LauraPendleton

Laura Pendleton, MS

Instructor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B Downs Blvd
MDC 7
Tampa, FL 33612

Academic Email: lpendlet@health.usf.edu

Academic Phone: (813) 974-6631

View My C.V.

Education

  • MS, Medical Sciences/Biochemistry, University Of South Florida, 1992

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology

Research Interests

  • Current research projects focus on the process of palmitoylation, a post-translational lipid modification that plays an important role in stability and trafficking of several important proteins such as Ras, as well as other proteins responsible for a variety of human diseases.

Recent Publications

  • Haines, RJ.Corbin, KD.Pendleton, LC.Meininger, CJ.Eichler, DC. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function. Biochemical and biophysical research communications. 421(1) : 9-14, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22452988
  • Haines, RJ.Corbin, KD.Pendleton, LC.Eichler, DC. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. The Journal of biological chemistry. 287(31) : 26168-76, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22696221
  • Pilon-Thomas, S.Nelson, N.Vohra, N.Jerald, M.Pendleton, L.Szekeres, K.Ghansah, T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PloS one. 6(11) : e27729, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22132131
  • Haines, RJ.Pendleton, LC.Eichler, DC. Argininosuccinate synthase: at the center of arginine metabolism. International journal of biochemistry and molecular biology. 2(1) : 8-23, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21494411
  • Corbin, KD.Pendleton, LC.Solomonson, LP.Eichler, DC. Phosphorylation of argininosuccinate synthase by protein kinase A. Biochemical and biophysical research communications. 377(4) : 1042-6, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18948083
  • Goodwin, BL.Corbin, KD.Pendleton, LC.Levy, MM.Solomonson, LP.Eichler, DC. Troglitazone up-regulates vascular endothelial argininosuccinate synthase. Biochemical and biophysical research communications. 370(2) : 254-8, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18375203
  • Goodwin, BL.Pendleton, LC.Levy, MM.Solomonson, LP.Eichler, DC. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. American journal of physiology. Heart and circulatory physiology. 293(2) : H1115-21, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17496212
  • Pendleton, LC.Goodwin, BL.Solomonson, LP.Eichler, DC. Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame. The Journal of biological chemistry. 280(25) : 24252-60, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15851478
  • Ness, GC.Pendleton, LC.McCreery, MJ. Target size analysis by radiation inactivation: the use of free radical scavengers. Experimental biology and medicine (Maywood, N.J.). 230(7) : 455-63, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15985620
  • Solomonson, LP.Flam, BR.Pendleton, LC.Goodwin, BL.Eichler, DC. The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells. The Journal of experimental biology. 206(Pt 12) : 2083-7, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12756290
  • Pendleton, LC.Goodwin, BL.Flam, BR.Solomonson, LP.Eichler, DC. Endothelial argininosuccinate synthase mRNA 5'-untranslated region diversity. Infrastructure for tissue-specific expression. The Journal of biological chemistry. 277(28) : 25363-9, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11967259