StephenLiggett

Stephen Liggett, MD

Assoc Vice President, Usf Health Personalized Medicine

Assoc Vp, Usf Health & Prof, Usf Health Personalized Medicine

Professor, College Of Medicine Internal Medicine

Professor, College Of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B. Downs Blvd., MDC02
Tampa, FL 33612

Academic Email: sliggett@health.usf.edu

Academic Phone: (813) 974-7715

View My C.V.

Education

  • MD, Medicine, Unviersity Of Miami School Of Medicine, 1982

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular

Research Interests

  • Dr. Stephen B. Liggett's laboratory has several major interrelated initiatives:
  • The study of the molecular basis of G-protein coupled receptor structure and function
  • Delineation and characterization of human genetic variants within this receptor signaling network
  • Association studies of genetic variants with heart and lung disease and their response to treatment to develop a platform for genetically-based personalized medicine
  • Creation of genetically modified mice to define the mechanisms of heart and lung disease and "humanized mice" to explore the effects of genetic variation of human genes
  • Determination of the full genome sequences of human Rhinoviruses using high throughput next-generation sequencing technologies; analysis of the relationships between viral genomes and asthma phenotypes
  • Genomic-based drug discovery, most recently identifying bitter taste receptors on airway smooth muscle and showing that they act to bronchodilate, thus being a potential new therapy for asthma and COPD

Recent Publications

  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus C isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2) , 2014. http://www.ncbi.nlm.nih.gov/pubmed/24675858
  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus B isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2) , 2014. http://www.ncbi.nlm.nih.gov/pubmed/24675857
  • Liggett, SB.Bochkov, YA.Pappas, T.Lemanske, RF.Gern, JE.Sengamalay, N.Zhao, X.Su, Q.Fraser, CM.Palmenberg, AC. Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies. Genome announcements. 2(2) , 2014. http://www.ncbi.nlm.nih.gov/pubmed/24675855
  • Aleong, RG.Sauer, WH.Davis, G.Murphy, GA.Port, JD.Anand, IS.Fiuzat, M.O'Connor, CM.Abraham, WT.Liggett, SB.Bristow, MR. Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta1389 Arg/Gly Adrenergic Receptor Polymorphism. JACC. Heart failure. 1(4) : 338-344, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24159564
  • Liggett, SB. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert opinion on therapeutic targets. 17(6) : 721-31, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23577615
  • Aleong, RG.Sauer, WH.Robertson, AD.Liggett, SB.Bristow, MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circulation. Arrhythmia and electrophysiology. 6(1) : 137-43, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23275278
  • Robinett, KS.Koziol-White, CJ.Akoluk, A.An, SS.Panettieri Jr, RA.Liggett, SB. Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells. American journal of respiratory cell and molecular biology. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24219573
  • Duan, QL.Du, R.Lasky-Su, J.Klanderman, BJ.Partch, AB.Peters, SP.Irvin, CG.Hanrahan, JP.Lima, JJ.Blake, KV.Liggett, SB.Litonjua, AA.Tantisira, KG. A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. The pharmacogenomics journal. 13(2) : 130-6, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22212731
  • Vandell, AG.Lobmeyer, MT.Gawronski, BE.Langaee, TY.Gong, Y.Gums, JG.Beitelshees, AL.Turner, ST.Chapman, AB.Cooper-DeHoff, RM.Bailey, KR.Boerwinkle, E.Pepine, CJ.Liggett, SB.Johnson, JA. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension. 60(4) : 957-64, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22949529
  • Clark, AA.Liggett, SB.Munger, SD. Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(12) : 4827-31, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22964302
  • O'Connor, CM.Fiuzat, M.Carson, PE.Anand, IS.Plehn, JF.Gottlieb, SS.Silver, MA.Lindenfeld, J.Miller, AB.White, M.Walsh, R.Nelson, P.Medway, A.Davis, G.Robertson, AD.Port, JD.Carr, J.Murphy, GA.Lazzeroni, LC.Abraham, WT.Liggett, SB.Bristow, MR. Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms. PloS one. 7(10) : e44324, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23071495
  • An, SS.Wang, WC.Koziol-White, CJ.Ahn, K.Lee, DY.Kurten, RC.Panettieri, RA.Liggett, SB. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. American journal of physiology. Lung cellular and molecular physiology. 303(4) : L304-11, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22683571
  • An, SS.Robinett, KS.Deshpande, DA.Wang, WC.Liggett, SB. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nature medicine. 18(5) : 650-1, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22561815
  • Wang, WC.Juan, AH.Panebra, A.Liggett, SB. MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108(15) : 6246-51, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21447718
  • Parsa, A.Chang, YP.Kelly, RJ.Corretti, MC.Ryan, KA.Robinson, SW.Gottlieb, SS.Kardia, SL.Shuldiner, AR.Liggett, SB. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clinical and translational science. 4(1) : 17-23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21348951
  • Johnson, JA.Liggett, SB. Cardiovascular pharmacogenomics of adrenergic receptor signaling: clinical implications and future directions. Clinical pharmacology and therapeutics. 89(3) : 366-78, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21289619
  • Wang, WC.Schillinger, RM.Malone, MM.Liggett, SB. Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. American journal of physiology. Lung cellular and molecular physiology. 300(3) : L472-8, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21131397
  • Duan, QL.Gaume, BR.Hawkins, GA.Himes, BE.Bleecker, ER.Klanderman, B.Irvin, CG.Peters, SP.Meyers, DA.Hanrahan, JP.Lima, JJ.Litonjua, AA.Tantisira, KG.Liggett, SB. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. American journal of respiratory and critical care medicine. 183(4) : 449-54, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20851928
  • Bochkov, YA.Palmenberg, AC.Lee, WM.Rathe, JA.Amineva, SP.Sun, X.Pasic, TR.Jarjour, NN.Liggett, SB.Gern, JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nature medicine. 17(5) : 627-32, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21483405
  • Trian, T.Burgess, JK.Niimi, K.Moir, LM.Ge, Q.Berger, P.Liggett, SB.Black, JL.Oliver, BG. β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. PloS one. 6(5) : e20000, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21611147
  • Robinett, KS.Deshpande, DA.Malone, MM.Liggett, SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. American journal of respiratory cell and molecular biology. 45(5) : 1069-74, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21642585
  • Liggett, SB. Phosphorylation barcoding as a mechanism of directing GPCR signaling. Science signaling. 4(185) : pe36, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21868354
  • Dockstader, K.Nunley, K.Karimpour-Fard, A.Medway, A.Nelson, P.Port, JD.Liggett, SB.Bristow, MR.Sucharov, CC. Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the β1-adrenergic receptor. Physiological genomics. 43(23) : 1294-306, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21954455
  • Nagele, P.Liggett, SB. Genetic variation, β-blockers, and perioperative myocardial infarction. Anesthesiology. 115(6) : 1316-27, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21918425
  • Rajan, S.Jagatheesan, G.Karam, CN.Alves, ML.Bodi, I.Schwartz, A.Bulcao, CF.D'Souza, KM.Akhter, SA.Boivin, GP.Dube, DK.Petrashevskaya, N.Herr, AB.Hullin, R.Liggett, SB.Wolska, BM.Solaro, RJ.Wieczorek, DF. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation. 121(3) : 410-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20065163
  • Liggett, SB. Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure. Heart failure clinics. 6(1) : 27-33, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19945058
  • Deshpande, DA.Wang, WC.McIlmoyle, EL.Robinett, KS.Schillinger, RM.An, SS.Sham, JS.Liggett, SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature medicine. 16(11) : 1299-304, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20972434
  • Jagatheesan, G.Rajan, S.Ahmed, RP.Petrashevskaya, N.Boivin, G.Arteaga, GM.Tae, HJ.Liggett, SB.Solaro, RJ.Wieczorek, DF. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. Journal of muscle research and cell motility. 31(3) : 227-39, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20803058
  • Panebra, A.Wang, WC.Malone, MM.Pitter, DR.Weiss, ST.Hawkins, GA.Liggett, SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. PloS one. 5(7) : e11819, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20686604
  • Palmenberg, AC.Rathe, JA.Liggett, SB. Analysis of the complete genome sequences of human rhinovirus. The Journal of allergy and clinical immunology. 125(6) : 1190-9; quiz 1200-1, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20471068
  • Bristow, MR.Murphy, GA.Krause-Steinrauf, H.Anderson, JL.Carlquist, JF.Thaneemit-Chen, S.Krishnan, V.Abraham, WT.Lowes, BD.Port, JD.Davis, GW.Lazzeroni, LC.Robertson, AD.Lavori, PW.Liggett, SB. An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Circulation. Heart failure. 3(1) : 21-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19880803
  • Rathe, JA.Liu, X.Tallon, LJ.Gern, JE.Liggett, SB. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. Archives of virology. 155(1) : 83-7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19936613
  • Palmenberg, AC.Spiro, D.Kuzmickas, R.Wang, S.Djikeng, A.Rathe, JA.Fraser-Liggett, CM.Liggett, SB. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science (New York, N.Y.). 324(5923) : 55-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19213880
  • Jagatheesan, G.Rajan, S.Schulz, EM.Ahmed, RP.Petrashevskaya, N.Schwartz, A.Boivin, GP.Arteaga, GM.Wang, T.Wang, YG.Ashraf, M.Liggett, SB.Lorenz, J.Solaro, RJ.Wieczorek, DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. American journal of physiology. Heart and circulatory physiology. 297(1) : H181-90, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19429821
  • Liggett, SB. alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes. Science translational medicine. 1(12) : 12ps15, 2009. http://www.ncbi.nlm.nih.gov/pubmed/20371458
  • Dorn, GW.Liggett, SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular pharmacology. 76(3) : 466-80, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19491328
  • Wang, WC.Mihlbachler, KA.Brunnett, AC.Liggett, SB. Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling. Proceedings of the National Academy of Sciences of the United States of America. 106(35) : 15007-12, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19706446
  • Small, KM.Mialet-Perez, J.Liggett, SB. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. Journal of cardiovascular pharmacology. 51(1) : 106-10, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18209576
  • Panebra, A.Schwarb, MR.Swift, SM.Weiss, ST.Bleecker, ER.Hawkins, GA.Liggett, SB. Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation. American journal of physiology. Lung cellular and molecular physiology. 294(2) : L190-5, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18024720
  • Dorn, GW.Liggett, SB. Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure. Clinical and translational science. 1(3) : 255-62, 2008. http://www.ncbi.nlm.nih.gov/pubmed/20443857
  • Petrashevskaya, N.Gaume, BR.Mihlbachler, KA.Dorn, GW.Liggett, SB. Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy. Clinical and translational science. 1(3) : 221-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/20443853
  • Kardia, SL.Kelly, RJ.Keddache, MA.Aronow, BJ.Grabowski, GA.Hahn, HS.Case, KL.Wagoner, LE.Dorn, GW.Liggett, SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. BMC medical genetics. 9: 93, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18947427
  • Einstein, R.Jordan, H.Zhou, W.Brenner, M.Moses, EG.Liggett, SB. Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors. Proceedings of the National Academy of Sciences of the United States of America. 105(13) : 5230-5, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18362331
  • Swift, SM.Gaume, BR.Small, KM.Aronow, BJ.Liggett, SB. Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs. Physiological genomics. 35(1) : 123-31, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18664629
  • Wang, WC.Mihlbachler, KA.Bleecker, ER.Weiss, ST.Liggett, SB. A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenetics and genomics. 18(8) : 729-32, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18622265
  • Sehnert, AJ.Daniels, SE.Elashoff, M.Wingrove, JA.Burrow, CR.Horne, B.Muhlestein, JB.Donahue, M.Liggett, SB.Anderson, JL.Kraus, WE. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology. 52(8) : 644-51, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18702968
  • Liggett, SB.Cresci, S.Kelly, RJ.Syed, FM.Matkovich, SJ.Hahn, HS.Diwan, A.Martini, JS.Sparks, L.Parekh, RR.Spertus, JA.Koch, WJ.Kardia, SL.Dorn, GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature medicine. 14(5) : 510-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18425130
  • Litonjua, AA.Lasky-Su, J.Schneiter, K.Tantisira, KG.Lazarus, R.Klanderman, B.Lima, JJ.Irvin, CG.Peters, SP.Hanrahan, JP.Liggett, SB.Hawkins, GA.Meyers, DA.Bleecker, ER.Lange, C.Weiss, ST. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. American journal of respiratory and critical care medicine. 178(7) : 688-94, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18617639
  • Panebra, A.Schwarb, MR.Glinka, CB.Liggett, SB. Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence. American journal of respiratory cell and molecular biology. 36(6) : 654-60, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17255556
  • Swift, SM.Schwarb, MR.Mihlbachler, KA.Liggett, SB. Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. American journal of respiratory cell and molecular biology. 36(2) : 236-43, 2007. http://www.ncbi.nlm.nih.gov/pubmed/16980553
  • Liggett, SB. Long-distance affair with adrenal GRK2 hangs up heart failure. Nature medicine. 13(3) : 246-8, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17342115
  • McGraw, DW.Elwing, JM.Fogel, KM.Wang, WC.Glinka, CB.Mihlbachler, KA.Rothenberg, ME.Liggett, SB. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of clinical investigation. 117(5) : 1391-8, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17415415
  • Jagatheesan, G.Rajan, S.Petrashevskaya, N.Schwartz, A.Boivin, G.Arteaga, GM.Solaro, RJ.Liggett, SB.Wieczorek, DF. Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. American journal of physiology. Heart and circulatory physiology. 293(2) : H949-58, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17416600
  • Rajan, S.Ahmed, RP.Jagatheesan, G.Petrashevskaya, N.Boivin, GP.Urboniene, D.Arteaga, GM.Wolska, BM.Solaro, RJ.Liggett, SB.Wieczorek, DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circulation research. 101(2) : 205-14, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17556658
  • Panebra, A.Schwarb, MR.Glinka, CB.Liggett, SB. Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 293(2) : L453-62, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17557803
  • Liggett, SB.Kelly, RJ.Parekh, RR.Matkovich, SJ.Benner, BJ.Hahn, HS.Syed, FM.Galvez, AS.Case, KL.McGuire, N.Odley, AM.Sparks, L.Kardia, SL.Dorn, GW. A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure. Human molecular genetics. 16(22) : 2740-50, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17720980
  • Petrashevskaya, N.Liggett, SB. Tight control of adrenal medulla catecholamine release by alpha 2C-adrenergic receptors influences susceptibility to heart failure. Cardiovascular research. 75(4) : 631-3, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17643402
  • Liggett, SB. Genetic variability of the beta2 adrenergic receptor and asthma exacerbations. Thorax. 61(11) : 925-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17071831
  • Hawkins, GA.Tantisira, K.Meyers, DA.Ampleford, EJ.Moore, WC.Klanderman, B.Liggett, SB.Peters, SP.Weiss, ST.Bleecker, ER. Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study. American journal of respiratory and critical care medicine. 174(10) : 1101-9, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16931635
  • Mialet-Perez, J.Liggett, SB. Pharmacogenetics of beta1-adrenergic receptors in heart failure and hypertension. Archives des maladies du coeur et des vaisseaux. 99(6) : 616-20, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16878723
  • McGraw, DW.Fogel, KM.Kong, S.Litonjua, AA.Kranias, EG.Aronow, BJ.Liggett, SB. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological genomics. 27(2) : 171-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16849635
  • Liggett, SB.Mialet-Perez, J.Thaneemit-Chen, S.Weber, SA.Greene, SM.Hodne, D.Nelson, B.Morrison, J.Domanski, MJ.Wagoner, LE.Abraham, WT.Anderson, JL.Carlquist, JF.Krause-Steinrauf, HJ.Lazzeroni, LC.Port, JD.Lavori, PW.Bristow, MR. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proceedings of the National Academy of Sciences of the United States of America. 103(30) : 11288-93, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16844790
  • McGraw, DW.Mihlbachler, KA.Schwarb, MR.Rahman, FF.Small, KM.Almoosa, KF.Liggett, SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of clinical investigation. 116(5) : 1400-9, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16670773
  • Liggett, SB. Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow. Circulation. 113(15) : 1818-20, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16618829
  • Small, KM.Schwarb, MR.Glinka, C.Theiss, CT.Brown, KM.Seman, CA.Liggett, SB. Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment. Biochemistry. 45(15) : 4760-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16605244
  • Liggett, SB. Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify. The Journal of clinical investigation. 116(4) : 875-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16585959
  • Small, KM.Brown, KM.Seman, CA.Theiss, CT.Liggett, SB. Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 103(14) : 5472-7, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16567612
  • Akhter, SA.D'Souza, KM.Petrashevskaya, NN.Mialet-Perez, J.Liggett, SB. Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. American journal of physiology. Heart and circulatory physiology. 290(4) : H1427-32, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16537791
  • Zhao, W.Yuan, Q.Qian, J.Waggoner, JR.Pathak, A.Chu, G.Mitton, B.Sun, X.Jin, J.Braz, JC.Hahn, HS.Marreez, Y.Syed, F.Pollesello, P.Annila, A.Wang, HS.Schultz, Jel J.Molkentin, JD.Liggett, SB.Dorn, GW.Kranias, EG. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113(7) : 995-1004, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16476846
  • McGraw, DW.Liggett, SB. Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society. 2(4) : 292-6; discussion 311-2, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16267351
  • Liggett, SB. Lymphocyte GRK levels as biomarkers in heart failure. European heart journal. 26(17) : 1695-6, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16055498
  • Tantisira, KG.Small, KM.Litonjua, AA.Weiss, ST.Liggett, SB. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. Human molecular genetics. 14(12) : 1671-7, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15879435
  • Braz, JC.Gregory, K.Pathak, A.Zhao, W.Sahin, B.Klevitsky, R.Kimball, TF.Lorenz, JN.Nairn, AC.Liggett, SB.Bodi, I.Wang, S.Schwartz, A.Lakatta, EG.DePaoli-Roach, AA.Robbins, J.Hewett, TE.Bibb, JA.Westfall, MV.Kranias, EG.Molkentin, JD. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature medicine. 10(3) : 248-54, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14966518
  • Small, KM.Mialet-Perez, J.Seman, CA.Theiss, CT.Brown, KM.Liggett, SB. Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects. Proceedings of the National Academy of Sciences of the United States of America. 101(35) : 13020-5, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15319474
  • Mialet-Perez, J.Green, SA.Miller, WE.Liggett, SB. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of biological chemistry. 279(37) : 38603-7, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15247302
  • Liggett, SB. The two-timing thyroid. Nature medicine. 10(6) : 582-3, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15170201
  • Tantisira, KG.Lake, S.Silverman, ES.Palmer, LJ.Lazarus, R.Silverman, EK.Liggett, SB.Gelfand, EW.Rosenwasser, LJ.Richter, B.Israel, E.Wechsler, M.Gabriel, S.Altshuler, D.Lander, E.Drazen, J.Weiss, ST. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human molecular genetics. 13(13) : 1353-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15128701
  • Liggett, SB. Polymorphisms of beta-adrenergic receptors in heart failure. The American journal of medicine. 117(7) : 525-7, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15464712
  • Lalchandani, SG.Zhang, X.Hong, SS.Liggett, SB.Li, W.Moore, BM.Miller, DD.Feller, DR. Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical pharmacology. 67(1) : 87-96, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14667931
  • Israel, E.Chinchilli, VM.Ford, JG.Boushey, HA.Cherniack, R.Craig, TJ.Deykin, A.Fagan, JK.Fahy, JV.Fish, J.Kraft, M.Kunselman, SJ.Lazarus, SC.Lemanske, RF.Liggett, SB.Martin, RJ.Mitra, N.Peters, SP.Silverman, E.Sorkness, CA.Szefler, SJ.Wechsler, ME.Weiss, ST.Drazen, JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 364(9444) : 1505-12, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15500895
  • Liggett, SB. Genetically modified mouse models for pharmacogenomic research. Nature reviews. Genetics. 5(9) : 657-63, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15372087
  • Hahn, HS.Marreez, Y.Odley, A.Sterbling, A.Yussman, MG.Hilty, KC.Bodi, I.Liggett, SB.Schwartz, A.Dorn, GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation research. 93(11) : 1111-9, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14605019
  • Gaussin, V.Tomlinson, JE.Depre, C.Engelhardt, S.Antos, CL.Takagi, G.Hein, L.Topper, JN.Liggett, SB.Olson, EN.Lohse, MJ.Vatner, SF.Vatner, DE. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 108(23) : 2926-33, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14623810
  • Gerson, MC.Wagoner, LE.McGuire, N.Liggett, SB. Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 10(6) : 583-9, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14668769
  • Liggett, SB. Polymorphisms of adrenergic receptors: variations on a theme. Assay and drug development technologies. 1(2) : 317-26, 2003. http://www.ncbi.nlm.nih.gov/pubmed/15090197
  • Mialet Perez, J.Rathz, DA.Petrashevskaya, NN.Hahn, HS.Wagoner, LE.Schwartz, A.Dorn, GW.Liggett, SB. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nature medicine. 9(10) : 1300-5, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14502278
  • Rathz, DA.Gregory, KN.Fang, Y.Brown, KM.Liggett, SB. Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling. The Journal of biological chemistry. 278(12) : 10784-9, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12525504
  • Small, KM.McGraw, DW.Liggett, SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual review of pharmacology and toxicology. 43: 381-411, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12540746
  • Small, KM.Tanguay, DA.Nandabalan, K.Zhan, P.Stephens, JC.Liggett, SB. Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. 3(1) : 65-71, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12562217
  • Haghighi, K.Kolokathis, F.Pater, L.Lynch, RA.Asahi, M.Gramolini, AO.Fan, GC.Tsiapras, D.Hahn, HS.Adamopoulos, S.Liggett, SB.Dorn, GW.MacLennan, DH.Kremastinos, DT.Kranias, EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of clinical investigation. 111(6) : 869-76, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12639993
  • Cuajungco, MP.Ando, Y.Axelrod, FB.Biaggioni, I.Goldstein, DS.Guttmacher, AE.Gwinn-Hardy, K.Hahn, MK.Hilz, MJ.Jacob, G.Jens, J.Kennedy, WR.Liggett, SB.O'Connor, DT.Peltzer, SR.Robertson, D.Rubin, BY.Scudder, Q.Smith, LJ.Sonenshein, GE.Svejstrup, JQ.Xu, Y.Slaugenhaupt, SA. Hereditary dysautonomias: current knowledge and collaborations for the future. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 13(3) : 180-95, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12822040
  • McGraw, DW.Almoosa, KF.Paul, RJ.Kobilka, BK.Liggett, SB. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of clinical investigation. 112(4) : 619-26, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12925702
  • Small, KM.Brown, KM.Theiss, CT.Seman, CA.Weiss, ST.Liggett, SB. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 13(9) : 535-41, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12972952
  • Liggett, SB. Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling. The Journal of allergy and clinical immunology. 110(6 Suppl) : S223-7, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12464928
  • Liggett, SB. Polymorphisms of the beta2-adrenergic receptor. The New England journal of medicine. 346(7) : 536-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11844862
  • Liang, M.Eason, MG.Theiss, CT.Liggett, SB. Phosphorylation of Ser360 in the third intracellular loop of the alpha2A-adrenoceptor during protein kinase C-mediated desensitization. European journal of pharmacology. 437(1-2) : 41-6, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11864637
  • Small, KM.Rathz, DA.Liggett, SB. Identification of adrenergic receptor polymorphisms. Methods in enzymology. 343: 459-75, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11665585
  • Rathz, DA.Brown, KM.Kramer, LA.Liggett, SB. Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking. Journal of cardiovascular pharmacology. 39(2) : 155-60, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11791000
  • Small, KM.Wagoner, LE.Levin, AM.Kardia, SL.Liggett, SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. The New England journal of medicine. 347(15) : 1135-42, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12374873
  • Wagoner, LE.Craft, LL.Zengel, P.McGuire, N.Rathz, DA.Dorn, GW.Liggett, SB. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. American heart journal. 144(5) : 840-6, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12422153
  • Lalchandani, SG.Lei, L.Zheng, W.Suni, MM.Moore, BM.Liggett, SB.Miller, DD.Feller, DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of pharmacology and experimental therapeutics. 303(3) : 979-84, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12438517
  • Small, KM.Seman, CA.Castator, A.Brown, KM.Liggett, SB. False positive non-synonymous polymorphisms of G-protein coupled receptor genes. FEBS letters. 516(1-3) : 253-6, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11959142
  • Liang, M.Freedman, NJ.Theiss, CT.Liggett, SB. Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. Biochemistry. 40(49) : 15031-7, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11732925
  • Silverman, ES.Liggett, SB.Gelfand, EW.Rosenwasser, LJ.Baron, RM.Bolk, S.Weiss, ST.Drazen, JM. The pharmacogenetics of asthma: a candidate gene approach. The pharmacogenomics journal. 1(1) : 27-37, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11913724
  • Small, KM.Brown, KM.Forbes, SL.Liggett, SB. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. The Journal of biological chemistry. 276(7) : 4917-22, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11056163
  • Dash, R.Kadambi, V.Schmidt, AG.Tepe, NM.Biniakiewicz, D.Gerst, MJ.Canning, AM.Abraham, WT.Hoit, BD.Liggett, SB.Lorenz, JN.Dorn, GW.Kranias, EG. Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation. 103(6) : 889-96, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11171800
  • Liggett, SB. Pharmacogenetic applications of the Human Genome project. Nature medicine. 7(3) : 281-3, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11231618
  • Liggett, SB. Beta-adrenergic receptors in the failing heart: the good, the bad, and the unknown. The Journal of clinical investigation. 107(8) : 947-8, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11306597
  • Israel, E.Drazen, JM.Liggett, SB.Boushey, HA.Cherniack, RM.Chinchilli, VM.Cooper, DM.Fahy, JV.Fish, JE.Ford, JG.Kraft, M.Kunselman, S.Lazarus, SC.Lemanske, RF.Martin, RJ.McLean, DE.Peters, SP.Silverman, EK.Sorkness, CA.Szefler, SJ.Weiss, ST.Yandava, CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. International archives of allergy and immunology. 124(1-3) : 183-6, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11306963
  • Small, KM.Brown, KM.Forbes, SL.Liggett, SB. Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. The Journal of biological chemistry. 276(34) : 31596-601, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11402033
  • Green, SA.Rathz, DA.Schuster, AJ.Liggett, SB. The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s). European journal of pharmacology. 421(3) : 141-7, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11516429
  • Small, KM.Liggett, SB. Identification and functional characterization of alpha(2)-adrenoceptor polymorphisms. Trends in pharmacological sciences. 22(9) : 471-7, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11543875
  • McGraw, DW.Fukuda, N.James, PF.Forbes, SL.Woo, AL.Lingrel, JB.Witte, DP.Matthay, MA.Liggett, SB. Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology. 281(4) : L895-903, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11557593
  • Drysdale, CM.McGraw, DW.Stack, CB.Stephens, JC.Judson, RS.Nandabalan, K.Arnold, K.Ruano, G.Liggett, SB. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America. 97(19) : 10483-8, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10984540
  • Dorn, GW.Tepe, NM.Wu, G.Yatani, A.Liggett, SB. Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction. Molecular pharmacology. 57(2) : 278-87, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10648637
  • Small, KM.Forbes, SL.Brown, KM.Liggett, SB. An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling. The Journal of biological chemistry. 275(49) : 38518-23, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10948191
  • McGraw, DW.Forbes, SL.Mak, JC.Witte, DP.Carrigan, PE.Leikauf, GD.Liggett, SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American journal of physiology. Lung cellular and molecular physiology. 279(2) : L379-89, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10926562
  • Israel, E.Drazen, JM.Liggett, SB.Boushey, HA.Cherniack, RM.Chinchilli, VM.Cooper, DM.Fahy, JV.Fish, JE.Ford, JG.Kraft, M.Kunselman, S.Lazarus, SC.Lemanske, RF.Martin, RJ.McLean, DE.Peters, SP.Silverman, EK.Sorkness, CA.Szefler, SJ.Weiss, ST.Yandava, CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. American journal of respiratory and critical care medicine. 162(1) : 75-80, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10903223
  • Jewell-Motz, EA.Small, KM.Theiss, CT.Liggett, SB. alpha 2A/alpha 2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase phosphorylation. The Journal of biological chemistry. 275(37) : 28989-93, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10893245
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  • Hoit, BD.Suresh, DP.Craft, L.Walsh, RA.Liggett, SB. beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. American heart journal. 139(3) : 537-42, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10689270
  • Small, KM.Forbes, SL.Rahman, FF.Liggett, SB. Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling. Biochemistry. 39(10) : 2815-21, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10704234
  • Tepe, NM.Liggett, SB. Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. Journal of receptor and signal transduction research. 20(1) : 75-85, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10711498
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  • Liggett, SB.Tepe, NM.Lorenz, JN.Canning, AM.Jantz, TD.Mitarai, S.Yatani, A.Dorn, GW. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 101(14) : 1707-14, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10758054
  • Wagoner, LE.Craft, LL.Singh, B.Suresh, DP.Zengel, PW.McGuire, N.Abraham, WT.Chenier, TC.Dorn, GW.Liggett, SB. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure. Circulation research. 86(8) : 834-40, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10785504
  • Small, KM.Forbes, SL.Rahman, FF.Bridges, KM.Liggett, SB. A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors. The Journal of biological chemistry. 275(30) : 23059-64, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10801795
  • Yan, L.Galinsky, RE.Bernstein, JA.Liggett, SB.Weinshilboum, RM. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics. 10(3) : 261-6, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10803682
  • Liggett, SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology. 61(3) : 167-73, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10971202
  • McGraw, DW.Liggett, SB. Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 29 Suppl 4: 43-5, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10641566
  • Tepe, NM.Lorenz, JN.Yatani, A.Dash, R.Kranias, EG.Dorn, GW.Liggett, SB. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry. 38(50) : 16706-13, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10600134
  • McGraw, DW.Forbes, SL.Kramer, LA.Witte, DP.Fortner, CN.Paul, RJ.Liggett, SB. Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry. 274(45) : 32241-7, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10542262
  • Liggett, SB. Plastic adenylyl cyclase. American journal of respiratory cell and molecular biology. 21(5) : 564-6, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10536115
  • Mason, DA.Moore, JD.Green, SA.Liggett, SB. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. The Journal of biological chemistry. 274(18) : 12670-4, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10212248
  • Moore, JD.Mason, DA.Green, SA.Hsu, J.Liggett, SB. Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C. Human mutation. 14(3) : 271, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10477438
  • Liggett, SB. Molecular and genetic basis of beta2-adrenergic receptor function. The Journal of allergy and clinical immunology. 104(2 Pt 2) : S42-6, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10452787
  • Small, K.Feng, JF.Lorenz, J.Donnelly, ET.Yu, A.Im, MJ.Dorn, GW.Liggett, SB. Cardiac specific overexpression of transglutaminase II (G(h)) results in a unique hypertrophy phenotype independent of phospholipase C activation. The Journal of biological chemistry. 274(30) : 21291-6, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10409687
  • Dorn, GW.Tepe, NM.Lorenz, JN.Koch, WJ.Liggett, SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96(11) : 6400-5, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10339599
  • Tepe, NM.Liggett, SB. Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse. FEBS letters. 458(2) : 236-40, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10481072
  • Liggett, SB.Wagoner, LE.Craft, LL.Hornung, RW.Hoit, BD.McIntosh, TC.Walsh, RA. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. The Journal of clinical investigation. 102(8) : 1534-9, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9788966
  • McGraw, DW.Forbes, SL.Kramer, LA.Liggett, SB. Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. The Journal of clinical investigation. 102(11) : 1927-32, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9835617
  • Jewell-Motz, EA.Donnelly, ET.Eason, MG.Liggett, SB. Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation. Biochemistry. 37(45) : 15720-5, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9843377
  • Weir, TD.Mallek, N.Sandford, AJ.Bai, TR.Awadh, N.Fitzgerald, JM.Cockcroft, D.James, A.Liggett, SB.Paré, PD. beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. American journal of respiratory and critical care medicine. 158(3) : 787-91, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9731005
  • Liggett, SB. Structural determinants of alpha 2-adrenergic receptor regulation. Advances in pharmacology (San Diego, Calif.). 42: 438-42, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9327933
  • Sakata, Y.Hoit, BD.Liggett, SB.Walsh, RA.Dorn, GW. Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation. 97(15) : 1488-95, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9576430
  • McGraw, DW.Donnelly, ET.Eason, MG.Green, SA.Liggett, SB. Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular signalling. 10(3) : 197-204, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9607143
  • Liggett, SB. Pharmacogenetics of relevant targets in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 28 Suppl 1: 77-9; discussion 80-1, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9641598
  • Liang, M.Eason, MG.Jewell-Motz, EA.Williams, MA.Theiss, CT.Dorn, GW.Liggett, SB. Phosphorylation and functional desensitization of the alpha2A-adrenergic receptor by protein kinase C. Molecular pharmacology. 54(1) : 44-9, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9658188
  • Adams, JW.Sakata, Y.Davis, MG.Sah, VP.Wang, Y.Liggett, SB.Chien, KR.Brown, JH.Dorn, GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95(17) : 10140-5, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9707614
  • McGraw, DW.Liggett, SB. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of biological chemistry. 272(11) : 7338-44, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9054432
  • Liggett, SB. Polymorphisms of the beta2-adrenergic receptor and asthma. American journal of respiratory and critical care medicine. 156(4 Pt 2) : S156-62, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9351598
  • Dorn, GW.Oswald, KJ.McCluskey, TS.Kuhel, DG.Liggett, SB. Alpha 2A-adrenergic receptor stimulated calcium release is transduced by Gi-associated G(beta gamma)-mediated activation of phospholipase C. Biochemistry. 36(21) : 6415-23, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9174358
  • Hoit, BD.Khoury, SF.Shao, Y.Gabel, M.Liggett, SB.Walsh, RA. Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. Circulation. 96(2) : 592-8, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9244231
  • Jewell-Motz, EA.Donnelly, ET.Eason, MG.Liggett, SB. Role of the amino terminus of the third intracellular loop in agonist-promoted downregulation of the alpha2A-adrenergic receptor. Biochemistry. 36(29) : 8858-63, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9220972
  • D'Angelo, DD.Sakata, Y.Lorenz, JN.Boivin, GP.Walsh, RA.Liggett, SB.Dorn, GW. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proceedings of the National Academy of Sciences of the United States of America. 94(15) : 8121-6, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9223325
  • Dewar, JC.Wilkinson, J.Wheatley, A.Thomas, NS.Doull, I.Morton, N.Lio, P.Harvey, JF.Liggett, SB.Holgate, ST.Hall, IP. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. The Journal of allergy and clinical immunology. 100(2) : 261-5, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9275150
  • Kiss, E.Edes, I.Sato, Y.Luo, W.Liggett, SB.Kranias, EG. beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts. The American journal of physiology. 272(2 Pt 2) : H785-90, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9124439
  • Jewell-Motz, EA.Liggett, SB. G protein-coupled receptor kinase specificity for phosphorylation and desensitization of alpha2-adrenergic receptor subtypes. The Journal of biological chemistry. 271(30) : 18082-7, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8663433
  • Turki, J.Lorenz, JN.Green, SA.Donnelly, ET.Jacinto, M.Liggett, SB. Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 93(19) : 10483-8, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8816827
  • Green, SA.Spasoff, AP.Coleman, RA.Johnson, M.Liggett, SB. Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor. The Journal of biological chemistry. 271(39) : 24029-35, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8798639
  • Eason, MG.Liggett, SB. Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains. The Journal of biological chemistry. 271(22) : 12826-32, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8662784
  • Eason, MG.Liggett, SB. Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the alpha 2A-adrenergic receptor. Evidence for distinct structural determinants that confer Gs versus Gi coupling. The Journal of biological chemistry. 270(42) : 24753-60, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7559592
  • Turki, J.Green, SA.Newman, KB.Meyers, MA.Liggett, SB. Human lung cell beta 2-adrenergic receptors desensitize in response to in vivo administered beta-agonist. The American journal of physiology. 269(5 Pt 1) : L709-14, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7491992
  • Liggett, SB. Genetics of beta 2-adrenergic receptor variants in asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 25 Suppl 2: 89-94; discussion 95-6, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8590354
  • Jewell-Motz, EA.Liggett, SB. An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization. Biochemistry. 34(37) : 11946-53, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7547931
  • Freedman, NJ.Liggett, SB.Drachman, DE.Pei, G.Caron, MG.Lefkowitz, RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. The Journal of biological chemistry. 270(30) : 17953-61, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7629102
  • Green, SA.Turki, J.Hall, IP.Liggett, SB. Implications of genetic variability of human beta 2-adrenergic receptor structure. Pulmonary pharmacology. 8(1) : 1-10, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8535093
  • Green, SA.Turki, J.Bejarano, P.Hall, IP.Liggett, SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. American journal of respiratory cell and molecular biology. 13(1) : 25-33, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7598936
  • Hall, IP.Wheatley, A.Wilding, P.Liggett, SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet. 345(8959) : 1213-4, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7739309
  • Turki, J.Liggett, SB. Receptor-specific functional properties of beta 2-adrenergic receptor autoantibodies in asthma. American journal of respiratory cell and molecular biology. 12(5) : 531-9, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7742016
  • Turki, J.Pak, J.Green, SA.Martin, RJ.Liggett, SB. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. The Journal of clinical investigation. 95(4) : 1635-41, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7706471
  • Eason, MG.Moreira, SP.Liggett, SB. Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor. The Journal of biological chemistry. 270(9) : 4681-8, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7876239
  • Liggett, SB.Levi, R.Metzger, H. G-protein coupled receptors, nitric oxide, and the IgE receptor in asthma. American journal of respiratory and critical care medicine. 152(1) : 394-402, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7599854
  • Green, SA.Turki, J.Innis, M.Liggett, SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 33(32) : 9414-9, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7915137
  • Green, SA.Liggett, SB. A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration. The Journal of biological chemistry. 269(42) : 26215-9, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7929336
  • Eason, MG.Jacinto, MT.Theiss, CT.Liggett, SB. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Proceedings of the National Academy of Sciences of the United States of America. 91(23) : 11178-82, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7972030
  • Eason, MG.Jacinto, MT.Liggett, SB. Contribution of ligand structure to activation of alpha 2-adrenergic receptor subtype coupling to Gs. Molecular pharmacology. 45(4) : 696-702, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7910371
  • Reihsaus, E.Innis, M.MacIntyre, N.Liggett, SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. American journal of respiratory cell and molecular biology. 8(3) : 334-9, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8383511
  • Thomas, RF.Liggett, SB. Lack of beta 3-adrenergic receptor mRNA expression in adipose and other metabolic tissues in the adult human. Molecular pharmacology. 43(3) : 343-8, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8383799
  • Liggett, SB.Raymond, JR. Pharmacology and molecular biology of adrenergic receptors. Baillière's clinical endocrinology and metabolism. 7(2) : 279-306, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8489482
  • Liggett, SB.Freedman, NJ.Schwinn, DA.Lefkowitz, RJ. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 90(8) : 3665-9, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8386380
  • Eason, MG.Liggett, SB. Functional alpha 2-adrenergic receptor-Gs coupling undergoes agonist-promoted desensitization in a subtype-selective manner. Biochemical and biophysical research communications. 193(1) : 318-23, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8099284
  • Eason, MG.Liggett, SB. Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. Molecular pharmacology. 44(1) : 70-5, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7688069
  • Green, SA.Cole, G.Jacinto, M.Innis, M.Liggett, SB. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. The Journal of biological chemistry. 268(31) : 23116-21, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7901205
  • Green, SA.Holt, BD.Liggett, SB. Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. Molecular pharmacology. 41(5) : 889-93, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1350321
  • Thomas, RF.Holt, BD.Schwinn, DA.Liggett, SB. Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements. Proceedings of the National Academy of Sciences of the United States of America. 89(10) : 4490-4, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1374904
  • Saffitz, JE.Liggett, SB. Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circulation research. 70(6) : 1320-5, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1315641
  • Kraus, WE.Longabaugh, JP.Liggett, SB. Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor. The American journal of physiology. 263(2 Pt 1) : E226-30, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1325124
  • Eason, MG.Kurose, H.Holt, BD.Raymond, JR.Liggett, SB. Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. The Journal of biological chemistry. 267(22) : 15795-801, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1322406
  • Liggett, SB. Functional properties of the rat and human beta 3-adrenergic receptors: differential agonist activation of recombinant receptors in Chinese hamster ovary cells. Molecular pharmacology. 42(4) : 634-7, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1331754
  • Liggett, SB.Ostrowski, J.Chesnut, LC.Kurose, H.Raymond, JR.Caron, MG.Lefkowitz, RJ. Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. The Journal of biological chemistry. 267(7) : 4740-6, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1311318
  • Eason, MG.Liggett, SB. Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2. The Journal of biological chemistry. 267(35) : 25473-9, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1334095
  • Schwinn, DA.Leone, BJ.Spahn, DR.Chesnut, LC.Page, SO.McRae, RL.Liggett, SB. Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation. Circulation. 84(6) : 2559-67, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1659956
  • Schwinn, DA.Page, SO.Middleton, JP.Lorenz, W.Liggett, SB.Yamamoto, K.Lapetina, EG.Caron, MG.Lefkowitz, RJ.Cotecchia, S. The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. Molecular pharmacology. 40(5) : 619-26, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1658600
  • Liggett, SB. Desensitization of the beta-adrenergic receptor: distinct molecular determinants of phosphorylation by specific kinases. Pharmacological research : the official journal of the Italian Pharmacological Society. 24 Suppl 1: 29-41, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1661007
  • Liggett, SB.Caron, MG.Lefkowitz, RJ.Hnatowich, M. Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. The Journal of biological chemistry. 266(8) : 4816-21, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1848226
  • Bates, MD.Senogles, SE.Bunzow, JR.Liggett, SB.Civelli, O.Caron, MG. Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. Molecular pharmacology. 39(1) : 55-63, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1846220
  • Liggett, SB.Ostrowski, J.Chesnut, LC.Caron, MG.Lefkowitz, RJ. Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. Transactions of the Association of American Physicians. 104: 40-7, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1668989
  • Liggett, SB.Schwinn, DA. Multiple potential regulatory elements in the 5' flanking region of the beta 3-adrenergic receptor. DNA sequence : the journal of DNA sequencing and mapping. 2(1) : 61-3, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1666313
  • Dejgaard, A.Liggett, SB.Christensen, NJ.Cryer, PE.Hilsted, J. Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity. Scandinavian journal of clinical and laboratory investigation. 51(8) : 659-66, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1666931
  • Liggett, SB.Renfro, AD. Energy expenditures of mechanically ventilated nonsurgical patients. Chest. 98(3) : 682-6, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2118448
  • Hausdorff, WP.Lohse, MJ.Bouvier, M.Liggett, SB.Caron, MG.Lefkowitz, RJ. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symposia of the Society for Experimental Biology. 44: 225-40, 1990. http://www.ncbi.nlm.nih.gov/pubmed/1983369
  • Liggett, SB.Shah, SD.Cryer, PE. Human tissue adrenergic receptors are not predictive of responses to epinephrine in vivo. The American journal of physiology. 256(5 Pt 1) : E600-9, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2541622
  • Liggett, SB.Bouvier, M.Hausdorff, WP.O'Dowd, B.Caron, MG.Lefkowitz, RJ. Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. Molecular pharmacology. 36(4) : 641-6, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2554115
  • Liggett, SB.Bouvier, M.O'Dowd, BF.Caron, MG.Lefkowitz, RJ.DeBlasi, A. Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochemical and biophysical research communications. 165(1) : 257-63, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2556136
  • Liggett, SB. Beta-adrenoceptor-effector system of the human macrophage U937 cell line. European journal of pharmacology. 163(1) : 171-4, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2545462
  • Liggett, SB. Identification and characterization of a homogeneous population of beta 2-adrenergic receptors on human alveolar macrophages. The American review of respiratory disease. 139(2) : 552-5, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2563322
  • Liggett, SB.Shah, SD.Cryer, PE. Increased fat and skeletal muscle beta-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. The Journal of clinical investigation. 83(3) : 803-9, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2537849
  • Boyle, PJ.Liggett, SB.Shah, SD.Cryer, PE. Direct muscarinic cholinergic inhibition of hepatic glucose production in humans. The Journal of clinical investigation. 82(2) : 445-9, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2900252
  • Liggett, SB.Marker, JC.Shah, SD.Roper, CL.Cryer, PE. Direct relationship between mononuclear leukocyte and lung beta-adrenergic receptors and apparent reciprocal regulation of extravascular, but not intravascular, alpha- and beta-adrenergic receptors by the sympathochromaffin system in humans. The Journal of clinical investigation. 82(1) : 48-56, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2839552
  • Liggett, SB.Daughaday, CC.Senior, RM. Ipratropium in patients with COPD receiving cholinesterase inhibitors. Chest. 94(1) : 210-2, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2968227
  • Liggett, SB.Shah, SD.Cryer, PE. Characterization of beta-adrenergic receptors of human skeletal muscle obtained by needle biopsy. The American journal of physiology. 254(6 Pt 1) : E795-8, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2837096