CaralinaMarin De Evsikova

Caralina Marin De Evsikova, PhD

Assistant Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B. Downs Blvd., MDC 7
Tampa, FL 33612

Academic Email: cmarinde@health.usf.edu

Academic Phone: (813) 974-2248

Education

  • PhD, Neuroscience, University Of California*, 1999

Research Interests

  • The early developmental environment plays a pivotal role in susceptibility to adulthood metabolic disease, such as obesity and diabetes. The long-term goal of this project is to understand how the maternal and embryonic environment alters gene expression, which ultimately leads to disease, via epigenetics. Epigenome of each individual is established during the egg-to-embryo transition, which is sensitive to teratogens, such as alcohol, bisphenol A, or dietary exposures. To identify the role of epigenetics in metabolic disease, I am using a naturally occurring “epigenetic barometer” allele (viable yellow) of the Agouti gene in mice, whose expression is controlled by methylation levels. Nutrigenomics & Healthspan. My long-term goal is to develop new mouse models of adult-onset metabolic diseases by monitoring in vivo physiology coupled with quantitative molecular genetics to detect genes and pathways involved with weight gain. This approach has been successful in identifying changes in eating, activity, and loss of circadian rhythms underlying “normal” weight fluctuations from across the lifespan.