TomarGhansah

Tomar Ghansah, Ph.D.

Assistant Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B. Downs Blvd
MDC07
Tampa, FL 33612

Academic Email: tghansah@health.usf.edu

Academic Phone: (813) 974-1825

View My C.V.

Education

  • PHD, Microbiolgy, Meharry Medical College, 1999

Interdisciplinary and Emerging Signature Programs

  • Cancer Biology

Research Interests

  • My specific research area is Tumor Immunology with an emphasis on Signal Transduction. Pancreatic cancer is one of the most aggressive and lethal cancers in humans. Current therapy modalities are less effective in treating solid tumors partly due to immunosuppression associated with the expansion of regulatory Myeloid Derived Suppressor Cells (MDSC) and T Cells (Tregs). Currently, in my lab, we have several pancreatic cancer mouse models that we use to investigate how the host immune system responds to tumors, as well as the effects of a variety of immunomodulatory drugs on restoring immune homeostasis, thus enhancing anti-tumor responses in vivo and in vitro.

Recent Publications

  • Ghansah, TJ.Ager, EC.Freeman-Junior, P.Villalta, F.Lima, MF. Epidermal growth factor binds to a receptor on Trypanosoma cruzi amastigotes inducing signal transduction events and cell proliferation. The Journal of eukaryotic microbiology. 49(5) : 383-90http://www.ncbi.nlm.nih.gov/pubmed/12425525
  • Nelson, N.Szekeres, K.Cooper, D.Ghansah, T. Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS). Journal of visualized experiments : JoVE. (64) , 2012. http://www.ncbi.nlm.nih.gov/pubmed/22733203
  • Pilon-Thomas, S.Nelson, N.Vohra, N.Jerald, M.Pendleton, L.Szekeres, K.Ghansah, T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function. PloS one. 6(11) : e27729, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22132131
  • Kleiman, E.Carter, G.Ghansah, T.Patel, NA.Cooper, DR. Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport. Biochemical and biophysical research communications. 388(3) : 554-9, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19686698
  • Jiang, K.Apostolatos, AH.Ghansah, T.Watson, JE.Vickers, T.Cooper, DR.Epling-Burnette, PK.Patel, NA. Identification of a novel antiapoptotic human protein kinase C delta isoform, PKCdeltaVIII in NT2 cells. Biochemistry. 47(2) : 787-97, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18092819
  • Paraiso, KH.Ghansah, T.Costello, A.Engelman, RW.Kerr, WG. Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950). 178(5) : 2893-900, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17312133
  • Ghansah, T.Paraiso, KH.Highfill, S.Desponts, C.May, S.McIntosh, JK.Wang, JW.Ninos, J.Brayer, J.Cheng, F.Sotomayor, E.Kerr, WG. Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. Journal of immunology (Baltimore, Md. : 1950). 173(12) : 7324-30, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15585856
  • Cheng, F.Wang, HW.Cuenca, A.Huang, M.Ghansah, T.Brayer, J.Kerr, WG.Takeda, K.Akira, S.Schoenberger, SP.Yu, H.Jove, R.Sotomayor, EM. A critical role for Stat3 signaling in immune tolerance. Immunity. 19(3) : 425-36, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14499117
  • Wang, JW.Howson, JM.Ghansah, T.Desponts, C.Ninos, JM.May, SL.Nguyen, KH.Toyama-Sorimachi, N.Kerr, WG. Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science (New York, N.Y.). 295(5562) : 2094-7, 2002. http://www.ncbi.nlm.nih.gov/pubmed/11896280
  • Tu, Z.Ninos, JM.Ma, Z.Wang, JW.Lemos, MP.Desponts, C.Ghansah, T.Howson, JM.Kerr, WG. Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood. 98(7) : 2028-38, 2001. http://www.ncbi.nlm.nih.gov/pubmed/11567986