BoskoStojanovski

Bosko Stojanovski

Graduate Research Assistant, College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B. Downs Blvd
MDC07
Tampa, FL 33612

Academic Email: bstojano@health.usf.edu

Education

  • B.S., Microbiology, Universtiy of South Florida, 2007

Research Interests

  • Research in our lab is aimed at studying the enzymological aspects of heme biosynthesis, particularly the initial enzyme of the pathway, 5-aminolevulinate synthase (ALAS), and the final enzyme, ferrochelatase. The main aim of my project is understanding how specific structural region of ALAS affect the enzymatic mechanism, kinetics, and conformational dynamics. Another area of interest is the characterization of the folding pathway of ALAS to its native state, as well as understanding the biochemical and biophysical properties of any stable, partially folded intermediates.

Recent Publications

  • Stojanovski, B.M., Breydo, L., Hunter, G.A., Uversky, V.N., and Ferreira, G.C. Catalytically active alkaline molten globular enzyme: Effect of pH and temperature on the structural integrity of 5-aminolevulinate synthase. Biochimica et biophysica acta. , 2014. http://www.ncbi.nlm.nih.gov/pubmed/25240868
  • Stojanovski, B.M., Hunter, G.A., Jahn, M., Jahn, D., and Ferreira, G.C. Unstable Reaction Intermediates and Hysteresis during the Catalytic Cycle of 5-Aminolevulinate Synthase: IMPLICATIONS FROM USING PSEUDO AND ALTERNATE SUBSTRATES AND A PROMISCUOUS ENZYME VARIANT. The Journal of biological chemistry. 289(33) : 22915-25, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24920668
  • Fratz, E. J., Stojanovski, B. M., and Ferreira, G. C. Toward Heme: 5-Aminolevulinate Synthase and Initiation of Porphyrin Synthesis The handbook of porphyrin science. 26: 1-78, 2013.