LauraHamel

Laura Hamel, MS

Graduate Research Assistant, College Of Medicine Molecular Medicine

Research Assistant, Molecular Medicine, University of South Florida

Contact Info 12901 Bruce B. Downs Blvd.
MDC 07
Tampa, FL 33612

Academic Email: lhamel@health.usf.edu

Academic Phone: (813) 974-5747

View My C.V.

Education

  • MS, Molecular Medicine, University of South Florida, 2012
  • MS, Pharmacology and Toxicology, University of Rhode Island, 2009
  • BS, Biochemistry, University of New Hampshire, 2006

Research Interests

  • Our lab is focused on understanding palmitoylation, a post-translational modification of Ras (an oncogene implicated in ~30% of all cancers, and up to 90% in specific cancer types) involved in its localization to the plasma membrane where Ras elicits a majority of its activity.
  • My project focuses on understanding the regulation of Ras palmitoylation in three ways. Initially, I used a candidate based approach to screen for the enzyme responsible for Ras depalmitoylation. More recently, I have been screening mutants of the enzyme that palmitoylated Ras to see the effect of the mutations on activity, and finally, I will perform high-through put inhibitor screens in an attempt to identify inhibitors of Ras palmitoylation.

Memberships

  • AMSGS (President, 2013 - Present)
  • AMSGS (Vice President, 2012 - 2013)
  • AMSGS (Secretary, 2011 - 2012)
  • AMSGS (Member, 2010 - 2011)

Recent Publications

  • Laura D. Hamel, Robert J. Deschenes, David A. MitchellCorresponding author contact information A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening Analytical Biochemistry. , 2014.
  • Mitchell DA, Hamel LD, Reddy KD, Farh L, Rettew LM, Sanchez PR, Deschenes RJ Mutations in the X-Linked Intellectual Disability Gene, zDHHC9, Alter Autopalmitoylation Activity by Distinct Mechanisms. J Biol Chem. , 2014.
  • Anna Lüning, Julia Schur, Laura Hamel, Ingo Ott, Axel Klein Strong Cytotoxicity of Organometallic Platinum Complexes with Alkynyl Ligands Organometallics. 13(32) : 3662–3672, 2013.
  • Mitchell DA, Hamel LD, Ishizuka K, Mitchell G, Schaefer LM, Deschenes RJ. The Erf4 subunit of the yeast Ras palmitoyl acyltransferase is required for stability of the Acyl-Erf2 intermediate and palmitoyl transfer to a Ras2 substrate J Biol Chem. 287(41) : 34337-48, 2012.
  • Linnea Anderson, Ann Dring, Laura Hamel, Matthew Stoner Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR) Toxicology Letters. 202(2) : 148-54, 2011.
  • Axel Klein, Anna Lüning, Ingo Ott, Laura Hamel, Michael Neugebauer, Katharina Butsch, Verena Lingen, Frank Heinrich, Said Elmas Organometallic palladium and platinum complexes with strongly donating alkyl co-ligands - Synthesis, structures, chemical and cytotoxic properties J. Organomet. Chem. 695(15-16) : 1898-1905, 2010.

Positions Held

  • Research Fellow (Pharmaceutical Chemistry, Technische Universität Braunschweig 2009 - 2010)
  • Research Assistant (Pharmacology and Toxicology, University of Rhode Island 2006 - 2009)

Awards/Honors

  • Travel Award (FASEB - 2011)
  • International Research Fellow (Technische Universität Braunschweig - 2009)