PaulaBickford

Paula Bickford, PHD

Professor, Center Of Excellence For Aging & Brain Repair

Professor, College Of Medicine Molecular Pharmacology & Physiology

Professor, Non Usf Health

Center Of Excellence For Aging & Brain Repair

Academic Email: pbickfor@health.usf.edu

Academic Phone: (813) 974-3238

View My C.V.

Education

  • PHD, Pharmacology, University Of Colorado, 1984

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cancer Biology
  • Neuroscience

Recent Publications

  • Pabon, MM.Bachstetter, AD.Hudson, CE.Gemma, C.Bickford, PC. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of neuroinflammation. 8(1) : 9, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21266082
  • Acosta, S.Jernberg, J.Sanberg, CD.Sanberg, PR.Small, BJ.Gemma, C.Bickford, PC. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation research. 13(5) : 581-8, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20586644
  • Willis, LM.Freeman, L.Bickford, PC.Quintero, EM.Umphlet, CD.Moore, AB.Goetzl, L.Granholm, AC. Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts. Glia. 58(6) : 679-90, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20014277
  • Bachstetter, AD.Jernberg, J.Schlunk, A.Vila, JL.Hudson, C.Cole, MJ.Shytle, RD.Tan, J.Sanberg, PR.Sanberg, CD.Borlongan, C.Kaneko, Y.Tajiri, N.Gemma, C.Bickford, PC. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. PloS one. 5(5) : e10496, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20463965
  • Smith, A.Giunta, B.Bickford, PC.Fountain, M.Tan, J.Shytle, RD. Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease. International journal of pharmaceutics. 389(1-2) : 207-12, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20083179
  • Shytle, DR.Tan, J.Ehrhart, J.Smith, AJ.Sanberg, CD.Sanberg, PR.Anderson, J.Bickford, PC. Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study. Medical science monitor : international medical journal of experimental and clinical research. 16(1) : BR1-5, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20037479
  • Shytle, RD.Bickford, PC.Rezai-zadeh, K.Hou, L.Zeng, J.Tan, J.Sanberg, PR.Sanberg, CD.Roschek, B.Fink, RC.Alberte, RS. Optimized turmeric extracts have potent anti-amyloidogenic effects. Current Alzheimer research. 6(6) : 564-71, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19715544
  • Bachstetter, AD.Morganti, JM.Jernberg, J.Schlunk, A.Mitchell, SH.Brewster, KW.Hudson, CE.Cole, MJ.Harrison, JK.Bickford, PC.Gemma, C. Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiology of aging. , 2009. http://www.ncbi.nlm.nih.gov/pubmed/20018408
  • Berglöf, E.Small, BJ.Bickford, PC.Strömberg, I. Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. The Journal of comparative neurology. 515(1) : 72-82, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19399894
  • Morgan, D.Landreth, G.Bickford, P. The promise and perils of an Alzheimer disease vaccine: a video debate. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 4(1) : 1-3, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18946741
  • Morgan, D.Munireddy, S.Alamed, J.DeLeon, J.Diamond, DM.Bickford, P.Hutton, M.Lewis, J.McGowan, E.Gordon, MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's disease : JAD. 15(4) : 605-14, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19096159
  • Bachstetter, AD.Pabon, MM.Cole, MJ.Hudson, CE.Sanberg, PR.Willing, AE.Bickford, PC.Gemma, C. Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC neuroscience. 9: 22, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18275610
  • Rezai-Zadeh, K.Ehrhart, J.Bai, Y.Sanberg, PR.Bickford, P.Tan, J.Shytle, RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. Journal of neuroinflammation. 5: 41, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18817573
  • Zhu, Y.Bickford, PC.Sanberg, P.Giunta, B.Tan, J. Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation research. 11(5) : 891-901, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18789000
  • Coultrap, SJ.Bickford, PC.Browning, MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age (Dordrecht, Netherlands). 30(4) : 263-72, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19424850
  • Zhu, Y.Hou, H.Nikolic, WV.Ehrhart, J.Rrapo, E.Bickford, P.Giunta, B.Tan, J. CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PloS one. 3(5) : e2135, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18478117
  • Willis, LM.Small, BJ.Bickford, PC.Umphlet, CD.Moore, AB.Granholm, AC. Dietary blueberry supplementation affects growth but not vascularization of neural transplants. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28(6) : 1150-64, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18285804
  • Yasuhara, T.Hara, K.Maki, M.Masuda, T.Sanberg, CD.Sanberg, PR.Bickford, PC.Borlongan, CV. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation research. 11(1) : 201-14, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18260778
  • Garbuzova-Davis, S.Sanberg, CD.Kuzmin-Nichols, N.Willing, AE.Gemma, C.Bickford, PC.Miller, C.Rossi, R.Sanberg, PR. Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PloS one. 3(6) : e2494, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18575617