JayaPadmanabhan

Jaya Padmanabhan, Ph.D.

Assistant Professor, College Of Medicine Molecular Medicine

College Of Medicine Molecular Medicine

Assistant Professor/Courtesy, CMMB, College of Arts and Sciences, USF

Assistant Professor, Department of Molecular Medicine, USF College of Medicine, Johnnie B. Byrd, Sr. Alzheimer's Center and Research Institute

Assistant Professor, Molecular Medicne, COM, USF Health Byrd Institute

Contact Info USF Health Byrd Alzheimer's Institute
4001 E. Fletcher Ave.
Tampa, FL 33613

Academic Email: jpadmana@health.usf.edu

Academic Phone: (813) 396-0721

View My C.V.

Education

  • PHD, Biochemistry, University Of Kerala, 1989
  • M.Sc., Biochemistry, University of Kerala, 1982
  • B.Sc., Chemistry, University of Kerala, 1980

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Neurodegenerative Disease

Research Interests

  • Our lab is interested in determining the molecular mechanisms involved in neurodegeneration associated with Alzheimer's disease (AD). Specifically, we are examining the role of cell cycle regulatory proteins and inflammatory proteins in neuritic plaque and neurofibrillary tangle formation. Experimental systems include transgenic mice and in vitro cultured transformed cells and primary neurons. While aberrant cell cycle activation is a characteristic feature of cancer progression, deregulated expression of cell cycle proteins in terminally differentiated neurons leads to catastrophe. Our recent studies showed that amyloid precursor protein (APP), which is associated with Alzheimer's disease may play a role in cancer progression. We are currently performing experiments to establish a correlative link between neurodegeneration and oncogenesis.

Memberships

  • Society for Neuroscience (Member, 2008 - Present)
  • AAAS (Member, 2006 - Present)

Recent Publications

  • Tyagi, E.Fiorelli, T.Norden, M.Padmanabhan, J. Alpha 1-Antichymotrypsin, an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer's Disease, Induces Tau Hyperphosphorylation through c-Jun N-Terminal Kinase Activation. International journal of Alzheimer's disease. 2013: 606083, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24175110
  • Woods, NK.Padmanabhan, J. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. The Journal of biological chemistry. 288(42) : 30114-24, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24022491
  • Fiorelli, T.Kirouac, L.Padmanabhan, J. Altered processing of amyloid precursor protein in cells undergoing apoptosis. PloS one. 8(2) : e57979, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23469123
  • Woods, NK.Padmanabhan, J. Neuronal calcium signaling and Alzheimer's disease. Advances in experimental medicine and biology. 740: 1193-217, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22453989
  • Chaput, D.Kirouac, LH.Bell-Temin, H.Stevens, SM.Padmanabhan, J. SILAC-based proteomic analysis to investigate the impact of amyloid precursor protein expression in neuronal-like B103 cells. Electrophoresis. 33(24) : 3728-37, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23161580
  • Judge, M.Hornbeck, L.Potter, H.Padmanabhan, J. Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes. Molecular neurodegeneration. 6: 80, 2011. http://www.ncbi.nlm.nih.gov/pubmed/22112898
  • Borysov, SI.Granic, A.Padmanabhan, J.Walczak, CE.Potter, H. Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors. Cell cycle (Georgetown, Tex.). 10(9) : 1397-410, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21566458
  • Abisambra, JF.Fiorelli, T.Padmanabhan, J.Neame, P.Wefes, I.Potter, H. LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease. PloS one. 5(1) : e8556, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20049331
  • Boyd, TD.Bennett, SP.Mori, T.Governatori, N.Runfeldt, M.Norden, M.Padmanabhan, J.Neame, P.Wefes, I.Sanchez-Ramos, J.Arendash, GW.Potter, H. GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice. Journal of Alzheimer's disease : JAD. 21(2) : 507-18, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20555144
  • Granic, A.Padmanabhan, J.Norden, M.Potter, H. Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Molecular biology of the cell. 21(4) : 511-20, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20032300
  • Bennett, SP.Boyd, TD.Norden, M.Padmanabhan, J.Neame, P.Wefes, I.Potter, H. A novel technique for simultaneous bilateral brain infusions in a mouse model of neurodegenerative disease. Journal of neuroscience methods. 184(2) : 320-6, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19732796
  • Padmanabhan, J. Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining. Methods in molecular biology (Clifton, N.J.). 523: 311-22, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19381929
  • Boeras, DI.Granic, A.Padmanabhan, J.Crespo, NC.Rojiani, AM.Potter, H. Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiology of aging. 29(3) : 319-28, 2008. http://www.ncbi.nlm.nih.gov/pubmed/17169464
  • Padmanabhan, J.Brown, K.Shelanski, ML. Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures. Developmental neurobiology. 67(6) : 818-26, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17443827
  • Dasgupta, P.Padmanabhan, J.Chellappan, S. Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: role in oncogenesis. Current molecular medicine. 6(7) : 719-29, 2006. http://www.ncbi.nlm.nih.gov/pubmed/17100598
  • Padmanabhan, J.Levy, M.Dickson, DW.Potter, H. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain : a journal of neurology. 129(Pt 11) : 3020-34, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16987932
  • Dasgupta, P.Sun, J.Wang, S.Fusaro, G.Betts, V.Padmanabhan, J.Sebti, SM.Chellappan, SP. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Molecular and cellular biology. 24(21) : 9527-41, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15485920
  • Wang, S.Fusaro, G.Padmanabhan, J.Chellappan, SP. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene. 21(55) : 8388-96, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12466959
  • Padmanabhan, J.Clayton, D.Shelanski, ML. Dibutyryl cyclic AMP-induced process formation in astrocytes is associated with a decrease in tyrosine phosphorylation of focal adhesion kinase and paxillin. Journal of neurobiology. 39(3) : 407-22, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10363913
  • Padmanabhan, J.Park, DS.Greene, LA.Shelanski, ML. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19(20) : 8747-56, 1999. http://www.ncbi.nlm.nih.gov/pubmed/10516294
  • Park, DS.Morris, EJ.Padmanabhan, J.Shelanski, ML.Geller, HM.Greene, LA. Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. The Journal of cell biology. 143(2) : 457-67, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9786955
  • Padmanabhan, J.Shelanski, ML. Process formation in astrocytes: modulation of cytoskeletal proteins. Neurochemical research. 23(3) : 377-84, 1998. http://www.ncbi.nlm.nih.gov/pubmed/9482250
  • Rao, KM.Padmanabhan, J.Kilby, DL.Cohen, HJ.Currie, MS.Weinberg, JB. Flow cytometric analysis of nitric oxide production in human neutrophils using dichlorofluorescein diacetate in the presence of a calmodulin inhibitor. Journal of leukocyte biology. 51(5) : 496-500, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1602242
  • Rao, KM.Currie, MS.Padmanabhan, J.Cohen, HJ. Age-related alterations in actin cytoskeleton and receptor expression in human leukocytes. Journal of gerontology. 47(2) : B37-44, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1538058
  • Rao, KM.Padmanabhan, J.Cohen, HJ. Cytochalasins induce actin polymerization in human leukocytes. Cell motility and the cytoskeleton. 21(1) : 58-64, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1540992

Positions Held

  • Associate Professor Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2007 - 2008)
  • Assistant Professor/Courtesy Faculty (Department of Molecular Medicine, College of Medicine, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2006 - 2007)
  • Co-appointment as Assistant Professor (Department of Biochemistry and Molecular Biology, USF College of Medicine, Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute 2004 - 2006)
  • Research Assistant Professor (Department of Biochemistry and Molecular Biology, University of South Florida 2002 - 2004)
  • Post Doctoral Staff Associate (Department of Pathology, Columbia University 1992 - 2001)
  • Post Doctoral Training (Division of Cardiology, Dept. of Medicine, Duke University 1991 - 1992)
  • Post Doctoral Training (Division of Geriatrics, Dept. of Medicine, Duke University 1988 - 1991)