NehaWoods

Neha Woods, PhD

College Of Medicine Molecular Medicine

Contact Info Byrd Alzheimer's Institute
4001 East Fletcher Avenue
Tampa, FL 33613

Academic Email: nkabra@health.usf.edu

Academic Phone: (813) 396-0000

Education

  • PhD, Cancer Biology, University Of South Florida, 2010
  • MS, Genetics, University of Delhi, 2004

Research Interests

  • My current research focuses on understanding the role of the Amyloid Precursor Protein (APP) in pancreatic cancer. It is well known that pancreatic cancer has a poor prognosis and very low 5-year survival rates. Early detection poses a challenge mainly owing to the location of this organ and a non-symptomatic progression. At the molecular level, the oncogene RAS is known to be mutated and overexpressed in this cancer and the signaling pathways are somewhat understood. Using several pancreatic cancer cells lines, our recent findings show that APP is overexpressed in most pancreatic cancer cells lines as well. Preliminary studies have shown that APP can regulate RAS transcription levels and knock down of APP can inhibit RAS protein expression. Using this information, my project aims to understand the mechanism of regulation of RAS by APP and to establish APP, its processed fragments, and associated signaling pathways as possible targets for drug development against pancreatic cancer.