PeterMedveczky

Peter Medveczky, MD

Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B. Downs Blvd.
MDC 7
Tampa, FL 33612

Academic Email: pmedvecz@health.usf.edu

Academic Phone: (813) 974-2372

View My C.V.

Education

  • MD, Medicine, Semmelweis Medical University, 1970

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease

Research Interests

  • We are virologists and molecular biologists interested in oncogenic and neurotropic herpesviruses. These large DNA viruses cause cancer and neurodegenerative diseases.
  • Project 1 involves experiments on the Kaposi's sarcoma Associated Herpesvirus (KSHV) related to latency and oncogenic transformation. In this context we also study the role of marijuanas major compound THC and its receptors in modulation of oncogenic herpesviruses. Project is funded by a 5 year NIH grant.

  • Project 2 is molecular biology of the viral interleukin-6 (vIL-6) of KSHV that is possibly involved in the oncogenic transformation process. Funding is pending.

  • Project 3 Identification novel oncogenic viruses in AIDS lymphomas (50% has no known etiology). Funding is pending.

  • Project 4 Human herpesvirus 6 (HHV-6) is implicated in the pathogenesis of multiple sclerosis (M.S.). Recent data show that variant HHV-6A infected marmosets develop an MS-like disease but variant B infected animals remain healthy suggesting that variant A virus encodes specific genes responsible for this phenotype. About 65 genes of the two variant genomes are highly homologous; however, about 15 genes show significant sequence divergence. Currently we are developing a system to identify genes of interest e.g. involved in neurotropism and M.S. Funded by a small grant and other grants are pending.

  • Project 5 HHV-6 is a unique human virus as we discovered that its genome integrates into telomeres of human chromosomes. We have identified families with integrated HHV-6 in chromosomes 17 and 18. These patients are diagnosed with various CNS conditions and show weakened immune responses.

Memberships

  • Clinical and Diagnostic Laboratory Immunology (Member Editorial Board, 2000 - Present)
  • NIH Immunological Sciences Immunity and Host Defense (Member, 2004 - 2006)
  • NIH Immunological Sciences Study Section Innate Immunity/Host Defense (Member, 2001 - 2003)

Recent Publications

  • Medveczky, MM.Sherwood, TA.Klein, TW.Friedman, H.Medveczky, PG. Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro. BMC medicine. 2: 34, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15369590
  • Meads, MB.Medveczky, PG. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. The Journal of biological chemistry. 279(50) : 51793-803, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15258150
  • Fej√©r, G.Medveczky, MM.Horvath, E.Lane, B.Chang, Y.Medveczky, PG. The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. The Journal of general virology. 84(Pt 6) : 1451-62, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12771414
  • Kjellen, P.Amdjadi, K.Lund, TC.Medveczky, PG.Sefton, BM. The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. Virology. 297(2) : 281-8, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12083826
  • Collins, CM.Medveczky, MM.Lund, T.Medveczky, PG. The terminal repeats and latency-associated nuclear antigen of herpesvirus saimiri are essential for episomal persistence of the viral genome. The Journal of general virology. 83(Pt 9) : 2269-78, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12185282
  • Collins, CM.Medveczky, PG. Genetic requirements for the episomal maintenance of oncogenic herpesvirus genomes. Advances in cancer research. 84: 155-74, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11883526
  • Hartley, DA.Amdjadi, K.Hurley, TR.Lund, TC.Medveczky, PG.Sefton, BM. Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions. Virology. 276(2) : 339-48, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11040125
  • Lund, TC.Coleman, C.Horvath, E.Sefton, BM.Jove, R.Medveczky, MM.Medveczky, PG. The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. Cellular signalling. 11(11) : 789-96, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10617281
  • Lund, TC.Prator, PC.Medveczky, MM.Medveczky, PG. The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. Journal of virology. 73(2) : 1689-94, 1999. http://www.ncbi.nlm.nih.gov/pubmed/9882381
  • Hartley, DA.Hurley, TR.Hardwick, JS.Lund, TC.Medveczky, PG.Sefton, BM. Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation. The Journal of biological chemistry. 274(29) : 20056-9, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10400611
  • Lund, TC.Medveczky, MM.Medveczky, PG. Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. Cellular immunology. 192(2) : 133-9, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10087181
  • Medveczky, MM.Horvath, E.Lund, T.Medveczky, PG. In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus. AIDS (London, England). 11(11) : 1327-32, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9302441
  • Lund, T.Medveczky, MM.Medveczky, PG. Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells. Journal of virology. 71(1) : 378-82, 1997. http://www.ncbi.nlm.nih.gov/pubmed/8985360
  • Lund, TC.Garcia, R.Medveczky, MM.Jove, R.Medveczky, PG. Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. Journal of virology. 71(9) : 6677-82, 1997. http://www.ncbi.nlm.nih.gov/pubmed/9261390
  • Kung, SH.Medveczky, PG. Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells. Journal of virology. 70(3) : 1738-44, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8627695
  • Lund, T.Medveczky, MM.Neame, PJ.Medveczky, PG. A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. Journal of virology. 70(1) : 600-6, 1996. http://www.ncbi.nlm.nih.gov/pubmed/8523578
  • Chou, CS.Medveczky, MM.Geck, P.Vercelli, D.Medveczky, PG. Expression of IL-2 and IL-4 in T lymphocytes transformed by herpesvirus saimiri. Virology. 208(2) : 418-26, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7747414
  • Lund, T.Medveczky, MM.Geck, P.Medveczky, PG. A herpesvirus saimiri protein required for interleukin-2 independence is associated with membranes of transformed T cells. Journal of virology. 69(7) : 4495-9, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7769710
  • Williams, L.Moscinski, LC.Medveczky, PG. Immunoglobulin germline mu transcripts in acute myelogenous leukemia cells vary in splicing pattern and are heterogeneous. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 9(12) : 2016-22, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8609711
  • Chou, CS.Geck, P.Medveczky, MM.Hernandez, OM.Medveczky, PG. Induction of a herpesvirus saimiri small RNA AU binding factor (AUBF70) activity and lymphokine mRNAs by T cell mitogens. Archives of virology. 140(3) : 415-35, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7733817
  • Whitaker, S.Geck, P.Medveczky, MM.Cus, J.Kung, SH.Lund, T.Medveczky, PG. A polycistronic transcript in transformed cells encodes the dihydrofolate reductase of herpesvirus saimiri. Virus genes. 10(2) : 163-72, 1995. http://www.ncbi.nlm.nih.gov/pubmed/8560776
  • Geck, P.Medveczky, MM.Chou, CS.Brown, A.Cus, J.Medveczky, PG. Herpesvirus saimiri small RNA and interleukin-4 mRNA AUUUA repeats compete for sequence-specific factors including a novel 70K protein. The Journal of general virology. 75 ( Pt 9): 2293-301, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8077927
  • Geck, P.Whitaker, SA.Medveczky, MM.Last, TJ.Medveczky, PG. Small RNA expression from the oncogenic region of a highly oncogenic strain of herpesvirus saimiri. Virus genes. 8(1) : 25-34, 1994. http://www.ncbi.nlm.nih.gov/pubmed/8209420
  • Medveczky, MM.Geck, P.Sullivan, JL.Serbousek, D.Djeu, JY.Medveczky, PG. IL-2 independent growth and cytotoxicity of herpesvirus saimiri-infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology. 196(2) : 402-12, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8396794
  • Medveczky, MM.Geck, P.Vassallo, R.Medveczky, PG. Expression of the collagen-like putative oncoprotein of Herpesvirus saimiri in transformed T cells. Virus genes. 7(4) : 349-65, 1993. http://www.ncbi.nlm.nih.gov/pubmed/8122395
  • Medveczky, PG. Western blotting and polymerase chain reaction for diagnosis of HIV infection. The Journal of the Florida Medical Association. 79(1) : 47-50, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1548458
  • Geck, P.Whitaker, SA.Medveczky, MM.Medveczky, PG. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. Journal of virology. 65(12) : 7084, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1658399
  • Sairenji, T.Bertoni, G.Medveczky, MM.Medveczky, PG.Humphreys, RE. Inhibition of Epstein-Barr virus production in P3HR-1 cells by Epstein-Barr virus-seropositive human serum. Intervirology. 32(1) : 37-51, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1849877
  • Geck, P.Whitaker, SA.Medveczky, MM.Medveczky, PG. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. Journal of virology. 64(7) : 3509-15, 1990. http://www.ncbi.nlm.nih.gov/pubmed/2161952
  • Medveczky, MM.Geck, P.Clarke, C.Byrnes, J.Sullivan, JL.Medveczky, PG. Arrangement of repetitive sequences in the genome of herpesvirus Sylvilagus. Journal of virology. 63(2) : 1010-4, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2911114
  • Medveczky, MM.Szomolanyi, E.Hesselton, R.DeGrand, D.Geck, P.Medveczky, PG. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits. Journal of virology. 63(9) : 3601-11, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2547988
  • Medveczky, PG.Medveczky, MM. Expression of interleukin 2 receptors in T cells transformed by strains of Herpesvirus saimiri representing three DNA subgroups. Intervirology. 30(4) : 213-26, 1989. http://www.ncbi.nlm.nih.gov/pubmed/2550388
  • Sairenji, T.Bertoni, G.Medveczky, MM.Medveczky, PG.Nguyen, QV.Humphreys, RE. Inhibition of Epstein-Barr virus (EBV) release from P3HR-1 and B95-8 cell lines by monoclonal antibodies to EBV membrane antigen gp350/220. Journal of virology. 62(8) : 2614-21, 1988. http://www.ncbi.nlm.nih.gov/pubmed/2839689

Positions Held

  • Associate Professor (Department of Microbiology and Immunology, University of South Florida 1990 - 2006)
  • Assistant Professor (Department of Pharmacology and Molecular Genetics and Microbiology, University of Massachusetts Medical School 1982 - 1990)
  • Assistant, then Associate Professor (Dept. of Microbiology, Semmelweis Medical University 1973 - 1982)