JahanshahAmin

Jahanshah Amin, Ph.D.

Associate Professor, College Of Medicine Molecular Pharmacology & Physiology

College Of Medicine Molecular Pharmacology & Physiology

Associate Professor, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 8
Tampa, FL 33612

Academic Email: jamin@health.usf.edu

Academic Phone: (813) 974-4577

Education

  • PHD, Biochemistry/Molecular Biology, Univ Of Miami, 1990
  • B.S., Biochemistry. Minor: Math, Chemistry, University of Miami, 1983

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Research Interests

  • The cerebellum has a primary function in motor control and learning, and may also participate in higher cognitive functions. There are two sets of inputs to the cerebellum: the climbing fibers and the mossy fibers. Information transmitted from mossy fibers to granule cells is modulated and recoded into action potentials. An important step in this recoding phenomenon is tuning the granule neuron excitability, which is set by the tonic activity of alpha6beta2/3delta GABAa receptor subtypes. This signal is then synaptically transmitted to Purkinje cells for output from the cerebellum. Cerebellar granule cells are the most abundant neurons in the CNS and are central to the control of information flow through the cerebellar cortex, where they may play a fundamental role in motor learning activity. The first aim of the laboratory is to elucidate the role of alpha6beta2/3delta GABAa receptor in the tuning the signal transmission through cerebellum and how this might contribute to motor learning activity.
  • The second goal of the laboratory is to find how structurally diverse drugs, known as general anesthetics, modulate the function of ligand-gated ion channels such as GABAa receptors.

Recent Publications

  • Hevers W, Hadley SH, L├╝ddens H and Amin J. Ketamine but not PCP selectively modulates cerebellar GABAA receptors containing a6 and d subunits J. Neuroscience. 28(20) : 5383-5393, 2008.
  • Hadley, SH.Amin, J. Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. The Journal of physiology. 581(Pt 3) : 1001-18, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17395622
  • Morris, KD.Amin, J. Insight into the mechanism of action of neuroactive steroids. Molecular pharmacology. 66(1) : 56-69, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15213296
  • Severance, EG.Zhang, H.Cruz, Y.Pakhlevaniants, S.Hadley, SH.Amin, J.Wecker, L.Reed, C.Cuevas, J. The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. Molecular pharmacology. 66(3) : 420-9, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15322233
  • Walters, RJ.Hadley, SH.Morris, KD.Amin, J. Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms. Nature neuroscience. 3(12) : 1274-81, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11100148
  • Amin, J. A single hydrophobic residue confers barbiturate sensitivity to gamma-aminobutyric acid type C receptor. Molecular pharmacology. 55(3) : 411-23, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10051524
  • Morris, KD.Moorefield, CN.Amin, J. Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids. Molecular pharmacology. 56(4) : 752-9, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10496958
  • Amin, J.Brooks-Kayal, A.Weiss, DS. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. Molecular pharmacology. 51(5) : 833-41, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9145922
  • Amin, J.Weiss, DS. Insights into the activation mechanism of rho1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proceedings. Biological sciences / The Royal Society. 263(1368) : 273-82, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8920250
  • Hsu, YN.Amin, J.Weiss, DS.Wecker, L. Sustained nicotine exposure differentially affects alpha 3 beta 2 and alpha 4 beta 2 neuronal nicotinic receptors expressed in Xenopus oocytes. Journal of neurochemistry. 66(2) : 667-75, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8592138
  • Chang, Y.Amin, J.Weiss, DS. Zinc is a mixed antagonist of homomeric rho 1 gamma-aminobutyric acid-activated channels. Molecular pharmacology. 47(3) : 595-602, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7535381
  • Amin, J.Weiss, DS. Homomeric rho 1 GABA channels: activation properties and domains. Receptors & channels. 2(3) : 227-36, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7874449
  • Amin, J.Dickerson, IM.Weiss, DS. The agonist binding site of the gamma-aminobutyric acid type A channel is not formed by the extracellular cysteine loop. Molecular pharmacology. 45(2) : 317-23, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7509443
  • Amin, J.Fernandez, M.Ananthan, J.Lis, JT.Voellmy, R. Cooperative binding of heat shock transcription factor to the Hsp70 promoter in vivo and in vitro. The Journal of biological chemistry. 269(7) : 4804-11, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8106450
  • de Forteza, R.Smith, CU.Amin, J.McKenzie, JM.Zakarija, M. Visualization of the thyrotropin receptor on the cell surface by potent autoantibodies. The Journal of clinical endocrinology and metabolism. 78(5) : 1271-3, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7909819
  • Amin, J.Weiss, DS. GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature. 366(6455) : 565-9, 1993. http://www.ncbi.nlm.nih.gov/pubmed/7504783
  • Luo, Y.Amin, J.Voellmy, R. Ecdysterone receptor is a sequence-specific transcription factor involved in the developmental regulation of heat shock genes. Molecular and cellular biology. 11(7) : 3660-75, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1904544
  • Amin, J.Mestril, R.Voellmy, R. Genes for Drosophila small heat shock proteins are regulated differently by ecdysterone. Molecular and cellular biology. 11(12) : 5937-44, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1944271
  • Brown, ME.Amin, J.Schiller, P.Voellmy, R.Scott, WA. Determinants for the DNase I-hypersensitive chromatin structure 5' to a human HSP70 gene. Journal of molecular biology. 203(1) : 107-17, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3184184
  • Schiller, P.Amin, J.Ananthan, J.Brown, ME.Scott, WA.Voellmy, R. Cis-acting elements involved in the regulated expression of a human HSP70 gene. Journal of molecular biology. 203(1) : 97-105, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3184191
  • Bai, G.Zhang, ZJ.Amin, J.Deans-Zirattu, SA.Lee, EY. Molecular cloning of a cDNA for the catalytic subunit of rabbit muscle phosphorylase phosphatase. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2(14) : 3010-6, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2846396
  • Amin, J.Ananthan, J.Voellmy, R. Key features of heat shock regulatory elements. Molecular and cellular biology. 8(9) : 3761-9, 1988. http://www.ncbi.nlm.nih.gov/pubmed/3146692

Positions Held

  • Assistant Professor (Department of Pharmacology and Therapeutics, College of Medicine, University of South Florida 1995 - 2001)
  • Post Doctoral Training (Department of Physiology and Biophysics, College of Medicine, University of South Florida 1992 - 1995)
  • Post Doctoral Training (Division of Endocrinology, School of Medicine, University of Miami 1990 - 1992)
  • Post Doctoral Training (Department of Biochemistry and Molecular Biology, School of Medicine, University of Miami 1989 - 1990)

Awards/Honors

  • Sophomore Class Outstanding Instructor Award (College of Medicine, University of South Florida - 2006)
  • Fellowship awardfor Postdoctoral research (NIH - 1991)
  • Elected Member (American Institute of Chemists - 1983)