JeromeBreslin

Jerome Breslin, PhD

Assoc Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B Downs Blvd MDC8
Tampa, FL 33612

Academic Email: jbreslin@health.usf.edu

Academic Phone: (813) 974-7631

View My C.V.

Education

  • PhD, Pharmacology & Physiology, University Of Medicine And Dentistry Of New Jersey, 2002
  • MS, Biology, Seton Hall Universtiy, 1998
  • BA, Biological Sciences, Rutgers University, 1993

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular
  • Cardiovascular Sciences
  • Cellular and Molecular Biology

Research Interests

  • My research area of interest is inflammation, with emphasis on the mechanisms that underlie swelling of tissues, or edema. Our laboratory focuses on two phenomena: First, we aim to understand the molecular signaling pathways and effector molecules in endothelial cells that initiate, sustain, and regulate the increased microvascular permeability that accompanies inflammation. This is important for understanding how excess fluid can accumulate in tissues. Second, we are studying the molecular mechanisms that control the intrinsic pumping of lymphatic vessels, which contributes to removing excess fluids from tissues. Understanding how these processes work is important for developing better strategies for resuscitation of trauma patients, wound healing, and optimizing immune function.

Memberships

  • Research Society on Alcoholism (Member, 2014 - Present)
  • American Heart Association (Member, 2007 - Present)
  • American Association for the Advancement of Science (Member, 2005 - Present)
  • American Society for Cell Biology (Member, 2003 - Present)
  • American Physiological Society (Member, 2001 - Present)
  • The Microcirculatory Society (Councilor, 2000 - Present)

Recent Publications

  • Adderley, SP.Zhang, XE.Breslin, JW Involvement of the H1 histamine receptor, p38 MAP kinase, MLCK, and Rho/ROCK in histamine-indcued endothelial barrier dysfunction. Microcirculation. : In Press, 2015.
  • Breslin, JW.Zhang, XE.Worthylake, RA.Souza-Smith, FM Involvement of local lamellipodia in endothelial barrier function. PLOS One. : In Press, 2015.
  • Doggett, TM.Breslin, JW. Acute alcohol intoxication-induced microvascular leakage. Alcoholism, clinical and experimental research. 38(9) : 2414-26, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25257290
  • Kurtz, KH.Moor, AN.Souza-Smith, FM.Breslin, JW. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation. 21(7) : 593-605, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24702851
  • Kurtz, KH.Souza-Smith, FM.Moor, AN.Breslin, JW. Rho kinase enhances contractions of rat mesenteric collecting lymphatics. PloS one. 9(4) : e94082, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24710574
  • Breslin, JW. Mechanical forces and lymphatic transport. Microvascular research. 96: 46-54, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25107458
  • Souza-Smith, FM.Molina, PE.Breslin, JW. Reduced RhoA Activity Mediates Acute Alcohol Intoxication-Induced Inhibition of Lymphatic Myogenic Constriction Despite Increased Cytosolic [Ca(2+) ]. Microcirculation (New York, N.Y. : 1994). 20(5) : 377-84, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23237297
  • Doggett, TM.Breslin, JW. Study of the actin cytoskeleton in live endothelial cells expressing GFP-actin. Journal of visualized experiments : JoVE. (57) , 2011. http://www.ncbi.nlm.nih.gov/pubmed/22126853
  • Souza-Smith, FM.Kurtz, KM.Breslin, JW. Measurement of cytosolic Ca2+ in isolated contractile lymphatics. Journal of visualized experiments : JoVE. (58) , 2011. http://www.ncbi.nlm.nih.gov/pubmed/22214883
  • Breslin, JW. ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction. Lymphatic research and biology. 9(1) : 3-11, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21417762
  • Souza-Smith, FM.Kurtz, KM.Molina, PE.Breslin, JW. Adaptation of mesenteric collecting lymphatic pump function following acute alcohol intoxication. Microcirculation (New York, N.Y. : 1994). 17(7) : 514-24, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21040117
  • Durán, WN.Breslin, JW.Sánchez, FA. The NO cascade, eNOS location, and microvascular permeability. Cardiovascular research. 87(2) : 254-61, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20462865
  • Breslin, JW.Kurtz, KM. Lymphatic endothelial cells adapt their barrier function in response to changes in shear stress. Lymphatic research and biology. 7(4) : 229-37, 2009. http://www.ncbi.nlm.nih.gov/pubmed/20143922

Awards/Honors

  • Travel Award for Outstanding Young Investigators (The Microcirculatory Society, Inc. - 2012)