bönnemann, CG.Birk, DE.Chu, ML. COL6A3 protein deficiency in mice leads to muscle and tendon defects similar to human collagen VI congenital muscular dystrophy. The Journal of biological chemistry. 288(20) : 14320-31, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23564457
  • Chen, S.Sun, M.Iozzo, RV.Kao, WW.Birk, DE. Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy. The American journal of pathology. 183(1) : 247-56, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23685109
  • Buckley, MR.Dunkman, AA.Reuther, KE.Kumar, A.Pathmanathan, L.Beason, DP.Birk, DE.Soslowsky, LJ. Validation of an empirical damage model for aging and in vivo injury of the murine patellar tendon. Journal of biomechanical engineering. 135(4) : 41005, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24231900
  • Ansorge, HL.Hsu, JE.Edelstein, L.Adams, S.Birk, DE.Soslowsky, LJ. Recapitulation of the Achilles tendon mechanical properties during neonatal development: A Study of differential healing during two stages of development in a mouse model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 30(3) : 448-56, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22267191
  • Smith, SM.Birk, DE. Focus on Molecules: Collagens V and XI. Experimental eye research. 98(1) : 105-6, 2012. http://www.ncbi.nlm.nih.gov/pubmed/20705069
  • Tao, G.Levay, AK.Peacock, JD.Huk, DJ.Both, SN.Purcell, NH.Pinto, JR.Galantowicz, ML.Koch, M.Lucchesi, PA.Birk, DE.Lincoln, J. Collagen XIV is important for growth and structural integrity of the myocardium. Journal of molecular and cellular cardiology. 53(5) : 626-38, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22906538
  • Smith, SM.Thomas, CE.Birk, DE. Pericellular proteins of the developing mouse tendon: a proteomic analysis. Connective tissue research. 53(1) : 2-13, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21851252
  • Dourte, LM.Pathmanathan, L.Jawad, AF.Iozzo, RV.Mienaltowski, MJ.Birk, DE.Soslowsky, LJ. Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon. Journal of biomechanical engineering. 134(3) : 031005, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22482685
  • Chervoneva, I.Zhan, T.Iglewicz, B.Hauck, WW.Birk, DE. Two-stage hierarchical modeling for analysis of subpopulations in conditional distributions. Journal of applied statistics. 39(2) : 445-460, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22523443
  • Ansorge, HL.Adams, S.Jawad, AF.Birk, DE.Soslowsky, LJ. Mechanical property changes during neonatal development and healing using a multiple regression model. Journal of biomechanics. 45: 1288-92, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22381737
  • Chen, S.Sun, M.Meng, X.Iozzo, RV.Kao, WW.Birk, DE. Pathophysiological Mechanisms of Autosomal Dominant Congenital Stromal Corneal Dystrophy C-Terminal-Truncated Decorin Results in Abnormal Matrix Assembly and Altered Expression of Small Leucine-Rich Proteoglycans. The American journal of pathology. 179: 2409-2419, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21893019
  • Sun, M.Chen, S.Adams, SM.Florer, JB.Liu, H.Kao, WW.Wenstrup, RJ.Birk, DE. Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model. Journal of cell science. 124(Pt 23) : 4096-105, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22159420
  • Chen, S.Birk, DE. Focus on Molecules: Decorin. Experimental eye research. 92: 444-445, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20493188
  • Izu, Y.Ansorge, HL.Zhang, G.Soslowsky, LJ.Bonaldo, P.Chu, ML.Birk, DE. Dysfunctional tendon collagen fibrillogenesis in collagen VI null mice. Matrix biology : journal of the International Society for Matrix Biology. 30(1) : 53-61, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20951202
  • Ansorge, HL.Adams, S.Birk, DE.Soslowsky, LJ. Mechanical, Compositional, and Structural Properties of the Post-natal Mouse Achilles Tendon. Annals of biomedical engineering. 39(7) : 1904-13, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21431455
  • Wenstrup, RJ.Smith, SM.Florer, JB.Zhang, G.Beason, DP.Seegmiller, RE.Soslowsky, LJ.Birk, DE. Regulation of Collagen Fibril Nucleation and Initial Fibril Assembly Involves Coordinate Interactions with Collagens V and XI in Developing Tendon. The Journal of biological chemistry. 286(23) : 20455-65, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21467034
  • Shao, H.Chaerkady, R.Chen, S.Pinto, SM.Sharma, R.Delanghe, B.Birk, DE.Pandey, A.Chakravarti, S. Proteome profiling of wild type and lumican-deficient mouse corneas. Journal of proteomics. 74: 1895-1905, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21616181
  • Izu, Y.Sun, M.Zwolanek, D.Veit, G.Williams, V.Cha, B.Jepsen, KJ.Koch, M.Birk, DE. Type XII collagen regulates osteoblast polarity and communication during bone formation. The Journal of cell biology. 193(6) : 1115-30, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21670218

Positions Held

  • Professor (Pathology & Cell Biology, College of Medicine, University of South Florida 2007 - 2012)
  • Professor (Pathology, Anatomy & Cell Biology, Jefferson Medical College, Thomas Jefferson University 1998 - 2008)
  • Professor (Anatomy and Cellular Biology, Tufts University School of Medicine 1996 - 1998)
  • Professor (Ophthalmology, Tufts University School of Medicine 1997 - 1998)
  • Associate Professor (Anatomy and Cellular Biology, Tufts University School of Medicine 1992 - 1996)
  • Graduate Faculty (Cell and Developmental Biology Program, Rutgers University 1984 - 1992)
  • Associate Professor (Pathology, University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School 1989 - 1992)
  • Assistant Professor (Pathology, University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School 1984 - 1989)

Awards/Honors

  • Fellow ARVO (Association for Research in Vision and Ophthalmology - 2010)
  • Dean's Citation for Significant Contributions to the Advancement of Education (Jefferson Medical College - 2006)
  • Excellence in Teaching Award (Awarded by Jefferson Medical College Class of 2008 - 2005)
  • Research Career Development Award (NIH NEI - 1984)
  • Individual NRSA (NIH NEI - 1982)