David EBirk

David E Birk, Ph.D.

College Of Medicine Molecular Pharmacology & Physiology

Professor, Orthopaedics & Sports Medicine, College of Medicine, University of South Florida

Professor, Molecular Pharmacology & Physiology, University of South Florida

Contact Info Department of Molecular Pharmacology & Physiology
12901 Bruce B. Downs Blvd., MDC 8
Tampa, FL 33612

Academic Email: dbirk@health.usf.edu

Academic Phone: (813) 974-8598

View My C.V.

Education

  • PHD, Anatomy, Wayne State University, 1981
  • MS, Biology, New York University, 1978
  • AB, Biology, Colgate University, 1973

Interdisciplinary and Emerging Signature Programs

  • Cellular and Molecular Biology

Research Interests

  • Our general research interests are the cell and molecular biology as well as pathobiology of the extracellular matrix. Our major focus is on acquisition and reacquisition of tissue-specific structure and function. We utilize a multidisciplinary approach integrating genetics and mouse models with cell, and molecular biology as well as biomechanics to elucidate the regulatory mechanisms involved in development, growth and aging as well as the relationship between a dysfunctional regulatory step and pathobiology. Our current work focuses on the regulatory roles of small leucine rich proteoglycans, collagen V/XI, as well as collagens XII and XIV in the regulation of matrix assembly. Our main projects address extracellular matrix in the dermis, tendons, ligaments and the corneal stroma. This work also addresses the molecular pathophysiology underlying human congenital disorders such as, Ehlers Danlos syndrome, congenital corneal stromal dystrophy, myopathies and osteogenesis imperfecta.

Memberships

  • American Society for Investigative Pathology (Member, 2014 - Present)
  • Orthopaedic Research Society (Member, 2009 - Present)
  • American Society for Biochemistry and Molecular Biology (Member, 2008 - Present)
  • American Society for Matrix Biology (Member, (Council 2014-2017), 1998 - Present)
  • American Association of Anatomists (Member, 1981 - Present)
  • Association for Research in Vision and Opthhalmology (Member, 1979 - Present)
  • International Society for Matrix Biology (Member, (Council 2009-2012), 1986 - 2013)

Recent Publications

  • Chen S, Mienaltowski MJ, Birk DE. Regulation of corneal stroma extracellular matrix assembly Exp Eye Res, In press..
  • Pan, TC.Zhang, RZ.Arita, M.Bogdanovich, S.Adams, SM.Gara, SK.Wagener, R.Khurana, TS.Birk, DE.Chu, ML. A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16. The Journal of biological chemistry. 289(15) : 10293-307, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24563484
  • Chen, S.Young, MF.Chakravarti, S.Birk, DE. Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly. Matrix biology : journal of the International Society for Matrix Biology. 35: 103-11, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24447998
  • Mienaltowski, MJ.Birk, DE. Structure, physiology, and biochemistry of collagens. Advances in experimental medicine and biology. 802: 5-29, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24443018
  • Mienaltowski, MJ.Birk, DE. Mouse models in tendon and ligament research. Advances in experimental medicine and biology. 802: 201-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24443029
  • Zou, Y.Zwolanek, D.Izu, Y.Gandhy, S.Schreiber, G.Brockmann, K.Devoto, M.Tian, Z.Hu, Y.Veit, G.Meier, M.Stetefeld, J.Hicks, D.Straub, V.Voermans, NC.Birk, DE.Barton, ER.Koch, M.Bönnemann, CG. Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in humans and mice. Human molecular genetics. 23(9) : 2339-52, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24334604
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Satchell, L.Kumar, A.Pathmanathan, L.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. The tendon injury response is influenced by decorin and biglycan. Annals of biomedical engineering. 42(3) : 619-30, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24072490
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Kumar, A.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. The injury response of aged tendons in the absence of biglycan and decorin. Matrix biology : journal of the International Society for Matrix Biology. 35: 232-8, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24157578
  • Smith, SM.Zhang, G.Birk, DE. Collagen V localizes to pericellular sites during tendon collagen fibrillogenesis. Matrix biology : journal of the International Society for Matrix Biology. 33: 47-53, 2014. http://www.ncbi.nlm.nih.gov/pubmed/23954412
  • Mienaltowski, MJ.Adams, SM.Birk, DE. Tendon proper- and peritenon-derived progenitor cells have unique tenogenic properties. Stem cell research & therapy. 5(4) : 86, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25005797
  • Chiquet, M.Birk, DE.Bönnemann, CG.Koch, M. Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils. The international journal of biochemistry & cell biology. 53C: 51-54, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24801612
  • Muir, AM.Ren, Y.Butz, DH.Davis, NA.Blank, RD.Birk, DE.Lee, SJ.Rowe, D.Feng, JQ.Greenspan, DS. Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice. Human molecular genetics. 23(12) : 3085-101, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24419319
  • Buckley, MR.Dunkman, AA.Reuther, KE.Kumar, A.Pathmanathan, L.Beason, DP.Birk, DE.Soslowsky, LJ. Validation of an empirical damage model for aging and in vivo injury of the murine patellar tendon. Journal of biomechanical engineering. 135(4) : 41005, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24231900
  • Buckley, MR.Huffman, GR.Iozzo, RV.Birk, DE.Soslowsky, LJ. The location-specific role of proteoglycans in the flexor carpi ulnaris tendon. Connective tissue research. 54(6) : 367-73, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23941206
  • Pan, TC.Zhang, RZ.Markova, D.Arita, M.Zhang, Y.Bogdanovich, S.Khurana, TS.Bönnemann, CG.Birk, DE.Chu, ML. COL6A3 protein deficiency in mice leads to muscle and tendon defects similar to human collagen VI congenital muscular dystrophy. The Journal of biological chemistry. 288(20) : 14320-31, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23564457
  • Chen, S.Sun, M.Iozzo, RV.Kao, WW.Birk, DE. Intracellularly-retained decorin lacking the C-terminal ear repeat causes ER stress: a cell-based etiological mechanism for congenital stromal corneal dystrophy. The American journal of pathology. 183(1) : 247-56, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23685109
  • Chen, S.Birk, DE. The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly. The FEBS journal. 280(10) : 2120-37, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23331954
  • Connizzo, BK.Sarver, JJ.Birk, DE.Soslowsky, LJ. Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. Journal of biomechanical engineering. 135(2) : 021019, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23445064
  • Dourte, LM.Pathmanathan, L.Mienaltowski, MJ.Jawad, AF.Birk, DE.Soslowsky, LJ. Mechanical, compositional, and structural properties of the mouse patellar tendon with changes in biglycan gene expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 31(9) : 1430-7, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23592048
  • Hemmavanh, C.Koch, M.Birk, DE.Espana, EM. Abnormal corneal endothelial maturation in collagen XII and XIV null mice. Investigative ophthalmology & visual science. 54(5) : 3297-308, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23599329
  • Dunkman, AA.Buckley, MR.Mienaltowski, MJ.Adams, SM.Thomas, SJ.Satchell, L.Kumar, A.Pathmanathan, L.Beason, DP.Iozzo, RV.Birk, DE.Soslowsky, LJ. Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix biology : journal of the International Society for Matrix Biology. 32(1) : 3-13, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23178232
  • Mienaltowski, MJ.Adams, SM.Birk, DE. Regional differences in stem cell/progenitor cell populations from the mouse achilles tendon. Tissue engineering. Part A. 19(1-2) : 199-210, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22871316
  • Chervoneva, I.Zhan, T.Iglewicz, B.Hauck, WW.Birk, DE. Two-stage hierarchical modeling for analysis of subpopulations in conditional distributions. Journal of applied statistics. 39(2) : 445-460, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22523443
  • Dourte, LM.Pathmanathan, L.Jawad, AF.Iozzo, RV.Mienaltowski, MJ.Birk, DE.Soslowsky, LJ. Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon. Journal of biomechanical engineering. 134(3) : 031005, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22482685
  • Ansorge, HL.Adams, S.Jawad, AF.Birk, DE.Soslowsky, LJ. Mechanical property changes during neonatal development and healing using a multiple regression model. Journal of biomechanics. 45: 1288-92, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22381737
  • Smith, SM.Thomas, CE.Birk, DE. Pericellular proteins of the developing mouse tendon: a proteomic analysis. Connective tissue research. 53(1) : 2-13, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21851252
  • Ansorge, HL.Hsu, JE.Edelstein, L.Adams, S.Birk, DE.Soslowsky, LJ. Recapitulation of the Achilles tendon mechanical properties during neonatal development: A Study of differential healing during two stages of development in a mouse model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 30(3) : 448-56, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22267191
  • Tao, G.Levay, AK.Peacock, JD.Huk, DJ.Both, SN.Purcell, NH.Pinto, JR.Galantowicz, ML.Koch, M.Lucchesi, PA.Birk, DE.Lincoln, J. Collagen XIV is important for growth and structural integrity of the myocardium. Journal of molecular and cellular cardiology. 53(5) : 626-38, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22906538
  • Smith, SM.Birk, DE. Focus on Molecules: Collagens V and XI. Experimental eye research. 98(1) : 105-6, 2012. http://www.ncbi.nlm.nih.gov/pubmed/20705069
  • Sun, M.Chen, S.Adams, SM.Florer, JB.Liu, H.Kao, WW.Wenstrup, RJ.Birk, DE. Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model. Journal of cell science. 124(Pt 23) : 4096-105, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22159420
  • Chen, S.Sun, M.Meng, X.Iozzo, RV.Kao, WW.Birk, DE. Pathophysiological Mechanisms of Autosomal Dominant Congenital Stromal Corneal Dystrophy C-Terminal-Truncated Decorin Results in Abnormal Matrix Assembly and Altered Expression of Small Leucine-Rich Proteoglycans. The American journal of pathology. 179: 2409-2419, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21893019
  • Shao, H.Chaerkady, R.Chen, S.Pinto, SM.Sharma, R.Delanghe, B.Birk, DE.Pandey, A.Chakravarti, S. Proteome profiling of wild type and lumican-deficient mouse corneas. Journal of proteomics. 74: 1895-1905, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21616181
  • Izu, Y.Sun, M.Zwolanek, D.Veit, G.Williams, V.Cha, B.Jepsen, KJ.Koch, M.Birk, DE. Type XII collagen regulates osteoblast polarity and communication during bone formation. The Journal of cell biology. 193(6) : 1115-30, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21670218
  • Ansorge, HL.Adams, S.Birk, DE.Soslowsky, LJ. Mechanical, Compositional, and Structural Properties of the Post-natal Mouse Achilles Tendon. Annals of biomedical engineering. 39(7) : 1904-13, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21431455
  • Wenstrup, RJ.Smith, SM.Florer, JB.Zhang, G.Beason, DP.Seegmiller, RE.Soslowsky, LJ.Birk, DE. Regulation of Collagen Fibril Nucleation and Initial Fibril Assembly Involves Coordinate Interactions with Collagens V and XI in Developing Tendon. The Journal of biological chemistry. 286(23) : 20455-65, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21467034
  • Izu, Y.Ansorge, HL.Zhang, G.Soslowsky, LJ.Bonaldo, P.Chu, ML.Birk, DE. Dysfunctional tendon collagen fibrillogenesis in collagen VI null mice. Matrix biology : journal of the International Society for Matrix Biology. 30(1) : 53-61, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20951202
  • Chen, S.Birk, DE. Focus on Molecules: Decorin. Experimental eye research. 92: 444-445, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20493188

Positions Held

  • Professor (Pathology & Cell Biology, College of Medicine, University of South Florida 2007 - 2012)
  • Professor (Pathology, Anatomy & Cell Biology, Jefferson Medical College, Thomas Jefferson University 1998 - 2008)
  • Professor (Anatomy and Cellular Biology, Tufts University School of Medicine 1996 - 1998)
  • Professor (Ophthalmology, Tufts University School of Medicine 1997 - 1998)
  • Associate Professor (Anatomy and Cellular Biology, Tufts University School of Medicine 1992 - 1996)
  • Graduate Faculty (Cell and Developmental Biology Program, Rutgers University 1984 - 1992)
  • Associate Professor (Pathology, University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School 1989 - 1992)
  • Assistant Professor (Pathology, University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School 1984 - 1989)

Awards/Honors

  • Fellow ARVO (Association for Research in Vision and Ophthalmology - 2010)
  • Dean's Citation for Significant Contributions to the Advancement of Education (Jefferson Medical College - 2006)
  • Excellence in Teaching Award (Awarded by Jefferson Medical College Class of 2008 - 2005)
  • Research Career Development Award (NIH NEI - 1984)
  • Individual NRSA (NIH NEI - 1982)