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Ryan Green, M.S.

Graduate Research Assistant, College Of Medicine Molecular Medicine

Contact Info 15501 Bruce B Downs Blvd.
Tampa, FL 33647

Academic Email: rgreen1@health.usf.edu

Academic Phone: (813) 546-1456

Education

  • MS, Biotechnology, USF, 2011
  • BS, Biology, FAU, 2010

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease

Research Interests

  • Cancer therapy is often initially successful only to be followed by recurrence of drug resistant disease. I am interested in studying this phenomenon. Work in my lab has revealed an important signaling pathway involved in tumorigenesis: natriuretic peptide receptor A (NPRA). The loss of NPRA signaling reduces angiogenesis and tumor growth and NPRA modulates the homing of somatic stem cells to tumors by altering the expression of C-X-C chemokine receptor 4. We have also developed a 3D fibrous scaffold to use as a cell culture environment. I would like to apply these findings to the study of cancer stem cells. CSCs are a sub population of cancer cells that express stem cell transcription factors associated with-self renewal, are drug resistant and initiate metastasis. My hypothesis is that NPRA signaling modulates CXCR4 expression in cancer cells leading to metastasis and an increase in the CSC population. I will also investigate the effects of 3D culture on the CSC population.

Memberships

  • American Heart Association (Student/Trainee, 2014 - Present)

Recent Publications

  • Kovacs G, Breydo L, Green R, Kis V, Puska G, Lőrincz P, Perju-Dumbrava L, Giera R, Pirker W, Lutz M, Lachmann I, Budka H, Uversky VN, Molnár K, László L Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread Neurobiology of Disease. 69: 76-92, 2014.
  • Girard, YK.Wang, C.Ravi, S.Howell, MC.Mallela, J.Alibrahim, M.Green, R.Hellermann, G.Mohapatra, SS.Mohapatra, S. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PloS one. 8(10) : e75345, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24146752
  • MARK HOWELL, RYAN GREEN, ALEXIS KILLEEN, LAMAR WEDDERBURN, VINCENT PICASCIO, ALEJANDRO RABIONET,ZHENLING PENG, MAYA LARINA, BIN XUE, LUKASZ KURGAN, VL NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS Journal of Biological Systems. 20(4) : 471-511, 2012.