JunTan

Jun Tan, PHD MD

Endowed Chair, College Of Medicine Psychiatry And Behavioral Neurosciences

Professor, College Of Medicine Molecular Medicine

Professor, College Of Medicine Molecular Pharmacology & Physiology

Professor, College Of Medicine Neurosurgery

Professor, College Of Medicine Psychiatry And Behavioral Neurosciences

Professor, Department of Psychiatry, USF

The Silver Endowed Chair in Developmental Neurobiology, Department of Psychiatry & Behavioral Medicine, USF

Contact Info 3515 E Fletcher Ave
Tampa, FL 33613

Academic Email: jtan@health.usf.edu

Academic Phone: (813) 974-9326

View My C.V.

Education

  • PHD, Third Military Medical University, 1992
  • MS, Human Genetics, Fudan University, 1989
  • MD, Third Military Medical University, 1983

Academic Philosophy

"Once Scientist, Always Scientist. If you believe then you will achieve."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Cancer Biology
  • Cellular and Molecular Biology
  • Metabolic Regulation and Disorders
  • Neurodegenerative Disease
  • Neuroscience

Research Interests

  • The current focus of the laboratory is to investigate novel treatments for Alzheimer's disease and abnormal brain development and its related mental disorders including autism. These studies include:
  • 1. Identifying several natural compounds which promote amyloid precursor protein (APP) α-secretase cleavage or inhibit amyloidogenic cleavage in vitro as well as in animal models.
  • 2. Analyzing the role of microglial activation in modulation of amyloid/tau pathology in experimental animal models following administration of human umbilical cord blood cells.
  • 3. Elucidating the role of molecular mechanisms in the creation of neurons and their growth in the developing fetus.

Memberships

  • The American Society for Neural Therapy and Repair (Member, 2003 - Present)
  • Florida Alzheimer Center Membership Program (Member, 2003 - Present)
  • The American Association of Immunologists (Member, 1999 - Present)

Recent Publications

  • Wang, C.Li, M.Sawmiller, D.Fan, Y.Ma, Y.Tan, J.Ren, Y.Li, S. Chronic mild stress-induced changes of risk assessment behaviors in mice are prevented by chronic treatment with fluoxetine but not diazepam. Pharmacology, biochemistry, and behavior. 116: 116-28, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24291732
  • Sawmiller D, Li S, Shahaduzzaman M, Smith AJ, Obregon D, Giunta B, Borlongan CV, Sanberg PR, Tan J. Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury. Int J Mol Sci. 1(15) : 895-904, 2014.
  • Obregon, DF.Zhu, Y.Bailey, AR.Portis, SM.Hou, H.Zeng, J.Stock, SL.Murphy, TK.Bengtson, MA.Tan, J. Potential Autoepitope within the Extracellular Region of Contactin-Associated Protein-like 2 in Mice. British journal of medicine and medical research. 4(1) : 416-432, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24466509
  • Small, B.Rawson, K.Martin, C.Eisel, S.Sanberg, CD.McEvoy, C.Sanberg, P.Shytle, RD.Tan, J.Bickford, PC. Nutraceutical Intervention Improves Older Adults' Cognitive Functioning. Rejuvenation research. , 2013. http://www.ncbi.nlm.nih.gov/pubmed/24134194
  • Zhang, SQ.Sawmiller, D.Li, S.Rezai-Zadeh, K.Hou, H.Zhou, S.Shytle, D.Giunta, B.Fernandez, F.Mori, T.Tan, J. Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PloS one. 8(8) : e71913, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23977176
  • Bailey, AR.Hou, H.Song, M.Obregon, DF.Portis, S.Barger, S.Shytle, D.Stock, S.Mori, T.Sanberg, PG.Murphy, T.Tan, J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPα. Glia. 61(9) : 1556-69, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23840007
  • Smith, AJ.Kavuru, P.Arora, KK.Kesani, S.Tan, J.Zaworotko, MJ.Shytle, RD. Crystal engineering of green tea epigallocatechin-3-gallate (EGCg) cocrystals and pharmacokinetic modulation in rats. Molecular pharmaceutics. 10(8) : 2948-61, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23730870
  • Hernandez-Ontiveros, DG.Tajiri, N.Acosta, S.Giunta, B.Tan, J.Borlongan, CV. Microglia activation as a biomarker for traumatic brain injury. Frontiers in neurology. 4: 30, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23531681
  • Darlington, D.Deng, J.Giunta, B.Hou, H.Sanberg, CD.Kuzmin-Nichols, N.Zhou, HD.Mori, T.Ehrhart, J.Sanberg, PR.Tan, J. Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice. Stem cells and development. 22(3) : 412-21, 2013. http://www.ncbi.nlm.nih.gov/pubmed/22816379
  • Smith, AJ.Kim, SH.Duggirala, NK.Jin, J.Wojtas, L.Ehrhart, J.Giunta, B.Tan, J.Zaworotko, MJ.Shytle, RD. Improving lithium therapeutics by crystal engineering of novel ionic cocrystals. Molecular pharmaceutics. 10(12) : 4728-38, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24191685
  • Zhang SQ, Sawmiller D, Li S, Rezai-Zadeh K, Hou H, Zhou S, Shytle D, Giunta B, Fernandez F, Mori T, Tan J. Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PLoS One.. 8(15) : e71913, 2013.
  • Bailey AR, Hou H, Song M, Obregon DF, Portis S, Barger S, Shytle D, Stock S, Mori T, Sanberg PG, Murphy T, Tan J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPα. Glia. 9(61) , 2013.
  • Habib, A.Deng, J.Hou, H.Zou, Q.Giunta, B.Wang, YJ.Obregon, D.Sawmiller, D.Li, S.Mori, T.Tan, J. Mycoplasma hyorhinis markedly degrades β-amyloid peptides in vitro and ex vivo: a novel biological approach for treating Alzheimer's disease? American journal of translational research. 5(6) : 634-42, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24093060
  • Portis, S.Giunta, B.Obregon, D.Tan, J. The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome. International journal of physiology, pathophysiology and pharmacology. 4(3) : 140-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23071871
  • Kaneko, Y.Tajiri, N.Yu, S.Hayashi, T.Stahl, CE.Bae, E.Mestre, H.Franzese, N.Rodrigues, A.Rodrigues, MC.Ishikawa, H.Shinozuka, K.Hethorn, W.Weinbren, N.Glover, LE.Tan, J.Achyuta, AH.van Loveren, H.Sanberg, PR.Shivsankar, S.Borlongan, CV. Nestin overexpression precedes caspase-3 upregulation in rats exposed to controlled cortical impact traumatic brain injury. Cell medicine. 4(2) : 55-63, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23101029
  • Obregon, D.Parker-Athill, EC.Tan, J.Murphy, T. Psychotropic effects of antimicrobials and immune modulation by psychotropics: implications for neuroimmune disorders. Neuropsychiatry. 2(4) : 331-343, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23148142
  • Giunta, B.Deng, J.Jin, J.Sadic, E.Rum, S.Zhou, H.Sanberg, P.Tan, J. EVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE. Technology and innovation. 14(1) : 39-48, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22997546
  • Shytle, RD.Tan, J.Bickford, PC.Rezai-Zadeh, K.Hou, L.Zeng, J.Sanberg, PR.Sanberg, CD.Alberte, RS.Fink, RC.Roschek, B. Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice. Current Alzheimer research. 9(4) : 500-6, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21875408
  • Bailey, AR.Hou, H.Obregon, DF.Tian, J.Zhu, Y.Zou, Q.Nikolic, WV.Bengtson, M.Mori, T.Murphy, T.Tan, J. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-α: implications for autism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(3) : 1040-51, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22085641
  • Deng, J.Hou, H.Giunta, B.Mori, T.Wang, YJ.Fernandez, F.Weggen, S.Araki, W.Obregon, D.Tan, J. Autoreactive-Aβ antibodies promote APP β-secretase processing. Journal of neurochemistry. 120(5) : 732-40, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22188568
  • Obregon, D.Hou, H.Deng, J.Giunta, B.Tian, J.Darlington, D.Shahaduzzaman, M.Zhu, Y.Mori, T.Mattson, MP.Tan, J. Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation. Nature communications. 3: 777, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22491325
  • Dragicevic, N.Smith, A.Lin, X.Yuan, F.Copes, N.Delic, V.Tan, J.Cao, C.Shytle, RD.Bradshaw, PC. Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunction. Journal of Alzheimer's disease : JAD. 26(3) : 507-21, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21694462
  • Giunta, B.Ehrhart, J.Obregon, DF.Lam, L.Le, L.Jin, J.Fernandez, F.Tan, J.Shytle, RD. Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders. Molecular brain. 4(1) : 23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21649911
  • Dragicevic, N.Copes, N.O'Neal-Moffitt, G.Jin, J.Buzzeo, R.Mamcarz, M.Tan, J.Cao, C.Olcese, JM.Arendash, GW.Bradshaw, PC. Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling. Journal of pineal research. 51(1) : 75-86, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21355879
  • Salemi, J.Obregon, DF.Cobb, A.Reed, S.Sadic, E.Jin, J.Fernandez, F.Tan, J.Giunta, B. Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD). Molecular neurodegeneration. 6(1) : 3, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21223591
  • Sanberg, PR.Eve, DJ.Willing, AE.Garbuzova-Davis, S.Tan, J.Sanberg, CD.Allickson, JG.Cruz, LE.Borlongan, CV. The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells. Cell transplantation. 20(1) : 85-94, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20887684
  • Zhu, Y.Obregon, D.Hou, H.Giunta, B.Ehrhart, J.Fernandez, F.Mori, T.Nikolic, W.Zhao, Y.Morgan, D.Town, T.Tan, J. Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. Journal of cellular and molecular medicine. 15(2) : 327-38, 2011. http://www.ncbi.nlm.nih.gov/pubmed/19900216
  • Zhu, Y.Hou, H.Rezai-Zadeh, K.Giunta, B.Ruscin, A.Gemma, C.Jin, J.Dragicevic, N.Bradshaw, P.Rasool, S.Glabe, CG.Ehrhart, J.Bickford, P.Mori, T.Obregon, D.Town, T.Tan, J. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(4) : 1355-65, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21273420
  • Mori, T.Koyama, N.Arendash, GW.Horikoshi-Sakuraba, Y.Tan, J.Town, T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. 58(3) : 300-14, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19705461
  • Parker-Athill, EC.Tan, J. Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway. Neuro-Signals. , 2010. http://www.ncbi.nlm.nih.gov/pubmed/20924155
  • Parker-Athill, E.Luo, D.Bailey, A.Giunta, B.Tian, J.Shytle, RD.Murphy, T.Legradi, G.Tan, J. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. Journal of neuroimmunology. 217(1-2) : 20-7, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19766327
  • Rrapo, E.Zhu, Y.Tian, J.Hou, H.Smith, A.Fernandez, F.Tan, J.Giunta, B. Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice. American journal of translational research. 1(1) : 72-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19966940
  • Rezai-Zadeh, K.Douglas Shytle, R.Bai, Y.Tian, J.Hou, H.Mori, T.Zeng, J.Obregon, D.Town, T.Tan, J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of cellular and molecular medicine. 13(3) : 574-88, 2009. http://www.ncbi.nlm.nih.gov/pubmed/18410522
  • Bailey, AR.Giunta, BN.Obregon, D.Nikolic, WV.Tian, J.Sanberg, CD.Sutton, DT.Tan, J. Peripheral biomarkers in Autism: secreted amyloid precursor protein-alpha as a probable key player in early diagnosis. International journal of clinical and experimental medicine. 1(4) : 338-44, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19079679
  • Giunta, B.Fernandez, F.Nikolic, WV.Obregon, D.Rrapo, E.Town, T.Tan, J. Inflammaging as a prodrome to Alzheimer's disease. Journal of neuroinflammation. 5: 51, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19014446
  • Rezai-Zadeh, K.Ehrhart, J.Bai, Y.Sanberg, PR.Bickford, P.Tan, J.Shytle, RD. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. Journal of neuroinflammation. 5: 41, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18817573
  • Zhu, Y.Bickford, PC.Sanberg, P.Giunta, B.Tan, J. Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation research. 11(5) : 891-901, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18789000
  • Giunta, B.Zhou, Y.Hou, H.Rrapo, E.Fernandez, F.Tan, J. HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide. International journal of clinical and experimental pathology. 1(3) : 260-75, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18784813
  • Town, T.Laouar, Y.Pittenger, C.Mori, T.Szekely, CA.Tan, J.Duman, RS.Flavell, RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature medicine. 14(6) : 681-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18516051
  • Wang, Y.Li, M.Song, M.Xu, X.Xiong, J.Yang, X.Tan, J.Bai, Y. Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro. Cellular immunology. 251(2) : 86-92, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18485335
  • Zhu, Y.Hou, H.Nikolic, WV.Ehrhart, J.Rrapo, E.Bickford, P.Giunta, B.Tan, J. CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PloS one. 3(5) : e2135, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18478117
  • Rezai-Zadeh, K.Arendash, GW.Hou, H.Fernandez, F.Jensen, M.Runfeldt, M.Shytle, RD.Tan, J. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain research. 1214: 177-87, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18457818
  • Mori, T.Tan, J.Arendash, GW.Koyama, N.Nojima, Y.Town, T. Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. Stroke; a journal of cerebral circulation. 39(7) : 2114-21, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18451356
  • Nikolic, WV.Hou, H.Town, T.Zhu, Y.Giunta, B.Sanberg, CD.Zeng, J.Luo, D.Ehrhart, J.Mori, T.Sanberg, PR.Tan, J. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem cells and development. 17(3) : 423-39, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18366296
  • Hou, H.Obregon, D.Lou, D.Ehrhart, J.Fernandez, F.Silver, A.Tan, J. Modulation of neuronal differentiation by CD40 isoforms. Biochemical and biophysical research communications. 369(2) : 641-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18312851
  • Nikolic, WV.Bai, Y.Obregon, D.Hou, H.Mori, T.Zeng, J.Ehrhart, J.Shytle, RD.Giunta, B.Morgan, D.Town, T.Tan, J. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proceedings of the National Academy of Sciences of the United States of America. 104(7) : 2507-12, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17264212
  • Shytle, RD.Ehrhart, J.Tan, J.Vila, J.Cole, M.Sanberg, CD.Sanberg, PR.Bickford, PC. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation research. 10(2) : 173-8, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17518694
  • Cracchiolo, JR.Mori, T.Nazian, SJ.Tan, J.Potter, H.Arendash, GW. Enhanced cognitive activity-over and above social or physical activity-is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity. 88(3) : 277-294, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17714960
  • Obregon, DF.Rezai-Zadeh, K.Bai, Y.Sun, N.Hou, H.Ehrhart, J.Zeng, J.Mori, T.Arendash, GW.Shytle, D.Town, T.Tan, J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. The Journal of biological chemistry. 281(24) : 16419-27, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16624814
  • Giunta, B.Obregon, D.Hou, H.Zeng, J.Sun, N.Nikolic, V.Ehrhart, J.Shytle, D.Fernandez, F.Tan, J. EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain research. 1123(1) : 216-25, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17078933
  • Bickford, PC.Tan, J.Shytle, RD.Sanberg, CD.El-Badri, N.Sanberg, PR. Nutraceuticals synergistically promote proliferation of human stem cells. Stem cells and development. 15(1) : 118-23, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16522169
  • Town, T.Jeng, D.Alexopoulou, L.Tan, J.Flavell, RA. Microglia recognize double-stranded RNA via TLR3. Journal of immunology (Baltimore, Md. : 1950). 176(6) : 3804-12, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16517751
  • Morgan, D.Gordon, MN.Tan, J.Wilcock, D.Rojiani, AM. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. Journal of neuropathology and experimental neurology. 64(9) : 743-53, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16141783
  • Rezai-Zadeh, K.Shytle, D.Sun, N.Mori, T.Hou, H.Jeanniton, D.Ehrhart, J.Townsend, K.Zeng, J.Morgan, D.Hardy, J.Town, T.Tan, J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(38) : 8807-14, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16177050
  • Town, T.Tan, J.Flavell, RA.Mullan, M. T-cells in Alzheimer's disease. Neuromolecular medicine. 7(3) : 255-64, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16247185
  • Town, T.Nikolic, V.Tan, J. The microglial "activation" continuum: from innate to adaptive responses. Journal of neuroinflammation. 2: 24, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16259628
  • Ehrhart, J.Obregon, D.Mori, T.Hou, H.Sun, N.Bai, Y.Klein, T.Fernandez, F.Tan, J.Shytle, RD. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. Journal of neuroinflammation. 2: 29, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16343349
  • Mori, T.Town, T.Tan, J.Tateishi, N.Asano, T. Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(6) : 748-62, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15689951
  • Townsend, KP.Town, T.Mori, T.Lue, LF.Shytle, D.Sanberg, PR.Morgan, D.Fernandez, F.Flavell, RA.Tan, J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European journal of immunology. 35(3) : 901-10, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15688347
  • Townsend, KP.Shytle, DR.Bai, Y.San, N.Zeng, J.Freeman, M.Mori, T.Fernandez, F.Morgan, D.Sanberg, P.Tan, J. Lovastatin modulation of microglial activation via suppression of functional CD40 expression. Journal of neuroscience research. 78(2) : 167-76, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15378516
  • Todd Roach, J.Volmar, CH.Dwivedi, S.Town, T.Crescentini, R.Crawford, F.Tan, J.Mullan, M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain research. 1015(1-2) : 161-8, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15223380
  • Mori, T.Town, T.Kobayashi, M.Tan, J.Fujita, SC.Asano, T. Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 24(6) : 646-56, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15181372
  • Townsend, KP.Vendrame, M.Ehrhart, J.Faza, B.Zeng, J.Town, T.Tan, J. CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice. Neuroscience letters. 362(1) : 26-30, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15147773
  • Mott, RT.Ait-Ghezala, G.Town, T.Mori, T.Vendrame, M.Zeng, J.Ehrhart, J.Mullan, M.Tan, J. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia. 46(4) : 369-79, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15095367
  • Shytle, RD.Mori, T.Townsend, K.Vendrame, M.Sun, N.Zeng, J.Ehrhart, J.Silver, AA.Sanberg, PR.Tan, J. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. Journal of neurochemistry. 89(2) : 337-43, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15056277
  • Tan, J.Town, T.Abdullah, L.Wu, Y.Placzek, A.Small, B.Kroeger, J.Crawford, F.Richards, D.Mullan, M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. Journal of neuroimmunology. 132(1-2) : 164-72, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12417447
  • Town, T.Vendrame, M.Patel, A.Poetter, D.DelleDonne, A.Mori, T.Smeed, R.Crawford, F.Klein, T.Tan, J.Mullan, M. Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). Journal of neuroimmunology. 132(1-2) : 49-59, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12417433
  • Tan, J.Town, T.Crawford, F.Mori, T.DelleDonne, A.Crescentini, R.Obregon, D.Flavell, RA.Mullan, MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature neuroscience. 5(12) : 1288-93, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12402041
  • Tan, J.Town, T.Mullan, M. CD40-CD40L interaction in Alzheimer's disease. Current opinion in pharmacology. 2(4) : 445-51, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12127879
  • Town, T.Zolton, J.Shaffner, R.Schnell, B.Crescentini, R.Wu, Y.Zeng, J.DelleDonne, A.Obregon, D.Tan, J.Mullan, M. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. Journal of neuroscience research. 69(3) : 362-72, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12125077
  • Tan, J.Town, T.Mori, T.Obregon, D.Wu, Y.DelleDonne, A.Rojiani, A.Crawford, F.Flavell, RA.Mullan, M. CD40 is expressed and functional on neuronal cells. The EMBO journal. 21(4) : 643-52, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11847112

Awards/Honors

  • Flavonoid-diosmin modulation of A and tau pathologies through GSK-3 signaling pathway (NIH/NCCAM - 2014)
  • Octyl gallate (OG) and Promotion of non-amyloidogenic processing of APP (Merit Award VA - 2013)