ShellyDeforte

Shelly Deforte

Graduate Research Assistant, College Of Medicine Molecular Medicine

Academic Email: sdeforte@health.usf.edu

Education

  • MSc, Biomathematics, Florida State University, 2010
  • BSc, Biomathematics, Florida State University, 2008

Research Interests

  • We study the structural and un-structural biology of proteins from an amino acid sequence based perspective. Both experimental evidence of intrinsically disordered regions in proteins, as well as computationally predicted regions of disorder, are used to study patterns in complete proteomes using bioinformatics approaches. Intrinsically disordered regions display different amino acid compositions, and different amino acid patterns than do structured regions. Furthermore, the distribution of intrinsic disorder throughout a protein deviates distinctively from random. Using innovative methods that exploit the unique properties of disordered regions, we are looking for subtle biomarkers of function and dysfunction within large bodies of protein sequence data. Currently, we are pursuing the role of disordered regions in enzyme function, and examining the unique properties of proteins associated with aging.