AlexeiEvsikov

Alexei Evsikov, PhD

Assistant Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Contact Info Department of Molecular Medicine
12901 Bruce B. Downs Blvd., MDC 7
Tampa, FL 33612

Academic Email: aevsikov@health.usf.edu

Academic Phone: (813) 974-6922

Education

  • PhD, Molecular Genetics, Ukrainian National Academy Of Sciences, 1997
  • Ph.D., Molecular Genetics, Institute of Molecular Biology and Genetics, 1997
  • M.Sc., Cytology and Genetics, Novosibirsk State University, 1993
  • B.S., Biology, Novosibirsk State University, 1991

Research Interests

  • The focus of our research program is to understand three seemingly disparate levels of biological organization during gametogenesis and early development: the molecular signatures for totipotency at the beginning of life, their variation among species, and their involvement as mechanisms of evolutionary change. We use comparative genomics and wet-lab approaches to understand how and why speciation primarily affects reproduction and its functions. Our approach provides a conceptual framework for personalized genomic medicine in human reproductive health.

Recent Publications

  • Taşkesen M, Collin GB, Evsikov AV, Güzel A, Özgül RK, Marshall JD, Naggert JK Novel Alu retrotransposon insertion leading to Alström syndrome. Hum Genet. 131(3) : 407-413, 2012. http://www.ncbi.nlm.nih.gov/pubmed/21877133
  • Bult CJ, Drabkin HJ, Evsikov A, Natale D, Arighi C, Roberts N, Ruttenberg A, D'Eustachio P, Smith B, Blake JA, Wu C The representation of protein complexes in the Protein Ontology (PRO). BMC Bioinformatics. 12: 371, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21929785
  • Staier F, Eipel H, Matula P, Evsikov AV, Kozubek M, Cremer C, Hausmann M Micro axial tomography: a miniaturized, versatile stage device to overcome resolution anisotropy in fluorescence light microscopy. Rev Sci Instrum. 82(9) : 093701, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21974588
  • Natale DA, Arighi CN, Barker WC, Blake JA, Bult CJ, Caudy M, Drabkin HJ, D'Eustachio P, Evsikov AV,Huang H, Nchoutmboube J, Roberts NV, Smith B, Zhang J, Wu CH The Protein Ontology: a structured representation of protein forms and complexes. Nucleic Acids Res. 39(Database issue) : D539-D545, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20935045
  • Ratzan WJ, Evsikov AV, Okamura Y, Jaffe LA Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence. J Cell Physiol. 226(11) : 2740-2746, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21618529
  • Bui LC, Evsikov AV, Khan DR, Archilla C, Peynot N, Hénaut A, Le Bourhis D, Vignon X, Renard JP, Duranthon V Retrotransposon expression as a defining event of genome reprogramming in fertilized and cloned bovine embryos. Reproduction. 138(2) : 289-299, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19465487
  • Evsikov AV, Marín de Evsikova C Gene expression during the oocyte-to-embryo transition in mammals. Mol Reprod Dev. 76(9) : 805-818, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19363788
  • Evsikov AV, Marín de Evsikova C Evolutionary origin and phylogenetic analysis of the novel oocyte-specific eukaryotic translation initiation factor 4E in Tetrapoda. Dev Genes Evol. 219(2) : 111-118, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19089447
  • Evsikov AV, Dolan ME, Genrich MP, Patek E, Bult CJ MouseCyc: a curated biochemical pathways database for the laboratory mouse. Genome Biol. 10(8) : R84, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19682380
  • de Vries WN, Evsikov AV, Brogan LJ, Anderson CP, Graber JH, Knowles BB, Solter D Reprogramming and differentiation in mammals: motifs and mechanisms. Cold Spring Harb Symp Quant Biol. 73: 33-38, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19022741
  • Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Genes Dev. 20(19) : 2713-2727, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17015433
  • Evsikov AV, de Vries WN, Peaston AE, Radford EE, Fancher KS, Chen FH, Blake JA, Bult CJ, Latham KE, Solter D, Knowles BB Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res. 105(2-4) : 240-250, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15237213
  • De Vries WN, Evsikov AV, Haac BE, Fancher KS, Holbrook AE, Kemler R, Solter D, Knowles BB Maternal beta-catenin and E-cadherin in mouse development. Development. 131(18) : 4435-4445, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15306566
  • Peaston AE, Evsikov AV, Graber JH, de Vries WN, Holbrook AE, Solter D, Knowles BB Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos. Dev Cell. 7(4) : 597-606, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15469847
  • Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science. 306(5703) : 1947-1950, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15591206
  • Solter D, Hiiragi T, Evsikov AV, Moyer J, De Vries WN, Peaston AE, Knowles BB Epigenetic mechanisms in early mammalian development. Cold Spring Harb Symp Quant Biol. 69: 11-17, 2004. http://www.ncbi.nlm.nih.gov/pubmed/16117628
  • Knowles BB, Evsikov AV, de Vries WN, Peaston AE, Solter D Molecular control of the oocyte to embryo transition. Philos Trans R Soc Lond B Biol Sci. 358(1436) : 1381-1387, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14511485
  • Evsikov AV, Solter D Comment on "'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Science. 302(5644) : 393, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14563991
  • Evsikov AV The regulatory mechanisms of early embryogenesis in the mouse. Ontogenez. 31(3) : 178-191, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10867932
  • Evsikov AV, Solomko AP The levels and patterns of translation in mouse preimplantation embryos with repressed cytokinesis. Ontogenez. 30(2) : 103-109, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10368822
  • Evsikov AV, Solomko AP Changes in the cavitation start time in chimeric CB6F1 <--> BALB/c embryos. Tsitol Genet. 32(3) : 84-87, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9879108
  • Evsikov AV, Evsikov SV The first and second polar bodies in mouse oogenesis. Ontogenez. 26(3) : 196-200, 1995. http://www.ncbi.nlm.nih.gov/pubmed/7666995
  • Evsikov SV, Evsikov AV Preimplantation development of manipulated mouse zygotes fused with the second polar bodies: a cytogenetic study. Int J Dev Biol. 38(4) : 725-730, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7779694

Positions Held

  • Associate Research Scientist The Jackson Laboratory 2004 - 2011)
  • Postdoc The Jackson Laboratory 2000 - 2004)