Graduate Research Assistant, College Of Medicine Molecular Medicine
4001 East Fletcher Avenue
Tampa, FL 33613
Academic Email: email@example.com
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- MS, Medical Science, University of South Florida, 2014
- MS, Biotechnology, University of South Florida, 2010
- BS, Biomedical Sciences, University of South Florida, 2008
Interdisciplinary and Emerging Signature Programs
- Cellular and Molecular Biology
- Neurodegenerative Disease
- Our lab studies the pathogenesis of Alzheimer's disease (AD). Specifically, we are interested in the molecular mechanisms that lead to the aberrant cell cycle that is observed in the AD brain. We have found that the amyloid precursor protein (APP), a central protein in AD, is modified and pathogenically processed in a cell-cycle specific manner. Furthermore, we have found that APP induces expression of proteins such as ras and gamma-synuclein, which are involved in cellular proliferation. The aim of my research is to elucidate the mechanisms by which APP induces the expression of these proliferation-associated proteins and determine how it leads to neurodegeneration and cognitive decline.
- Fiorelli, T.Kirouac, L.Padmanabhan, J. Altered processing of amyloid precursor protein in cells undergoing apoptosis. PloS one. 8(2) : e57979, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23469123
- Chaput, D.Kirouac, LH.Bell-Temin, H.Stevens, SM.Padmanabhan, J. SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cells. Electrophoresis. 33(24) : 3728-37, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23161580
- Judge, M.Hornbeck, L.Potter, H.Padmanabhan, J. Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes. Molecular neurodegeneration. 6: 80, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22112898