CaralinaMarin De Evsikova

Caralina Marin De Evsikova, PhD

Assistant Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info 12901 Bruce B. Downs Blvd., MDC 7
Tampa, FL 33612

Academic Email: cmarinde@health.usf.edu

Academic Phone: (813) 974-2248

View My C.V.

Education

  • PhD, Psychology, University Of California, Santa Barbara, 1998

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Metabolic Regulation and Disorders
  • Neuroscience
  • Women & Children's Health

Research Interests

  • The early developmental environment plays a pivotal role in susceptibility to adulthood metabolic disease, such as obesity and diabetes. The long-term goal of this project is to understand how the maternal and embryonic environment alters gene expression, which ultimately leads to disease, via epigenetics. Epigenome of each individual is established during the egg-to-embryo transition, which is sensitive to teratogens, such as alcohol, bisphenol A, or dietary exposures. To identify the role of epigenetics in metabolic disease, I am using a naturally occurring “epigenetic barometer” allele (viable yellow) of the Agouti gene in mice, whose expression is controlled by methylation levels. Nutrigenomics & Healthspan. My long-term goal is to develop new mouse models of adult-onset metabolic diseases by monitoring in vivo physiology coupled with quantitative molecular genetics to detect genes and pathways involved with weight gain. This approach has been successful in identifying changes in eating, activity, and loss of circadian rhythms underlying “normal” weight fluctuations from across the lifespan.

Recent Publications

  • Won, J., Marín de Evsikova, C.,Smith, RS.,Hicks, WL.,Edwards, MM.,Longo-Guess, C.,Li, T.,Naggert, JK.,Nishina, PM. NPHP4 is necessary for normal photoreceptor ribbon synapse maintenance and outer segment formation, and for sperm development. Human molecular genetics. 20(3) : 482-496, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21078623
  • Edwards, MM., Marín de Evsikova, C., Collin, GB., Gifford, E., Wu, J., Hicks, WL., Whiting, C., Varvel, NH., Maphis, N., Lamb, BT., Naggert, JK., Nishina, PM., Peachey, NS. Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2. Investigative ophthalmology & visual science. 51(6) : 3264-3272, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20071672
  • DeMambro, VE.Kawai, M.Clemens, TL.Fulzele, K.Maynard, JA.Marín de Evsikova, C.Johnson, KR.Canalis, E.Beamer, WG.Rosen, CJ.Donahue, LR. A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. The Journal of endocrinology. 204(3) : 241-253, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20032200
  • Matsumura, H.Kano, K.Marín de Evsikova, C.Young, JA.Nishina, PM.Naggert, JK.Naito, K. Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function. Physiological genomics. 39(2) : 120-129, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19671659
  • Yuan, R.,Tsaih, SW., Petkova, SB., Marin de Evsikova, C., Xing, S., Marion, MA., Bogue, MA., Mills, KD., Peters, LL., Bult, CJ., Rosen, CJ., Sundberg, JP., Harrison, DE., Churchill, GA., Paigen, B. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging cell. 8(3) : 277-287, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19627267
  • Evsikov, AV., Marín de Evsikova, C. Evolutionary origin and phylogenetic analysis of the novel oocyte-specific eukaryotic translation initiation factor 4E in Tetrapoda. Development genes and evolution. 219(2) : 111-118, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19089447
  • Evsikov, AV., Marín de Evsikova, C. Gene expression during the oocyte-to-embryo transition in mammals. Molecular reproduction and development. 76(9) : 805-818, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19363788
  • Kano, K., Marín de Evsikova, C., Young, J., Wnek, C., Maddatu, TP., Nishina, PM., Naggert, JK. A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse. Molecular endocrinology (Baltimore, Md.). 22(8) : 1866-1880, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18483174
  • Ackert-Bicknell, CLDemissie, S.Marín de Evsikova, C.Hsu, YH.DeMambro, VE.Karasik, D.Cupples, LA.Ordovas, JM.Tucker, KL.Cho, K.Canalis, E.Paigen, B.Churchill, GA.Forejt, J.Beamer, WG.Ferrari, S.Bouxsein, ML.Kiel, DP.Rosen, CJ. PPARG by dietary fat interaction influences bone mass in mice and humans. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 23(9) : 1398-1408, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18707223