JinyiZhu

Jinyi Zhu, Ph.D.

Contact Info 12901 Bruce B. Downs Blvd. MDC07
Tampa, FL 33612

Academic Email: jzhu1@health.usf.edu

Education

  • Ph.D., Chemistry, University of Georgia, 2008
  • B.S., Chemistry, Nanjing University, 2002

Interdisciplinary and Emerging Signature Programs

  • Other

Research Interests

  • The Core is focused on providing a cost-effective resource to the USF and neighborhood community for expression and purification of recombinant proteins, utilizing E. coli, yeast and insect cell expression systems. A matrix buffer screening system would be applied to select suitable buffer conditions for proteins which have limited solubility. Our services also include biophysical characterization of structural and functional properties of proteins.

Recent Publications

  • Zhu, JY.Yang, Y.Han, H.Betzi, S.Olesen, SH.Marsilio, F.Schönbrunn, E. Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA). The Journal of biological chemistry. 287(16) : 12657-67, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22378791
  • Li, R.Martin, MP.Liu, Y.Wang, B.Patel, RA.Zhu, JY.Sun, N.Pireddu, R.Lawrence, NJ.Li, J.Haura, EB.Sung, SS.Guida, WC.Schonbrunn, E.Sebti, SM. Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors. Journal of medicinal chemistry. 55(5) : 2474-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22272748
  • Martin, MP.Zhu, JY.Lawrence, HR.Pireddu, R.Luo, Y.Alam, R.Ozcan, S.Sebti, SM.Lawrence, NJ.Schönbrunn, E. A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A. ACS chemical biology. 7(4) : 698-706, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22248356
  • Lee, JC.Francis, S.Dutta, D.Gupta, V.Yang, Y.Zhu, JY.Tash, JS.Schönbrunn, E.Georg, GI. Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases. The Journal of organic chemistry. 77(7) : 3082-98, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22432895
  • Lawrence, H.Martin, MP.Luo, Y.Pireddu, R.Yang, H.Gevariya, H.Ozcan, S.Zhu, JY.Kendig, R.Rodriguez, M.Elias, R.Cheng, J.Sebti, SM.Schonbrunn, E.Lawrence, NJ. Development of ortho-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora A Inhibitors. Journal of medicinal chemistry. 55(17) : 7392-416, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22803810
  • Zhu, JY.Fu, ZQ.Chen, L.Xu, H.Chrzas, J.Rose, J.Wang, BC. Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal. Acta crystallographica. Section D, Biological crystallography. 68(Pt 9) : 1242-52, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22948926
  • Pireddu, R. Forinash, KD. Sun, N. Martin, MP. Sung, SS. Alexander, B. Zhu, JY. Guida, WC. Schönbrunn, E. Sebti, SM. Lawrence, NJ. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) MedChemComm. 3(6) : 699-709, 2012.
  • Martin, MP.Alam, R.Betzi, S.Ingles, DJ.Zhu, JY.Schönbrunn, E. A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2. Chembiochem : a European journal of chemical biology. 13(14) : 2128-36, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22893598
  • Li, Y.Bahti, P.Shaw, N.Song, G.Chen, S.Zhang, X.Zhang, M.Cheng, C.Yin, J.Zhu, JY.Zhang, H.Che, D.Xu, H.Abbas, A.Wang, BC.Liu, ZJ. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Proteins. 71(4) : 2109-13, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18361456
  • Zhu, JY.Liu, L.Lu, CS.Meng, QJ Inclusion compound of beta-cyclodextrin with p-azidobenzoic acid CHINESE JOURNAL OF ORGANIC CHEMISTRY. 23(11) : 1303-05, 2003.

Positions Held

  • Postdoctoral Fellow (Dept. of Drug Discovery, H. Lee Moffitt Cancer Center 2008 - 2012)

Awards/Honors

  • Travel Grant (American Crystallographic Association - 2008)
  • Young Scientist Travel Award (International Structural Genomics Organization / the NIH Protein Structure Initiative - 2006)